ATE317687T1 - Methode zur herstellung von beschichteten partikeln und diese enthaltende pharmazeutische formulierungen - Google Patents

Methode zur herstellung von beschichteten partikeln und diese enthaltende pharmazeutische formulierungen

Info

Publication number
ATE317687T1
ATE317687T1 AT99967110T AT99967110T ATE317687T1 AT E317687 T1 ATE317687 T1 AT E317687T1 AT 99967110 T AT99967110 T AT 99967110T AT 99967110 T AT99967110 T AT 99967110T AT E317687 T1 ATE317687 T1 AT E317687T1
Authority
AT
Austria
Prior art keywords
controlled
coated
pharmaceutical formulations
formulations containing
coated particles
Prior art date
Application number
AT99967110T
Other languages
German (de)
English (en)
Inventor
James D Talton
Guenther Hochhaus
Rajiv K Singh
James M Fitz-Gerald
Original Assignee
Univ Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida filed Critical Univ Florida
Application granted granted Critical
Publication of ATE317687T1 publication Critical patent/ATE317687T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C14/00—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
    • C23C14/22—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the process of coating
    • C23C14/223—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the process of coating specially adapted for coating particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C14/00—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
    • C23C14/22—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the process of coating
    • C23C14/24—Vacuum evaporation
    • C23C14/28—Vacuum evaporation by wave energy or particle radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Mechanical Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Metallurgy (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Toxicology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT99967110T 1998-11-18 1999-11-18 Methode zur herstellung von beschichteten partikeln und diese enthaltende pharmazeutische formulierungen ATE317687T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10884798P 1998-11-18 1998-11-18
US11029198P 1998-11-30 1998-11-30

Publications (1)

Publication Number Publication Date
ATE317687T1 true ATE317687T1 (de) 2006-03-15

Family

ID=26806343

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99967110T ATE317687T1 (de) 1998-11-18 1999-11-18 Methode zur herstellung von beschichteten partikeln und diese enthaltende pharmazeutische formulierungen

Country Status (19)

Country Link
EP (1) EP1131054B1 (fr)
JP (1) JP2003516926A (fr)
KR (1) KR20010082309A (fr)
CN (1) CN1200693C (fr)
AT (1) ATE317687T1 (fr)
AU (1) AU757121B2 (fr)
BR (1) BR9915462A (fr)
CA (1) CA2350894C (fr)
CZ (1) CZ300323B6 (fr)
DE (1) DE69929904T2 (fr)
ES (1) ES2257881T3 (fr)
HK (1) HK1043548B (fr)
HU (1) HUP0104687A3 (fr)
IL (2) IL143234A0 (fr)
NO (1) NO20012395L (fr)
NZ (1) NZ511689A (fr)
PL (1) PL349953A1 (fr)
TR (1) TR200101401T2 (fr)
WO (1) WO2000028969A2 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6984404B1 (en) 1998-11-18 2006-01-10 University Of Florida Research Foundation, Inc. Methods for preparing coated drug particles and pharmaceutical formulations thereof
US6406745B1 (en) 1999-06-07 2002-06-18 Nanosphere, Inc. Methods for coating particles and particles produced thereby
EP1183018A1 (fr) * 1999-06-07 2002-03-06 Nanosphere, Inc. Procedes de revetement de particules et particules ainsi produites
AU2005201757B2 (en) * 1999-06-07 2007-04-26 Nanotherapeutics, Inc. Methods for coating particles and particles produced thereby
WO2001090260A2 (fr) * 2000-05-19 2001-11-29 Ppg Industries Ohio, Inc. Compositions de revetement a matrice ordonnee de maniere geometrique de particules polymeres et substrats revetus par ces compositions
EP2168571B1 (fr) 2000-11-30 2018-08-22 Vectura Limited Compositions pharmaceutiques pour inhalation
ES2708961T3 (es) 2000-11-30 2019-04-12 Vectura Ltd Composiciones farmacéuticas para inhalación
ES2292634T3 (es) * 2000-12-21 2008-03-16 Alrise Biosystems Gmbh Procedimiento de transicion de fase inducida para la produccion de microparticulas que contienen agentes hidrofilos activos.
JP2003342196A (ja) * 2002-05-31 2003-12-03 Mukku:Kk 静脈注射用組成物、その製造法およびその製剤
CA2496902C (fr) 2002-08-27 2012-01-03 Hiroshi Terada Medicament activant la capacite de phagocytose des macrophages
ATE371436T1 (de) 2003-05-19 2007-09-15 Euro Celtique Sa Trockene liposomale pvp-jod zubereitungen
JPWO2004110405A1 (ja) * 2003-06-11 2006-08-17 株式会社奈良機械製作所 薬物ナノ粒子、その粒子を使用した薬剤の製造方法および薬剤の製造装置
JP2006218346A (ja) * 2005-02-08 2006-08-24 Honda Motor Co Ltd 水素吸着材及びその製造方法
KR101476167B1 (ko) * 2007-03-30 2014-12-24 히로후미 다케우치 약물 송달 제어용 경폐 투여 리포좀
US20090004231A1 (en) 2007-06-30 2009-01-01 Popp Shane M Pharmaceutical dosage forms fabricated with nanomaterials for quality monitoring
AU2008314500A1 (en) * 2007-10-15 2009-04-23 Cooperative Research Centre For Asthma A method of prophylaxis and agents for use therein
EP2279283A1 (fr) * 2008-03-27 2011-02-02 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Procédé pour produire un système de couches multicomposant contenant des polymères et des métaux, dispositif et objet revêtu
US20110104282A1 (en) * 2008-04-25 2011-05-05 Karolinska Institutet Innovations Ab New Therapy of Treatment of the Irritable Bowel Syndrome
GB0814302D0 (en) 2008-08-05 2008-10-01 Coretherapix Slu Compounds and methods
WO2010044089A1 (fr) * 2008-10-15 2010-04-22 Lifecare, Innovations Pvt. Ltd Système de délivrance de médicaments pour l’éconazole, la moxifloxacine, et la rifampicine
JPWO2010058840A1 (ja) * 2008-11-20 2012-04-19 テルモ株式会社 リポソームからの薬物放出手段および放出性評価法
SE535381C2 (sv) 2010-02-24 2012-07-17 Plasmadvance Ab Plasmasputtringsprocess för att producera partiklar
CA2851566C (fr) * 2011-10-14 2020-01-14 Dsm Ip Assets B.V. Nouveau systeme d'enrobage
JP6334214B2 (ja) * 2013-03-08 2018-05-30 学校法人慶應義塾 レーザーを用いた薬剤放出方法
KR20220144378A (ko) * 2020-02-19 2022-10-26 나노 파마솔루션즈, 인코포레이티드 치료제 나노입자 및 제조 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200669A (en) * 1978-11-22 1980-04-29 The United States Of America As Represented By The Secretary Of The Navy Laser spraying
US4623588A (en) * 1984-02-06 1986-11-18 Biotek, Inc. Controlled release composite core coated microparticles
DE3541999A1 (de) * 1985-11-28 1987-06-04 Bbc Brown Boveri & Cie Verfahren und vorrichtung zur beschichtung von flaechen
WO1990002546A1 (fr) * 1988-09-09 1990-03-22 The Ronald T. Dodge Company Microcapsules de produits pharmaceutiques formes par polymeres deposes en phase vapeur et procede correspondant
DE4239244A1 (de) * 1992-11-21 1994-05-26 Basf Ag Retard-Form für pharmazeutische Wirkstoffe
US6025036A (en) * 1997-05-28 2000-02-15 The United States Of America As Represented By The Secretary Of The Navy Method of producing a film coating by matrix assisted pulsed laser deposition
AU6472798A (en) * 1998-03-19 1999-10-11 University Of Florida Process for depositing atomic to nanometer particle coatings on host particles

Also Published As

Publication number Publication date
HUP0104687A2 (en) 2002-06-29
HK1043548A1 (en) 2002-09-20
HUP0104687A3 (en) 2006-07-28
WO2000028969A3 (fr) 2000-11-09
JP2003516926A (ja) 2003-05-20
CZ20011747A3 (cs) 2001-10-17
ES2257881T3 (es) 2006-08-01
KR20010082309A (ko) 2001-08-29
HK1043548B (zh) 2006-01-06
EP1131054A2 (fr) 2001-09-12
BR9915462A (pt) 2001-12-11
NO20012395D0 (no) 2001-05-15
WO2000028969A2 (fr) 2000-05-25
NO20012395L (no) 2001-07-16
CN1348361A (zh) 2002-05-08
NZ511689A (en) 2003-03-28
AU2345700A (en) 2000-06-05
CA2350894C (fr) 2009-01-27
AU757121B2 (en) 2003-02-06
PL349953A1 (en) 2002-10-21
TR200101401T2 (tr) 2001-11-21
EP1131054B1 (fr) 2006-02-15
DE69929904D1 (de) 2006-04-20
CA2350894A1 (fr) 2000-05-25
CN1200693C (zh) 2005-05-11
IL143234A (en) 2007-05-15
CZ300323B6 (cs) 2009-04-22
IL143234A0 (en) 2002-04-21
DE69929904T2 (de) 2006-08-31

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