ATE249886T1 - Verfahren und vorrichtung zum kontrollierten bewegen und plazieren von flüssigkeitstropfen - Google Patents

Verfahren und vorrichtung zum kontrollierten bewegen und plazieren von flüssigkeitstropfen

Info

Publication number
ATE249886T1
ATE249886T1 AT00966067T AT00966067T ATE249886T1 AT E249886 T1 ATE249886 T1 AT E249886T1 AT 00966067 T AT00966067 T AT 00966067T AT 00966067 T AT00966067 T AT 00966067T AT E249886 T1 ATE249886 T1 AT E249886T1
Authority
AT
Austria
Prior art keywords
placing
liquid drops
sup
controlled moving
moving
Prior art date
Application number
AT00966067T
Other languages
English (en)
Inventor
Karsten Reihs
Burkhard Koehler
Dieter Ruehle
Original Assignee
Sunyx Surface Nanotechnologies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunyx Surface Nanotechnologies filed Critical Sunyx Surface Nanotechnologies
Application granted granted Critical
Publication of ATE249886T1 publication Critical patent/ATE249886T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/089—Virtual walls for guiding liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Vibration Prevention Devices (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Micromachines (AREA)
  • Manipulator (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
AT00966067T 1999-10-05 2000-09-22 Verfahren und vorrichtung zum kontrollierten bewegen und plazieren von flüssigkeitstropfen ATE249886T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19947788A DE19947788A1 (de) 1999-10-05 1999-10-05 Verfahren und Vorrichtung zum Bewegen von Flüssigkeiten
PCT/EP2000/009272 WO2001024934A1 (de) 1999-10-05 2000-09-22 Verfahren und vorrichtung zum kontrollierten bewegen und plazieren von flüssigkeitstropfen

Publications (1)

Publication Number Publication Date
ATE249886T1 true ATE249886T1 (de) 2003-10-15

Family

ID=7924464

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00966067T ATE249886T1 (de) 1999-10-05 2000-09-22 Verfahren und vorrichtung zum kontrollierten bewegen und plazieren von flüssigkeitstropfen

Country Status (8)

Country Link
US (1) US7214302B1 (de)
EP (1) EP1222031B1 (de)
JP (1) JP2003511247A (de)
AT (1) ATE249886T1 (de)
AU (1) AU779566B2 (de)
CA (1) CA2387581C (de)
DE (2) DE19947788A1 (de)
WO (1) WO2001024934A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10162064A1 (de) * 2001-12-17 2003-06-26 Sunyx Surface Nanotechnologies Hydrophobe Oberfläche mit einer Vielzahl von Elektroden
DE10162188A1 (de) * 2001-12-17 2003-06-18 Sunyx Surface Nanotechnologies Hydrophobe Oberfläche mit einer Vielzahl von Elektroden
DE10162816A1 (de) * 2001-12-19 2003-07-03 Sunyx Surface Nanotechnologies Optischer Schalter
US7833800B2 (en) 2002-04-01 2010-11-16 Palo Alto Research Center Incorporated Thermal sensing with bridge circuitry
US7147763B2 (en) * 2002-04-01 2006-12-12 Palo Alto Research Center Incorporated Apparatus and method for using electrostatic force to cause fluid movement
US7754492B2 (en) 2002-04-01 2010-07-13 Palo Alto Research Center Incorporated Thermal sensing device
US7473031B2 (en) 2002-04-01 2009-01-06 Palo Alto Research Center, Incorporated Resistive thermal sensing
US7141210B2 (en) 2002-04-01 2006-11-28 Palo Alto Research Center Incorporated Apparatus and method for a nanocalorimeter for detecting chemical reactions
US7473030B2 (en) 2002-04-01 2009-01-06 Palo Alto Research Center Incorporated Thermal sensing
WO2005118129A1 (en) * 2004-05-27 2005-12-15 Stratos Biosystems, Llc Solid-phase affinity-based method for preparing and manipulating an analyte-containing solution
WO2008071430A1 (en) * 2006-12-13 2008-06-19 Qiagen Gmbh Transfection microarrays
DE102007018056A1 (de) * 2007-04-17 2008-10-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren und Vorrichtung zur Tropfenmanipulation
CA2639954C (en) * 2008-02-11 2017-08-15 Aaron R. Wheeler Droplet-based cell culture and cell assays using digital microfluidics
US8187864B2 (en) * 2008-10-01 2012-05-29 The Governing Council Of The University Of Toronto Exchangeable sheets pre-loaded with reagent depots for digital microfluidics
US8053239B2 (en) 2008-10-08 2011-11-08 The Governing Council Of The University Of Toronto Digital microfluidic method for protein extraction by precipitation from heterogeneous mixtures
EP2346777A4 (de) 2008-10-10 2014-10-01 Univ Toronto Hybride digitale mikrofluidische kanalvorrichtungen und herstellungsverfahren dafür
US8202736B2 (en) * 2009-02-26 2012-06-19 The Governing Council Of The University Of Toronto Method of hormone extraction using digital microfluidics
US9851365B2 (en) 2009-02-26 2017-12-26 The Governing Council Of The University Of Toronto Digital microfluidic liquid-liquid extraction device and method of use thereof
US10232374B2 (en) 2010-05-05 2019-03-19 Miroculus Inc. Method of processing dried samples using digital microfluidic device
US9476811B2 (en) 2010-10-01 2016-10-25 The Governing Council Of The University Of Toronto Digital microfluidic devices and methods incorporating a solid phase
US10695762B2 (en) * 2015-06-05 2020-06-30 Miroculus Inc. Evaporation management in digital microfluidic devices
CN108026494A (zh) 2015-06-05 2018-05-11 米罗库鲁斯公司 限制蒸发和表面结垢的空气基质数字微流控装置和方法
WO2018039281A1 (en) 2016-08-22 2018-03-01 Miroculus Inc. Feedback system for parallel droplet control in a digital microfluidic device
WO2018126082A1 (en) 2016-12-28 2018-07-05 Miroculis Inc. Digital microfluidic devices and methods
US11623219B2 (en) 2017-04-04 2023-04-11 Miroculus Inc. Digital microfluidics apparatuses and methods for manipulating and processing encapsulated droplets
EP3658908B1 (de) 2017-07-24 2025-11-12 Integra Biosciences AG Digitale mikrofluidiksysteme und verfahren mit integrierter plasmasammelvorrichtung
WO2019046860A1 (en) 2017-09-01 2019-03-07 Miroculus Inc. DIGITAL MICROFLUIDIC DEVICES AND METHODS OF USE
CN107649223B (zh) * 2017-09-27 2019-10-15 京东方科技集团股份有限公司 液滴控制检测器件及其工作方法
CA3096855A1 (en) 2018-05-23 2019-11-28 Miroculus Inc. Control of evaporation in digital microfluidics
US12233390B2 (en) 2019-01-31 2025-02-25 Miroculus Inc. Nonfouling compositions and methods for manipulating and processing encapsulated droplets
WO2020176816A1 (en) 2019-02-28 2020-09-03 Miroculus Inc. Digital microfluidics devices and methods of using them
WO2020210292A1 (en) 2019-04-08 2020-10-15 Miroculus Inc. Multi-cartridge digital microfluidics apparatuses and methods of use
US11524298B2 (en) 2019-07-25 2022-12-13 Miroculus Inc. Digital microfluidics devices and methods of use thereof
US11857961B2 (en) 2022-01-12 2024-01-02 Miroculus Inc. Sequencing by synthesis using mechanical compression

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4525425A (en) * 1981-05-11 1985-06-25 El-Chem Corporation Water and oil repellent metal oxide-organic combination coating systems and method of making same
JPH05208387A (ja) * 1992-01-29 1993-08-20 Shimadzu Corp マイクロマニピュレータ
US5726026A (en) * 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
JP3059307B2 (ja) * 1992-09-01 2000-07-04 株式会社神戸製鋼所 撥水性及び着霜防止性が優れた部材及びその製造方法
JPH07316546A (ja) * 1994-05-23 1995-12-05 Matsushita Electric Ind Co Ltd 撥水表面構造及びその形成方法
EP0772514B1 (de) 1994-07-29 1998-12-23 Wilhelm Barthlott Selbstreinigende oberflächen von gegenständen sowie verfahren zur herstellung derselben
JPH08246163A (ja) 1995-01-11 1996-09-24 Kao Corp 金属表面への撥液性付与方法
US5674592A (en) 1995-05-04 1997-10-07 Minnesota Mining And Manufacturing Company Functionalized nanostructured films
MY118037A (en) * 1996-02-01 2004-08-30 Matsushita Electric Industrial Co Ltd Water repellent coating film, method and apparatus for manufacturing the same, and water repellent coating material composition
FR2756276B1 (fr) 1996-11-26 1998-12-24 Saint Gobain Vitrage Substrat a proprietes hydrophiles ou hydrophobes ameliorees, comportant des irregularites
JP3274077B2 (ja) * 1996-12-25 2002-04-15 株式会社神戸製鋼所 撥水性及び着霜防止性が優れたアルミニウム又はアルミニウム合金部材
JP3791999B2 (ja) * 1997-03-24 2006-06-28 株式会社アドバンス 液体微粒子ハンドリング装置
FI980874A7 (fi) 1998-04-20 1999-10-21 Wallac Oy Menetelmä ja laite pienten nestemäärien kemiallisen analyysin suorittamiseksi
DE19825100A1 (de) * 1998-06-05 1999-12-16 Merck Patent Gmbh Mittel zur Herstellung von wasserabweisenden Beschichtungen auf optischen Substraten
DE19847421A1 (de) 1998-10-14 2000-04-20 Easy Lab Gmbh Pipettier- oder Dosierverfahren und -vorrichtung
AU3040100A (en) * 1998-12-24 2000-07-31 Bayer Aktiengesellschaft Method for producing an ultraphobic surface by sand blasting
DE19860135C2 (de) 1998-12-24 2003-02-06 Sunyx Surface Nanotechnologies Ultraphobe Oberfläche auf Basis von Wolframcarbit, ein Verfahren zu ihrer Herstellung und ihre Verwendung
EP1144537B1 (de) 1998-12-24 2004-03-17 Sunyx Surface Nanotechnologies GmbH Ultraphobe oberfläche
DE19860137C2 (de) 1998-12-24 2002-07-18 Sunyx Surface Nanotechnologies Verfahren zur Herstellung einer ultraphoben Oberfläche auf Basis von strukturiertem Aluminium und deren Verwendung
DE19860136C2 (de) 1998-12-24 2002-11-28 Sunyx Surface Nanotechnologies Ultraphobe Oberfläche, deren Verwendung und Verfahren zu ihrer Herstellung
DE19860139C1 (de) * 1998-12-24 2000-07-06 Bayer Ag Verfahren zur Herstellung einer ultraphoben Oberfläche auf der Basis von Nickelhydroxid, ultraphobe Oberfläche und ihre Verwendung
EP1144732A2 (de) 1998-12-24 2001-10-17 Bayer Aktiengesellschaft Verfahren zur herstellung einer ultraphoben oberfläche auf basis von aluminium
US6294063B1 (en) * 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing

Also Published As

Publication number Publication date
AU779566B2 (en) 2005-01-27
EP1222031B1 (de) 2003-09-17
AU7658900A (en) 2001-05-10
US7214302B1 (en) 2007-05-08
JP2003511247A (ja) 2003-03-25
CA2387581A1 (en) 2001-04-12
CA2387581C (en) 2009-06-16
WO2001024934A1 (de) 2001-04-12
DE19947788A1 (de) 2001-04-12
DE50003758D1 (de) 2003-10-23
EP1222031A1 (de) 2002-07-17

Similar Documents

Publication Publication Date Title
DE50003758D1 (de) Verfahren und vorrichtung zum kontrollierten bewegen und plazieren von flüssigkeitstropfen
DE60026688D1 (de) Vorrichtung zur fokussierter probennahme von formations flüssigkeit.
DE69128700D1 (de) Vorrichtung zur quantitativen Entnahme von Flüssigkeitsproben
DE69522549D1 (de) Vorrichtung zur abgabe von steriler flüssigkeit
ATE217962T1 (de) Vorrichtung zur parallel-ausrichtung von makromolekülen und verwendung davon
DE60303609D1 (de) Vorrichtung zur zufuhr von flüssigkeit für ein augenchirurgisches handstück
DE69518321D1 (de) Verfahren und vorrichtung zum mischen von flüssigkeiten
DE60136661D1 (de) Vorrichtung zur Absaugung von Flüssigkeitsproben und Verfahren zur Vorortsanalyse der Formationsflüssigkeiten
PT87385A (pt) Apparatus for distributing sample liquid
DE60212522D1 (de) Vorrichtung für die Entnahme von flüssigen Proben
DE60019240D1 (de) Vorrichtung zur Trennung von Bestandteilen einer flüssigen Probe
DE60023823D1 (de) Vorrichtung zur Trennung von Bestandteilen einer flüssigen Probe
DE60018392D1 (de) Verfahren und vorichtung zum abgaben von tröpfchen auf einem substrat
DE69315521D1 (de) Vorrichtung zum Entklumpen von cytologischen Proben
DE69002612D1 (de) Vorrichtung zur durchfuehrung rheologischer messungen an materialien.
DE602004020605D1 (de) Verfahren und vorrichtung zur entfernung von organ
ATA455675A (de) Verfahren zum beschichten von glas und vorrichtung zur durchfuehrung des verfahrens
DE69932101D1 (de) Verfahren und vorrichtung zur kontinuierlichen durchführung von gas-flüssigkeitsreaktionen
DE69411283D1 (de) Vorrichtung zum mit genauigkeit zuführen von flüssigkeit
DE69514509D1 (de) Vorrichtung zur flussigkeitsanalyse
DE69618467D1 (de) Vorrichtung zum übertragen von mikro-mengen von flüssigen proben
DE50003731D1 (de) Verfahren und vorrichtung zum aufbringen kleiner flüssigkeitsmengen
DE69300229D1 (de) Vorrichtung zum Entfernen von Drahtverbindungen unter Verwendung eines wechselnden Flüssigkeitsstromes.
DE60020634D1 (de) Vorrichtung zur Präsentation von Sehtest-Zeichenträgern
DE69513364D1 (de) Optoelektronische Vorrichtung zur Unterstützung der Führung eines Flugzeuges

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee