ATE334226T1 - Immobilisierung von molekülen auf oberflächen über polymerbürsten - Google Patents

Immobilisierung von molekülen auf oberflächen über polymerbürsten

Info

Publication number
ATE334226T1
ATE334226T1 AT00909103T AT00909103T ATE334226T1 AT E334226 T1 ATE334226 T1 AT E334226T1 AT 00909103 T AT00909103 T AT 00909103T AT 00909103 T AT00909103 T AT 00909103T AT E334226 T1 ATE334226 T1 AT E334226T1
Authority
AT
Austria
Prior art keywords
polymer
immobilization
molecules
polymer brushes
multitude
Prior art date
Application number
AT00909103T
Other languages
German (de)
English (en)
Inventor
Holger Klapproth
Oswald Prucker
Juergen Ruehe
Original Assignee
Micronas Holding Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP99104278A external-priority patent/EP1035218A1/en
Application filed by Micronas Holding Gmbh filed Critical Micronas Holding Gmbh
Application granted granted Critical
Publication of ATE334226T1 publication Critical patent/ATE334226T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/545—Synthetic resin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00529—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00608—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polymerisation Methods In General (AREA)
  • Polymerization Catalysts (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Materials For Medical Uses (AREA)
AT00909103T 1999-01-25 2000-01-25 Immobilisierung von molekülen auf oberflächen über polymerbürsten ATE334226T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99101340 1999-01-25
EP99104278A EP1035218A1 (en) 1999-03-03 1999-03-03 Immobilization of molecules on surfaces via polymer brushes

Publications (1)

Publication Number Publication Date
ATE334226T1 true ATE334226T1 (de) 2006-08-15

Family

ID=26152863

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00909103T ATE334226T1 (de) 1999-01-25 2000-01-25 Immobilisierung von molekülen auf oberflächen über polymerbürsten

Country Status (8)

