DE60004363D1 - Faktor viia inhibitore - Google Patents

Faktor viia inhibitore

Info

Publication number
DE60004363D1
DE60004363D1 DE60004363T DE60004363T DE60004363D1 DE 60004363 D1 DE60004363 D1 DE 60004363D1 DE 60004363 T DE60004363 T DE 60004363T DE 60004363 T DE60004363 T DE 60004363T DE 60004363 D1 DE60004363 D1 DE 60004363D1
Authority
DE
Germany
Prior art keywords
inhibitore
factor viia
viia
factor
viia inhibitore
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60004363T
Other languages
English (en)
Other versions
DE60004363T2 (de
Inventor
Otmar Klingler
Manfred Schudok
Gerhard Zoller
Uwe Heinelt
Elisabeth Defossa
Hans Matter
Pavel Safar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Application granted granted Critical
Publication of DE60004363D1 publication Critical patent/DE60004363D1/de
Publication of DE60004363T2 publication Critical patent/DE60004363T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60004363T 1999-06-08 2000-05-27 Faktor viia inhibitore Expired - Lifetime DE60004363T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99111109 1999-06-08
EP99111109A EP1059302A1 (de) 1999-06-08 1999-06-08 Faktor VIIa Inhibitore
PCT/EP2000/004846 WO2000075172A2 (en) 1999-06-08 2000-05-27 FACTOR VIIa INHIBITORS

Publications (2)

Publication Number Publication Date
DE60004363D1 true DE60004363D1 (de) 2003-09-11
DE60004363T2 DE60004363T2 (de) 2004-06-24

Family

ID=8238315

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60004363T Expired - Lifetime DE60004363T2 (de) 1999-06-08 2000-05-27 Faktor viia inhibitore

Country Status (32)

Country Link
US (1) US6500803B1 (de)
EP (2) EP1059302A1 (de)
JP (1) JP4546683B2 (de)
KR (1) KR100979069B1 (de)
CN (1) CN1359390B (de)
AR (1) AR024292A1 (de)
AT (1) ATE246707T1 (de)
AU (1) AU774037B2 (de)
BR (1) BR0011461A (de)
CA (1) CA2376064C (de)
CZ (1) CZ300365B6 (de)
DE (1) DE60004363T2 (de)
DK (1) DK1189929T3 (de)
EE (1) EE04855B1 (de)
ES (1) ES2202137T3 (de)
HK (1) HK1047289B (de)
HR (1) HRP20010912B1 (de)
HU (1) HUP0201451A3 (de)
IL (2) IL146731A0 (de)
ME (1) MEP57708A (de)
MX (1) MXPA01012568A (de)
NO (1) NO328249B1 (de)
NZ (1) NZ515966A (de)
PL (1) PL202879B1 (de)
PT (1) PT1189929E (de)
RS (1) RS50415B (de)
RU (1) RU2248359C2 (de)
SI (1) SI1189929T1 (de)
SK (1) SK286902B6 (de)
TR (1) TR200103550T2 (de)
WO (1) WO2000075172A2 (de)
ZA (1) ZA200110053B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1059302A1 (de) * 1999-06-08 2000-12-13 Aventis Pharma Deutschland GmbH Faktor VIIa Inhibitore
DE10005631A1 (de) * 2000-02-09 2001-08-23 Max Planck Gesellschaft Arginin-Mimetika als Faktor X¶a¶-Inhibitoren
GB0014134D0 (en) * 2000-06-10 2000-08-02 Astrazeneca Ab Combination therapy
WO2002062829A1 (fr) * 2001-02-02 2002-08-15 Chugai Seiyaku Kabushiki Kaisha Derives de peptide
GB0127615D0 (en) * 2001-07-09 2002-01-09 Aventis Pharm Prod Inc Substituted amides, sulfonamides and ureas useful for inhibiting kinase activity
AU2004265021B2 (en) 2003-08-18 2010-05-27 H. Lundbeck A/S Succinate and malonate salt of trans-4-(IR,3S)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and the use as a medicament
TWI376373B (en) 2005-02-16 2012-11-11 Lundbeck & Co As H Crystalline base of a pharmaceutical compound
TWI453198B (zh) 2005-02-16 2014-09-21 Lundbeck & Co As H 製造反式-1-((1r,3s)-6-氯基-3-苯基茚滿-1-基) -3 , 3 -二甲基六氫吡與其鹽類之方法及製造4-((1r , 3s）-6 -氯基-3-苯基茚滿-1-基 )-1,2,2-三甲基六氫吡與其鹽類之方法
WO2007002313A2 (en) * 2005-06-24 2007-01-04 Bristol-Myers Squibb Company Phenylglycinamide and pyridylglycinamide derivatives useful as anticoagulants
WO2007131996A1 (en) * 2006-05-12 2007-11-22 Genmedica Therapeutics Sl Meta-xylylenediamine vanadate salts
JP2019525947A (ja) 2016-06-01 2019-09-12 エムスリー・バイオテクノロジー・インコーポレイテッドＭ３ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ， Ｉｎｃ． 化合物
CA3145453A1 (en) 2019-07-01 2021-01-07 Tonix Pharma Limited Anti-cd154 antibodies and uses thereof
JP2024503625A (ja) 2021-01-06 2024-01-26 トニックス ファーマ リミテッド 改変された抗ｃｄ１５４抗体により免疫寛容を誘導する方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5023236A (en) * 1988-04-07 1991-06-11 Corvas, Inc. Factor VII/VIIA active site inhibitors
US5506134A (en) 1990-10-22 1996-04-09 Corvas International, Inc. Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex
US5788965A (en) 1991-02-28 1998-08-04 Novo Nordisk A/S Modified factor VII
US5833982A (en) 1991-02-28 1998-11-10 Zymogenetics, Inc. Modified factor VII
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
KR100380124B1 (ko) * 1994-04-26 2003-08-02 셀렉타이드 코포레이션 인자Xa억제제
DK0892780T3 (da) * 1996-02-22 2003-03-03 Bristol Myers Squibb Pharma Co m-Amidinophenylanaloger som faktor Xa-inhibitorer
AR013084A1 (es) * 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
EP0987274A1 (de) * 1998-09-15 2000-03-22 Hoechst Marion Roussel Deutschland GmbH Faktor VIIa Inhibitore
EP1059302A1 (de) * 1999-06-08 2000-12-13 Aventis Pharma Deutschland GmbH Faktor VIIa Inhibitore

Also Published As

Publication number Publication date
MXPA01012568A (es) 2002-04-10
EP1189929B1 (de) 2003-08-06
KR20020020728A (ko) 2002-03-15
CZ300365B6 (cs) 2009-04-29
ATE246707T1 (de) 2003-08-15
IL146731A (en) 2007-07-24
HUP0201451A3 (en) 2003-08-28
JP4546683B2 (ja) 2010-09-15
NO20016005D0 (no) 2001-12-07
EP1059302A1 (de) 2000-12-13
WO2000075172A3 (en) 2001-05-31
SI1189929T1 (en) 2004-02-29
SK286902B6 (sk) 2009-07-06
WO2000075172A2 (en) 2000-12-14
ES2202137T3 (es) 2004-04-01
DE60004363T2 (de) 2004-06-24
NO328249B1 (no) 2010-01-18
CN1359390A (zh) 2002-07-17
US6500803B1 (en) 2002-12-31
RU2248359C2 (ru) 2005-03-20
CA2376064C (en) 2011-04-26
HK1047289A1 (en) 2003-02-14
AR024292A1 (es) 2002-09-25
TR200103550T2 (tr) 2002-05-21
NZ515966A (en) 2003-09-26
HRP20010912B1 (en) 2010-10-31
PL202879B1 (pl) 2009-07-31
EE04855B1 (et) 2007-06-15
PL352200A1 (en) 2003-08-11
CN1359390B (zh) 2010-05-26
AU5397600A (en) 2000-12-28
CA2376064A1 (en) 2000-12-14
BR0011461A (pt) 2002-03-19
IL146731A0 (en) 2002-07-25
SK17592001A3 (sk) 2002-05-09
HRP20010912A2 (en) 2003-04-30
NO20016005L (no) 2002-02-06
DK1189929T3 (da) 2003-11-24
RS50415B (sr) 2009-12-31
EP1189929A2 (de) 2002-03-27
HK1047289B (zh) 2010-10-22
PT1189929E (pt) 2003-12-31
ZA200110053B (en) 2002-07-03
AU774037B2 (en) 2004-06-17
MEP57708A (en) 2011-05-10
HUP0201451A2 (en) 2002-08-28
CZ20014357A3 (cs) 2002-03-13
JP2003502294A (ja) 2003-01-21
EE200100662A (et) 2003-04-15
YU86101A (sh) 2004-07-15
KR100979069B1 (ko) 2010-08-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, 65929 FRANKFURT,