DE602004011028D1 - Verfahren und vorrichtung zum nachweis von biomolekülen - Google Patents
Verfahren und vorrichtung zum nachweis von biomolekülenInfo
- Publication number
- DE602004011028D1 DE602004011028D1 DE602004011028T DE602004011028T DE602004011028D1 DE 602004011028 D1 DE602004011028 D1 DE 602004011028D1 DE 602004011028 T DE602004011028 T DE 602004011028T DE 602004011028 T DE602004011028 T DE 602004011028T DE 602004011028 D1 DE602004011028 D1 DE 602004011028D1
- Authority
- DE
- Germany
- Prior art keywords
- nanoelectrodes
- biomolecules
- tag
- segment
- probe molecules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000000523 sample Substances 0.000 abstract 3
- 238000000018 DNA microarray Methods 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 238000000840 electrochemical analysis Methods 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/125—Nucleic acid detection characterized by the use of physical, structural and functional properties the label being enzymatic, i.e. proteins, and non proteins, such as nucleic acid with enzymatic activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/10—Detection mode being characterised by the assay principle
- C12Q2565/113—Detection mode being characterised by the assay principle based on agglutination/precipitation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/60—Detection means characterised by use of a special device
- C12Q2565/607—Detection means characterised by use of a special device being a sensor, e.g. electrode
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/701—Integrated with dissimilar structures on a common substrate
- Y10S977/702—Integrated with dissimilar structures on a common substrate having biological material component
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/701—Integrated with dissimilar structures on a common substrate
- Y10S977/702—Integrated with dissimilar structures on a common substrate having biological material component
- Y10S977/704—Nucleic acids, e.g. DNA or RNA
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/701—Integrated with dissimilar structures on a common substrate
- Y10S977/702—Integrated with dissimilar structures on a common substrate having biological material component
- Y10S977/705—Protein or peptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/701—Integrated with dissimilar structures on a common substrate
- Y10S977/72—On an electrically conducting, semi-conducting, or semi-insulating substrate
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Nanotechnology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Medical Informatics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10311315A DE10311315A1 (de) | 2003-03-14 | 2003-03-14 | Verfahren und Vorrichtung zur Detektion von Biomolekülen |
DE10311315 | 2003-03-14 | ||
PCT/EP2004/002685 WO2004081566A2 (en) | 2003-03-14 | 2004-03-15 | Method and device for detecting biomolecules |
Publications (2)
Publication Number | Publication Date |
---|---|
DE602004011028D1 true DE602004011028D1 (de) | 2008-02-14 |
DE602004011028T2 DE602004011028T2 (de) | 2009-01-02 |
Family
ID=32920804
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE10311315A Ceased DE10311315A1 (de) | 2003-03-14 | 2003-03-14 | Verfahren und Vorrichtung zur Detektion von Biomolekülen |
DE602004011028T Expired - Lifetime DE602004011028T2 (de) | 2003-03-14 | 2004-03-15 | Verfahren und vorrichtung zum nachweis von biomolekülen |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE10311315A Ceased DE10311315A1 (de) | 2003-03-14 | 2003-03-14 | Verfahren und Vorrichtung zur Detektion von Biomolekülen |
Country Status (7)
Country | Link |
---|---|
US (1) | US7879594B2 (de) |
EP (1) | EP1604042B1 (de) |
JP (1) | JP4625547B2 (de) |
AT (1) | ATE382713T1 (de) |
DE (2) | DE10311315A1 (de) |
ES (1) | ES2298730T3 (de) |
WO (1) | WO2004081566A2 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102004024364A1 (de) * | 2004-05-17 | 2005-12-15 | Apibio Sas | Verfahren zur Herstellung von Polymeren |
US20070231794A1 (en) * | 2005-09-21 | 2007-10-04 | Combimatrix Corporation | Process to detect binding events on an electrode microarray using enzymes |
DE102007055386B4 (de) * | 2007-11-20 | 2015-07-16 | Boehringer Ingelheim Vetmedica Gmbh | Verfahren zur Kalibrierung eines Sensorelements |
CA2735735C (en) * | 2008-09-02 | 2016-11-22 | The Governing Council Of The University Of Toronto | Nanostructured microelectrodes and biosensing devices incorporating the same |
CA2800257C (en) * | 2010-05-26 | 2019-03-05 | The Board Of Trustees Of The University Of Illinois | Personal glucose meters for detection and quantification of a broad range of analytes |
US8877022B2 (en) * | 2011-06-21 | 2014-11-04 | National Taiwan University | Biosensor |
GB201120118D0 (en) | 2011-11-22 | 2012-01-04 | Iti Scotland Ltd | Detecting analytes |
CN103278621A (zh) * | 2013-04-25 | 2013-09-04 | 中国科学院广州生物医药与健康研究院 | 一种利用生物传感器与血糖仪检测转录因子的方法 |
CN103558396B (zh) * | 2013-10-29 | 2015-08-26 | 宁波大学 | 一种甲胎蛋白的定量检测方法 |
FR3034523B1 (fr) * | 2015-04-03 | 2020-01-17 | Universite De Bourgogne | Nouvelle methode pour detecter la presence de bacteries productrices de beta-lactamases. |
KR101701618B1 (ko) * | 2015-06-23 | 2017-02-13 | 국립암센터 | 전도성 고분자를 이용한 세포 유리 dna 검출용 구조체 및 이의 용도 |
ZA201607865B (en) | 2015-11-18 | 2019-10-30 | Univ Stellenbosch | A device for detecting target biomolecules |
CN115856046B (zh) * | 2023-01-09 | 2023-05-26 | 中南大学 | 一种基于钙钛矿纳米材料的光电化学生物传感器检测alp的应用 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6060237A (en) | 1985-02-26 | 2000-05-09 | Biostar, Inc. | Devices and methods for optical detection of nucleic acid hybridization |
US4916075A (en) * | 1987-08-19 | 1990-04-10 | Ohmicron Corporation | Differential homogeneous immunosensor device |
US4999284A (en) * | 1988-04-06 | 1991-03-12 | E. I. Du Pont De Nemours And Company | Enzymatically amplified piezoelectric specific binding assay |
US5202261A (en) * | 1990-07-19 | 1993-04-13 | Miles Inc. | Conductive sensors and their use in diagnostic assays |
IL103674A0 (en) * | 1991-11-19 | 1993-04-04 | Houston Advanced Res Center | Method and apparatus for molecule detection |
US5364797A (en) * | 1993-05-20 | 1994-11-15 | Mobil Oil Corp. | Sensor device containing mesoporous crystalline material |
FR2720832A1 (fr) * | 1994-04-22 | 1995-12-08 | Francis Garnier | Electrodes et membranes électroactives à base de peptides bioactifs, pour la reconnaissance, l'extraction ou le relargage d'espèces biologiquement actives. |
AU729118B2 (en) * | 1997-02-06 | 2001-01-25 | University Of North Carolina At Chapel Hill, The | Electrochemical probes for detection of molecular interactions and drug discovery |
US6123819A (en) | 1997-11-12 | 2000-09-26 | Protiveris, Inc. | Nanoelectrode arrays |
US6055106A (en) | 1998-02-03 | 2000-04-25 | Arch Development Corporation | Apparatus for applying optical gradient forces |
JP2003508730A (ja) * | 1999-06-10 | 2003-03-04 | モトローラ・インコーポレイテッド | 電荷中性共役ポリマーを用いるバイオセンサー |
FR2796465B1 (fr) * | 1999-07-16 | 2001-11-23 | Suisse Electronique Microtech | Systeme capteur biochimique a sensibilite accrue par amplification moleculaire du signal |
KR100348786B1 (ko) * | 1999-10-01 | 2002-08-17 | 엘지전자주식회사 | 핵산검출방법, 및 핵산검출기와 이의 제조방법 |
IL138229A (en) | 2000-09-04 | 2005-03-20 | Yissum Res Dev Co | Method and system for detecting nucleic acids |
WO2002079514A1 (en) * | 2001-01-10 | 2002-10-10 | The Trustees Of Boston College | Dna-bridged carbon nanotube arrays |
EP2801624B1 (de) * | 2001-03-16 | 2019-03-06 | Singular Bio, Inc | Arrays und Verfahren zur Verwendung |
US6661279B2 (en) | 2001-04-11 | 2003-12-09 | Kabushiki Kaisha Toshiba | Semiconductor integrated circuit which outputs first internal power supply voltage and second internal power supply voltage lower than first internal supply power voltage |
FR2828284B1 (fr) * | 2001-08-01 | 2003-10-31 | Bio Merieux | Procede de detection au niveau d'un support solide d'une complexation ou d'une hybridation entre au moins deux molecules base sur un signal amplifie au niveau du support |
EP1425275B1 (de) * | 2001-09-12 | 2007-11-28 | Pusan National University Industry-University Cooperation Foundation | Neue terthiophen-3-carbonsäure verbindung und verfahren zu deren herstellung, funktionalisierter leitender terthiophenpolymer mit der verbindung als monomer und verfahren zum nachweis von dna-hybridisierung unter anwendung des polymers |
US20030148335A1 (en) * | 2001-10-10 | 2003-08-07 | Li Shen | Detecting targets by unique identifier nucleotide tags |
US6869671B1 (en) * | 2002-06-03 | 2005-03-22 | University Of Notre Dame | Enabling nanostructured materials via multilayer thin film precursor and applications to biosensors |
WO2004046685A2 (en) * | 2002-07-15 | 2004-06-03 | Technical Instrument San Francisco | Quality control of assays |
US7470533B2 (en) * | 2002-12-20 | 2008-12-30 | Acea Biosciences | Impedance based devices and methods for use in assays |
EP1556506A1 (de) * | 2002-09-19 | 2005-07-27 | The Chancellor, Masters And Scholars Of The University Of Oxford | Molekulare arrays und einzelmolekülnachweis |
-
2003
- 2003-03-14 DE DE10311315A patent/DE10311315A1/de not_active Ceased
-
2004
- 2004-03-15 EP EP04720593A patent/EP1604042B1/de not_active Expired - Lifetime
- 2004-03-15 WO PCT/EP2004/002685 patent/WO2004081566A2/en active IP Right Grant
- 2004-03-15 AT AT04720593T patent/ATE382713T1/de not_active IP Right Cessation
- 2004-03-15 US US10/548,869 patent/US7879594B2/en not_active Expired - Fee Related
- 2004-03-15 JP JP2006504693A patent/JP4625547B2/ja not_active Expired - Fee Related
- 2004-03-15 ES ES04720593T patent/ES2298730T3/es not_active Expired - Lifetime
- 2004-03-15 DE DE602004011028T patent/DE602004011028T2/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1604042A2 (de) | 2005-12-14 |
JP2006520469A (ja) | 2006-09-07 |
US20070037153A1 (en) | 2007-02-15 |
DE10311315A1 (de) | 2004-09-30 |
ES2298730T3 (es) | 2008-05-16 |
WO2004081566A3 (en) | 2004-12-02 |
WO2004081566A2 (en) | 2004-09-23 |
JP4625547B2 (ja) | 2011-02-02 |
ATE382713T1 (de) | 2008-01-15 |
US7879594B2 (en) | 2011-02-01 |
DE602004011028T2 (de) | 2009-01-02 |
EP1604042B1 (de) | 2008-01-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |