ATE315028T1 - Herstellungsverfahren für (-)-(2r,4s)-4-((3,5-bis-trifluoromethyl-benzyl) methoxycarbonylamino)-2- ethyl-6-trifluoromethyl-3,4-dihydro-2h-chinolin 1-carbonylsäureethylester - Google Patents

Herstellungsverfahren für (-)-(2r,4s)-4-((3,5-bis-trifluoromethyl-benzyl) methoxycarbonylamino)-2- ethyl-6-trifluoromethyl-3,4-dihydro-2h-chinolin 1-carbonylsäureethylester

Info

Publication number
ATE315028T1
ATE315028T1 AT00310064T AT00310064T ATE315028T1 AT E315028 T1 ATE315028 T1 AT E315028T1 AT 00310064 T AT00310064 T AT 00310064T AT 00310064 T AT00310064 T AT 00310064T AT E315028 T1 ATE315028 T1 AT E315028T1
Authority
AT
Austria
Prior art keywords
trifluoromethyl
methoxycarbonylamino
quinoline
dihydro
benzyl
Prior art date
Application number
AT00310064T
Other languages
German (de)
English (en)
Inventor
David Burns Damon
Robert Wayne Dugger
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of ATE315028T1 publication Critical patent/ATE315028T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT00310064T 1999-11-30 2000-11-13 Herstellungsverfahren für (-)-(2r,4s)-4-((3,5-bis-trifluoromethyl-benzyl) methoxycarbonylamino)-2- ethyl-6-trifluoromethyl-3,4-dihydro-2h-chinolin 1-carbonylsäureethylester ATE315028T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16796799P 1999-11-30 1999-11-30

Publications (1)

Publication Number Publication Date
ATE315028T1 true ATE315028T1 (de) 2006-02-15

Family

ID=22609556

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00310064T ATE315028T1 (de) 1999-11-30 2000-11-13 Herstellungsverfahren für (-)-(2r,4s)-4-((3,5-bis-trifluoromethyl-benzyl) methoxycarbonylamino)-2- ethyl-6-trifluoromethyl-3,4-dihydro-2h-chinolin 1-carbonylsäureethylester

Country Status (44)

Country Link
US (1) US6313142B1 (cs)
EP (1) EP1125929B1 (cs)
JP (1) JP3579345B2 (cs)
KR (1) KR100408177B1 (cs)
CN (1) CN1173953C (cs)
AP (1) AP2000002011A0 (cs)
AR (1) AR029775A1 (cs)
AT (1) ATE315028T1 (cs)
AU (1) AU784694B2 (cs)
BG (1) BG105009A (cs)
BR (1) BR0005636A (cs)
CA (1) CA2327029C (cs)
CO (1) CO5261552A1 (cs)
CY (1) CY1104989T1 (cs)
CZ (1) CZ20004407A3 (cs)
DE (1) DE60025317T2 (cs)
DK (1) DK1125929T3 (cs)
DZ (1) DZ3079A1 (cs)
EA (1) EA003668B1 (cs)
EE (1) EE200000659A (cs)
ES (1) ES2254109T3 (cs)
GE (1) GEP20022798B (cs)
GT (1) GT200000190A (cs)
HN (1) HN2000000203A (cs)
HR (1) HRP20000804A2 (cs)
HU (1) HUP0004747A3 (cs)
ID (1) ID28489A (cs)
IL (1) IL139849A (cs)
IS (1) IS5715A (cs)
MA (1) MA25223A1 (cs)
NO (1) NO20006039L (cs)
NZ (1) NZ508509A (cs)
OA (1) OA11494A (cs)
PA (1) PA8503801A1 (cs)
PE (1) PE20010913A1 (cs)
PL (1) PL344208A1 (cs)
SG (1) SG102603A1 (cs)
SK (1) SK17792000A3 (cs)
TN (1) TNSN00230A1 (cs)
TW (1) TW591016B (cs)
UA (1) UA65615C2 (cs)
UY (1) UY26451A1 (cs)
YU (1) YU71500A (cs)
ZA (1) ZA200006947B (cs)

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IL162533A0 (en) * 2001-12-19 2005-11-20 Atherogenics Inc Chalcone derivatives and their use to treat diseases
US7202247B2 (en) 2001-12-19 2007-04-10 Atherogenics, Inc. 1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders
AU2003230916A1 (en) * 2002-04-11 2003-10-27 Roar Holding Llc Ex vivo method for determination of cetp activity and efficacy of heart disease treatment
KR20050055747A (ko) * 2002-10-04 2005-06-13 밀레니엄 파머슈티컬스 인코퍼레이티드 염증 질환 치료용의 ｐｇｄ2 수용체 길항제
US7504508B2 (en) * 2002-10-04 2009-03-17 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US20090181966A1 (en) * 2002-10-04 2009-07-16 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US7223870B2 (en) 2002-11-01 2007-05-29 Pfizer Inc. Methods for preparing N-arylated oxazolidinones via a copper catalyzed cross coupling reaction
AU2003303239A1 (en) * 2002-12-19 2004-07-14 Atherogenics, Inc. Process of making chalcone derivatives
US20040132771A1 (en) * 2002-12-20 2004-07-08 Pfizer Inc Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors
BR0317521A (pt) 2002-12-20 2005-11-16 Pfizer Prod Inc Formas de dosagem compreendendo um inibidor da cetp e um inibidor da redutase hmg-coa
EP1601655A2 (en) * 2003-03-04 2005-12-07 Takasago International Corporation Method for producing optically active amines
WO2004082675A1 (en) * 2003-03-17 2004-09-30 Japan Tobacco Inc. Method for increasing the oral bioavailability of s-[2- ([[1- (2-ethylbutyl) cyclohexyl] carbonyl] amino) phenyl] 2-methylpropanethioate
JP5546715B2 (ja) * 2003-03-17 2014-07-09 日本たばこ産業株式会社 Ｃｅｔｐ阻害剤の医薬組成物
TWI393560B (zh) * 2003-05-02 2013-04-21 Japan Tobacco Inc 包含ｓ-〔２（〔〔１-（２-乙基丁基）環己基〕羰基〕胺基）苯基〕２-甲基丙烷硫酯及ｈｍｇ輔酶ａ還原酶抑制劑之組合
SI1670768T1 (sl) * 2003-10-08 2010-01-29 Lilly Co Eli Spojine in metode za zdravljenje dislipidemije
UA90269C2 (ru) * 2004-04-02 2010-04-26 Мицубиси Танабе Фарма Корпорейшн Тетрагидрохинолиновые производные и способ их получения
WO2006012093A1 (en) * 2004-06-24 2006-02-02 Eli Lilly And Company Compounds and methods for treating dyslipidemia
DOP2005000123A (es) 2004-07-02 2011-07-15 Merck Sharp & Dohme Inhibidores de cetp
WO2006033001A1 (en) * 2004-09-23 2006-03-30 Pfizer Products Inc. Quinoline compounds
US7700774B2 (en) * 2004-12-20 2010-04-20 Dr. Reddy's Laboratories Ltd. Heterocyclic compounds and their pharmaceutical compositions
JP2008543726A (ja) * 2005-02-24 2008-12-04 ミレニアム・ファーマシューティカルズ・インコーポレイテッド 炎症性疾患の処置のためのｐｇｄ２受容体アンタゴニスト
TW200808731A (en) 2006-03-30 2008-02-16 Tanabe Seiyaku Co A process for preparing tetrahydroquinoline derivatives
TW200901959A (en) 2007-03-09 2009-01-16 Indigene Pharmaceuticals Inc Combination of metformin R-(+) lipoate and antihyperlipidemic agents for the treatment of diabetic hyperglycemia and diabetic complications
CN101429160B (zh) * 2007-11-06 2011-10-19 上海药明康德新药开发有限公司 一种1-r-4-氨基-1,2,3,4-四氢喹啉的合成方法
TWI450896B (zh) * 2009-06-30 2014-09-01 Lilly Co Eli 反式－４－〔〔（５ｓ）－５－〔〔〔３，５－雙（三氟甲基）苯基〕甲基〕（２－甲基－２ｈ－四唑－５－基）胺基〕－２，３，４，５－四氫－７，９－二甲基－１ｈ－１－苯并氮呯－１－基〕甲基〕－環己基羧酸
CR20250038A (es) 2022-07-05 2025-05-26 Newamsterdam Pharma B V Sales de obicetrapib y procesos para su fabricación y productos intermedios de estos

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US4839368A (en) 1986-05-02 1989-06-13 Mochida Pharmaceutical Co., Ltd. 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives
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US6147089A (en) 1998-09-17 2000-11-14 Pfizer Inc. Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines
US6197786B1 (en) * 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
US6140342A (en) 1998-09-17 2000-10-31 Pfizer Inc. Oxy substituted 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines
HN2000000203A (es) * 1999-11-30 2001-06-13 Pfizer Prod Inc Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas.

Also Published As

Publication number Publication date
ES2254109T3 (es) 2006-06-16
TNSN00230A1 (fr) 2005-11-10
CN1302800A (zh) 2001-07-11
DE60025317T2 (de) 2006-08-03
NZ508509A (en) 2001-06-29
AU784694B2 (en) 2006-06-01
UA65615C2 (uk) 2004-04-15
CZ20004407A3 (cs) 2002-06-12
HUP0004747A3 (en) 2002-12-28
KR100408177B1 (ko) 2003-12-01
EE200000659A (et) 2001-08-15
DK1125929T3 (da) 2006-04-03
UY26451A1 (es) 2001-06-29
OA11494A (en) 2004-05-07
AR029775A1 (es) 2003-07-16
BR0005636A (pt) 2001-07-17
CN1173953C (zh) 2004-11-03
MA25223A1 (fr) 2001-07-02
AU7178900A (en) 2001-05-31
NO20006039L (no) 2001-05-31
PA8503801A1 (es) 2002-07-30
CA2327029A1 (en) 2001-05-30
JP3579345B2 (ja) 2004-10-20
PL344208A1 (en) 2001-06-04
DZ3079A1 (fr) 2004-10-24
GEP20022798B (en) 2002-09-25
AP2000002011A0 (en) 2000-12-31
TW591016B (en) 2004-06-11
HUP0004747A2 (hu) 2001-10-28
GT200000190A (es) 2002-04-27
CA2327029C (en) 2005-08-09
YU71500A (sh) 2003-02-28
SK17792000A3 (sk) 2002-10-08
EA003668B1 (ru) 2003-08-28
IS5715A (is) 2001-05-31
CO5261552A1 (es) 2003-03-31
EP1125929B1 (en) 2006-01-04
IL139849A (en) 2006-10-31
HRP20000804A2 (en) 2001-06-30
CY1104989T1 (el) 2010-03-03
PE20010913A1 (es) 2001-09-10
KR20010052012A (ko) 2001-06-25
EP1125929A1 (en) 2001-08-22
EA200001129A3 (ru) 2001-10-22
HU0004747D0 (cs) 2001-02-28
JP2001163859A (ja) 2001-06-19
DE60025317D1 (de) 2006-03-30
US6313142B1 (en) 2001-11-06
EA200001129A2 (ru) 2001-06-25
ZA200006947B (en) 2002-05-27
IL139849A0 (en) 2002-02-10
HN2000000203A (es) 2001-06-13
NO20006039D0 (no) 2000-11-29
BG105009A (en) 2001-11-30
ID28489A (id) 2001-05-31
SG102603A1 (en) 2004-03-26
HK1038007A1 (en) 2002-03-01

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