ATE289873T1 - Verfahren und vorichtung zum abgaben von tröpfchen auf einem substrat - Google Patents
Verfahren und vorichtung zum abgaben von tröpfchen auf einem substratInfo
- Publication number
- ATE289873T1 ATE289873T1 AT00916334T AT00916334T ATE289873T1 AT E289873 T1 ATE289873 T1 AT E289873T1 AT 00916334 T AT00916334 T AT 00916334T AT 00916334 T AT00916334 T AT 00916334T AT E289873 T1 ATE289873 T1 AT E289873T1
- Authority
- AT
- Austria
- Prior art keywords
- substrate
- liquid
- drops onto
- raised
- lowered positions
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
- B01L3/0244—Drop counters; Drop formers using pins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
- B01L3/0244—Drop counters; Drop formers using pins
- B01L3/0251—Pin and ring type or pin in tube type dispenser
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
- B01L3/0262—Drop counters; Drop formers using touch-off at substrate or container
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1016—Control of the volume dispensed or introduced
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1065—Multiple transfer devices
- G01N35/1067—Multiple transfer devices for transfer to or from containers having different spacing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00364—Pipettes
- B01J2219/00367—Pipettes capillary
- B01J2219/00369—Pipettes capillary in multiple or parallel arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00373—Hollow needles
- B01J2219/00376—Hollow needles in multiple or parallel arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00387—Applications using probes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00527—Sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/0061—The surface being organic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00623—Immobilisation or binding
- B01J2219/00626—Covalent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00623—Immobilisation or binding
- B01J2219/0063—Other, e.g. van der Waals forces, hydrogen bonding
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00632—Introduction of reactive groups to the surface
- B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00686—Automatic
- B01J2219/00689—Automatic using computers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0819—Microarrays; Biochips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
- B01L2300/0838—Capillaries
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/02—Drop detachment mechanisms of single droplets from nozzles or pins
- B01L2400/028—Pin is moved through a ring which is filled with a fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1034—Transferring microquantities of liquid
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1034—Transferring microquantities of liquid
- G01N2035/1037—Using surface tension, e.g. pins or wires
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1034—Transferring microquantities of liquid
- G01N2035/1039—Micropipettes, e.g. microcapillary tubes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1065—Multiple transfer devices
- G01N35/1067—Multiple transfer devices for transfer to or from containers having different spacing
- G01N2035/1069—Multiple transfer devices for transfer to or from containers having different spacing by adjusting the spacing between multiple probes of a single transferring head
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1065—Multiple transfer devices
- G01N35/1074—Multiple transfer devices arranged in a two-dimensional array
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Clinical Laboratory Science (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
- Spray Control Apparatus (AREA)
- Sampling And Sample Adjustment (AREA)
- Devices For Use In Laboratory Experiments (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/270,218 US6296702B1 (en) | 1999-03-15 | 1999-03-15 | Apparatus and method for spotting a substrate |
PCT/US2000/006721 WO2000054883A1 (en) | 1999-03-15 | 2000-03-09 | Apparatus and method for spotting a substrate |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE289873T1 true ATE289873T1 (de) | 2005-03-15 |
Family
ID=23030403
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00916334T ATE289873T1 (de) | 1999-03-15 | 2000-03-09 | Verfahren und vorichtung zum abgaben von tröpfchen auf einem substrat |
Country Status (8)
Country | Link |
---|---|
US (8) | US6296702B1 (de) |
EP (2) | EP1156880B1 (de) |
JP (3) | JP2002538953A (de) |
AT (1) | ATE289873T1 (de) |
AU (1) | AU761013B2 (de) |
CA (1) | CA2361835A1 (de) |
DE (1) | DE60018392T2 (de) |
WO (1) | WO2000054883A1 (de) |
Families Citing this family (93)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6893877B2 (en) * | 1998-01-12 | 2005-05-17 | Massachusetts Institute Of Technology | Methods for screening substances in a microwell array |
AU2102699A (en) * | 1998-01-12 | 1999-07-26 | Massachusetts Institute Of Technology | Method and apparatus for performing microassays |
EP1250955A1 (de) * | 1998-09-08 | 2002-10-23 | Tibotec N.V. | Schnelles Screeningverfahren für Analyten |
US6689323B2 (en) * | 1998-10-30 | 2004-02-10 | Agilent Technologies | Method and apparatus for liquid transfer |
US6296702B1 (en) | 1999-03-15 | 2001-10-02 | Pe Corporation (Ny) | Apparatus and method for spotting a substrate |
US6306578B1 (en) | 1999-03-19 | 2001-10-23 | Genencor International, Inc. | Multi-through hole testing plate for high throughput screening |
DE60045451D1 (de) * | 1999-08-09 | 2011-02-10 | Riken | Vorrichtung zur Herstellung von Mikroarrays |
AU2610201A (en) * | 2000-01-06 | 2001-07-16 | Caliper Technologies Corporation | Ultra high throughput sampling and analysis systems and methods |
US20020151040A1 (en) | 2000-02-18 | 2002-10-17 | Matthew O' Keefe | Apparatus and methods for parallel processing of microvolume liquid reactions |
US6471917B1 (en) * | 2000-04-11 | 2002-10-29 | Affymax, Inc. | System and method for single or multiple bead distribution with an adjustable capillary |
SE0002003D0 (sv) * | 2000-04-18 | 2000-05-26 | Amersham Pharm Biotech Ab | Improved spot picker head |
US6353774B1 (en) * | 2000-09-22 | 2002-03-05 | Virtek Engineering Sciences Inc. | High precision vision guided positioning device |
EP1333926B1 (de) * | 2000-11-17 | 2004-09-22 | Tecan Trading AG | Vorrichtung und system zur abgabe bzw. aufnahme/abgabe von flüssigkeitsproben |
US6915928B2 (en) * | 2001-01-29 | 2005-07-12 | Pemstar, Inc. | Fluid dispenser |
JP4587421B2 (ja) * | 2001-02-28 | 2010-11-24 | キヤノン株式会社 | プローブ担体の製造用の液体吐出装置、該液体吐出装置を用いたプローブ担体製造装置及びプローブ担体の製造方法 |
JP2002323509A (ja) * | 2001-04-26 | 2002-11-08 | Thk Co Ltd | マイクロアレイ作製用ヘッド、このヘッドを用いたマイクロアレイ作製装置、マイクロアレイ作製方法、及びマイクロアレイ |
US20030003025A1 (en) * | 2001-06-19 | 2003-01-02 | Macaulay Calum E. | Microvolume liquid dispenser suitable for microarrays and methods related thereto |
US7041257B2 (en) * | 2001-09-25 | 2006-05-09 | Cytonome, Inc. | Microfabricated two-pin liquid sample dispensing system |
WO2003013718A1 (en) * | 2001-08-10 | 2003-02-20 | Oxford Glycosciences (Uk) Ltd | Liquid delivery apparatus and method |
US20050019223A1 (en) * | 2001-08-10 | 2005-01-27 | Platt Albert Edward | Liquid delivery apparatus and method |
US20070054408A1 (en) * | 2001-09-25 | 2007-03-08 | Cytonome, Inc. | Microfabricated two-pin system for biomolecule crystallization |
US7153699B2 (en) * | 2001-12-21 | 2006-12-26 | Cytonome, Inc. | Microfabricated two-pin system for biomolecule crystallization |
JP3634796B2 (ja) * | 2001-11-30 | 2005-03-30 | 財団法人工業技術研究院 | 生化学分析用マイクロディスペンサおよび計量分配装置 |
US7258839B2 (en) * | 2001-12-21 | 2007-08-21 | Cytonome, Inc. | Temperature controlled microfabricated two-pin liquid sample dispensing system |
WO2003069333A1 (en) * | 2002-02-14 | 2003-08-21 | Illumina, Inc. | Automated information processing in randomly ordered arrays |
MXPA04011083A (es) | 2002-05-17 | 2005-02-14 | Becton Dickinson Co | Sistema automatizado para aislar, amplificar y detectar una secuencia de acido nucleico de meta. |
US6789965B2 (en) * | 2002-05-31 | 2004-09-14 | Agilent Technologies, Inc. | Dot printer with off-axis loading |
US20030231986A1 (en) * | 2002-06-18 | 2003-12-18 | Eastman Kodak Company | Micro-array identification means |
JP2004045346A (ja) * | 2002-07-16 | 2004-02-12 | Nisshinbo Ind Inc | マイクロアレイの作製方法 |
US8277753B2 (en) | 2002-08-23 | 2012-10-02 | Life Technologies Corporation | Microfluidic transfer pin |
JP4426968B2 (ja) * | 2002-09-17 | 2010-03-03 | オリンパス株式会社 | 基体上での複数成分間の反応によりターゲット物質を検出するために基体表面に液状反応成分を配置する方法および装置、並びにこの方法に使用するための物品 |
US20040115830A1 (en) * | 2002-09-25 | 2004-06-17 | Igor Touzov | Components for nano-scale Reactor |
US20040109045A1 (en) * | 2002-12-06 | 2004-06-10 | Eastman Kodak Company | Print head for micro-deposition of bio-molecules |
CA2521999A1 (en) | 2002-12-20 | 2004-09-02 | Biotrove, Inc. | Assay apparatus and method using microfluidic arrays |
US20060094108A1 (en) * | 2002-12-20 | 2006-05-04 | Karl Yoder | Thermal cycler for microfluidic array assays |
US20040120859A1 (en) * | 2002-12-20 | 2004-06-24 | Kocher Thomas E. | Biomolecular micro-deposition system |
US6832733B2 (en) * | 2003-01-16 | 2004-12-21 | Harold J. Engel | Nozzle end configuration |
US7125727B2 (en) * | 2003-01-29 | 2006-10-24 | Protedyne Corporation | Sample handling tool with piezoelectric actuator |
JP2004290962A (ja) * | 2003-03-11 | 2004-10-21 | Seiko Epson Corp | 薄膜形成装置、電子光学装置及び電子機器 |
DE10316580A1 (de) * | 2003-04-10 | 2004-11-04 | Infineon Technologies Ag | Vorrichtung zum beschädigungsfreien Aufbringen von Bio-Molekülen in Lösung auf empfindlichen Substraten |
US7964237B2 (en) * | 2003-08-21 | 2011-06-21 | International Business Machines Corporation | Fully automated paste dispense process for dispensing small dots and lines |
US7570443B2 (en) | 2003-09-19 | 2009-08-04 | Applied Biosystems, Llc | Optical camera alignment |
US20050233472A1 (en) * | 2003-09-19 | 2005-10-20 | Kao H P | Spotting high density plate using a banded format |
US20050220675A1 (en) * | 2003-09-19 | 2005-10-06 | Reed Mark T | High density plate filler |
US20050226771A1 (en) * | 2003-09-19 | 2005-10-13 | Lehto Dennis A | High speed microplate transfer |
WO2005042146A2 (en) | 2003-10-24 | 2005-05-12 | Aushon Biosystems, Inc. | Apparatus and method for dispensing fluid, semi-solid and solid samples |
FR2862239B1 (fr) * | 2003-11-14 | 2007-11-23 | Commissariat Energie Atomique | Dispositif de reception d'un echantillon de fluide, et ses applications |
DE102004062280A1 (de) * | 2003-12-29 | 2005-07-28 | Siemens Ag | Verfahren und Vorrichtung zum Dispensieren von Flüssigkeiten im Mikroraster |
WO2005065954A1 (en) * | 2003-12-30 | 2005-07-21 | Applera Corporation | Apparatus and methods of depositing fluid |
CA2559171A1 (en) | 2004-03-12 | 2005-09-29 | Biotrove, Inc. | Nanoliter array loading |
US20060063159A1 (en) * | 2004-09-22 | 2006-03-23 | Applera Corporation | Post-synthesis processing system for supported oligonucleotides, and method |
CA2601918A1 (en) * | 2005-01-20 | 2006-07-27 | The Regents Of The University Of California | Cellular microarrays for screening differentiation factors |
DE102005005518A1 (de) * | 2005-02-01 | 2006-08-10 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Einführvorrichtung für biologische Proben |
US20060183261A1 (en) * | 2005-02-15 | 2006-08-17 | Dudenhoefer Christie L | Method of forming a biological sensor |
TWI411007B (zh) * | 2005-03-28 | 2013-10-01 | Ntn Toyo Bearing Co Ltd | 圖案修正裝置、圖案修正方法及塗佈單元 |
JP4767567B2 (ja) * | 2005-03-28 | 2011-09-07 | Ntn株式会社 | パターン修正装置 |
JP4767708B2 (ja) * | 2005-03-28 | 2011-09-07 | Ntn株式会社 | 塗布ユニットおよびパターン修正装置 |
EP1888780A4 (de) * | 2005-05-06 | 2009-11-11 | Applera Corp | Mehrfachkapillarenvorrichtung sowie verfahren zur synthese und abgabe |
WO2007130434A2 (en) * | 2006-05-02 | 2007-11-15 | Applera Corporation | Variable volume dispenser and method |
EP2040983A4 (de) * | 2006-06-26 | 2011-08-03 | Life Technologies Corp | Komprimierbare transparente dichtung für offene mikroplatten |
WO2008002563A2 (en) * | 2006-06-26 | 2008-01-03 | Applera Corporation | Heated cover methods and technology |
JP4875507B2 (ja) * | 2007-02-07 | 2012-02-15 | 国立大学法人電気通信大学 | 液滴塗布装置 |
US20080216698A1 (en) * | 2007-03-06 | 2008-09-11 | Bio-Rad Laboratories, Inc. | Microdot printing head |
TWI367857B (en) * | 2007-05-09 | 2012-07-11 | Nat Univ Tsing Hua | Fluidic nano/micro array chip and chipset thereof |
US8003056B2 (en) * | 2007-06-14 | 2011-08-23 | Honeywell International Inc. | Gas analyzer apparatus and method of analyzing gases |
WO2009091416A2 (en) * | 2007-06-22 | 2009-07-23 | Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University | Gas dynamic virtual nozzle for generation of microscopic droplet streams |
EP2249701B1 (de) * | 2008-03-05 | 2020-04-29 | Becton, Dickinson and Company | Sammelbehälteranordnung mit kapillarwirkung |
FR2929859B1 (fr) * | 2008-04-11 | 2012-10-19 | Dioscure | Dispositif et procede pour la formation de micro depots. |
US20120260853A1 (en) * | 2008-08-21 | 2012-10-18 | Nation Taiwan University | Conformable capillary coating devices for a substrate with variable heights |
EP2163901A1 (de) * | 2008-09-10 | 2010-03-17 | Roche Diagnostics GmbH | Verfahren und Dosiereinrichtung zum Dosieren einer Flüssigkeit in einen Aufnahmekanal eines Testelementes zur Analyse von Körperflüssigkeiten |
US9162249B2 (en) * | 2008-10-01 | 2015-10-20 | Panasonic Intellectual Property Management Co., Ltd. | Paste dispenser for applying paste containing fillers using nozzle with pin and application method using the same |
US8434422B2 (en) * | 2009-04-20 | 2013-05-07 | Dow Global Technologies Llc | Coating apparatus and method |
TWI458563B (zh) * | 2009-12-22 | 2014-11-01 | Hon Hai Prec Ind Co Ltd | 點膠裝置 |
US8894181B2 (en) * | 2010-01-04 | 2014-11-25 | King Saud University | Printing system and method |
US8236256B2 (en) * | 2010-04-27 | 2012-08-07 | Thomas Friedlander | Apparatus and method for efficient and precise transfer of liquids |
WO2011150368A1 (en) | 2010-05-28 | 2011-12-01 | Arizona Board Of Regents Acting For And On Behalf Of Arziona State University | Apparatus and methods for a gas dynamic virtual nozzle |
US9417418B2 (en) | 2011-09-12 | 2016-08-16 | Commscope Technologies Llc | Flexible lensed optical interconnect device for signal distribution |
WO2014153188A2 (en) | 2013-03-14 | 2014-09-25 | Life Technologies Corporation | High efficiency, small volume nucleic acid synthesis |
US20130109596A1 (en) | 2011-09-26 | 2013-05-02 | Life Technologies Corporation | High efficiency, small volume nucleic acid synthesis |
RU2654358C2 (ru) | 2012-09-28 | 2018-05-17 | Тайко Электроникс Юк Лтд. | Волоконно-оптическая кассета |
RU2642523C2 (ru) * | 2012-09-28 | 2018-01-25 | Тайко Электроникс Юк Лтд. | Способ изготовления и тестирования волоконно-оптической кассеты |
US9223094B2 (en) | 2012-10-05 | 2015-12-29 | Tyco Electronics Nederland Bv | Flexible optical circuit, cassettes, and methods |
EP2777818A1 (de) | 2013-03-15 | 2014-09-17 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Verfahren und Vorrichtung zur Herstellung eines intermittierenden Flüssigkeitsstrahls |
WO2014179193A1 (en) | 2013-04-30 | 2014-11-06 | Uwe Weierstall | Apparatus and methods for lipidic cubic phase (lcp) injection for membrane protein investigations |
US9682396B2 (en) * | 2014-03-24 | 2017-06-20 | Carterra, Inc. | Dual flow cell fluid delivery systems |
EP3177707B1 (de) | 2014-08-08 | 2020-04-15 | Applied Materials, Inc. | Gemusterte abscheidung von flüssigkeitsfilmen für biomedizinische vorrichtungen |
CA2970477C (en) | 2014-12-09 | 2022-03-15 | Life Technologies Corporation | High efficiency, small volume nucleic acid synthesis |
US9968962B2 (en) * | 2015-03-19 | 2018-05-15 | The Boeing Company | Material applicator comprising a surface interface guide forming a continuous ring shaped flow channel with an unobstructive guding assembly therein |
US20170212016A1 (en) * | 2016-01-25 | 2017-07-27 | Helena Laboratories Corporation | Method for Depositing Amounts of Liquid |
JP6333323B2 (ja) * | 2016-08-29 | 2018-05-30 | Ntn株式会社 | 塗布装置および塗布方法 |
MX2020002878A (es) | 2017-10-02 | 2020-07-22 | Commscope Technologies Llc | Circuito de fibra optica y metodo de preparacion. |
JP6937466B2 (ja) * | 2018-02-26 | 2021-09-22 | パナソニックIpマネジメント株式会社 | 塗布方法と塗布装置と部品の製造方法 |
WO2023091750A1 (en) * | 2021-11-19 | 2023-05-25 | Cornell University | Surface-patterned, omniphobic tiles (spots), fabrication, loading, and use thereof |
Family Cites Families (95)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2643801A (en) | 1948-12-22 | 1953-06-30 | Herman R Kollmeyer | Watch oiler |
US3164304A (en) | 1961-05-08 | 1965-01-05 | Standard Thomson Corp | Liquid dispensing apparatus for small quantities |
US3329964A (en) | 1965-06-24 | 1967-07-04 | Xerox Corp | Facsimile recording apparatus |
US3334354A (en) | 1966-03-17 | 1967-08-01 | Xerox Corp | Dotting ink recorder |
US3799742A (en) * | 1971-12-20 | 1974-03-26 | C Coleman | Miniaturized integrated analytical test container |
US3843053A (en) | 1973-03-29 | 1974-10-22 | Kontes Glass Co | Spotter for use in thin layer chromatography and method of forming drops therewith |
US4155229A (en) | 1976-02-27 | 1979-05-22 | Mathias Mitter | Printing apparatus |
US4023716A (en) | 1976-04-20 | 1977-05-17 | Justin Joel Shapiro | Micro-dispensing liquid pipet |
US4133918A (en) | 1977-05-16 | 1979-01-09 | The Computervision Corporation | Method of marking semiconductors |
US4153855A (en) * | 1977-12-16 | 1979-05-08 | The United States Of America As Represented By The Secretary Of The Army | Method of making a plate having a pattern of microchannels |
US4165646A (en) | 1978-07-26 | 1979-08-28 | Shapiro Justin J | Adjustable micro-dispensing liquid pipet |
US4225410A (en) * | 1978-12-04 | 1980-09-30 | Technicon Instruments Corporation | Integrated array of electrochemical sensors |
US4258761A (en) * | 1979-05-03 | 1981-03-31 | Bennett John T Jr | Rehydrator |
JPS5675886A (en) | 1979-11-27 | 1981-06-23 | Ricoh Co Ltd | Recorder |
US4426451A (en) * | 1981-01-28 | 1984-01-17 | Eastman Kodak Company | Multi-zoned reaction vessel having pressure-actuatable control means between zones |
US4351799A (en) | 1981-07-15 | 1982-09-28 | Gross Valery N | Micrometering liquid sample dispenser |
US4400708A (en) | 1981-08-28 | 1983-08-23 | Sachs Richard L | Disposable inker cartridge and holder therefor |
US4517089A (en) * | 1982-09-29 | 1985-05-14 | Hydrotreat, Inc. | Method and apparatus for constructing filter element |
DE3407849A1 (de) | 1984-02-29 | 1985-08-29 | Alois 3201 Algermissen Höft | Verfahren und einrichtung zum gleichzeitigen aufbringen einer vielzahl von fluessigkeitsproben auf einen objekttraeger |
US4654127A (en) * | 1984-04-11 | 1987-03-31 | Sentech Medical Corporation | Self-calibrating single-use sensing device for clinical chemistry and method of use |
EP0171148B1 (de) * | 1984-06-13 | 1991-04-17 | ARES-SERONO RESEARCH & DEVELOPMENT LIMITED PARTNERSHIP | Vorrichtungen zur Verwendung in chemischen Analyseverfahren |
US4681742A (en) | 1984-10-01 | 1987-07-21 | Cetus Corporation | Assay tray |
US4952518A (en) | 1984-10-01 | 1990-08-28 | Cetus Corporation | Automated assay machine and assay tray |
US4686041A (en) * | 1984-11-26 | 1987-08-11 | Den Berg Teunis T Van | Molecular differentiation filter |
US4963498A (en) * | 1985-08-05 | 1990-10-16 | Biotrack | Capillary flow device |
US4853020A (en) | 1985-09-30 | 1989-08-01 | Itt Electro Optical Products, A Division Of Itt Corporation | Method of making a channel type electron multiplier |
JPS62187977A (ja) * | 1986-02-13 | 1987-08-17 | Dainippon Screen Mfg Co Ltd | 画像デ−タ処理装置 |
US4726900A (en) * | 1986-07-29 | 1988-02-23 | Vacco Industries | Stacked sheet filter element |
US4795560A (en) * | 1987-04-16 | 1989-01-03 | The Black Clawson Company | Screen plates |
US5011779A (en) | 1988-01-21 | 1991-04-30 | Long Island Jewish Medical Center | Apparatus for rapid deposition of test samples on an absorbent support |
US5503803A (en) * | 1988-03-28 | 1996-04-02 | Conception Technologies, Inc. | Miniaturized biological assembly |
GB8809611D0 (en) | 1988-04-22 | 1988-05-25 | Darougar S | Deposition apparatus |
US5204268A (en) | 1988-06-02 | 1993-04-20 | Fuji Photo Film Co., Ltd. | Method and apparatus for applying liquid samples |
US4908112A (en) * | 1988-06-16 | 1990-03-13 | E. I. Du Pont De Nemours & Co. | Silicon semiconductor wafer for analyzing micronic biological samples |
CA1303901C (en) | 1988-06-24 | 1992-06-23 | Normand Nadeau | Low profile inker |
US5108704A (en) * | 1988-09-16 | 1992-04-28 | W. R. Grace & Co.-Conn. | Microfiltration apparatus with radially spaced nozzles |
US5046539A (en) | 1989-05-26 | 1991-09-10 | The Rockefeller University | Automatic fluid dispenser for multi-welled dish |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5262128A (en) * | 1989-10-23 | 1993-11-16 | The United States Of America As Represented By The Department Of Health And Human Services | Array-type multiple cell injector |
US5770029A (en) * | 1996-07-30 | 1998-06-23 | Soane Biosciences | Integrated electrophoretic microdevices |
EP0478753B1 (de) | 1990-04-06 | 1997-07-02 | The Perkin-Elmer Corporation | Automatisiertes labor für molekularbiologie |
SE470347B (sv) * | 1990-05-10 | 1994-01-31 | Pharmacia Lkb Biotech | Mikrostruktur för vätskeflödessystem och förfarande för tillverkning av ett sådant system |
US5147606A (en) * | 1990-08-06 | 1992-09-15 | Miles Inc. | Self-metering fluid analysis device |
EP0484278B1 (de) * | 1990-11-01 | 1995-04-12 | Ciba-Geigy Ag | Vorrichtung zur Aufbereitung oder Vorbereitung von flüssigen Proben für eine chemische Analyse |
EP0497077B1 (de) * | 1991-01-28 | 1996-07-17 | Ciba-Geigy Ag | Vorrichtung zur Vorbereitung von Proben insbesondere für Analysezwecke |
SE9100392D0 (sv) * | 1991-02-08 | 1991-02-08 | Pharmacia Biosensor Ab | A method of producing a sealing means in a microfluidic structure and a microfluidic structure comprising such sealing means |
EP0972564B1 (de) | 1991-11-22 | 2003-05-28 | Affymetrix, Inc. (a Delaware Corporation) | Verfahren zur Herstellung von Polymerarrays |
US5296375A (en) * | 1992-05-01 | 1994-03-22 | Trustees Of The University Of Pennsylvania | Mesoscale sperm handling devices |
US5486335A (en) * | 1992-05-01 | 1996-01-23 | Trustees Of The University Of Pennsylvania | Analysis based on flow restriction |
US5304487A (en) * | 1992-05-01 | 1994-04-19 | Trustees Of The University Of Pennsylvania | Fluid handling in mesoscale analytical devices |
US5508200A (en) | 1992-10-19 | 1996-04-16 | Tiffany; Thomas | Method and apparatus for conducting multiple chemical assays |
US5482608A (en) * | 1993-01-19 | 1996-01-09 | Hewlett Packard Company | Capillary electrophoresis flow control system |
US5525515A (en) | 1993-02-03 | 1996-06-11 | Blattner; Frederick R. | Process of handling liquids in an automated liquid handling apparatus |
US5427663A (en) * | 1993-06-08 | 1995-06-27 | British Technology Group Usa Inc. | Microlithographic array for macromolecule and cell fractionation |
RU2041263C1 (ru) | 1993-08-11 | 1995-08-09 | Геннадий Моисеевич Ершов | Способ микродозирования водных растворов веществ на носитель и устройство для его осуществления |
US5429734A (en) * | 1993-10-12 | 1995-07-04 | Massachusetts Institute Of Technology | Monolithic capillary electrophoretic device |
US5574594A (en) | 1993-11-05 | 1996-11-12 | Nikon Inc. | Automated microscope slide marking device |
SE9400437D0 (sv) * | 1994-02-10 | 1994-02-10 | Pharmacia Lkb Biotech | Filterbrunn och förfarande vid dess tillverkning |
US5540889A (en) | 1994-05-11 | 1996-07-30 | Whitehead Institute For Biomedical Research | Apparatus and method for a highly parallel pipetter |
US5513757A (en) * | 1994-06-02 | 1996-05-07 | Sulzer Papertec Mansfield Inc. | Continuous cut slotted screen basket |
US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
US5460782A (en) | 1994-07-18 | 1995-10-24 | Safe-Tec Clinical Products, Inc. | Automatic filling micropipette with dispensing means |
US5601980A (en) | 1994-09-23 | 1997-02-11 | Hewlett-Packard Company | Manufacturing method and apparatus for biological probe arrays using vision-assisted micropipetting |
US5571410A (en) * | 1994-10-19 | 1996-11-05 | Hewlett Packard Company | Fully integrated miniaturized planar liquid sample handling and analysis device |
US5500071A (en) * | 1994-10-19 | 1996-03-19 | Hewlett-Packard Company | Miniaturized planar columns in novel support media for liquid phase analysis |
US5603351A (en) * | 1995-06-07 | 1997-02-18 | David Sarnoff Research Center, Inc. | Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device |
CA2204912C (en) | 1994-11-10 | 2005-01-04 | David Sarnoff Research Center, Inc. | Liquid distribution system |
US5725153A (en) * | 1995-01-10 | 1998-03-10 | Georgia Tech Research Corporation | Oscillating capillary nebulizer |
US5551487A (en) | 1995-03-10 | 1996-09-03 | Hewlett-Packard Company | Micro-dispenser for preparing assay plates |
US5560811A (en) * | 1995-03-21 | 1996-10-01 | Seurat Analytical Systems Incorporated | Capillary electrophoresis apparatus and method |
US5763263A (en) | 1995-11-27 | 1998-06-09 | Dehlinger; Peter J. | Method and apparatus for producing position addressable combinatorial libraries |
US5587522A (en) | 1995-12-26 | 1996-12-24 | Selby; Theodore W. | Multiple-part and/or supported gas-containing vessel to establish desired heat flux |
US5849598A (en) | 1996-03-15 | 1998-12-15 | Washington University | Method for transferring micro quantities of liquid samples to discrete locations |
US5840256A (en) | 1996-04-09 | 1998-11-24 | David Sarnoff Research Center Inc. | Plate for reaction system |
US5885470A (en) * | 1997-04-14 | 1999-03-23 | Caliper Technologies Corporation | Controlled fluid transport in microfabricated polymeric substrates |
US5958342A (en) * | 1996-05-17 | 1999-09-28 | Incyte Pharmaceuticals, Inc. | Jet droplet device |
US5770151A (en) | 1996-06-05 | 1998-06-23 | Molecular Dynamics, Inc. | High-speed liquid deposition device for biological molecule array formation |
US5779868A (en) * | 1996-06-28 | 1998-07-14 | Caliper Technologies Corporation | Electropipettor and compensation means for electrophoretic bias |
DE19628178C1 (de) | 1996-07-12 | 1997-09-18 | Bruker Franzen Analytik Gmbh | Verfahren zum Beladen von Probenträgern für Massenspektrometer |
US5766193A (en) * | 1996-11-05 | 1998-06-16 | Millner; Don E. | Tongue cleaner |
JP2001518179A (ja) * | 1997-01-09 | 2001-10-09 | マーキュリー ダイアグノスティックス インコーポレイテッド | 分析試験装置へ試薬を適用する方法 |
US5772966A (en) | 1997-01-24 | 1998-06-30 | Maracas; George N. | Assay dispensing apparatus |
US5904824A (en) * | 1997-03-07 | 1999-05-18 | Beckman Instruments, Inc. | Microfluidic electrophoresis device |
DE19712195B4 (de) | 1997-03-22 | 2007-12-27 | Friedrich-Schiller-Universität Jena | Verfahren und Vorrichtung zur Bereitstellung von Proben für den off-line Nachweis von Analyten nach der MALDI-Massenspektrometrie |
US6143496A (en) * | 1997-04-17 | 2000-11-07 | Cytonix Corporation | Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly |
US6090251A (en) * | 1997-06-06 | 2000-07-18 | Caliper Technologies, Inc. | Microfabricated structures for facilitating fluid introduction into microfluidic devices |
US5882930A (en) * | 1997-11-10 | 1999-03-16 | Hyseq, Inc. | Reagent transfer device |
AU2102699A (en) | 1998-01-12 | 1999-07-26 | Massachusetts Institute Of Technology | Method and apparatus for performing microassays |
US6762061B1 (en) * | 1998-07-03 | 2004-07-13 | Corning Incorporated | Redrawn capillary imaging reservoir |
US6116880A (en) * | 1998-07-10 | 2000-09-12 | Fuisz Technologies Ltd. | Apparatus for melt spinning feedstock material |
EP1002570A1 (de) * | 1998-11-20 | 2000-05-24 | Corning Incorporated | Kapillare Übergabevorrichtung für Matrizen von hohen Dichten |
AU762897B2 (en) * | 1999-02-16 | 2003-07-10 | Applera Corporation | Bead dispensing system |
US6296702B1 (en) * | 1999-03-15 | 2001-10-02 | Pe Corporation (Ny) | Apparatus and method for spotting a substrate |
US20020164824A1 (en) * | 2001-02-16 | 2002-11-07 | Jianming Xiao | Method and apparatus based on bundled capillaries for high throughput screening |
US7045069B2 (en) * | 2002-11-14 | 2006-05-16 | Gennady Ozeryansky | Microfabrication method based on metal matrix composite technology |
-
1999
- 1999-03-15 US US09/270,218 patent/US6296702B1/en not_active Expired - Lifetime
-
2000
- 2000-03-09 CA CA002361835A patent/CA2361835A1/en not_active Abandoned
- 2000-03-09 JP JP2000604948A patent/JP2002538953A/ja active Pending
- 2000-03-09 AU AU37454/00A patent/AU761013B2/en not_active Ceased
- 2000-03-09 EP EP00916334A patent/EP1156880B1/de not_active Expired - Lifetime
- 2000-03-09 WO PCT/US2000/006721 patent/WO2000054883A1/en active IP Right Grant
- 2000-03-09 EP EP05004387A patent/EP1541236A3/de not_active Withdrawn
- 2000-03-09 AT AT00916334T patent/ATE289873T1/de not_active IP Right Cessation
- 2000-03-09 DE DE60018392T patent/DE60018392T2/de not_active Expired - Lifetime
-
2001
- 2001-03-20 US US09/813,233 patent/US6467700B2/en not_active Expired - Lifetime
- 2001-03-20 US US09/812,961 patent/US6413586B2/en not_active Expired - Lifetime
- 2001-03-20 US US09/812,643 patent/US6440217B2/en not_active Expired - Lifetime
-
2002
- 2002-07-30 US US10/209,565 patent/US6579367B2/en not_active Expired - Fee Related
-
2003
- 2003-04-21 US US10/419,563 patent/US6849127B2/en not_active Expired - Fee Related
-
2005
- 2005-01-18 US US11/038,334 patent/US7211148B2/en not_active Expired - Fee Related
- 2005-07-11 JP JP2005202336A patent/JP2006010701A/ja active Pending
- 2005-07-11 JP JP2005202335A patent/JP2006010700A/ja active Pending
-
2007
- 2007-03-08 US US11/683,794 patent/US20070148050A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1156880A1 (de) | 2001-11-28 |
US20010010206A1 (en) | 2001-08-02 |
EP1541236A2 (de) | 2005-06-15 |
US20010009136A1 (en) | 2001-07-26 |
JP2006010700A (ja) | 2006-01-12 |
US20010016359A1 (en) | 2001-08-23 |
WO2000054883A1 (en) | 2000-09-21 |
EP1156880B1 (de) | 2005-03-02 |
US6440217B2 (en) | 2002-08-27 |
EP1541236A3 (de) | 2007-01-17 |
US20020174831A1 (en) | 2002-11-28 |
US7211148B2 (en) | 2007-05-01 |
US6413586B2 (en) | 2002-07-02 |
DE60018392T2 (de) | 2006-02-09 |
US20030205200A1 (en) | 2003-11-06 |
AU3745400A (en) | 2000-10-04 |
US20050120949A1 (en) | 2005-06-09 |
US6467700B2 (en) | 2002-10-22 |
US6849127B2 (en) | 2005-02-01 |
AU761013B2 (en) | 2003-05-29 |
JP2006010701A (ja) | 2006-01-12 |
CA2361835A1 (en) | 2000-09-21 |
US6296702B1 (en) | 2001-10-02 |
DE60018392D1 (de) | 2005-04-07 |
US20070148050A1 (en) | 2007-06-28 |
JP2002538953A (ja) | 2002-11-19 |
US6579367B2 (en) | 2003-06-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE289873T1 (de) | Verfahren und vorichtung zum abgaben von tröpfchen auf einem substrat | |
DE60000539D1 (de) | Vorrichtung und verfahren zur übertragung von kleinen substanzvolumen | |
DE60015530D1 (de) | Vorrichtung und verfahren zum testen einer biologischen flüssigkeit | |
CN104364659B (zh) | 微生物的自动化选择和利用maldi的鉴定 | |
DE69022600D1 (de) | Reinigungsverfahren und vorrichtung für reagenzverteilungspipetten. | |
GB2248840B (en) | Substrate carrying ligands to screen for biological activity | |
ATE314888T1 (de) | Verfahren und vorrichtung für die abgabe von flüssigkeiten | |
DE19882221T1 (de) | Verfahren und Vorrichtung zum automatischen Impfen von Kulturmedien mit bakteriellen Proben aus klinischen Probenbehältern | |
DE602004027284D1 (de) | Vorrichtung und Verfahren zur Handhabung von Analyseflüssigkeiten | |
EP1200841A1 (de) | Vorrichtung zur handhabung von flüssigen proben | |
DE60136661D1 (de) | Vorrichtung zur Absaugung von Flüssigkeitsproben und Verfahren zur Vorortsanalyse der Formationsflüssigkeiten | |
NZ504061A (en) | Assay device for determination of analyte in a solution has sample uptake islands on an elongate support housed within a pipette | |
CA2387581A1 (en) | Method and device for moving and placing liquid drops in a controlled manner | |
DE60128550D1 (de) | Verfahren und gerät zur automatischen pin-detektion in instrumenten zur erzeugung von mikroarrays | |
DE69322966D1 (de) | Vorrichtung zum aufbringen einer flüssigen probe auf ein kulturmedium | |
EP0331057A3 (de) | Automatische Reagenzabgabevorrichtung | |
DE60115860D1 (de) | Mikroarray-dosiervorrichtungen mit sensoren | |
DE69109802D1 (de) | Flüssigkeitsabgabevorrichtung mit positionsgeber. | |
WO2004085064A3 (en) | Methods and apparata for precisely dispensing microvolumes of fluids | |
DE60230966D1 (de) | Automatisierte Kassette für eine Vorrichtung zur Durchführung von immunoanalytischen Tests und Verfahren zu ihrer Verwendung | |
ATE9045T1 (de) | Vorrichtung zur zu- oder abfuhr einer fluessigkeit zum oder vom randteil einer flachen brennstoffzellelektrode und eine solche vorrichtung enthaltende elektrode und brennstoffzelle. | |
DE60308571D1 (de) | System und Verfahren zur Kontrolle der Integrität des Zustands und der Operation von Pipettiervorrichtungen zur Manipulation flüssiger Proben | |
DE602004017074D1 (de) | Testelemente-Halter mit Sonden-Führung für einen Analysator | |
DE60011671T2 (de) | Piezoelektrische drop-on-demand technik und spüllung von kapillaren | |
CN1422175A (zh) | 产生生物聚合物场的过程和设备 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |