DE60000539D1 - Vorrichtung und verfahren zur übertragung von kleinen substanzvolumen - Google Patents
Vorrichtung und verfahren zur übertragung von kleinen substanzvolumenInfo
- Publication number
- DE60000539D1 DE60000539D1 DE60000539T DE60000539T DE60000539D1 DE 60000539 D1 DE60000539 D1 DE 60000539D1 DE 60000539 T DE60000539 T DE 60000539T DE 60000539 T DE60000539 T DE 60000539T DE 60000539 D1 DE60000539 D1 DE 60000539D1
- Authority
- DE
- Germany
- Prior art keywords
- reagent
- conveyor
- supply location
- substrates
- intervening region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
- B01L3/0244—Drop counters; Drop formers using pins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
- B01L3/0262—Drop counters; Drop formers using touch-off at substrate or container
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00009—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with a sample supporting tape, e.g. with absorbent zones
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00364—Pipettes
- B01J2219/00367—Pipettes capillary
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00457—Dispensing or evacuation of the solid phase support
- B01J2219/00459—Beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00527—Sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/0059—Sequential processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00646—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports
- B01J2219/00648—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports by the use of solid beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
- B01L2300/0838—Capillaries
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/110833—Utilizing a moving indicator strip or tape
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/112499—Automated chemical analysis with sample on test slide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack
- Y10T436/114998—Automated chemical analysis with conveyance of sample along a test line in a container or rack with treatment or replacement of aspirator element [e.g., cleaning, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25625—Dilution
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/293,659 US6245297B1 (en) | 1999-04-16 | 1999-04-16 | Apparatus and method for transferring small volumes of substances |
PCT/US2000/009670 WO2000063705A1 (en) | 1999-04-16 | 2000-04-11 | Apparatus and method for transferring small volumes of substances |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60000539D1 true DE60000539D1 (de) | 2002-11-07 |
DE60000539T2 DE60000539T2 (de) | 2003-03-06 |
Family
ID=23129993
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60000539T Expired - Lifetime DE60000539T2 (de) | 1999-04-16 | 2000-04-11 | Vorrichtung und verfahren zur übertragung von kleinen substanzvolumen |
Country Status (8)
Country | Link |
---|---|
US (3) | US6245297B1 (de) |
EP (1) | EP1159622B1 (de) |
JP (1) | JP3659890B2 (de) |
AT (1) | ATE225516T1 (de) |
AU (1) | AU751309B2 (de) |
CA (1) | CA2368660C (de) |
DE (1) | DE60000539T2 (de) |
WO (1) | WO2000063705A1 (de) |
Families Citing this family (81)
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US6511849B1 (en) * | 1999-04-23 | 2003-01-28 | The Sir Mortimer B. Davis - Jewish General Hospital | Microarrays of biological materials |
US6245297B1 (en) * | 1999-04-16 | 2001-06-12 | Pe Corporation (Ny) | Apparatus and method for transferring small volumes of substances |
US8298485B2 (en) * | 1999-07-08 | 2012-10-30 | Lee H. Angros | In situ heat induced antigen recovery and staining apparatus and method |
US7951612B2 (en) * | 1999-07-08 | 2011-05-31 | Lee H. Angros | In situ heat induced antigen recovery and staining apparatus and method |
US6979425B1 (en) * | 1999-10-04 | 2005-12-27 | Robodesign International, Inc. | High capacity microarray dispensing |
US6656432B1 (en) | 1999-10-22 | 2003-12-02 | Ngk Insulators, Ltd. | Micropipette and dividedly injectable apparatus |
GB2356253B (en) * | 1999-11-09 | 2003-11-05 | Bruker Daltonik Gmbh | Contamination-free transfer of biological specimens |
AU2610201A (en) * | 2000-01-06 | 2001-07-16 | Caliper Technologies Corporation | Ultra high throughput sampling and analysis systems and methods |
JP3750460B2 (ja) * | 2000-02-18 | 2006-03-01 | 日立工機株式会社 | 分注装置及び分注方法 |
US6447723B1 (en) | 2000-03-13 | 2002-09-10 | Packard Instrument Company, Inc. | Microarray spotting instruments incorporating sensors and methods of using sensors for improving performance of microarray spotting instruments |
US6878554B1 (en) | 2000-03-20 | 2005-04-12 | Perkinelmer Las, Inc. | Method and apparatus for automatic pin detection in microarray spotting instruments |
US7521245B1 (en) | 2000-06-05 | 2009-04-21 | Perkinelmer Las, Inc. | Method for washing and drying pins in microarray spotting instruments |
JP2002005942A (ja) * | 2000-06-23 | 2002-01-09 | Teruaki Ito | 検体処理ユニット及び検体処理システム |
US6902702B1 (en) * | 2000-08-16 | 2005-06-07 | University Health Network | Devices and methods for producing microarrays of biological samples |
EP1245278A3 (de) * | 2000-09-15 | 2003-12-10 | Agfa-Gevaert | Bahnförmiges Material mit Mikroöffnungen für Anwendungen in der kombinatorischen Chemie |
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US20030170148A1 (en) * | 2001-01-31 | 2003-09-11 | Mcentee John F. | Reaction chamber roll pump |
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US6855925B2 (en) | 2001-02-14 | 2005-02-15 | Picoliter Inc. | Methods, devices, and systems using acoustic ejection for depositing fluid droplets on a sample surface for analysis |
EP1364072B1 (de) * | 2001-02-28 | 2007-01-03 | Iogen Energy Corporation | Methode zur behandlung von lignin- und zellulosehaltigen beschickungen zur erhöhten produktion von xylose und ethanol |
US7588725B2 (en) | 2001-04-25 | 2009-09-15 | Biotrove, Inc. | High throughput autosampler |
US8414774B2 (en) | 2001-04-25 | 2013-04-09 | Agilent Technologies, Inc. | Systems and methods for high-throughput screening of fluidic samples |
US6812030B2 (en) | 2001-04-25 | 2004-11-02 | Biotrove, Inc. | System and method for high throughput sample preparation and analysis using column chromatography |
WO2009059286A1 (en) | 2007-11-02 | 2009-05-07 | Biotrove, Inc. | Devices and methods for coupling mass spectrometry devices with chromatography systems |
CN1524017A (zh) * | 2001-05-03 | 2004-08-25 | ÷ | 高吞吐量微阵列定位系统及方法 |
US7041257B2 (en) * | 2001-09-25 | 2006-05-09 | Cytonome, Inc. | Microfabricated two-pin liquid sample dispensing system |
US6579724B2 (en) * | 2001-09-13 | 2003-06-17 | First Ten Angstroms | Dispensing method and apparatus for dispensing very small quantities of fluid |
US7153699B2 (en) * | 2001-12-21 | 2006-12-26 | Cytonome, Inc. | Microfabricated two-pin system for biomolecule crystallization |
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DE20210451U1 (de) * | 2002-07-05 | 2002-10-17 | Leica Microsystems | Antrieb für eine Vorrichtung zum Einfärben von Objekten |
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US6881588B2 (en) * | 2002-10-18 | 2005-04-19 | Indiana University Research & Technology Corporation | Fluid treatment device |
JP3765788B2 (ja) * | 2002-11-29 | 2006-04-12 | 照明 伊藤 | 検体分注システム |
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1999
- 1999-04-16 US US09/293,659 patent/US6245297B1/en not_active Expired - Lifetime
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2000
- 2000-04-11 JP JP2000612759A patent/JP3659890B2/ja not_active Expired - Fee Related
- 2000-04-11 DE DE60000539T patent/DE60000539T2/de not_active Expired - Lifetime
- 2000-04-11 AU AU42307/00A patent/AU751309B2/en not_active Ceased
- 2000-04-11 AT AT00922064T patent/ATE225516T1/de not_active IP Right Cessation
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- 2000-04-11 EP EP00922064A patent/EP1159622B1/de not_active Expired - Lifetime
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2001
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- 2001-12-12 US US10/016,979 patent/US6916447B2/en not_active Expired - Lifetime
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US6245297B1 (en) | 2001-06-12 |
ATE225516T1 (de) | 2002-10-15 |
JP2002542490A (ja) | 2002-12-10 |
JP3659890B2 (ja) | 2005-06-15 |
WO2000063705A1 (en) | 2000-10-26 |
DE60000539T2 (de) | 2003-03-06 |
EP1159622B1 (de) | 2002-10-02 |
CA2368660A1 (en) | 2000-10-26 |
US20020041829A1 (en) | 2002-04-11 |
AU4230700A (en) | 2000-11-02 |
CA2368660C (en) | 2005-09-06 |
US6355487B2 (en) | 2002-03-12 |
EP1159622A1 (de) | 2001-12-05 |
AU751309B2 (en) | 2002-08-15 |
US20010018216A1 (en) | 2001-08-30 |
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