WO2000018767A3 - 2-piperazino alkylamino benzoazole derivatives: dopamine receptor subtype specific ligands - Google Patents
2-piperazino alkylamino benzoazole derivatives: dopamine receptor subtype specific ligands Download PDFInfo
- Publication number
- WO2000018767A3 WO2000018767A3 PCT/US1999/022791 US9922791W WO0018767A3 WO 2000018767 A3 WO2000018767 A3 WO 2000018767A3 US 9922791 W US9922791 W US 9922791W WO 0018767 A3 WO0018767 A3 WO 0018767A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- piperazino
- alkylamino
- dopamine receptor
- receptor subtype
- specific ligands
- Prior art date
Links
- DWVZBHVWBBUWCG-UHFFFAOYSA-N CC(C)Oc1ccccc1CN1CCN(CCNc([s]c2c3)nc2ccc3F)CC1 Chemical compound CC(C)Oc1ccccc1CN1CCN(CCNc([s]c2c3)nc2ccc3F)CC1 DWVZBHVWBBUWCG-UHFFFAOYSA-N 0.000 description 1
- ZARIXUKMKDHMSK-UHFFFAOYSA-N Fc1cnc(N2CCN(CCCCNc3nc4ccccc4[s]3)CC2)nc1 Chemical compound Fc1cnc(N2CCN(CCCCNc3nc4ccccc4[s]3)CC2)nc1 ZARIXUKMKDHMSK-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002345944A CA2345944A1 (en) | 1998-09-30 | 1999-09-30 | 2-piperazino alkylamino benzoazole derivatives: dopamine receptor subtype specific ligands |
JP2000572226A JP2002525373A (en) | 1998-09-30 | 1999-09-30 | 2-piperazinoalkylaminobenzoazole derivatives: dopamine receptor subtype special ligand |
AU62801/99A AU6280199A (en) | 1998-09-30 | 1999-09-30 | 2-piperazino alkylamino benzoazole derivatives: dopamine receptor subtype specific ligands |
EP99950068A EP1117663A2 (en) | 1998-09-30 | 1999-09-30 | 2-piperazino alkylamino benzoazole derivatives: dopamine receptor subtype specific ligands |
HK02100301.2A HK1038749A1 (en) | 1998-09-30 | 2002-01-15 | 2-piperazino alkylamino benzoazole derivatives: dopamine receptor subtype specific ligands |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16357398A | 1998-09-30 | 1998-09-30 | |
US09/163,573 | 1998-09-30 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2000018767A2 WO2000018767A2 (en) | 2000-04-06 |
WO2000018767A3 true WO2000018767A3 (en) | 2000-07-27 |
WO2000018767A9 WO2000018767A9 (en) | 2001-04-19 |
Family
ID=22590612
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/022791 WO2000018767A2 (en) | 1998-09-30 | 1999-09-30 | 2-piperazino alkylamino benzoazole derivatives: dopamine receptor subtype specific ligands |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1117663A2 (en) |
JP (1) | JP2002525373A (en) |
CN (1) | CN1325397A (en) |
AU (1) | AU6280199A (en) |
CA (1) | CA2345944A1 (en) |
HK (1) | HK1038749A1 (en) |
WO (1) | WO2000018767A2 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100571161B1 (en) | 2000-06-21 | 2006-04-17 | 에프. 호프만-라 로슈 아게 | Benzothiazole derivatives |
US6713499B2 (en) | 2001-12-12 | 2004-03-30 | Hoffman-La Roche Inc. | 7-Amino-benzothiazole derivatives |
GB0203299D0 (en) * | 2002-02-12 | 2002-03-27 | Glaxo Group Ltd | Novel compounds |
TW200400035A (en) | 2002-03-28 | 2004-01-01 | Glaxo Group Ltd | Novel compounds |
US7087761B2 (en) | 2003-01-07 | 2006-08-08 | Hoffmann-La Roche Inc. | Cyclization process for substituted benzothiazole derivatives |
WO2005021547A2 (en) * | 2003-08-28 | 2005-03-10 | Pharmaxis Pty Ltd. | Heterocyclic cannabinoid cb2 receptor antagonists |
KR20060061393A (en) * | 2003-10-24 | 2006-06-07 | 에프. 호프만-라 로슈 아게 | Ccr3 receptor antagonists |
PL1753760T3 (en) | 2004-05-24 | 2008-06-30 | Hoffmann La Roche | 4-hydroxy-4-methyl-piperidine-1-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide |
FR2877005A1 (en) * | 2004-10-22 | 2006-04-28 | Bioprojet Soc Civ Ile | NEW ARYLPIPERAZINE DERIVATIVES |
CA2586931C (en) | 2004-11-05 | 2013-08-06 | Paul Spurr | Process for preparation of isonicotinic acid derivatives |
BRPI0609719B8 (en) | 2005-03-23 | 2021-05-25 | Hoffmann La Roche | acetylenyl-pyrazole-pyrimidine derivatives as mgbur2 antagonists |
BRPI0616571A2 (en) | 2005-09-27 | 2011-06-21 | Hoffmann La Roche | oxadiazolyl pyrazol pyridimines as mglur2 antagonists, process for their preparation, pharmaceutical composition containing them and use thereof |
DK2938597T3 (en) | 2012-12-27 | 2017-01-09 | Alzprotect | N- (3- (4- (3- (diisobutylamino) propyl) piperazine-1-yl) -propyl) -1H-benzo [d] imidazol-2-amine sulfate salts, PREPARATION THEREOF AND USE OF SAME |
CN105753811A (en) * | 2016-03-31 | 2016-07-13 | 湖南工程学院 | Dopamine D4 receptor ligand and preparation method thereof |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994022839A1 (en) * | 1993-03-30 | 1994-10-13 | Merck Sharp & Dohme Limited | Antipsychotic benzimidazole derivatives |
WO1996039403A1 (en) * | 1995-06-05 | 1996-12-12 | Neurogen Corporation | 1-(n'-(arylalkylaminoalkyl)) aminoisoindoles as dopamine receptor ligands |
WO1997043271A1 (en) * | 1996-05-10 | 1997-11-20 | Janssen Pharmaceutica N.V. | Alkylaminobenzothiazole and -benzoxazole derivatives |
WO1998056786A1 (en) * | 1997-06-13 | 1998-12-17 | Neurogen Corporation | 2-aminoalkylaminoquinolines as dopamine d4 ligands |
WO1999023092A2 (en) * | 1997-10-31 | 1999-05-14 | Neurogen Corporation | 3-aminoalkylamino-2h-1,4-benzoxa(thia-)zines and pharmaceutical compositions containing them |
-
1999
- 1999-09-30 EP EP99950068A patent/EP1117663A2/en not_active Withdrawn
- 1999-09-30 CN CN99813074A patent/CN1325397A/en active Pending
- 1999-09-30 JP JP2000572226A patent/JP2002525373A/en active Pending
- 1999-09-30 WO PCT/US1999/022791 patent/WO2000018767A2/en not_active Application Discontinuation
- 1999-09-30 CA CA002345944A patent/CA2345944A1/en not_active Abandoned
- 1999-09-30 AU AU62801/99A patent/AU6280199A/en not_active Abandoned
-
2002
- 2002-01-15 HK HK02100301.2A patent/HK1038749A1/en unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994022839A1 (en) * | 1993-03-30 | 1994-10-13 | Merck Sharp & Dohme Limited | Antipsychotic benzimidazole derivatives |
WO1996039403A1 (en) * | 1995-06-05 | 1996-12-12 | Neurogen Corporation | 1-(n'-(arylalkylaminoalkyl)) aminoisoindoles as dopamine receptor ligands |
WO1997043271A1 (en) * | 1996-05-10 | 1997-11-20 | Janssen Pharmaceutica N.V. | Alkylaminobenzothiazole and -benzoxazole derivatives |
WO1998056786A1 (en) * | 1997-06-13 | 1998-12-17 | Neurogen Corporation | 2-aminoalkylaminoquinolines as dopamine d4 ligands |
WO1999023092A2 (en) * | 1997-10-31 | 1999-05-14 | Neurogen Corporation | 3-aminoalkylamino-2h-1,4-benzoxa(thia-)zines and pharmaceutical compositions containing them |
Also Published As
Publication number | Publication date |
---|---|
AU6280199A (en) | 2000-04-17 |
CN1325397A (en) | 2001-12-05 |
HK1038749A1 (en) | 2002-03-28 |
WO2000018767A9 (en) | 2001-04-19 |
CA2345944A1 (en) | 2000-04-06 |
JP2002525373A (en) | 2002-08-13 |
EP1117663A2 (en) | 2001-07-25 |
WO2000018767A2 (en) | 2000-04-06 |
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