ATE295841T1 - Substituierte benzylthiazolidin-2,4-dion derivate - Google Patents
Substituierte benzylthiazolidin-2,4-dion derivateInfo
- Publication number
- ATE295841T1 ATE295841T1 AT00953476T AT00953476T ATE295841T1 AT E295841 T1 ATE295841 T1 AT E295841T1 AT 00953476 T AT00953476 T AT 00953476T AT 00953476 T AT00953476 T AT 00953476T AT E295841 T1 ATE295841 T1 AT E295841T1
- Authority
- AT
- Austria
- Prior art keywords
- dione derivatives
- substituted benzylthiazolidine
- preparing
- benzylthiazolidine
- receptor
- Prior art date
Links
- JIMXJAFZPUUCAD-UHFFFAOYSA-N 3-benzyl-1,3-thiazolidine-2,4-dione Chemical class O=C1CSC(=O)N1CC1=CC=CC=C1 JIMXJAFZPUUCAD-UHFFFAOYSA-N 0.000 title abstract 3
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 abstract 2
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 230000023603 positive regulation of transcription initiation, DNA-dependent Effects 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP23552899 | 1999-08-23 | ||
| PCT/JP2000/005520 WO2001014350A1 (en) | 1999-08-23 | 2000-08-18 | Substituted benzylthiazolidine-2,4-dione derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE295841T1 true ATE295841T1 (de) | 2005-06-15 |
Family
ID=16987319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00953476T ATE295841T1 (de) | 1999-08-23 | 2000-08-18 | Substituierte benzylthiazolidin-2,4-dion derivate |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6545026B1 (de) |
| EP (1) | EP1207156B1 (de) |
| KR (1) | KR20020022811A (de) |
| CN (1) | CN1152025C (de) |
| AT (1) | ATE295841T1 (de) |
| AU (1) | AU778723B2 (de) |
| CA (1) | CA2382581C (de) |
| DE (1) | DE60020246T2 (de) |
| HU (1) | HUP0202893A3 (de) |
| TW (1) | TWI225051B (de) |
| WO (1) | WO2001014350A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1348698A4 (de) | 2000-12-05 | 2005-01-19 | Kyorin Seiyaku Kk | Substituierte carbonsäurederivate |
| US6982251B2 (en) | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| SI1413331T1 (sl) | 2001-01-26 | 2008-02-29 | Schering Corp | Kombinacije fenofibrata peroksisomskega proliferator aktivirajocega receptorja (PPAR) z ezetimib zaviralcem absorpcije sterola za vaskularne indikacije |
| JP4711600B2 (ja) | 2001-01-26 | 2011-06-29 | シェーリング コーポレイション | シトステロール血症の処置のための置換アゼチジノン化合物の使用 |
| EP1911462A3 (de) | 2001-01-26 | 2011-11-30 | Schering Corporation | Zusammensetzungen enthaltend einen Sterolabsorptionshemmer |
| US7071181B2 (en) | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
| US7132415B2 (en) | 2001-09-21 | 2006-11-07 | Schering Corporation | Methods and therapeutic combinations for the treatment of xanthoma using sterol absorption inhibitors |
| US7053080B2 (en) | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
| US7056906B2 (en) | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
| JPWO2003050097A1 (ja) * | 2001-12-11 | 2005-04-21 | 杏林製薬株式会社 | ベンジルチアゾリジン−２，４−ジオン誘導体のナトリウム塩及びその水和物 |
| JPWO2003062214A1 (ja) * | 2002-01-23 | 2005-05-19 | 杏林製薬株式会社 | ベンジルチアゾリジンジオン誘導体の新規な安定結晶とその製法 |
| CA2504878A1 (en) | 2002-11-06 | 2004-05-27 | Schering Corporation | Cholesterol absorption inhibitors for the treatment of demyelination |
| US7459442B2 (en) | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| CN1756755A (zh) | 2003-03-07 | 2006-04-05 | 先灵公司 | 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途 |
| CN100439361C (zh) | 2003-03-07 | 2008-12-03 | 先灵公司 | 取代的2-吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途 |
| JP4589919B2 (ja) | 2003-03-07 | 2010-12-01 | シェーリング コーポレイション | 高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用 |
| CN101233129A (zh) * | 2005-05-31 | 2008-07-30 | 普法尔家族联合企业（1996.7.9） | 取代的联芳杂环衍生物作为蛋白激酶抑制剂治疗癌症及其他疾病 |
| US20080241215A1 (en) * | 2007-03-28 | 2008-10-02 | Robert Falotico | Local vascular delivery of probucol alone or in combination with sirolimus to treat restenosis, vulnerable plaque, aaa and stroke |
| WO2012027331A1 (en) | 2010-08-27 | 2012-03-01 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3929512B2 (ja) | 1995-06-02 | 2007-06-13 | 杏林製薬株式会社 | Ｎ−置換ジオキソチアゾリジルベンズアミド誘導体及びその製造法 |
| US6001862A (en) * | 1995-06-02 | 1999-12-14 | Kyorin Pharameuticals Co., Ltd. | N-benzyldioxothiazolidylbenzamide derivatives and processes for preparing the same |
| JP3144624B2 (ja) * | 1995-06-02 | 2001-03-12 | 杏林製薬株式会社 | Ｎ−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法 |
| JP3906935B2 (ja) * | 1995-12-18 | 2007-04-18 | 杏林製薬株式会社 | Ｎ−置換ジオキソチアゾリジルベンズアミド誘導体及びその製造法 |
| WO1997032863A1 (en) * | 1996-03-08 | 1997-09-12 | Torii Pharmaceutical Co., Ltd. | Thiazolidine-2,4-dione derivatives |
| JPH09301963A (ja) | 1996-05-17 | 1997-11-25 | Kyorin Pharmaceut Co Ltd | Ｎ−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法 |
-
2000
- 2000-08-18 EP EP00953476A patent/EP1207156B1/de not_active Expired - Lifetime
- 2000-08-18 AT AT00953476T patent/ATE295841T1/de not_active IP Right Cessation
- 2000-08-18 CA CA002382581A patent/CA2382581C/en not_active Expired - Fee Related
- 2000-08-18 KR KR1020027001993A patent/KR20020022811A/ko not_active Ceased
- 2000-08-18 AU AU65946/00A patent/AU778723B2/en not_active Ceased
- 2000-08-18 US US10/049,905 patent/US6545026B1/en not_active Expired - Fee Related
- 2000-08-18 WO PCT/JP2000/005520 patent/WO2001014350A1/ja not_active Ceased
- 2000-08-18 DE DE60020246T patent/DE60020246T2/de not_active Expired - Fee Related
- 2000-08-18 CN CNB008147108A patent/CN1152025C/zh not_active Expired - Fee Related
- 2000-08-18 HU HU0202893A patent/HUP0202893A3/hu unknown
- 2000-08-22 TW TW089116994A patent/TWI225051B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU778723B2 (en) | 2004-12-16 |
| CN1382131A (zh) | 2002-11-27 |
| CA2382581A1 (en) | 2001-03-01 |
| EP1207156A1 (de) | 2002-05-22 |
| DE60020246D1 (de) | 2005-06-23 |
| WO2001014350A1 (en) | 2001-03-01 |
| EP1207156B1 (de) | 2005-05-18 |
| CN1152025C (zh) | 2004-06-02 |
| EP1207156A4 (de) | 2002-09-18 |
| KR20020022811A (ko) | 2002-03-27 |
| CA2382581C (en) | 2007-06-12 |
| AU6594600A (en) | 2001-03-19 |
| DE60020246T2 (de) | 2006-01-19 |
| TWI225051B (en) | 2004-12-11 |
| US6545026B1 (en) | 2003-04-08 |
| HUP0202893A2 (hu) | 2002-12-28 |
| HUP0202893A3 (en) | 2004-12-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |