ATE290528T1 - Verfahren zur herstellung von 4-(1-hydroxy-4-(4- (hydroxydiphenylmethyl)-1-piperidinyl)-butyl)- alpha, alpha-dimethylphenylessigsäure - Google Patents
Verfahren zur herstellung von 4-(1-hydroxy-4-(4- (hydroxydiphenylmethyl)-1-piperidinyl)-butyl)- alpha, alpha-dimethylphenylessigsäureInfo
- Publication number
- ATE290528T1 ATE290528T1 AT02010234T AT02010234T ATE290528T1 AT E290528 T1 ATE290528 T1 AT E290528T1 AT 02010234 T AT02010234 T AT 02010234T AT 02010234 T AT02010234 T AT 02010234T AT E290528 T1 ATE290528 T1 AT E290528T1
- Authority
- AT
- Austria
- Prior art keywords
- alpha
- hydroxydiphenylmethyl
- hydroxy
- piperidinyl
- butyl
- Prior art date
Links
- RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 229960003592 fexofenadine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001RM000260A ITRM20010260A1 (it) | 2001-05-17 | 2001-05-17 | Processo per la preparazione della fexofenadina o acido 4 1-idrossi-4-4- (idrossidifenilmetil)-1-piperidinil|-butil|-alfa,alfa-dimetilbenz |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE290528T1 true ATE290528T1 (de) | 2005-03-15 |
Family
ID=11455529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02010234T ATE290528T1 (de) | 2001-05-17 | 2002-05-16 | Verfahren zur herstellung von 4-(1-hydroxy-4-(4- (hydroxydiphenylmethyl)-1-piperidinyl)-butyl)- alpha, alpha-dimethylphenylessigsäure |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6815549B2 (https=) |
| EP (1) | EP1260505B1 (https=) |
| JP (1) | JP2003026658A (https=) |
| AT (1) | ATE290528T1 (https=) |
| CA (1) | CA2386452A1 (https=) |
| CZ (1) | CZ295949B6 (https=) |
| DE (1) | DE60203142T2 (https=) |
| ES (1) | ES2237631T3 (https=) |
| HU (1) | HUP0201673A3 (https=) |
| IT (1) | ITRM20010260A1 (https=) |
| PL (1) | PL353977A1 (https=) |
| PT (1) | PT1260505E (https=) |
| SI (1) | SI1260505T1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2239554T1 (es) * | 2002-06-10 | 2005-10-01 | Teva Pharmaceutical Industries Ltd. | Forma xvi polimorfica de hidrocloruro de fexofenadina. |
| EP1616861A3 (en) * | 2004-06-15 | 2006-02-08 | Dipharma S.p.A. | A process for the preparation of keto compounds |
| ITMI20041568A1 (it) * | 2004-07-30 | 2004-10-30 | Dipharma Spa | "polimorfi di fexofenadina base" |
| ITMI20061492A1 (it) * | 2006-07-27 | 2008-01-28 | Archimica Srl | Processo per la preparazione di fexofenadina. |
| ITMI20070987A1 (it) | 2007-05-16 | 2008-11-17 | Dipharma Francis Srl | Procedimento per la preparazione di composti chetonici |
| IT1395337B1 (it) * | 2009-03-04 | 2012-09-14 | Dipharma Francis Srl | Procedimento per la preparazione di intermedi chetonici |
| WO2011158262A1 (en) * | 2010-06-15 | 2011-12-22 | Chemelectiva S.R.L. | Polymorphic form of fexofenadine hydrochloride, intermediates and process for its preparation |
| CN102079708B (zh) * | 2011-02-11 | 2013-10-02 | 浙江启明药业有限公司 | 4-(4-卤丁酰基)-α,α-二甲基苯乙酸酯的合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2176201T3 (es) | 1992-04-10 | 2002-12-01 | Merrell Pharma Inc | Derivados de 4-difenilmetil piperidina y procedimiento de preparacion. |
| US6147216A (en) * | 1993-06-25 | 2000-11-14 | Merrell Pharmaceuticals Inc. | Intermediates useful for the preparation of antihistaminic piperidine derivatives |
| US6153754A (en) * | 1995-12-21 | 2000-11-28 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
| US6201124B1 (en) | 1995-12-21 | 2001-03-13 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
-
2001
- 2001-05-17 IT IT2001RM000260A patent/ITRM20010260A1/it unknown
-
2002
- 2002-05-15 CA CA002386452A patent/CA2386452A1/en not_active Abandoned
- 2002-05-16 PT PT02010234T patent/PT1260505E/pt unknown
- 2002-05-16 AT AT02010234T patent/ATE290528T1/de not_active IP Right Cessation
- 2002-05-16 US US10/145,765 patent/US6815549B2/en not_active Expired - Fee Related
- 2002-05-16 SI SI200230095T patent/SI1260505T1/xx unknown
- 2002-05-16 ES ES02010234T patent/ES2237631T3/es not_active Expired - Lifetime
- 2002-05-16 EP EP02010234A patent/EP1260505B1/en not_active Expired - Lifetime
- 2002-05-16 DE DE60203142T patent/DE60203142T2/de not_active Expired - Fee Related
- 2002-05-16 HU HU0201673A patent/HUP0201673A3/hu unknown
- 2002-05-17 PL PL02353977A patent/PL353977A1/xx not_active Application Discontinuation
- 2002-05-17 JP JP2002143142A patent/JP2003026658A/ja not_active Ceased
- 2002-05-17 CZ CZ20021726A patent/CZ295949B6/cs not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ITRM20010260A0 (it) | 2001-05-17 |
| EP1260505A1 (en) | 2002-11-27 |
| HUP0201673A2 (hu) | 2003-02-28 |
| SI1260505T1 (en) | 2005-06-30 |
| US20020198233A1 (en) | 2002-12-26 |
| DE60203142D1 (de) | 2005-04-14 |
| CA2386452A1 (en) | 2002-11-17 |
| CZ20021726A3 (cs) | 2003-01-15 |
| ITRM20010260A1 (it) | 2002-11-18 |
| DE60203142T2 (de) | 2006-04-13 |
| PT1260505E (pt) | 2005-05-31 |
| PL353977A1 (en) | 2002-11-18 |
| EP1260505B1 (en) | 2005-03-09 |
| ES2237631T3 (es) | 2005-08-01 |
| HUP0201673A3 (en) | 2004-07-28 |
| HU0201673D0 (https=) | 2002-07-29 |
| US6815549B2 (en) | 2004-11-09 |
| JP2003026658A (ja) | 2003-01-29 |
| CZ295949B6 (cs) | 2005-12-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1260505 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |