ATE299882T1 - Imidozo-pyrimidine derivate als liganden für gaba rezeptoren - Google Patents
Imidozo-pyrimidine derivate als liganden für gaba rezeptorenInfo
- Publication number
- ATE299882T1 ATE299882T1 AT02706976T AT02706976T ATE299882T1 AT E299882 T1 ATE299882 T1 AT E299882T1 AT 02706976 T AT02706976 T AT 02706976T AT 02706976 T AT02706976 T AT 02706976T AT E299882 T1 ATE299882 T1 AT E299882T1
- Authority
- AT
- Austria
- Prior art keywords
- pyrimidine derivatives
- ligands
- imidozo
- phenyl ring
- gaba receptors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Addiction (AREA)
- Toxicology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0107134A GB0107134D0 (en) | 2001-03-21 | 2001-03-21 | Therapeutic agents |
| GB0127938A GB0127938D0 (en) | 2001-11-21 | 2001-11-21 | Therapeutic agents |
| PCT/GB2002/001352 WO2002074773A1 (en) | 2001-03-21 | 2002-03-19 | Imidazo-pyrimidine derivatives as ligands for gaba receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE299882T1 true ATE299882T1 (de) | 2005-08-15 |
Family
ID=26245875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02706976T ATE299882T1 (de) | 2001-03-21 | 2002-03-19 | Imidozo-pyrimidine derivate als liganden für gaba rezeptoren |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP1381606B1 (de) |
| JP (1) | JP4409174B2 (de) |
| KR (1) | KR20030083001A (de) |
| CN (1) | CN1294133C (de) |
| AT (1) | ATE299882T1 (de) |
| AU (1) | AU2002241138B2 (de) |
| BG (1) | BG108166A (de) |
| BR (1) | BR0207994A (de) |
| CA (1) | CA2461426C (de) |
| CZ (1) | CZ20032539A3 (de) |
| DE (1) | DE60205101T2 (de) |
| EA (1) | EA006234B1 (de) |
| EE (1) | EE200300455A (de) |
| ES (1) | ES2244752T3 (de) |
| HU (1) | HUP0303630A3 (de) |
| IL (1) | IL157641A0 (de) |
| MX (1) | MXPA03008572A (de) |
| NO (1) | NO20034170L (de) |
| NZ (1) | NZ527901A (de) |
| PE (1) | PE20020970A1 (de) |
| PL (1) | PL363804A1 (de) |
| SK (1) | SK11672003A3 (de) |
| TW (1) | TWI248936B (de) |
| WO (2) | WO2002074773A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0117277D0 (en) | 2001-07-16 | 2001-09-05 | Merck Sharp & Dohme | Therapeutic agents |
| GB0128499D0 (en) * | 2001-11-28 | 2002-01-23 | Merck Sharp & Dohme | Therapeutic agents |
| GB0226462D0 (en) * | 2002-11-13 | 2002-12-18 | Merck Sharp & Dohme | Therapeutic agents |
| US7271170B2 (en) * | 2003-07-25 | 2007-09-18 | Neurogen Corporation | Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands |
| JP5442448B2 (ja) | 2006-12-22 | 2014-03-12 | アステックス、セラピューティックス、リミテッド | Ｆｇｆｒインヒビターとしての二環式ヘテロ環式化合物 |
| CA2672213C (en) | 2006-12-22 | 2016-02-16 | Astex Therapeutics Limited | Bicyclic amine derivatives as protein tyrosine kinase inhibitors |
| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
| GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| MX359743B (es) | 2009-10-16 | 2018-10-08 | Melinta Therapeutics Inc | Compuestos antimicrobianos y métodos para fabricar y utilizar los mismos. |
| CN104628729B (zh) * | 2009-10-16 | 2018-11-06 | 梅琳塔治疗公司 | 抗微生物化合物和其制备和使用方法 |
| US9216979B2 (en) | 2009-10-16 | 2015-12-22 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
| CN102898315B (zh) * | 2012-11-05 | 2015-01-28 | 上海毕得医药科技有限公司 | 3-乙炔基-4-氟苯胺的制备方法 |
| MX2016002975A (es) | 2013-09-09 | 2016-10-21 | Melinta Therapeutics Inc | Compuestos antimicrobianos y métodos de fabricación y utilización de los mismos. |
| AU2014315045A1 (en) | 2013-09-09 | 2016-03-24 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
| SG11201707346RA (en) | 2015-03-11 | 2017-10-30 | Melinta Therapeutics Inc | Antimicrobial compounds and methods of making and using the same |
| JP2018536677A (ja) * | 2015-12-10 | 2018-12-13 | ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ | てんかんおよび疼痛の治療において使用するための、ＧＡＢＡ受容体モジュレーターとしての式（Ｉ）の４−（ビフェン−３−イル）−１Ｈ−ピラゾロ［３，４−ｃ］ピリダジン誘導体 |
| CA3012791C (en) | 2016-01-27 | 2024-01-23 | Universitat Zurich | Use of gabaa receptor modulators for treatment of itch |
| CN110312722A (zh) | 2016-05-06 | 2019-10-08 | 生物验证系统股份公司 | 抗微生物剂及其制备和使用方法 |
| TW202012402A (zh) | 2018-04-18 | 2020-04-01 | 美商紐羅塞克醫療公司 | Gabaa正向異位性調節劑化合物、其製造方法及用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5185446A (en) * | 1990-09-04 | 1993-02-09 | Neurogen Corporation | Certain cycloalkyl imidazopyrimidines; a new class of gaba brainreceptor ligands |
| ATE194836T1 (de) * | 1995-04-21 | 2000-08-15 | Neurosearch As | Benzimidazolverbindungen und ihre verwendung als modulatoren des gabaa-rezeptorkomplexes |
| PA8535601A1 (es) * | 2000-12-21 | 2002-11-28 | Pfizer | Derivados benzimidazol y piridilimidazol como ligandos para gabaa |
-
2002
- 2002-03-12 TW TW091104588A patent/TWI248936B/zh active
- 2002-03-19 EE EEP200300455A patent/EE200300455A/xx unknown
- 2002-03-19 EA EA200301037A patent/EA006234B1/ru not_active IP Right Cessation
- 2002-03-19 PL PL02363804A patent/PL363804A1/xx not_active Application Discontinuation
- 2002-03-19 SK SK1167-2003A patent/SK11672003A3/sk not_active Application Discontinuation
- 2002-03-19 AT AT02706976T patent/ATE299882T1/de not_active IP Right Cessation
- 2002-03-19 BR BR0207994-1A patent/BR0207994A/pt not_active IP Right Cessation
- 2002-03-19 WO PCT/GB2002/001352 patent/WO2002074773A1/en not_active Ceased
- 2002-03-19 PE PE2002000211A patent/PE20020970A1/es not_active Application Discontinuation
- 2002-03-19 WO PCT/GB2002/001351 patent/WO2002074772A1/en not_active Ceased
- 2002-03-19 DE DE60205101T patent/DE60205101T2/de not_active Expired - Lifetime
- 2002-03-19 NZ NZ527901A patent/NZ527901A/en unknown
- 2002-03-19 ES ES02706976T patent/ES2244752T3/es not_active Expired - Lifetime
- 2002-03-19 CZ CZ20032539A patent/CZ20032539A3/cs unknown
- 2002-03-19 EP EP02706976A patent/EP1381606B1/de not_active Expired - Lifetime
- 2002-03-19 AU AU2002241138A patent/AU2002241138B2/en not_active Ceased
- 2002-03-19 KR KR10-2003-7012252A patent/KR20030083001A/ko not_active Withdrawn
- 2002-03-19 CA CA2461426A patent/CA2461426C/en not_active Expired - Fee Related
- 2002-03-19 JP JP2002573781A patent/JP4409174B2/ja not_active Expired - Fee Related
- 2002-03-19 HU HU0303630A patent/HUP0303630A3/hu unknown
- 2002-03-19 CN CNB028070577A patent/CN1294133C/zh not_active Expired - Fee Related
- 2002-03-19 MX MXPA03008572A patent/MXPA03008572A/es unknown
- 2002-03-19 IL IL15764102A patent/IL157641A0/xx unknown
-
2003
- 2003-09-09 BG BG108166A patent/BG108166A/xx unknown
- 2003-09-19 NO NO20034170A patent/NO20034170L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0303630A2 (hu) | 2004-03-01 |
| WO2002074772A1 (en) | 2002-09-26 |
| AU2002241138B2 (en) | 2007-09-20 |
| EE200300455A (et) | 2003-12-15 |
| NO20034170D0 (no) | 2003-09-19 |
| KR20030083001A (ko) | 2003-10-23 |
| NZ527901A (en) | 2005-09-30 |
| BG108166A (en) | 2004-09-30 |
| NO20034170L (no) | 2003-11-19 |
| JP2004523584A (ja) | 2004-08-05 |
| PL363804A1 (en) | 2004-11-29 |
| CA2461426A1 (en) | 2002-09-26 |
| DE60205101D1 (de) | 2005-08-25 |
| ES2244752T3 (es) | 2005-12-16 |
| EP1381606B1 (de) | 2005-07-20 |
| WO2002074773A1 (en) | 2002-09-26 |
| HUP0303630A3 (en) | 2005-06-28 |
| SK11672003A3 (sk) | 2004-05-04 |
| EP1381606A1 (de) | 2004-01-21 |
| TWI248936B (en) | 2006-02-11 |
| IL157641A0 (en) | 2004-03-28 |
| PE20020970A1 (es) | 2002-11-01 |
| CA2461426C (en) | 2010-08-03 |
| DE60205101T2 (de) | 2006-05-24 |
| CN1294133C (zh) | 2007-01-10 |
| EA200301037A1 (ru) | 2004-04-29 |
| EA006234B1 (ru) | 2005-10-27 |
| CZ20032539A3 (en) | 2004-03-17 |
| BR0207994A (pt) | 2004-03-02 |
| MXPA03008572A (es) | 2003-12-08 |
| JP4409174B2 (ja) | 2010-02-03 |
| CN1498218A (zh) | 2004-05-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |