BR0112746A - Acoplamento de ullmann mediado por ligante eficiente de anilinas e azóis - Google Patents

Acoplamento de ullmann mediado por ligante eficiente de anilinas e azóis

Info

Publication number
BR0112746A
BR0112746A BR0112746-2A BR0112746A BR0112746A BR 0112746 A BR0112746 A BR 0112746A BR 0112746 A BR0112746 A BR 0112746A BR 0112746 A BR0112746 A BR 0112746A
Authority
BR
Brazil
Prior art keywords
azoles
anilines
ullmann coupling
efficient
efficient binder
Prior art date
Application number
BR0112746-2A
Other languages
English (en)
Inventor
Jia Cheng Zhou
Pasquale N Confalone
Hui-Yin Li
Lynette M Oh
Lucius T Rossano
Charles G Clark
Christopher A Teleha
Original Assignee
Bristol Myers Squibb Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co
Publication of BR0112746A publication Critical patent/BR0112746A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Executing Machine-Instructions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrane Compounds (AREA)

Abstract

"ACOPLAMENTO DE ULLMANN MEDIADO POR LIGANTE EFICIENTE DE ANILINAS E AZóIS". A presente invenção proporciona o método de preparar azóis substituídos por fenila. Esse método usa uma reação de acoplamento de Ullmann acelerada por ligante eficiente de anilinas com azóis. Os produtos de acoplamento são úteis para preparar os inibidores do fator Xa.
BR0112746-2A 2000-07-26 2001-07-26 Acoplamento de ullmann mediado por ligante eficiente de anilinas e azóis BR0112746A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22093200P 2000-07-26 2000-07-26
PCT/US2001/023541 WO2002008199A2 (en) 2000-07-26 2001-07-26 Efficient ligand-mediated ullmann coupling of anilines and azoles

Publications (1)

Publication Number Publication Date
BR0112746A true BR0112746A (pt) 2003-09-09

Family

ID=22825611

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0112746-2A BR0112746A (pt) 2000-07-26 2001-07-26 Acoplamento de ullmann mediado por ligante eficiente de anilinas e azóis

Country Status (22)

Country Link
US (1) US6541639B2 (pt)
EP (1) EP1307431B1 (pt)
JP (1) JP2004504384A (pt)
KR (1) KR20030060872A (pt)
CN (1) CN1444565A (pt)
AT (1) ATE307804T1 (pt)
AU (1) AU2001280813A1 (pt)
BR (1) BR0112746A (pt)
CA (1) CA2417426A1 (pt)
DE (1) DE60114424T2 (pt)
EC (1) ECSP034453A (pt)
ES (1) ES2251501T3 (pt)
HU (1) HUP0301699A3 (pt)
IL (1) IL153547A0 (pt)
IS (1) IS6695A (pt)
MX (1) MXPA03000686A (pt)
NO (1) NO20030393L (pt)
NZ (1) NZ523271A (pt)
PL (1) PL361233A1 (pt)
RU (1) RU2003103706A (pt)
WO (1) WO2002008199A2 (pt)
ZA (1) ZA200300039B (pt)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1266112C (zh) * 2001-04-24 2006-07-26 麻省理工学院 铜－催化的碳－杂原子键和碳－碳键的形成
DK1482931T3 (da) * 2002-03-05 2011-12-19 Transtech Pharma Inc Mono- og bicycliske azolderivater der inhiberer interaktionen af ligander med RAGE
EP1509502A1 (fr) * 2002-05-31 2005-03-02 Rhodia Chimie Procede de formation d une liaison carbone-carbone ou carbone-heteroatome
AU2003257062A1 (en) 2002-08-02 2004-02-23 Massachusetts Institute Of Technology Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds
US20040067995A1 (en) * 2002-10-02 2004-04-08 Wong Pancras C. Novel combination of a factor Xa inhibitor and clopidogrel
CN1805743A (zh) * 2003-05-20 2006-07-19 特兰斯泰克制药公司 用作逆转淀粉样变性及其他与之相关疾病的rage拮抗剂
CN1984872A (zh) * 2004-07-16 2007-06-20 帝斯曼知识产权资产管理有限公司 制备（杂）芳胺的方法
JP5567349B2 (ja) 2007-03-12 2014-08-06 イントラ−セルラー・セラピーズ・インコーポレイテッド 置換ヘテロ環縮合ガンマ−カルボリンの合成
US8580833B2 (en) 2009-09-30 2013-11-12 Transtech Pharma, Inc. Substituted imidazole derivatives and methods of use thereof
ES2727815T3 (es) 2012-04-14 2019-10-18 Intra Cellular Therapies Inc Tratamiento del TEPT y de trastornos del control de impulsos
EP2968320B1 (en) 2013-03-15 2020-11-11 Intra-Cellular Therapies, Inc. Organic compounds
KR102495941B1 (ko) 2013-12-03 2023-02-06 인트라-셀룰라 써래피스, 인코퍼레이티드. 신규한 방법
MX2016013046A (es) 2014-04-04 2017-02-15 Intra-Cellular Therapies Inc Compuestos organicos.
BR112016023162B1 (pt) 2014-04-04 2022-11-29 Intra-Cellular Therapies, Inc Compostos orgânicos gama-carbolinas, composições farmacêuticas compreendendo os ditos compostos e uso dos mesmos no tratamento ou na profilaxia de transtornos de sistema nervoso central
WO2015171951A1 (en) * 2014-05-07 2015-11-12 The Regents Of The University Of Colorado, A Body Corporate 2-(4-aryl-1h-imidazol-1-yl)aniline compounds
BR112018015283B1 (pt) 2016-01-26 2023-09-26 Intra-Cellular Therapies, Inc Compostos orgânicos, composição farmacêutica compreendendo os ditos compostos e uso dos mesmos para o tratamento ou profilaxia de um distúrbio do sistema nervoso central
EP3888656A1 (en) 2016-03-25 2021-10-06 Intra-Cellular Therapies, Inc. Deuterated heterocyclic gamma-carboline compounds and their use in the treatment or prophylaxis of a central nervous system disorder
WO2017172795A1 (en) 2016-03-28 2017-10-05 Intra-Cellular Therapies, Inc. Novel compositions and methods
EP3436016B1 (en) 2016-03-28 2022-04-27 Intra-Cellular Therapies, Inc. Novel co-crystals
EP3436455A4 (en) 2016-03-28 2019-09-04 Intra-Cellular Therapies, Inc. NOVEL SALTS AND CRYSTALS
US11331316B2 (en) 2016-10-12 2022-05-17 Intra-Cellular Therapies, Inc. Amorphous solid dispersions
WO2018126143A1 (en) 2016-12-29 2018-07-05 Intra-Cellular Therapies, Inc. Organic compounds
US10961245B2 (en) 2016-12-29 2021-03-30 Intra-Cellular Therapies, Inc. Substituted heterocycle fused gamma-carbolines for treatment of central nervous system disorders
CA3054841A1 (en) 2017-03-24 2018-09-27 Intra-Cellular Therapies, Inc. Novel compositions and methods
MX2020000968A (es) 2017-07-26 2020-09-28 Intra Cellular Therapies Inc Compuestos organicos.
WO2019023063A1 (en) 2017-07-26 2019-01-31 Intra-Cellular Therapies, Inc. ORGANIC COMPOUNDS
HUE057970T2 (hu) 2018-03-08 2022-06-28 Incyte Corp Aminopirazindiol-vegyületek mint PI3K-Y inhibitorok
JP7483671B2 (ja) 2018-06-11 2024-05-15 イントラ－セルラー・セラピーズ・インコーポレイテッド 置換ヘテロ環縮合ガンマ－カルボリン類合成
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
EP3843738A4 (en) 2018-08-31 2022-06-01 Intra-Cellular Therapies, Inc. NEW METHODS
WO2020047408A1 (en) 2018-08-31 2020-03-05 Intra-Cellular Therapies, Inc. Novel methods
WO2020113094A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6372658A (ja) 1986-09-17 1988-04-02 Sumitomo Chem Co Ltd ニトロジフエニルアミン類の製造方法
US5705697A (en) 1997-01-30 1998-01-06 Xerox Corporation Arylamine processes
ZA985247B (en) 1997-06-19 1999-12-17 Du Pont Merck Pharma Guanidine mimics as factor Xa inhibitors.

Also Published As

Publication number Publication date
HUP0301699A2 (hu) 2003-12-29
IS6695A (is) 2003-01-22
CA2417426A1 (en) 2002-01-31
US6541639B2 (en) 2003-04-01
DE60114424T2 (de) 2006-07-27
IL153547A0 (en) 2003-07-06
DE60114424D1 (de) 2005-12-01
WO2002008199A2 (en) 2002-01-31
HUP0301699A3 (en) 2004-03-29
EP1307431A2 (en) 2003-05-07
MXPA03000686A (es) 2003-06-06
ECSP034453A (es) 2003-03-31
NO20030393L (no) 2003-03-24
NO20030393D0 (no) 2003-01-24
KR20030060872A (ko) 2003-07-16
CN1444565A (zh) 2003-09-24
ATE307804T1 (de) 2005-11-15
RU2003103706A (ru) 2004-08-10
NZ523271A (en) 2005-01-28
ZA200300039B (en) 2004-04-02
US20020099225A1 (en) 2002-07-25
JP2004504384A (ja) 2004-02-12
EP1307431B1 (en) 2005-10-26
WO2002008199A3 (en) 2002-06-13
AU2001280813A1 (en) 2002-02-05
ES2251501T3 (es) 2006-05-01
PL361233A1 (en) 2004-10-04

Similar Documents

Publication Publication Date Title
BR0112746A (pt) Acoplamento de ullmann mediado por ligante eficiente de anilinas e azóis
CY1106486T1 (el) Μεθοδος παρασκευης 2-(κινοξαλιν-5-υλσουλφονυλαμινο) βενζαμιδικων ενωσεων
BRPI0615705A2 (pt) processo para preparar um composto, e, composto
BR0206943A (pt) Inibidores de fosfodiesterase 4
BR0115482A (pt) Composição de sacralose melhorada e processo para sua preparação
BR0307432B1 (pt) difluormetiltiazolilcarboxanilidas
SE0104251D0 (sv) Novel compounds
ITMI20050801A1 (it) Procedimento per la preparazione di telmisartan
HK1096549A1 (en) Imidazopyridine-derivatives as inducible no-synthase inhibitors
BR0311242A (pt) Processo para preparar modafinil
WO2005009951A3 (en) Diphenyl substituted cycloalkanes, compositions containing such compounds and methods of use
UY27842A1 (es) Fluorobenzamidas
SE0103710D0 (sv) Compounds
DK0882726T3 (da) Carbazolcarboxamider som 5-HT1F-agonister
BR0213481A (pt) Sondas
CY1111432T1 (el) Τετραϋδροκινολινες για χρηση ως διαμορφωτες της μιτοτικης κινητικης πρωτεϊνης eg5
BR0301667A (pt) Processo para a preparação de polìmeros em emulsão com pureza elevada
BR0212772A (pt) Processo para a preparação de repaglinida
BR0316400A (pt) agentes branqueadores fluorescentes anfotéricos
BRPI0414107A (pt) produtos intermediários para a preparação de hìbridos de oxazolidinon-quinolona
RS20060206A (en) Aminopyridine-derivatives as inducible no-synthase inhibitors
SE0202693D0 (sv) Compounds
RS20060196A (en) Imidazopyridine-derivatives as inducible no-synthase inhibitors
BR0315508A (pt) Processo para preparação de compostos de pirazol
BRPI0411921A (pt) processo para preparar intermediários úteis para preparar determinadas hidroxilaminas de n-formila antibacterianas

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5O, 6O, 7O E 8O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2021 DE 29/09/2009.