Country Link
US (1) US7250253B1 (https=)
EP (1) EP1144677B1 (https=)
JP (1) JP4970654B2 (https=)
AT (1) ATE334226T1 (https=)
AU (1) AU3150400A (https=)
CA (1) CA2360027A1 (https=)
DE (1) DE60029561T2 (https=)
WO (1) WO2000043539A2 (https=)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60027309T2 (de) 1999-07-02 2006-08-31 Symyx Technologies, Inc., Santa Clara Polymerverzweigungen zur immobilisierung von molekülen auf oberflächen oder substraten, wobei die polymere wasserlösliche oder wasserdispergierbare segmente und sonden aufweisen
KR100608152B1 (ko) * 1999-07-07 2006-08-04 미러스 코포레이션 고체 지지체 상에 핵산을 고정시키기 위한 기판
CA2317179A1 (en) 1999-09-01 2001-03-01 Affymetrix, Inc. Macromolecular arrays on polymeric brushes and methods for preparing the same
FR2802550B1 (fr) * 1999-12-17 2004-03-05 Centre Nat Rech Scient Biopuces, preparation et utilisations
DE60033648T2 (de) * 2000-07-27 2007-11-08 Micronas Holding Gmbh Auf einer Oberfläche befestigte polyfunktionelle Polymernetzwerke für Sensorchips
ATE316581T1 (de) 2000-09-05 2006-02-15 Zeltz Patrick Dr Verfahren zur spezifischen bestimmung von dna- sequenzen mittels paralleler amplifikation
ATE355526T1 (de) * 2000-10-31 2006-03-15 Micronas Gmbh Gemusterte polymeroberflächen geeignet für biokonjugationen und verfahren zu ihrer herstellung
WO2002056021A2 (en) * 2001-01-10 2002-07-18 Symyx Technologies Inc Polymer brushes for immobilizing molecules to a surface
US20030068317A1 (en) * 2001-04-20 2003-04-10 William Lee High capacity methods for separation, purification, concentration, immobilization and synthesis of compounds and applications based thereupon
EP1572896A4 (en) * 2001-07-30 2006-06-07 Angiotech Biocoatings Corp PFROPFPOLYMERMATRIZES
AU2002361223A1 (en) * 2001-08-27 2003-03-18 Zeptosens Ag Bioanalytical recognition surface with optimised recognition element density
US6867295B2 (en) 2001-09-07 2005-03-15 Dionex Corporation Ion exchange cryptands covalently bound to substrates
AU2002360298A1 (en) * 2001-12-10 2003-06-23 Emembrane, Inc. Functionalized materials and libraries thereof
JP2003294742A (ja) * 2002-03-29 2003-10-15 Inst Of Physical & Chemical Res ハイブリダイゼーション用基板及びその使用方法
US20060111517A1 (en) * 2002-08-08 2006-05-25 Hans-Dieter Feucht Recognition layers made of hydrogel based on polyacrylamide for use in biosensor technology
DE60312525T2 (de) * 2002-08-09 2007-12-06 Ottawa Health Research Institute, Ottawa Biosynthetische matrix und deren verwendung
AU2003270769A1 (en) * 2002-09-18 2004-04-08 Emembrane, Inc. Functionalized materials and methods of using same
DE10245435B4 (de) 2002-09-27 2006-03-16 Micronas Gmbh Vorrichtung zur Detektion mindestens eines in einer zu untersuchenden Probe enthaltenen Liganden
DE10328730B4 (de) * 2003-06-25 2006-08-17 Micronas Gmbh Verfahren zum Herstellen eines Microarrays und Vorrichtung zum Versehen eines Trägers für ein Microarray mit Beschichtungsstoffen
US7354706B2 (en) 2003-09-09 2008-04-08 The Regents Of The University Of Colorado, A Body Corporate Use of photopolymerization for amplification and detection of a molecular recognition event
US20090163375A1 (en) 2003-09-09 2009-06-25 Bowman Christopher N Use of Photopolymerization for Amplification and Detection of a Molecular Recognition Event
DE102004010430A1 (de) 2004-03-01 2005-09-22 Rühe, Jürgen, Prof. Dr. Verfahren zur kovalenten Immobilisierung von Biomolekülen an organischen Oberflächen
US7514764B2 (en) * 2005-03-23 2009-04-07 Wisconsin Alumni Research Foundation Materials and methods for creating imaging layers
DE102005022782A1 (de) 2005-05-12 2006-11-16 Tesa Ag Haftklebemassen und Verfahren zu deren Herstellung
WO2006128644A1 (en) * 2005-05-30 2006-12-07 Giovanna Pirri Polymer coating and functionalization of solid surfaces
US8357433B2 (en) 2005-06-14 2013-01-22 Siemens Energy, Inc. Polymer brushes
US7862886B2 (en) * 2005-08-12 2011-01-04 Fujifilm Corporation Optical film, antireflection film, processes for producing the same, and polarizing plate and display employing the same
EP1811300B1 (de) 2005-12-23 2008-11-12 Micronas GmbH Sensorchip mit in einem Polymer-Netzwerk eingelagerten Rezeptoren
KR100838124B1 (ko) * 2007-02-01 2008-06-13 포항공과대학교 산학협력단 생체적합성 지방족 브러쉬 고분자 및 그 제조 방법
DE102008032570A1 (de) 2008-07-11 2010-01-14 Tesa Se Haftklebemassen und Verfahren zu deren Herstellung
EP2192409B1 (en) 2008-11-26 2014-04-23 Corning Incorporated Label independent detection biosensor composition and methods thereof
DE102009060626A1 (de) 2009-12-24 2011-06-30 Klapproth, Holger, Dr., 79108 Kalibrierte Flusszelle zur IR-Analytik
EP2598562A4 (en) * 2010-07-30 2014-01-15 United Resource Recovery Corp SURFACE FUNCTIONALIZATION OF POLYESTERS
US20130316430A1 (en) 2011-02-01 2013-11-28 Maharshi Dayanand University Polyvinyl chloride surface co-immobilized with enzymes and uses thereof
EP2718691B1 (de) 2011-06-09 2017-12-13 QFood GmbH Verfahren und vorrichtung zum bestimmen der konzentration eines in einer flüssigen probe enthaltenen analyten
EP2812091B1 (en) 2012-09-17 2021-03-10 W.R. Grace & CO. - CONN. Chromatography media and devices
EP2811983B1 (en) 2012-09-17 2019-05-01 W.R. Grace & CO. - CONN. Functionalized particulate support material and methods of making and using the same
JP6453210B2 (ja) 2013-05-13 2019-01-16 国立研究開発法人科学技術振興機構 新規複合材料およびそれを用いるポリマー被覆材前駆体
CN107002117B (zh) 2013-12-05 2021-12-10 生捷科技控股公司 核酸测序方法
US10385335B2 (en) 2013-12-05 2019-08-20 Centrillion Technology Holdings Corporation Modified surfaces
CN106460032B (zh) 2013-12-05 2019-12-24 生捷科技控股公司 图案化阵列的制备
ES2887110T3 (es) 2014-01-16 2021-12-21 Grace W R & Co Medios para cromatografía de afinidad y dispositivos para cromatografía
US11060139B2 (en) 2014-03-28 2021-07-13 Centrillion Technology Holdings Corporation Methods for sequencing nucleic acids
PL3137209T3 (pl) 2014-05-02 2023-01-02 W.R. Grace & Co. - Conn. Funkcjonalizowany materiał nośnikowy i sposoby wytwarzania oraz stosowania funkcjonalizowanego materiału nośnikowego
KR102566292B1 (ko) 2015-06-05 2023-08-10 더블유.알. 그레이스 앤드 캄파니-콘. 흡착성 바이오프로세싱 정화제와 이의 제조 및 사용 방법

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63233360A (ja) * 1986-12-15 1988-09-29 Fuji Photo Film Co Ltd 電気泳動用媒体
SE8801070D0 (sv) * 1988-03-23 1988-03-23 Pharmacia Ab Method for immobilizing a dna sequence on a solid support
SE462454B (sv) 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
JPH05502585A (ja) * 1989-12-04 1993-05-13 ベクトン　ディッキンソン　アンド　カンパニー ポリマーに共有結合したオリゴヌクレオチドの利用により向上される標的核酸の捕獲
BR9206705A (pt) * 1991-11-01 1995-11-21 Adelaide Children S Hospital Processo de amplificação de fase sólida
US5624711A (en) * 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
SE9502608D0 (sv) 1995-07-14 1995-07-14 Pharmacia Biosensor Ab Method for nucleic acid senquencing
CA2235762A1 (en) * 1995-11-14 1997-05-22 Genometrix Genomics, Inc. Integrated nucleic acid hybridization devices based upon active surface chemistry
US6132765A (en) * 1996-04-12 2000-10-17 Uroteq Inc. Drug delivery via therapeutic hydrogels
US6130037A (en) * 1996-04-25 2000-10-10 Pence And Mcgill University Biosensor device and method
WO1997041425A1 (en) 1996-04-25 1997-11-06 Pence, Inc. Biosensor device and method
US6485703B1 (en) * 1998-07-31 2002-11-26 The Texas A&M University System Compositions and methods for analyte detection
JP3919958B2 (ja) * 1998-11-11 2007-05-30 独立行政法人科学技術振興機構 高分子薄膜の製造方法
ATE269114T1 (de) * 1998-11-20 2004-07-15 Univ Connecticut Verfahren und vorrichtung zur steuerung der gewebeimplantat-interaktionen
US6413587B1 (en) * 1999-03-02 2002-07-02 International Business Machines Corporation Method for forming polymer brush pattern on a substrate surface

Also Published As

Publication number Publication date
US7250253B1 (en) 2007-07-31
JP4970654B2 (ja) 2012-07-11
EP1144677A2 (en) 2001-10-17
EP1144677B1 (en) 2006-07-26
DE60029561T2 (de) 2007-07-19
AU3150400A (en) 2000-08-07
JP2002535450A (ja) 2002-10-22
CA2360027A1 (en) 2000-07-27
WO2000043539A3 (en) 2000-11-30
WO2000043539A2 (en) 2000-07-27
DE60029561D1 (de) 2006-09-07

Similar Documents

Publication Publication Date Title
ATE334226T1 (de) Immobilisierung von molekülen auf oberflächen über polymerbürsten
CY1106984T1 (el) Νεα βιοσυγκολλητικη συνθεση που περιεχει μια βιοσυγκολλητικη πολυφαινολικη πρωτεϊνη, ενα πολυμερες που περιεχει ομαδες υδατανθρακα, φαρμακευτικως αποδεκτα λεπτα νηματα και οι χρησεις τους
BR0014703B1 (pt) dispersão polimérica aquosa, processo para preparação da mesma, substrato ligado, e, uso de uma dispersão polimérica aquosa.
IT1317727B1 (it) Sostanze che assorbono i raggi ultravioletti costituite dabenzotriazoli aventi una aumentata durata.
DE69723369D1 (de) Mikrobieller Stamm, Verfahren zum biologischen Abbau von organischen Verbindungen und Verfahren zur Engiftung der Umwelt damit
ATE359215T1 (de) Gestell für den transport von rohrförmigen elementen
BR9805745B1 (pt) processo de construÇço de um pneu.
ES2066760T3 (es) Nucleotidos de alquinilamino.
DE60238940D1 (de) Verfahren zur isolierung und markierung von probenmolekülen
FI972333A7 (fi) Entsymaattiset DNA-molekyylit
BR0017027B1 (pt) composição secada por spray e processo de polimerização.
NO20014319L (no) B¶rere som har biologisk forbindelse
DE60003128D1 (de) Organometall-komplex-moleküle und organische elektrolumineszenz-vorrichtung, in welcher diese verwendung finden
DE69910538D1 (de) Nukleinsäuresequenzen, welche für capsaicin-rezeptoren kodieren
BR0313229B1 (pt) vernizes de eletroimersão e uso de tais vernizes
ATE383172T1 (de) Oligonukleotide welche spezifisch retrovirale nukleokapsid-proteine binden
ATE505549T1 (de) Männliche fertilitätvermittelnde nukleotidsequenzen und deren verwendung
DE19882401B8 (de) Blockoligomere, enthaltend 1-Kohlenwasserstoffoxy-2,2,6,6-tetramethyl-4-piperidyl-Gruppen als Stabilisatoren für organische Materialien
ATE355525T1 (de) Auf einer oberfläche befestigte multifunktionelle polymere-netzwerke für sensorchips
EP1083980A4 (en) MODULATION OF MOLECULAR INTERACTION POSITIONS IN RNS AND OTHER BIOMOLECULES
BR0317288A (pt) Corrente de presilhas com presilhas internas e externas formadas de presilhas individuais
BR0311288A (pt) Processo para a ligação de polìmeros contendo grupo ácidos absorventes de água particulados em um material de suporte por meio de compostos compreendendo grupos amino, material de suporte, artigo de higiene, e, uso de compostos
FI960375A0 (fi) Rakenneyksiköitä, joissa on nukleosidienvälisiä karbamaattisidoksia, ja niistä saatuja uusia oligonukleotideja
DE19882402T1 (de) Blockoligomere, enthaltend 1-Kohlenwasserstoffoxy-2,2,6,6-tetramethyl-4-piperidyl-Gruppen als Stabilisatoren für organische Materialien
DE69812612D1 (de) 1-hydrocarbyloxy-2,2,6,6-tetramethyl-4-piperidylgruppen enthaltende blockoligomere als stabilisatoren für organische materialien

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties