ATE341554T1 - Cephemverbindungen und medikamente die diese verbindungen enthalten - Google Patents
Cephemverbindungen und medikamente die diese verbindungen enthaltenInfo
- Publication number
- ATE341554T1 ATE341554T1 AT97914600T AT97914600T ATE341554T1 AT E341554 T1 ATE341554 T1 AT E341554T1 AT 97914600 T AT97914600 T AT 97914600T AT 97914600 T AT97914600 T AT 97914600T AT E341554 T1 ATE341554 T1 AT E341554T1
- Authority
- AT
- Austria
- Prior art keywords
- optionally substituted
- compounds
- single bond
- substituted lower
- cephem
- Prior art date
Links
- -1 CEPHEM COMPOUNDS Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000001782 cephems Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000003367 polycyclic group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8253196 | 1996-04-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE341554T1 true ATE341554T1 (de) | 2006-10-15 |
Family
ID=13777098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97914600T ATE341554T1 (de) | 1996-04-04 | 1997-04-04 | Cephemverbindungen und medikamente die diese verbindungen enthalten |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6214818B1 (cg-RX-API-DMAC7.html) |
| EP (3) | EP0893446B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4064462B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20000005238A (cg-RX-API-DMAC7.html) |
| CN (2) | CN1088711C (cg-RX-API-DMAC7.html) |
| AT (1) | ATE341554T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2178497A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2250002C (cg-RX-API-DMAC7.html) |
| DE (1) | DE69736775T2 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2273364T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO1997037996A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998022469A1 (en) * | 1996-11-22 | 1998-05-28 | Meiji Seika Kaisha, Ltd. | Cephem intermediates and process for producing the same |
| EP1394159A1 (fr) * | 2002-08-13 | 2004-03-03 | Warner-Lambert Company LLC | Nouveaux dérivés de thiophène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent |
| TW200637559A (en) * | 2005-03-29 | 2006-11-01 | Shionogi & Co | 3-propenylcefem derivative |
| US20080021026A1 (en) * | 2006-07-20 | 2008-01-24 | Mehmet Kahraman | Benzothiophene inhibitors of rho kinase |
| CN101153028B (zh) * | 2006-09-30 | 2010-12-15 | 山东轩竹医药科技有限公司 | 具有抗菌抗病毒活性的化合物 |
| WO2013019561A1 (en) * | 2011-07-29 | 2013-02-07 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
| UA115532C2 (uk) | 2011-07-29 | 2017-11-27 | Каріофарм Терапеутікс, Інк. | Модулятори нуклеарного транспорту, що містять гідразид, і їхнє застосування |
| PL3616695T3 (pl) | 2011-09-09 | 2025-03-10 | Merck Sharp & Dohme Llc | Ceftolozan/tazobaktam do leczenia zakażeń wewnątrzpłucnych |
| KR102163377B1 (ko) | 2012-05-09 | 2020-10-08 | 바이오젠 엠에이 인코포레이티드 | 핵 수송 조절인자 및 이의 용도 |
| US8809314B1 (en) | 2012-09-07 | 2014-08-19 | Cubist Pharmacueticals, Inc. | Cephalosporin compound |
| US8476425B1 (en) | 2012-09-27 | 2013-07-02 | Cubist Pharmaceuticals, Inc. | Tazobactam arginine compositions |
| US9872906B2 (en) | 2013-03-15 | 2018-01-23 | Merck Sharp & Dohme Corp. | Ceftolozane antibiotic compositions |
| EP2968278B8 (en) | 2013-03-15 | 2019-05-22 | Karyopharm Therapeutics Inc. | Methods of promoting wound healing using crm1 inhibitors |
| LT2893929T (lt) | 2013-03-15 | 2025-06-10 | Merck Sharp & Dohme Llc | Ceftolozano antibiotiko kompozicijos |
| US20140275000A1 (en) | 2013-03-15 | 2014-09-18 | Cubist Pharmaceuticals, Inc. | Ceftolozane pharmaceutical compositions |
| AU2014284168B2 (en) | 2013-06-21 | 2018-10-25 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| EP3043797B1 (en) | 2013-09-09 | 2020-04-08 | Merck Sharp & Dohme Corp. | Treating infections with ceftolozane/tazobactam in subjects having impaired renal function |
| US20150094293A1 (en) | 2013-09-27 | 2015-04-02 | Calixa Therapeutics, Inc. | Solid forms of ceftolozane |
| WO2016025904A1 (en) | 2014-08-15 | 2016-02-18 | Karyopharm Therapeutics Inc. | Polymorphs of selinexor |
| EP3397634A1 (en) | 2015-12-31 | 2018-11-07 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
| US10526295B2 (en) | 2015-12-31 | 2020-01-07 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| US11602530B2 (en) | 2016-11-28 | 2023-03-14 | Biogen Ma Inc. | CRM1 inhibitors for treating epilepsy |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5271239A (en) * | 1975-12-10 | 1977-06-14 | Matsushita Electric Ind Co Ltd | Electron beam sensitive material |
| DE3118732A1 (de) * | 1981-05-12 | 1982-12-02 | Hoechst Ag, 6000 Frankfurt | Cephalosporinderivate und verfahren zu ihrer herstellung |
| DE3207840A1 (de) * | 1982-03-04 | 1983-09-15 | Hoechst Ag, 6230 Frankfurt | "cephalosporinderivate und verfahren zu ihrer herstellung" |
| JPS6064988A (ja) * | 1983-09-21 | 1985-04-13 | Sankyo Co Ltd | セフアロスポリン誘導体 |
| JPS60237090A (ja) * | 1984-02-21 | 1985-11-25 | Takeda Chem Ind Ltd | セフエム化合物 |
| GB8520155D0 (en) * | 1985-08-10 | 1985-09-18 | Beecham Group Plc | Compounds |
| JPS62158290A (ja) * | 1985-12-28 | 1987-07-14 | Banyu Pharmaceut Co Ltd | 新規セフアロスポリン誘導体 |
| JPS62158291A (ja) * | 1986-01-07 | 1987-07-14 | Sagami Chem Res Center | セフアロスポリン誘導体 |
| JPH0459730A (ja) * | 1990-06-26 | 1992-02-26 | Dai Ichi Seiyaku Co Ltd | セフェム系抗生物質含有凍結乾燥製剤 |
| US5202321A (en) * | 1991-06-13 | 1993-04-13 | Merck Frosst Canada, Inc. | Thiopyrano[2,3,4-c,d]indoles as inhibitors of leukotriene biosynthesis |
| JPH05217239A (ja) * | 1991-10-31 | 1993-08-27 | Sony Corp | 光磁気ディスク記録再生装置 |
| EP0554004A3 (en) * | 1992-01-27 | 1993-11-24 | Katayama Seisakusho | Cephem compounds and antibacterial agents |
| JPH0741485A (ja) * | 1993-07-30 | 1995-02-10 | Katayama Seiyakushiyo:Kk | セフェム誘導体およびそれを含有する抗菌剤 |
-
1997
- 1997-04-04 EP EP97914600A patent/EP0893446B1/en not_active Expired - Lifetime
- 1997-04-04 US US09/147,074 patent/US6214818B1/en not_active Expired - Fee Related
- 1997-04-04 AT AT97914600T patent/ATE341554T1/de not_active IP Right Cessation
- 1997-04-04 CN CN97193623A patent/CN1088711C/zh not_active Expired - Fee Related
- 1997-04-04 EP EP05006670A patent/EP1544197A1/en not_active Withdrawn
- 1997-04-04 AU AU21784/97A patent/AU2178497A/en not_active Abandoned
- 1997-04-04 EP EP06005931A patent/EP1671966A1/en not_active Withdrawn
- 1997-04-04 WO PCT/JP1997/001161 patent/WO1997037996A1/ja not_active Ceased
- 1997-04-04 ES ES97914600T patent/ES2273364T3/es not_active Expired - Lifetime
- 1997-04-04 CA CA002250002A patent/CA2250002C/en not_active Expired - Fee Related
- 1997-04-04 DE DE69736775T patent/DE69736775T2/de not_active Expired - Fee Related
- 1997-04-04 KR KR1019980707925A patent/KR20000005238A/ko not_active Ceased
- 1997-04-04 JP JP53604897A patent/JP4064462B2/ja not_active Expired - Fee Related
-
2000
- 2000-08-03 US US09/631,947 patent/US6458950B1/en not_active Expired - Fee Related
- 2000-08-15 CN CN00124231A patent/CN1129596C/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0893446B1 (en) | 2006-10-04 |
| CN1129596C (zh) | 2003-12-03 |
| JP4064462B2 (ja) | 2008-03-19 |
| DE69736775D1 (de) | 2006-11-16 |
| EP0893446A4 (cg-RX-API-DMAC7.html) | 1999-01-27 |
| KR20000005238A (ko) | 2000-01-25 |
| EP1671966A1 (en) | 2006-06-21 |
| DE69736775T2 (de) | 2007-08-23 |
| EP1544197A1 (en) | 2005-06-22 |
| WO1997037996A1 (en) | 1997-10-16 |
| US6458950B1 (en) | 2002-10-01 |
| CN1290702A (zh) | 2001-04-11 |
| CN1088711C (zh) | 2002-08-07 |
| ES2273364T3 (es) | 2007-05-01 |
| CA2250002C (en) | 2008-03-25 |
| EP0893446A1 (en) | 1999-01-27 |
| CA2250002A1 (en) | 1997-10-16 |
| US6214818B1 (en) | 2001-04-10 |
| AU2178497A (en) | 1997-10-29 |
| CN1215403A (zh) | 1999-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |