ATE329014T1 - Mikrobielle transglutaminasen, ihre herstellung und ihre verwendung - Google Patents

Mikrobielle transglutaminasen, ihre herstellung und ihre verwendung

Info

Publication number
ATE329014T1
ATE329014T1 AT95929013T AT95929013T ATE329014T1 AT E329014 T1 ATE329014 T1 AT E329014T1 AT 95929013 T AT95929013 T AT 95929013T AT 95929013 T AT95929013 T AT 95929013T AT E329014 T1 ATE329014 T1 AT E329014T1
Authority
AT
Austria
Prior art keywords
production
microbial transglutaminases
transglutaminases
microbial
transglutaminase
Prior art date
Application number
AT95929013T
Other languages
English (en)
Inventor
Lisbeth Bech
Iben Angelica Norrevang
Torben Halkier
Grethe Rasmussen
Thomas Schaefer
Jens Tonne Andersen
Original Assignee
Novozymes As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes As filed Critical Novozymes As
Application granted granted Critical
Publication of ATE329014T1 publication Critical patent/ATE329014T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/104—Aminoacyltransferases (2.3.2)
    • C12N9/1044—Protein-glutamine gamma-glutamyltransferase (2.3.2.13), i.e. transglutaminase or factor XIII
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/02—Aminoacyltransferases (2.3.2)
    • C12Y203/02013—Protein-glutamine gamma-glutamyltransferase (2.3.2.13), i.e. transglutaminase or factor XIII
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/1203—Addition of, or treatment with, enzymes or microorganisms other than lactobacteriaceae
    • A23C9/1216—Other enzymes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT95929013T 1994-08-26 1995-08-28 Mikrobielle transglutaminasen, ihre herstellung und ihre verwendung ATE329014T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK99094 1994-08-26
DK94795 1995-08-24

Publications (1)

Publication Number Publication Date
ATE329014T1 true ATE329014T1 (de) 2006-06-15

Family

ID=26064950

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95929013T ATE329014T1 (de) 1994-08-26 1995-08-28 Mikrobielle transglutaminasen, ihre herstellung und ihre verwendung

Country Status (9)

Country Link
US (2) US6100053A (de)
EP (1) EP0777726B1 (de)
JP (1) JP3720363B2 (de)
AT (1) ATE329014T1 (de)
AU (1) AU705803B2 (de)
DE (1) DE69535037T2 (de)
ES (1) ES2267103T3 (de)
NZ (1) NZ291414A (de)
WO (1) WO1996006931A1 (de)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3669390B2 (ja) * 1995-02-09 2005-07-06 味の素株式会社 バチルス属細菌由来のトランスグルタミナーゼ
EP0851029A4 (de) 1995-06-08 2001-05-23 Ajinomoto Kk Mikrobieller przess zur produktion von transglutaminase
WO1998051803A1 (en) 1997-05-16 1998-11-19 Novo Nordisk Biotech, Inc. Polypeptides having prolyl pipeptidyl aminopeptidase activity and nucleic acids encoding same
US6821763B2 (en) 1997-07-04 2004-11-23 Ajinomoto Co., Inc. Process for producing microbial transglutaminase
DE69822251T2 (de) * 1997-07-04 2005-01-27 Ajinomoto Co., Inc. Verfahren zur Herstellung von mikrobieller Transglutaminase
DE19814860A1 (de) * 1998-04-02 1999-10-07 Fuchsbauer Hans Lothar Bakterielle Transglutaminasen
US6617122B1 (en) * 1999-03-15 2003-09-09 Xenon Genetics, Inc. Process for identifying modulators of ABC1 activity
BR0014811A (pt) * 1999-10-18 2002-08-27 Ajinomoto Kk Bactéria pertencente a streptomyces, e métodos para produzir uma pró-transglutaminase, e, uma transglutaminase madura derivadas de actinomicetos
DK1223813T3 (da) * 1999-10-28 2013-06-24 Dsm Ip Assets Bv Fremgangsmåde til fremstilling af ost ved brug af svækkede kluyveromyces lactis-celler
JP2002253272A (ja) * 2000-08-17 2002-09-10 Ajinomoto Co Inc 微生物由来トランスグルタミナーゼの改変方法
BR0113304A (pt) 2000-08-17 2004-01-06 Ajinomoto Kk Método para planejar e preparar uma transglutaminase mutante, mtg mutante transglutaminase mutante, gene, dna recombinante, microorganismos, método para produzir uma mtg mutante ou uma transglutaminase mutante, e, cristais de mtg monoclìnicos
DE10046605A1 (de) 2000-09-20 2002-03-28 Roehm Enzyme Gmbh Verwendung von Transglutaminasen zur Herstellung von weizenarmen Backwaren
CN100445745C (zh) 2001-01-31 2008-12-24 诺和酶股份有限公司 荧光分析法分析颗粒组合物的方法
US6416797B1 (en) * 2001-02-14 2002-07-09 Kraft Foods Holdings, Inc. Process for making a wheyless cream cheese using transglutaminase
US20030027293A1 (en) * 2001-03-28 2003-02-06 Council Of Scientific & Industrial Research Process for the isolation of polyhydroxybutyrate from Bacillus mycoides RLJ B-017
US6664299B2 (en) * 2002-02-14 2003-12-16 Dow Corning Corporation Masterbatch method for economically and efficiently producing soap dispersions in textile fluids for synthetic fiber treatment
US20030219853A1 (en) * 2002-03-01 2003-11-27 Szu-Yi Chou Method of cross-linking a compound
US7101695B2 (en) * 2002-03-01 2006-09-05 Szu-Yi Chou Method of producing transglutaminase having broad substrate activity
US7485438B2 (en) 2002-03-01 2009-02-03 Szu-Yi Chou Method of producing polyvalent antigens
AU2003214037A1 (en) 2002-03-27 2003-10-08 Novozymes A/S Granules with filamentous coatings
ES2223227B1 (es) * 2002-05-31 2006-04-16 Consejo Sup. Investig. Cientificas Secuencia de nucleotidos de maiz codificante de una proteina con actividad transglutaminasa, y su uso.
DE602004026032D1 (de) 2003-01-27 2010-04-29 Novozymes As Enzymstabilisierung
CA2518049C (en) * 2003-03-07 2013-05-07 Ajinomoto Co., Inc. Method of producing microbial transglutaminase
US6908634B2 (en) * 2003-03-20 2005-06-21 Solae, Llc Transglutaminase soy fish and meat products and analogs thereof
JP4524076B2 (ja) * 2003-04-02 2010-08-11 天野エンザイム株式会社 安定化トランスグルタミナーゼ
TWI227273B (en) * 2003-09-22 2005-02-01 Food Industry Res & Dev Inst DNA molecule encoding transglutaminase, transglutaminase, expression vector containing the sequence and cell containing the expression vector
ES2642214T3 (es) 2004-01-21 2017-11-15 Novo Nordisk Health Care Ag Conjugación de péptidos mediante transglutaminasa
CN101006174B (zh) 2004-06-21 2010-05-26 诺维信公司 以相同取向稳定保持的至少两个orf的多拷贝
JP4874105B2 (ja) * 2004-06-28 2012-02-15 太陽化学株式会社 テアニンの製造法
DE202005021811U1 (de) 2004-09-27 2010-04-15 Novozymes A/S Körnchen mit einem Kern und einer Beschichtung
US9303256B2 (en) 2005-09-30 2016-04-05 Novozymes A/S Immobilization of enzymes
WO2007098756A1 (en) 2006-03-02 2007-09-07 Novozymes A/S High capacity encapsulation process
EP2383330A1 (de) 2006-03-31 2011-11-02 Novozymes A/S Stabilisierte flüssige Enzymzusammensetzung
US9578891B2 (en) 2006-08-07 2017-02-28 Novozymes A/S Enzyme granules for animal feed
EP2051591B1 (de) 2006-08-07 2016-04-20 Novozymes A/S Enzymgranulat für tierfutter
MX2009006369A (es) 2006-12-15 2010-02-24 Lifebond Ltd Apositos y selladores hemostaticos de gelatina-transglutaminasa.
JPWO2008099898A1 (ja) 2007-02-15 2010-05-27 味の素株式会社 ジスルフィド結合導入トランスグルタミナーゼ
EP2138049B1 (de) 2007-03-29 2014-06-25 Ajinomoto Co., Inc. Enzymherstellung für adhäsion und verfahren zur herstellung eines adhäsionsgeformten lebensmittelprodukts
US20090061046A1 (en) * 2007-08-02 2009-03-05 Novozymes A/S Method for producing an acidified milk drink
KR20100085083A (ko) 2007-11-19 2010-07-28 아지노모토 가부시키가이샤 섬유 가공물 및 이의 제조법
CN104031393B (zh) 2008-06-18 2017-08-01 生命连结有限公司 改进的交联组合物
WO2009153751A2 (en) * 2008-06-18 2009-12-23 Lifebond Ltd A method for enzymatic cross-linking of a protein
EP2303344A2 (de) * 2008-06-18 2011-04-06 Lifebond Ltd Verfahren und vorrichtungen zur verwendung mit dichtungsmitteln
PL2310483T3 (pl) 2008-07-07 2016-09-30 Kompozycja enzymatyczna zawierająca cząstki polimerowe zawierające enzym
AU2009279090A1 (en) 2008-08-06 2010-02-11 Novo Nordisk Health Care Ag Conjugated proteins with prolonged in vivo efficacy
TWI444146B (zh) 2008-09-25 2014-07-11 Ajinomoto Kk 黏著成型食品用酵素製劑及黏著成型食品之製造方法
ES2338200B2 (es) * 2008-10-23 2011-02-14 Univ Santiago Compostela Aditivo alimentario obtenido por fermentacion conteniendo la enzima transglutaminasa a partir de hidrolizados acidos de patata
US8633030B2 (en) 2008-12-16 2014-01-21 Novozymes, Inc. Polypeptides having carboxypeptidase activity and polynucleotides encoding same
CA2747825A1 (en) 2009-01-22 2010-07-29 Novo Nordisk Health Care Ag Stable growth hormone compounds
JP2012518029A (ja) 2009-02-19 2012-08-09 ノヴォ・ノルディスク・アー／エス 第ｖｉｉｉ因子の修飾
WO2010101256A1 (ja) 2009-03-06 2010-09-10 味の素株式会社 放線菌由来の耐熱性トランスグルタミナーゼ
US20100316764A1 (en) * 2009-06-10 2010-12-16 Engrain, LLC Flour supplement compositions and methods for preparing wheat flour
EP2461831B1 (de) 2009-08-06 2018-11-21 Novo Nordisk Health Care AG Wachstumshormone mit verlängerter in-vivo-wirksamkeit
JP5796860B2 (ja) 2009-12-22 2015-10-21 ライフボンド リミテッドＬｉｆｅｂｏｎｄ Ｌｔｄ 架橋マトリックスの特性を調節するための酵素的架橋剤の改変
RU2012134974A (ru) 2010-01-22 2014-02-27 Ново Нордиск Хелс Кеа Аг Стабилизированное соединение гормона роста
RU2605627C2 (ru) 2010-01-22 2016-12-27 Ново Нордиск Хелс Кеа Аг Гормоны роста с пролонгированной эффективностью in vivo
ITPD20100155A1 (it) 2010-05-19 2011-11-20 Univ Padova Metodo per la preparazione di coniugati mediante transglutaminasi
EP2600910B1 (de) 2010-08-05 2016-01-20 Lifebond Ltd Wundverbände mit einer trockenzusammung und haftstoffe
FI126442B (en) 2011-11-01 2016-12-15 Valio Oy Liquid enzyme preparation and process for its preparation
WO2013065869A1 (en) 2011-11-02 2013-05-10 Ajinomoto Co.,Inc. Method for secretory production of protein
ES2376439B2 (es) * 2011-12-15 2012-06-26 Universidade De Santiago De Compostela Aditivo alimentario conteniendo la enzima transglutaminasa obtenido por fermentación de medios de cultivo formulados con leche, patata y glicerol.
AU2012356894B2 (en) 2011-12-23 2018-01-18 Araris Biotech Ltd. Enzymatic conjugation of polypeptides
DK2839290T3 (da) 2012-04-17 2019-06-11 Aeneas Gmbh & Co Kg Fremgangsmåde til præsymptomatisk diagnose af cøliaki og glutensensitivitet
WO2014009426A2 (en) 2012-07-13 2014-01-16 Innate Pharma Screening of conjugated antibodies
EP2916872B1 (de) 2012-11-09 2019-02-27 Innate Pharma Kennungen für tgase-vermittelte konjugation
CN103222481B (zh) * 2013-01-07 2015-03-11 中国计量学院 盐屋链霉菌代谢产物在防治水稻纹枯病菌中的应用
CN103222478B (zh) * 2013-01-07 2015-03-04 中国计量学院 盐屋链霉菌代谢产物在防治西瓜枯萎病菌中的应用
CN103222479B (zh) * 2013-01-07 2015-03-25 中国计量学院 盐屋链霉菌代谢产物在防治菜豆炭疽病菌中的应用
WO2014140300A1 (en) 2013-03-15 2014-09-18 Innate Pharma Solid phase tgase-mediated conjugation of antibodies
EP2981282B1 (de) 2013-04-05 2020-11-04 Novo Nordisk Health Care AG Wachstumshormonverbindungsformulierung
RU2013119826A (ru) 2013-04-29 2014-11-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") Коринеформная бактерия и способ получения гетерологичных гибридных белков
WO2014202773A1 (en) 2013-06-20 2014-12-24 Innate Pharma Enzymatic conjugation of polypeptides
JP6744212B2 (ja) 2013-06-21 2020-08-19 イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． ポリペプチドの酵素的結合
BR112016000585A2 (pt) 2013-07-11 2018-03-20 Novartis Ag modificações quimioenzimáticas sítio-específicas de proteína
CN103421753B (zh) * 2013-07-25 2015-02-11 江南大学 一种酶活和热稳定性提高的谷氨酰胺转胺酶突变体及其构建方法
RU2728235C2 (ru) 2014-06-12 2020-07-28 СиЭсПиСи ДОФЕН КОРПОРЕЙШН Конъюгат антитела и лекарственного средства, композиции на его основе и способы их получения
KR20160077750A (ko) 2014-12-24 2016-07-04 한국생명공학연구원 재조합 트랜스 글루타미나아제의 대량 생산 방법
CA2990822A1 (en) 2015-06-26 2016-12-29 Dupont Nutrition Biosciences Aps Aminopeptidases for protein hydrlyzates
US11786603B2 (en) 2016-02-26 2023-10-17 Regeneron Pharmaceuticals, Inc. Optimized transglutaminase site-specific antibody conjugation
KR102335301B1 (ko) 2016-10-21 2021-12-06 아지노모토 가부시키가이샤 단백질의 분비 생산법
EP3530747A4 (de) 2016-10-21 2020-07-22 Ajinomoto Co., Inc. Verfahren zur herstellung von proteinsekreten
AU2018334768B2 (en) 2017-09-25 2024-08-08 Ajinomoto Co., Inc. Protein production method and disaccharide production method
EP3696274A4 (de) 2017-10-10 2021-07-28 Ajinomoto Co., Inc. Verfahren zur herstellung von protein
CA3080512A1 (en) 2017-11-07 2019-05-16 Codexis, Inc. Transglutaminase variants
WO2019092148A1 (en) 2017-11-10 2019-05-16 Innate Pharma Antibodies with functionalized glutamine residues
WO2019203368A1 (ja) 2018-04-20 2019-10-24 味の素株式会社 タンパク質の分泌生産法
US11998654B2 (en) 2018-07-12 2024-06-04 Bard Shannon Limited Securing implants and medical devices
AU2019364829B2 (en) 2018-10-25 2025-11-20 Ajinomoto Co., Inc. Method for secretory production of protein
WO2020257525A1 (en) 2019-06-20 2020-12-24 Cspc Dophen Corporation Modified il-2 proteins, peg conjugates, and uses thereof
CN113993384B (zh) * 2019-06-20 2024-07-16 诺维信公司 交联乳蛋白共沉淀物
CN111394331B (zh) * 2020-05-06 2022-11-25 江南大学 一种谷氨酰胺转氨酶及其编码基因、表达载体及重组菌
KR20230023751A (ko) 2020-06-11 2023-02-17 아지노모토 가부시키가이샤 단백질의 제조법
CN111944778B (zh) * 2020-08-14 2022-06-21 安徽医学高等专科学校 谷氨酰胺转胺酶突变体及其编码基因和应用
CN114686389B (zh) * 2020-12-25 2024-05-07 泰兴市东圣生物科技有限公司 一种增强vgbS基因转录水平的谷氨酰胺转氨酶高产菌株及其制备与发酵方法
KR20240032941A (ko) 2021-07-07 2024-03-12 아지노모토 가부시키가이샤 비천연 아미노산 함유 단백질의 분비 생산법
KR20250151452A (ko) 2023-02-16 2025-10-21 아지노모토 가부시키가이샤 단백질의 분비 생산법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0665280B2 (ja) * 1987-03-04 1994-08-24 味の素株式会社 タンパクゲル化剤及びそれを用いるタンパクのゲル化方法
US5124358A (en) * 1990-01-16 1992-06-23 The Board Of Reagents The University Of Texas System Effect of transglutaminase inhibition on microfilariae development and macrofilariae viability
JP2849773B2 (ja) * 1990-08-27 1999-01-27 天野製薬株式会社 ストレプトミセス属由来のトランスグルタミナーゼの製造法
EP0481504B1 (de) * 1990-10-19 1996-01-17 Amano Pharmaceutical Co., Ltd. Rekombinante Transglutaminase
US5650276A (en) * 1991-03-11 1997-07-22 Creative Biomolecules, Inc. Morphogenic protein screening method
JPH0678783A (ja) * 1992-08-31 1994-03-22 Ajinomoto Co Inc タンパクゲル化物の製造方法

Also Published As

Publication number Publication date
US6190879B1 (en) 2001-02-20
DE69535037D1 (de) 2006-07-20
AU3253895A (en) 1996-03-22
US6100053A (en) 2000-08-08
ES2267103T3 (es) 2007-03-01
WO1996006931A1 (en) 1996-03-07
JP3720363B2 (ja) 2005-11-24
DE69535037T2 (de) 2006-12-07
AU705803B2 (en) 1999-06-03
EP0777726A1 (de) 1997-06-11
EP0777726B1 (de) 2006-06-07
NZ291414A (en) 1998-05-27
JPH10504721A (ja) 1998-05-12

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