ATE310533T1 - Zusammensetzungen mit stabilem faktor viii - Google Patents
Zusammensetzungen mit stabilem faktor viiiInfo
- Publication number
- ATE310533T1 ATE310533T1 AT00948452T AT00948452T ATE310533T1 AT E310533 T1 ATE310533 T1 AT E310533T1 AT 00948452 T AT00948452 T AT 00948452T AT 00948452 T AT00948452 T AT 00948452T AT E310533 T1 ATE310533 T1 AT E310533T1
- Authority
- AT
- Austria
- Prior art keywords
- compositions
- factor viii
- stable factor
- stable
- viii
- Prior art date
Links
- 108010023321 Factor VII Proteins 0.000 title 1
- 229960000301 factor viii Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9902685A SE9902685D0 (sv) | 1999-07-13 | 1999-07-13 | Stable protein compositions |
US14682899P | 1999-08-02 | 1999-08-02 | |
SE0001743A SE0001743D0 (sv) | 2000-05-11 | 2000-05-11 | Stable protein compositions II |
PCT/SE2000/001454 WO2001003726A1 (en) | 1999-07-13 | 2000-07-07 | Stable factor viii compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE310533T1 true ATE310533T1 (de) | 2005-12-15 |
Family
ID=27354553
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00948452T ATE310533T1 (de) | 1999-07-13 | 2000-07-07 | Zusammensetzungen mit stabilem faktor viii |
Country Status (14)
Country | Link |
---|---|
US (1) | US6599724B1 (de) |
EP (1) | EP1194161B1 (de) |
JP (1) | JP4674021B2 (de) |
AR (1) | AR024735A1 (de) |
AT (1) | ATE310533T1 (de) |
AU (1) | AU780415B2 (de) |
CA (1) | CA2378751C (de) |
CY (1) | CY1104986T1 (de) |
DE (1) | DE60024268T2 (de) |
DK (1) | DK1194161T3 (de) |
ES (1) | ES2252028T3 (de) |
NO (1) | NO330048B1 (de) |
NZ (1) | NZ516400A (de) |
WO (1) | WO2001003726A1 (de) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU777972B2 (en) | 1999-02-22 | 2004-11-04 | Baxalta GmbH | Novel albumin-free factor VIII formulations |
WO2003055512A1 (en) * | 2001-12-21 | 2003-07-10 | Novo Nordisk Health Care Ag | Liquid composition of factor vii polypeptides |
KR20040065278A (ko) * | 2001-12-21 | 2004-07-21 | 노보 노르디스크 에이/에스 | 변경된 인자 ⅶ 폴리펩티드의 액체 조성물 |
GB0202633D0 (en) * | 2002-02-05 | 2002-03-20 | Delta Biotechnology Ltd | Stabilization of protein preparations |
GB0207092D0 (en) * | 2002-03-26 | 2002-05-08 | Sod Conseils Rech Applic | Stable pharmaceutical composition containing factor VIII |
US20040009918A1 (en) * | 2002-05-03 | 2004-01-15 | Hanne Nedergaard | Stabilised solid compositions of modified factor VII |
AU2003240438A1 (en) | 2002-06-21 | 2004-01-06 | Novo Nordisk A/S | Stabilised solid compositions of factor vii polypeptides |
ATE513283T1 (de) † | 2002-12-27 | 2011-07-15 | Nippon Kinsen Kikai Kk | Optische messeinrichtung zur erkennung optischer merkmale von wertpapieren |
RU2005132164A (ru) * | 2003-03-18 | 2006-06-10 | Ново Нордиск Хелт Кэр Аг (Ch) | Жидкие, водные фармацевтические композиции полипептидов фактора vii |
US7897734B2 (en) * | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
MXPA05012476A (es) * | 2003-05-23 | 2006-02-22 | Novo Nordisk Healthcare Ag | Estabilizacion de proteina en solucion. |
US7485291B2 (en) | 2003-06-03 | 2009-02-03 | Cell Genesys, Inc. | Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof |
US7498024B2 (en) | 2003-06-03 | 2009-03-03 | Cell Genesys, Inc. | Compositions and methods for enhanced expression of immunoglobulins from a single vector using a peptide cleavage site |
ATE547114T1 (de) * | 2003-06-25 | 2012-03-15 | Novo Nordisk Healthcare Ag | Flüssige zusammensetzungen von factor vii polypeptiden |
ATE446768T1 (de) * | 2003-07-01 | 2009-11-15 | Novo Nordisk Healthcare Ag | Flüssige wässrige pharmazeutische zusammnesetzung von factor vii polypeptiden |
KR101293503B1 (ko) | 2003-08-14 | 2013-08-07 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 인자 vii 폴리펩티드의 액상 수성 약학적 조성물 |
ES2229931B1 (es) * | 2003-10-03 | 2006-01-16 | Grifols, S.A. | Composicion liquida bilogicamente estable de fviii, de fvw o del complejo fviii/fvw humanos. |
US20050090551A1 (en) * | 2003-10-27 | 2005-04-28 | Board Of Trustees Of Southern Illinois University | Therapeutic use of methionine for the treatment or prevention of mucositis |
DE602004026474D1 (de) * | 2003-12-03 | 2010-05-20 | Univ Rochester | Rekombinanter faktor viii mit erhöhter spezifischer aktivität |
BRPI0417721B8 (pt) * | 2003-12-19 | 2021-05-25 | Novo Nordisk Healthcare Ag | kit contendo um medicamento farmacêutico, método para preparar uma formulação líquida de um fator recombinante viia, composição e métodos para preparar as composições |
US7422875B2 (en) | 2004-07-20 | 2008-09-09 | Board Of Regents Of The University Of Nebraska | Compositions and methods for increasing protein production |
EP1919498A2 (de) * | 2005-08-26 | 2008-05-14 | Maxygen Holdings Ltd. | Flüssige faktor-vii-zusammensetzung |
FR2908892B1 (fr) * | 2006-11-21 | 2009-02-20 | Hyphen Biomed Soc Par Actions | Procede pour le dosage chromogenique de l'activite du facteur viii:c et necessaire de dosage chromogenique de l'activite du facteur viii:c,dans les plasmas ou les fractions therapeutiques |
EP2209908B1 (de) * | 2007-11-01 | 2014-09-03 | University Of Rochester | Rekombinanter faktor viii mit erhöhter stabilität |
MX343269B (es) | 2007-12-27 | 2016-10-31 | Baxter Int | Procesos de cultivo celular. |
JP5779780B2 (ja) | 2008-11-07 | 2015-09-16 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | 第viii因子製剤 |
GB0915481D0 (en) | 2009-09-04 | 2009-10-07 | Arecor Ltd | Stable manufacture of factor V111 |
GB0915480D0 (en) | 2009-09-04 | 2009-10-07 | Arecor Ltd | Stable formulation of factor viii |
MY165089A (en) | 2010-11-05 | 2018-02-28 | Baxalta Inc | A new variant of antihemophilic factor viii having increased specific activity |
JP6178786B2 (ja) * | 2011-05-13 | 2017-08-09 | オクタファルマ・アーゲー | 組換えfviiiの生産において真核細胞の生産性を向上させる方法 |
KR20140084208A (ko) | 2011-10-18 | 2014-07-04 | 시에스엘 리미티드 | 정제된 인자 viii의 재구성 후의 안정성을 향상시키는 방법 |
CN106413741A (zh) * | 2014-04-01 | 2017-02-15 | 爱德技术生物科学有限公司 | 含低糖‑甘氨酸的稳定因子viii制剂 |
KR20160146763A (ko) * | 2014-04-01 | 2016-12-21 | 어드밴텍 바이오사이언스 파마큐티카 엘티디에이 | 부형제로서 칼슘이 첨가되지 않은 factor viii의 안정화 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU607927B2 (en) | 1986-06-24 | 1991-03-21 | Nordisk Gentofte A/S | A process for producing a coagulation active complex of factor viii fragments |
JP3905921B2 (ja) | 1992-10-02 | 2007-04-18 | ジェネティクス インスチチュート リミテッド ライアビリティー カンパニー | 凝固第▲viii▼因子を含む組成物及びその製造方法並びに安定剤としての界面活性剤の使用方法 |
SE9301581D0 (sv) * | 1993-05-07 | 1993-05-07 | Kabi Pharmacia Ab | Protein formulation |
WO1995003332A1 (en) * | 1993-07-23 | 1995-02-02 | Baxter International Inc. | Activated human factor viii and method of preparation |
US5576291A (en) * | 1993-09-13 | 1996-11-19 | Baxter International Inc. | Activated factor VIII as a therapeutic agent and method of treating factor VIII deficiency |
DE69737455T2 (de) * | 1996-10-11 | 2007-12-06 | Invitrogen Corp., Carlsbad | Definierte systeme zur kultivierung epithelialer zellen und anwendung derselben |
US5804420A (en) * | 1997-04-18 | 1998-09-08 | Bayer Corporation | Preparation of recombinant Factor VIII in a protein free medium |
-
2000
- 2000-07-07 DE DE60024268T patent/DE60024268T2/de not_active Expired - Lifetime
- 2000-07-07 WO PCT/SE2000/001454 patent/WO2001003726A1/en active IP Right Grant
- 2000-07-07 CA CA2378751A patent/CA2378751C/en not_active Expired - Lifetime
- 2000-07-07 AT AT00948452T patent/ATE310533T1/de active
- 2000-07-07 AU AU61933/00A patent/AU780415B2/en not_active Expired
- 2000-07-07 JP JP2001509201A patent/JP4674021B2/ja not_active Expired - Lifetime
- 2000-07-07 DK DK00948452T patent/DK1194161T3/da active
- 2000-07-07 NZ NZ516400A patent/NZ516400A/xx not_active IP Right Cessation
- 2000-07-07 EP EP00948452A patent/EP1194161B1/de not_active Expired - Lifetime
- 2000-07-07 ES ES00948452T patent/ES2252028T3/es not_active Expired - Lifetime
- 2000-07-12 US US09/615,001 patent/US6599724B1/en not_active Expired - Lifetime
- 2000-07-13 AR ARP000103610A patent/AR024735A1/es not_active Application Discontinuation
-
2002
- 2002-01-10 NO NO20020120A patent/NO330048B1/no not_active IP Right Cessation
-
2006
- 2006-02-21 CY CY20061100247T patent/CY1104986T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE60024268D1 (de) | 2005-12-29 |
NO20020120L (no) | 2002-02-28 |
JP2003504345A (ja) | 2003-02-04 |
CA2378751C (en) | 2012-11-06 |
NZ516400A (en) | 2004-02-27 |
DE60024268T2 (de) | 2006-08-03 |
CY1104986T1 (el) | 2009-11-04 |
AR024735A1 (es) | 2002-10-23 |
AU780415B2 (en) | 2005-03-17 |
AU6193300A (en) | 2001-01-30 |
NO330048B1 (no) | 2011-02-07 |
WO2001003726A1 (en) | 2001-01-18 |
NO20020120D0 (no) | 2002-01-10 |
EP1194161A1 (de) | 2002-04-10 |
EP1194161B1 (de) | 2005-11-23 |
US6599724B1 (en) | 2003-07-29 |
DK1194161T3 (da) | 2006-02-13 |
ES2252028T3 (es) | 2006-05-16 |
JP4674021B2 (ja) | 2011-04-20 |
CA2378751A1 (en) | 2001-01-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
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