DE50003758D1 - Verfahren und vorrichtung zum kontrollierten bewegen und plazieren von flüssigkeitstropfen - Google Patents

Verfahren und vorrichtung zum kontrollierten bewegen und plazieren von flüssigkeitstropfen

Info

Publication number
DE50003758D1
DE50003758D1 DE50003758T DE50003758T DE50003758D1 DE 50003758 D1 DE50003758 D1 DE 50003758D1 DE 50003758 T DE50003758 T DE 50003758T DE 50003758 T DE50003758 T DE 50003758T DE 50003758 D1 DE50003758 D1 DE 50003758D1
Authority
DE
Germany
Prior art keywords
liquid drops
controlled moving
sup
placing liquid
moving
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE50003758T
Other languages
English (en)
Inventor
Karsten Reihs
Burkhard Koehler
Dieter Ruehle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sunyx Surface Nanotechnologies GmbH
Original Assignee
Sunyx Surface Nanotechnologies GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunyx Surface Nanotechnologies GmbH filed Critical Sunyx Surface Nanotechnologies GmbH
Priority to DE50003758T priority Critical patent/DE50003758D1/de
Application granted granted Critical
Publication of DE50003758D1 publication Critical patent/DE50003758D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/089—Virtual walls for guiding liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
DE50003758T 1999-10-05 2000-09-22 Verfahren und vorrichtung zum kontrollierten bewegen und plazieren von flüssigkeitstropfen Expired - Lifetime DE50003758D1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE50003758T DE50003758D1 (de) 1999-10-05 2000-09-22 Verfahren und vorrichtung zum kontrollierten bewegen und plazieren von flüssigkeitstropfen

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19947788A DE19947788A1 (de) 1999-10-05 1999-10-05 Verfahren und Vorrichtung zum Bewegen von Flüssigkeiten
DE50003758T DE50003758D1 (de) 1999-10-05 2000-09-22 Verfahren und vorrichtung zum kontrollierten bewegen und plazieren von flüssigkeitstropfen
PCT/EP2000/009272 WO2001024934A1 (de) 1999-10-05 2000-09-22 Verfahren und vorrichtung zum kontrollierten bewegen und plazieren von flüssigkeitstropfen

Publications (1)

Publication Number Publication Date
DE50003758D1 true DE50003758D1 (de) 2003-10-23

Family

ID=7924464

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19947788A Withdrawn DE19947788A1 (de) 1999-10-05 1999-10-05 Verfahren und Vorrichtung zum Bewegen von Flüssigkeiten
DE50003758T Expired - Lifetime DE50003758D1 (de) 1999-10-05 2000-09-22 Verfahren und vorrichtung zum kontrollierten bewegen und plazieren von flüssigkeitstropfen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19947788A Withdrawn DE19947788A1 (de) 1999-10-05 1999-10-05 Verfahren und Vorrichtung zum Bewegen von Flüssigkeiten

Country Status (8)

Country Link
US (1) US7214302B1 (de)
EP (1) EP1222031B1 (de)
JP (1) JP2003511247A (de)
AT (1) ATE249886T1 (de)
AU (1) AU779566B2 (de)
CA (1) CA2387581C (de)
DE (2) DE19947788A1 (de)
WO (1) WO2001024934A1 (de)

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DE10162188A1 (de) * 2001-12-17 2003-06-18 Sunyx Surface Nanotechnologies Hydrophobe Oberfläche mit einer Vielzahl von Elektroden
DE10162064A1 (de) * 2001-12-17 2003-06-26 Sunyx Surface Nanotechnologies Hydrophobe Oberfläche mit einer Vielzahl von Elektroden
DE10162816A1 (de) * 2001-12-19 2003-07-03 Sunyx Surface Nanotechnologies Optischer Schalter
US7754492B2 (en) 2002-04-01 2010-07-13 Palo Alto Research Center Incorporated Thermal sensing device
US7473031B2 (en) 2002-04-01 2009-01-06 Palo Alto Research Center, Incorporated Resistive thermal sensing
US7833800B2 (en) 2002-04-01 2010-11-16 Palo Alto Research Center Incorporated Thermal sensing with bridge circuitry
US7473030B2 (en) 2002-04-01 2009-01-06 Palo Alto Research Center Incorporated Thermal sensing
US7141210B2 (en) 2002-04-01 2006-11-28 Palo Alto Research Center Incorporated Apparatus and method for a nanocalorimeter for detecting chemical reactions
US7147763B2 (en) * 2002-04-01 2006-12-12 Palo Alto Research Center Incorporated Apparatus and method for using electrostatic force to cause fluid movement
US20090215192A1 (en) * 2004-05-27 2009-08-27 Stratos Biosystems, Llc Solid-phase affinity-based method for preparing and manipulating an analyte-containing solution
WO2008071430A1 (en) * 2006-12-13 2008-06-19 Qiagen Gmbh Transfection microarrays
DE102007018056A1 (de) * 2007-04-17 2008-10-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren und Vorrichtung zur Tropfenmanipulation
CA2639954C (en) * 2008-02-11 2017-08-15 Aaron R. Wheeler Droplet-based cell culture and cell assays using digital microfluidics
US8187864B2 (en) * 2008-10-01 2012-05-29 The Governing Council Of The University Of Toronto Exchangeable sheets pre-loaded with reagent depots for digital microfluidics
US8053239B2 (en) 2008-10-08 2011-11-08 The Governing Council Of The University Of Toronto Digital microfluidic method for protein extraction by precipitation from heterogeneous mixtures
CA2740113C (en) 2008-10-10 2019-12-24 The Governing Council Of The University Of Toronto Hybrid digital and channel microfluidic devices and methods of use thereof
US9851365B2 (en) 2009-02-26 2017-12-26 The Governing Council Of The University Of Toronto Digital microfluidic liquid-liquid extraction device and method of use thereof
US8202736B2 (en) * 2009-02-26 2012-06-19 The Governing Council Of The University Of Toronto Method of hormone extraction using digital microfluidics
WO2011137533A1 (en) 2010-05-05 2011-11-10 The Governing Council Of The University Of Toronto Method of processing dried samples using digital microfluidic device
CA2813090C (en) 2010-10-01 2019-11-12 The Governing Council Of The University Of Toronto Digital microfluidic devices and methods incorporating a solid phase
US10464067B2 (en) 2015-06-05 2019-11-05 Miroculus Inc. Air-matrix digital microfluidics apparatuses and methods for limiting evaporation and surface fouling
WO2016197106A1 (en) 2015-06-05 2016-12-08 Miroculus Inc. Evaporation management in digital microfluidic devices
EP3500660A4 (de) 2016-08-22 2020-03-04 Miroculus Inc. Rückkopplungssystem für parallele tröpfchensteuerung in einer digitalen mikrofluidischen vorrichtung
JP2020515815A (ja) 2016-12-28 2020-05-28 ミロキュラス インコーポレイテッド デジタルマイクロ流体デバイスおよび方法
US11623219B2 (en) 2017-04-04 2023-04-11 Miroculus Inc. Digital microfluidics apparatuses and methods for manipulating and processing encapsulated droplets
WO2019023133A1 (en) 2017-07-24 2019-01-31 Miroculus Inc. DIGITAL MICROFLUIDIC SYSTEMS AND METHODS WITH INTEGRATED PLASMA COLLECTION DEVICE
CA3073058A1 (en) 2017-09-01 2019-03-07 Miroculus Inc. Digital microfluidics devices and methods of using them
CN107649223B (zh) * 2017-09-27 2019-10-15 京东方科技集团股份有限公司 液滴控制检测器件及其工作方法
CN114206499A (zh) 2019-04-08 2022-03-18 米罗库鲁斯公司 多盒式数字微流控装置和使用方法
WO2021016614A1 (en) 2019-07-25 2021-01-28 Miroculus Inc. Digital microfluidics devices and methods of use thereof
US11772093B2 (en) 2022-01-12 2023-10-03 Miroculus Inc. Methods of mechanical microfluidic manipulation

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US4525425A (en) * 1981-05-11 1985-06-25 El-Chem Corporation Water and oil repellent metal oxide-organic combination coating systems and method of making same
JPH05208387A (ja) * 1992-01-29 1993-08-20 Shimadzu Corp マイクロマニピュレータ
US5726026A (en) * 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
JP3059307B2 (ja) * 1992-09-01 2000-07-04 株式会社神戸製鋼所 撥水性及び着霜防止性が優れた部材及びその製造方法
JPH07316546A (ja) * 1994-05-23 1995-12-05 Matsushita Electric Ind Co Ltd 撥水表面構造及びその形成方法
US6660363B1 (en) 1994-07-29 2003-12-09 Wilhelm Barthlott Self-cleaning surfaces of objects and process for producing same
JPH08246163A (ja) 1995-01-11 1996-09-24 Kao Corp 金属表面への撥液性付与方法
US5674592A (en) * 1995-05-04 1997-10-07 Minnesota Mining And Manufacturing Company Functionalized nanostructured films
US6042948A (en) * 1996-02-01 2000-03-28 Matsushita Electric Industrial Co., Ltd. Water repellent coating film, method and apparatus for manufacturing the same, and water repellent coating material composition
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FI980874A (fi) 1998-04-20 1999-10-21 Wallac Oy Menetelmä ja laite pienten nestemäärien kemiallisen analyysin suorittamiseksi
DE19825100A1 (de) * 1998-06-05 1999-12-16 Merck Patent Gmbh Mittel zur Herstellung von wasserabweisenden Beschichtungen auf optischen Substraten
DE19847421A1 (de) * 1998-10-14 2000-04-20 Easy Lab Gmbh Pipettier- oder Dosierverfahren und -vorrichtung
DE19860137C2 (de) * 1998-12-24 2002-07-18 Sunyx Surface Nanotechnologies Verfahren zur Herstellung einer ultraphoben Oberfläche auf Basis von strukturiertem Aluminium und deren Verwendung
WO2000038845A1 (de) * 1998-12-24 2000-07-06 Sunyx Surface Nanotechnologies Gmbh Verfahren zur herstellung einer ultraphoben oberfläche durch sandstrahlen
DE19860136C2 (de) * 1998-12-24 2002-11-28 Sunyx Surface Nanotechnologies Ultraphobe Oberfläche, deren Verwendung und Verfahren zu ihrer Herstellung
EP1144732A2 (de) 1998-12-24 2001-10-17 Bayer Aktiengesellschaft Verfahren zur herstellung einer ultraphoben oberfläche auf basis von aluminium
DE19860135C2 (de) * 1998-12-24 2003-02-06 Sunyx Surface Nanotechnologies Ultraphobe Oberfläche auf Basis von Wolframcarbit, ein Verfahren zu ihrer Herstellung und ihre Verwendung
DE19860139C1 (de) 1998-12-24 2000-07-06 Bayer Ag Verfahren zur Herstellung einer ultraphoben Oberfläche auf der Basis von Nickelhydroxid, ultraphobe Oberfläche und ihre Verwendung
CA2356178C (en) 1998-12-24 2010-04-13 Sunyx Surface Nanotechnologies Gmbh Ultraphobic surface
US6294063B1 (en) * 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing

Also Published As

Publication number Publication date
CA2387581C (en) 2009-06-16
ATE249886T1 (de) 2003-10-15
AU7658900A (en) 2001-05-10
EP1222031B1 (de) 2003-09-17
DE19947788A1 (de) 2001-04-12
EP1222031A1 (de) 2002-07-17
CA2387581A1 (en) 2001-04-12
WO2001024934A1 (de) 2001-04-12
US7214302B1 (en) 2007-05-08
AU779566B2 (en) 2005-01-27
JP2003511247A (ja) 2003-03-25

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