ATE307804T1 - Effiziente durch liganden vermittelte ullmann kupplung von anilinen und azolen - Google Patents
Effiziente durch liganden vermittelte ullmann kupplung von anilinen und azolenInfo
- Publication number
- ATE307804T1 ATE307804T1 AT01959231T AT01959231T ATE307804T1 AT E307804 T1 ATE307804 T1 AT E307804T1 AT 01959231 T AT01959231 T AT 01959231T AT 01959231 T AT01959231 T AT 01959231T AT E307804 T1 ATE307804 T1 AT E307804T1
- Authority
- AT
- Austria
- Prior art keywords
- azoles
- anilines
- ullmann coupling
- efficient ligand
- mediated ullmann
- Prior art date
Links
- 238000006887 Ullmann reaction Methods 0.000 title abstract 2
- 150000001448 anilines Chemical class 0.000 title abstract 2
- 150000003851 azoles Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 229940123583 Factor Xa inhibitor Drugs 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- -1 phenyl-substituted azoles Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Executing Machine-Instructions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrane Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22093200P | 2000-07-26 | 2000-07-26 | |
| PCT/US2001/023541 WO2002008199A2 (en) | 2000-07-26 | 2001-07-26 | Efficient ligand-mediated ullmann coupling of anilines and azoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE307804T1 true ATE307804T1 (de) | 2005-11-15 |
Family
ID=22825611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01959231T ATE307804T1 (de) | 2000-07-26 | 2001-07-26 | Effiziente durch liganden vermittelte ullmann kupplung von anilinen und azolen |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6541639B2 (de) |
| EP (1) | EP1307431B1 (de) |
| JP (1) | JP2004504384A (de) |
| KR (1) | KR20030060872A (de) |
| CN (1) | CN1444565A (de) |
| AT (1) | ATE307804T1 (de) |
| AU (1) | AU2001280813A1 (de) |
| BR (1) | BR0112746A (de) |
| CA (1) | CA2417426A1 (de) |
| DE (1) | DE60114424T2 (de) |
| EC (1) | ECSP034453A (de) |
| ES (1) | ES2251501T3 (de) |
| HU (1) | HUP0301699A3 (de) |
| IL (1) | IL153547A0 (de) |
| IS (1) | IS6695A (de) |
| MX (1) | MXPA03000686A (de) |
| NO (1) | NO20030393L (de) |
| NZ (1) | NZ523271A (de) |
| PL (1) | PL361233A1 (de) |
| RU (1) | RU2003103706A (de) |
| WO (1) | WO2002008199A2 (de) |
| ZA (1) | ZA200300039B (de) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050026811A1 (en) * | 2003-05-20 | 2005-02-03 | Mjalli Adnan M. M. | Rage antagonists as agents to reverse amyloidosis and diseases associated therewith |
| DK2272813T3 (en) * | 2001-04-24 | 2017-02-27 | Massachusetts Inst Of Tech (Mit) | COPPER CATALYST CREATION OF CARBON OXYGEN COMPOUNDS |
| EP2324830A1 (de) * | 2002-03-05 | 2011-05-25 | TransTech Pharma Inc. | Verfahren zur Herstellung von einem monozylische Azolderivat das die Interaktion von Liganden mit Rage hemmt |
| JP2006501159A (ja) * | 2002-05-31 | 2006-01-12 | ロデイア・シミ | 炭素−炭素結合又は炭素−ヘテロ原子結合の形成方法 |
| WO2004013094A2 (en) | 2002-08-02 | 2004-02-12 | Massachusetts Institute Of Technology | Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds |
| AU2003270861A1 (en) * | 2002-10-02 | 2004-04-23 | Bristol-Myers Squibb Company | Novel combination of a factor xa inhibitor and clopidogrel |
| WO2006009431A1 (en) * | 2004-07-16 | 2006-01-26 | Dsm Ip Assets B.V. | Process for the preparation of an (hetero)arylamine |
| KR101999300B1 (ko) | 2007-03-12 | 2019-07-12 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 치환된 헤테로환 융합 감마-카르볼린 합성 |
| WO2011041198A1 (en) | 2009-09-30 | 2011-04-07 | Transtech Pharma, Inc. | Substituted imidazole derivatives for treatment of alzheimers disease |
| CA2870303A1 (en) | 2012-04-14 | 2013-10-17 | Intra-Cellular Therapies, Inc. | Organic compounds |
| HUE053159T2 (hu) | 2013-03-15 | 2021-06-28 | Intra Cellular Therapies Inc | Szerves vegyületek |
| IL246002B2 (en) | 2013-12-03 | 2024-11-01 | Intra Cellular Therapies Inc | Converted compounds of gamma-carboline fused with heterocycles for use in the treatment of residual symptoms of psychosis and a long-acting injectable preparation containing these compounds in a matrix |
| JP2017509677A (ja) | 2014-04-04 | 2017-04-06 | イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． | 有機化合物 |
| KR20220054908A (ko) | 2014-04-04 | 2022-05-03 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
| WO2015171951A1 (en) * | 2014-05-07 | 2015-11-12 | The Regents Of The University Of Colorado, A Body Corporate | 2-(4-aryl-1h-imidazol-1-yl)aniline compounds |
| IL318649A (en) | 2016-01-26 | 2025-03-01 | Intra Cellular Therapies Inc | Organic compounds |
| BR112018069594B1 (pt) | 2016-03-25 | 2023-12-05 | Intra-Cellular Therapies, Inc | Compostos orgânicos, composição farmacêutica compreendendo os ditos compostos e uso dos mesmos para o tratamento ou profilaxia de um distúrbio do sistema nervoso central |
| WO2017172795A1 (en) | 2016-03-28 | 2017-10-05 | Intra-Cellular Therapies, Inc. | Novel compositions and methods |
| US11014925B2 (en) | 2016-03-28 | 2021-05-25 | Intra-Cellular Therapies, Inc. | Co-crystals of 1-(4-fluoro-phenyl)-4-((6bR,1OaS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H- pyrido[3′,4′:4,51_pyrrolo [1,2,3-delqcuinoxalin-8-yl)-butan-1-one with nicotinamide or isonicotinamide |
| JP2019513143A (ja) | 2016-03-28 | 2019-05-23 | イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． | 新規塩類および結晶 |
| WO2018071233A1 (en) | 2016-10-12 | 2018-04-19 | Intra-Cellular Therapies, Inc. | Amorphous solid dispersions |
| EP3562484B1 (de) | 2016-12-29 | 2021-08-25 | Intra-Cellular Therapies, Inc. | Pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalinderivate zur behandlung von erkrankungen des zns |
| WO2018126140A1 (en) | 2016-12-29 | 2018-07-05 | Intra-Cellular Therapies, Inc. | Organic compounds |
| IL304026B2 (en) | 2017-03-24 | 2024-11-01 | Intra Cellular Therapies Inc | A pharmaceutical preparation containing 1-(4-fluoro-phenyl)-4-((Sa10,Rb6)-3-D2-2,2-methyl-2, 3, a10, 10, 9, b6- hexahydro-H7, H1- Pyrido[3',4',:4,5]pyrrolo[3,2,1-de]quioxalin-8-yl)-butan-1-one and its uses |
| IL272252B2 (en) | 2017-07-26 | 2024-03-01 | Intra Cellular Therapies Inc | Derivatives of substituted heterocycle fused gamma-carbolines, pharmaceutical compositions comnprising them and their use in treatment |
| MX2020000968A (es) | 2017-07-26 | 2020-09-28 | Intra Cellular Therapies Inc | Compuestos organicos. |
| SMT202200134T1 (it) | 2018-03-08 | 2022-05-12 | Incyte Corp | Composti di amminopirazindiolo come inibitori di pi3k-y |
| WO2019183341A1 (en) | 2018-03-23 | 2019-09-26 | Intra-Cellular Therapies, Inc. | Organic compounds |
| JP7476115B2 (ja) | 2018-06-06 | 2024-04-30 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 新規の塩および結晶 |
| MX2020013335A (es) | 2018-06-08 | 2021-05-27 | Intra Cellular Therapies Inc | Metodos novedosos. |
| CA3240552A1 (en) | 2018-06-11 | 2019-12-19 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines synthesis |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
| US12144808B2 (en) | 2018-08-29 | 2024-11-19 | Intra-Cellular Therapies, Inc. | Compositions and methods |
| BR112021003838A2 (pt) | 2018-08-31 | 2021-05-18 | Intra-Cellular Therapies, Inc. | métodos novos |
| MX2021002322A (es) | 2018-08-31 | 2021-04-28 | Intra Cellular Therapies Inc | Nuevos metodos. |
| EP3886854A4 (de) | 2018-11-30 | 2022-07-06 | Nuvation Bio Inc. | Pyrrol- und pyrazolverbindungen und verfahren zu deren verwendung |
| US12297200B2 (en) | 2018-12-17 | 2025-05-13 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines synthesis |
| IL315005B1 (en) | 2018-12-17 | 2025-12-01 | Intra Cellular Therapies Inc | Substituted heterocycle fused gamma-carbolines synthesis |
| MX2022000143A (es) | 2019-07-07 | 2022-02-17 | Intra Cellular Therapies Inc | Metodos novedosos. |
| US12414948B2 (en) | 2022-05-18 | 2025-09-16 | Intra-Cellular Therapies, Inc. | Methods |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6372658A (ja) | 1986-09-17 | 1988-04-02 | Sumitomo Chem Co Ltd | ニトロジフエニルアミン類の製造方法 |
| US5705697A (en) | 1997-01-30 | 1998-01-06 | Xerox Corporation | Arylamine processes |
| ZA985247B (en) | 1997-06-19 | 1999-12-17 | Du Pont Merck Pharma | Guanidine mimics as factor Xa inhibitors. |
-
2001
- 2001-07-25 US US09/912,950 patent/US6541639B2/en not_active Expired - Fee Related
- 2001-07-26 HU HU0301699A patent/HUP0301699A3/hu unknown
- 2001-07-26 JP JP2002514105A patent/JP2004504384A/ja active Pending
- 2001-07-26 WO PCT/US2001/023541 patent/WO2002008199A2/en not_active Ceased
- 2001-07-26 RU RU2003103706/04A patent/RU2003103706A/ru not_active Application Discontinuation
- 2001-07-26 CN CN01813378A patent/CN1444565A/zh active Pending
- 2001-07-26 DE DE60114424T patent/DE60114424T2/de not_active Expired - Fee Related
- 2001-07-26 AU AU2001280813A patent/AU2001280813A1/en not_active Abandoned
- 2001-07-26 AT AT01959231T patent/ATE307804T1/de not_active IP Right Cessation
- 2001-07-26 KR KR10-2003-7001155A patent/KR20030060872A/ko not_active Withdrawn
- 2001-07-26 EP EP01959231A patent/EP1307431B1/de not_active Expired - Lifetime
- 2001-07-26 ES ES01959231T patent/ES2251501T3/es not_active Expired - Lifetime
- 2001-07-26 NZ NZ523271A patent/NZ523271A/en unknown
- 2001-07-26 IL IL15354701A patent/IL153547A0/xx unknown
- 2001-07-26 PL PL36123301A patent/PL361233A1/xx not_active Application Discontinuation
- 2001-07-26 BR BR0112746-2A patent/BR0112746A/pt not_active IP Right Cessation
- 2001-07-26 CA CA002417426A patent/CA2417426A1/en not_active Abandoned
- 2001-07-26 MX MXPA03000686A patent/MXPA03000686A/es unknown
-
2003
- 2003-01-02 ZA ZA200300039A patent/ZA200300039B/en unknown
- 2003-01-22 IS IS6695A patent/IS6695A/is unknown
- 2003-01-24 EC EC2003004453A patent/ECSP034453A/es unknown
- 2003-01-24 NO NO20030393A patent/NO20030393L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ECSP034453A (es) | 2003-03-31 |
| BR0112746A (pt) | 2003-09-09 |
| DE60114424T2 (de) | 2006-07-27 |
| KR20030060872A (ko) | 2003-07-16 |
| DE60114424D1 (de) | 2005-12-01 |
| HUP0301699A3 (en) | 2004-03-29 |
| US20020099225A1 (en) | 2002-07-25 |
| HUP0301699A2 (hu) | 2003-12-29 |
| WO2002008199A3 (en) | 2002-06-13 |
| IS6695A (is) | 2003-01-22 |
| NZ523271A (en) | 2005-01-28 |
| EP1307431B1 (de) | 2005-10-26 |
| JP2004504384A (ja) | 2004-02-12 |
| AU2001280813A1 (en) | 2002-02-05 |
| MXPA03000686A (es) | 2003-06-06 |
| EP1307431A2 (de) | 2003-05-07 |
| RU2003103706A (ru) | 2004-08-10 |
| CN1444565A (zh) | 2003-09-24 |
| IL153547A0 (en) | 2003-07-06 |
| CA2417426A1 (en) | 2002-01-31 |
| PL361233A1 (en) | 2004-10-04 |
| ES2251501T3 (es) | 2006-05-01 |
| ZA200300039B (en) | 2004-04-02 |
| WO2002008199A2 (en) | 2002-01-31 |
| NO20030393D0 (no) | 2003-01-24 |
| NO20030393L (no) | 2003-03-24 |
| US6541639B2 (en) | 2003-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |