ATE310740T1 - Imidazotriazin-derivate als liganden für gaba- rezeptoren - Google Patents

Imidazotriazin-derivate als liganden für gaba- rezeptoren

Info

Publication number
ATE310740T1
ATE310740T1 AT01980742T AT01980742T ATE310740T1 AT E310740 T1 ATE310740 T1 AT E310740T1 AT 01980742 T AT01980742 T AT 01980742T AT 01980742 T AT01980742 T AT 01980742T AT E310740 T1 ATE310740 T1 AT E310740T1
Authority
AT
Austria
Prior art keywords
ligands
sub
gaba receptors
gaba
receptors
Prior art date
Application number
AT01980742T
Other languages
German (de)
English (en)
Inventor
Michela Bettati
Peter Blurton
William Robert Carling
Mark Stuart Chambers
David James Hallett
Andrew Jennings
Richard Thomas Lewis
Michael Geoffrey Neil Russell
Leslie Joseph Street
Helen Jane Szekeres
Niel Monique Bodil Van
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0027562A external-priority patent/GB0027562D0/en
Priority claimed from GBGB0117277.4A external-priority patent/GB0117277D0/en
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE310740T1 publication Critical patent/ATE310740T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT01980742T 2000-11-10 2001-11-08 Imidazotriazin-derivate als liganden für gaba- rezeptoren ATE310740T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0027562A GB0027562D0 (en) 2000-11-10 2000-11-10 Therapeutic agents
GBGB0117277.4A GB0117277D0 (en) 2001-07-16 2001-07-16 Therapeutic agents
PCT/GB2001/004948 WO2002038568A1 (en) 2000-11-10 2001-11-08 Imidazo-triazine derivatives as ligands for gaba receptors

Publications (1)

Publication Number Publication Date
ATE310740T1 true ATE310740T1 (de) 2005-12-15

Family

ID=26245271

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01980742T ATE310740T1 (de) 2000-11-10 2001-11-08 Imidazotriazin-derivate als liganden für gaba- rezeptoren

Country Status (9)

Country Link
US (1) US6936608B2 (cg-RX-API-DMAC7.html)
EP (1) EP1343788B1 (cg-RX-API-DMAC7.html)
JP (1) JP4302980B2 (cg-RX-API-DMAC7.html)
AT (1) ATE310740T1 (cg-RX-API-DMAC7.html)
AU (2) AU2002212530B2 (cg-RX-API-DMAC7.html)
CA (1) CA2427779A1 (cg-RX-API-DMAC7.html)
DE (1) DE60115282T2 (cg-RX-API-DMAC7.html)
ES (1) ES2251518T3 (cg-RX-API-DMAC7.html)
WO (1) WO2002038568A1 (cg-RX-API-DMAC7.html)

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GB0117277D0 (en) 2001-07-16 2001-09-05 Merck Sharp & Dohme Therapeutic agents
GB0128499D0 (en) * 2001-11-28 2002-01-23 Merck Sharp & Dohme Therapeutic agents
GB0210127D0 (en) 2002-05-02 2002-06-12 Merck Sharp & Dohme Therapeutic agents
GB0212048D0 (en) 2002-05-24 2002-07-03 Merck Sharp & Dohme Therapeutic agents
US20060235021A1 (en) * 2002-08-13 2006-10-19 Wesley Blackaby Phenylpyridazine derivatives as ligands for gaba receptors
US7485640B2 (en) 2002-11-06 2009-02-03 Merck Sharp & Dohme Limited Imidazopyrazinones as GABA-A receptor anxiolytics
EP1661904A1 (en) 2003-08-22 2006-05-31 Meiji Seika Kaisha Ltd. Novel azalide and azalactam derivatives and process for the production of the same
EP2275095A3 (en) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
AU2006308889A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
US7465795B2 (en) 2005-12-20 2008-12-16 Astrazeneca Ab Compounds and uses thereof
US7425556B2 (en) 2005-12-20 2008-09-16 Astrazeneca Ab Compounds and uses thereof
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
JP2009536667A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド ５ｈｔ受容体介在性の神経新生
EP2382975A3 (en) 2006-05-09 2012-02-29 Braincells, Inc. Neurogenesis by modulating angiotensin
AU2007292848A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
RS54510B1 (sr) 2006-11-22 2016-06-30 Incyte Holdings Corporation Imidazotriazini i imidazopirimidini kao inhibitori kinaze
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
WO2011011712A1 (en) * 2009-07-24 2011-01-27 Concert Pharmaceuticals, Inc. Substituted imidazotriazines
CN102030770B (zh) * 2009-09-25 2012-10-31 北京大学 一种芳香硼酸酯化合物的制备方法
EP2468726B1 (en) * 2010-12-06 2013-08-28 Siena Biotech S.p.A. Compound for the treatment of tumours and tumour metastases
CN102898315B (zh) * 2012-11-05 2015-01-28 上海毕得医药科技有限公司 3-乙炔基-4-氟苯胺的制备方法
UA112028C2 (uk) 2012-12-14 2016-07-11 Пфайзер Лімітед Похідні імідазопіридазину як модулятори гамка-рецептора
CN104177304A (zh) * 2013-05-28 2014-12-03 海洋王照明科技股份有限公司 双极性蓝光磷光主体材料及其制备方法和有机电致发光器件
GB201321732D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
JP6602779B2 (ja) 2014-02-13 2019-11-06 インサイト・コーポレイション Ｌｓｄ１阻害剤としてのシクロプロピルアミン類
EP3105218B1 (en) 2014-02-13 2019-09-25 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
CA2951497C (en) 2014-06-12 2019-04-09 Pfizer Limited Imidazopyridazine derivatives as modulators of the gabaa receptor activity
US9695167B2 (en) 2014-07-10 2017-07-04 Incyte Corporation Substituted triazolo[1,5-a]pyridines and triazolo[1,5-a]pyrazines as LSD1 inhibitors
US9695180B2 (en) 2014-07-10 2017-07-04 Incyte Corporation Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors
WO2016007731A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Imidazopyridines and imidazopyrazines as lsd1 inhibitors
EP3277689B1 (en) 2015-04-03 2019-09-04 Incyte Corporation Heterocyclic compounds as lsd1 inhibitors
MY189367A (en) 2015-08-12 2022-02-08 Incyte Corp Salts of an lsd1 inhibitor
WO2017129801A1 (en) 2016-01-27 2017-08-03 Universität Zürich Use of gabaa receptor modulators for treatment of itch
CN110799267B (zh) 2017-03-21 2023-05-26 密西西比州立大学 不对称盐、ccc-nhc钳形金属配合物及其制备方法
BR112020021104A2 (pt) * 2018-04-18 2021-02-23 Neurocycle Therapeutics, Inc compostos moduladores alostéricos positivos gabaa, métodos de produção e usos dos mesmos
US10968200B2 (en) 2018-08-31 2021-04-06 Incyte Corporation Salts of an LSD1 inhibitor and processes for preparing the same
JP2022553718A (ja) * 2019-10-22 2022-12-26 ニューロサイクル・セラピューティクス・インコーポレイテッド Ｇａｂａａ陽性アロステリック調節因子化合物、作成方法、およびその使用
CN120267677A (zh) * 2019-10-23 2025-07-08 纽罗塞克医疗公司 用gabaa受体调节剂的癫痫状况的治疗
KR102537615B1 (ko) * 2020-02-25 2023-05-30 주식회사 종근당 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물
CN116693555B (zh) * 2022-02-25 2025-07-04 上海赛默罗生物科技有限公司 咪唑并哒嗪类衍生物、其制备方法、药物组合物和用途
CN117069725A (zh) 2022-05-10 2023-11-17 上海赛默罗生物科技有限公司 咪唑并哒嗪取代苯环类衍生物、制备方法、药物组合物及用途

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DE1581125B1 (de) 1966-03-26 1970-08-27 Maierform Trust Reg Bug fuer Verdraengungsschiffe
US3422194A (en) * 1967-08-15 1969-01-14 Smithkline Corp The treatment of depression with imidazo(1,2-b)-as-triazines and compositions thereof
IL146403A0 (en) * 1999-06-22 2002-07-25 Neurosearch As Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds
GB0117277D0 (en) * 2001-07-16 2001-09-05 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
JP2004513171A (ja) 2004-04-30
DE60115282T2 (de) 2006-08-10
DE60115282D1 (de) 2005-12-29
US20040023964A1 (en) 2004-02-05
WO2002038568A1 (en) 2002-05-16
AU1253002A (en) 2002-05-21
EP1343788A1 (en) 2003-09-17
ES2251518T3 (es) 2006-05-01
JP4302980B2 (ja) 2009-07-29
EP1343788B1 (en) 2005-11-23
US6936608B2 (en) 2005-08-30
AU2002212530B2 (en) 2006-08-17
CA2427779A1 (en) 2002-05-16

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