DE69903054D1 - Vorrichtung zur handhabung von mikroflüssigkeitsmengen - Google Patents

Vorrichtung zur handhabung von mikroflüssigkeitsmengen

Info

Publication number
DE69903054D1
DE69903054D1 DE69903054T DE69903054T DE69903054D1 DE 69903054 D1 DE69903054 D1 DE 69903054D1 DE 69903054 T DE69903054 T DE 69903054T DE 69903054 T DE69903054 T DE 69903054T DE 69903054 D1 DE69903054 D1 DE 69903054D1
Authority
DE
Germany
Prior art keywords
solvent
microarea
microchannel
reservoir
micro liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69903054T
Other languages
English (en)
Other versions
DE69903054T2 (de
Inventor
Marten Stjernstroem
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gyros Patent AB
Original Assignee
Gyros AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gyros AB filed Critical Gyros AB
Publication of DE69903054D1 publication Critical patent/DE69903054D1/de
Application granted granted Critical
Publication of DE69903054T2 publication Critical patent/DE69903054T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0642—Filling fluids into wells by specific techniques
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00079—Evaporation covers for slides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2525—Stabilizing or preserving
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25625—Dilution
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
DE69903054T 1998-10-30 1999-10-29 Vorrichtung zur handhabung von mikroflüssigkeitsmengen Expired - Lifetime DE69903054T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9803734A SE9803734D0 (sv) 1998-10-30 1998-10-30 Liquid handling system
PCT/SE1999/001958 WO2000025921A1 (en) 1998-10-30 1999-10-29 Liquid microvolume handling system

Publications (2)

Publication Number Publication Date
DE69903054D1 true DE69903054D1 (de) 2002-10-24
DE69903054T2 DE69903054T2 (de) 2003-04-24

Family

ID=20413144

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69903054T Expired - Lifetime DE69903054T2 (de) 1998-10-30 1999-10-29 Vorrichtung zur handhabung von mikroflüssigkeitsmengen

Country Status (8)

Country Link
US (1) US7323345B1 (de)
EP (1) EP1124638B1 (de)
JP (1) JP2002528264A (de)
AT (1) ATE224231T1 (de)
DE (1) DE69903054T2 (de)
ES (1) ES2187216T3 (de)
SE (1) SE9803734D0 (de)
WO (1) WO2000025921A1 (de)

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* Cited by examiner, † Cited by third party
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GB9808836D0 (en) * 1998-04-27 1998-06-24 Amersham Pharm Biotech Uk Ltd Microfabricated apparatus for cell based assays
US6555389B1 (en) 1999-05-11 2003-04-29 Aclara Biosciences, Inc. Sample evaporative control
SE9902474D0 (sv) 1999-06-30 1999-06-30 Amersham Pharm Biotech Ab Polymer valves
SE0004296D0 (sv) 2000-11-23 2000-11-23 Gyros Ab Device and method for the controlled heating in micro channel systems
US7429354B2 (en) 2001-03-19 2008-09-30 Gyros Patent Ab Structural units that define fluidic functions
CA2441206A1 (en) 2001-03-19 2002-09-26 Gyros Ab Characterization of reaction variables
EP1390144A2 (de) * 2001-03-19 2004-02-25 Gyros AB Fluidische funktionen definierende konstruktionseinheiten
EP2269736B1 (de) 2001-08-28 2013-04-24 Gyros Patent Ab Mikrokammern und mikrofluidische Strukturen zur Handhabung kleiner Flüssigkeitsmengen
US6919058B2 (en) 2001-08-28 2005-07-19 Gyros Ab Retaining microfluidic microcavity and other microfluidic structures
ATE477054T1 (de) 2001-09-17 2010-08-15 Gyros Patent Ab Einen kontrollierten strom in einer mikrofluidvorrichtung ermöglichende funktionseinheit
DE10222228A1 (de) 2002-05-16 2003-11-27 Roche Diagnostics Gmbh Mikropumpe mit Heizelementen für einen pulsierten Betrieb
JP4519124B2 (ja) 2003-01-30 2010-08-04 ユィロス・パテント・アクチボラグ 微小流動性デバイスの内部の壁
SE0300823D0 (sv) 2003-03-23 2003-03-23 Gyros Ab Preloaded Microscale Devices
WO2004103890A1 (en) 2003-05-23 2004-12-02 Gyros Patent Ab Hydrophilic/hydrophobic surfaces
DE10354806A1 (de) * 2003-11-21 2005-06-02 Boehringer Ingelheim Microparts Gmbh Probenträger
SE0400181D0 (sv) 2004-01-29 2004-01-29 Gyros Ab Segmented porous and preloaded microscale devices
WO2006075965A1 (en) * 2005-01-17 2006-07-20 Gyros Patent Ab A method for detecting an at least bivalent analyte using two affinity reactants
US7998418B1 (en) * 2006-06-01 2011-08-16 Nanotek, Llc Evaporator and concentrator in reactor and loading system
CA2798123C (en) 2010-05-05 2020-06-23 The Governing Council Of The University Of Toronto Method of processing dried samples using digital microfluidic device
US9993819B2 (en) 2014-12-30 2018-06-12 Stmicroelectronics S.R.L. Apparatus for actuating and reading a centrifugal microfluidic disk for biological and biochemical analyses, and use of the apparatus
WO2016197103A1 (en) 2015-06-05 2016-12-08 Miroculus Inc. Air-matrix digital microfluidics apparatuses and methods for limiting evaporation and surface fouling
WO2016197106A1 (en) 2015-06-05 2016-12-08 Miroculus Inc. Evaporation management in digital microfluidic devices
US10596572B2 (en) 2016-08-22 2020-03-24 Miroculus Inc. Feedback system for parallel droplet control in a digital microfluidic device
WO2018126082A1 (en) 2016-12-28 2018-07-05 Miroculis Inc. Digital microfluidic devices and methods
WO2018156460A1 (en) * 2017-02-22 2018-08-30 The Trustees Of Columbia University In The City Of New York Method and apparatus for computer-vision guided targeted delivery of small liquid volumes into selected lung regions
WO2018187476A1 (en) 2017-04-04 2018-10-11 Miroculus Inc. Digital microfluidic apparatuses and methods for manipulating and processing encapsulated droplets
US11413617B2 (en) 2017-07-24 2022-08-16 Miroculus Inc. Digital microfluidics systems and methods with integrated plasma collection device
WO2019046860A1 (en) 2017-09-01 2019-03-07 Miroculus Inc. DIGITAL MICROFLUIDIC DEVICES AND METHODS OF USE
EP3796999A4 (de) 2018-05-23 2022-03-09 Miroculus Inc. Steuerung der verdampfung in digitaler mikrofluidik
CA3133124A1 (en) 2019-04-08 2020-10-15 Miroculus Inc. Multi-cartridge digital microfluidics apparatuses and methods of use
US11524298B2 (en) 2019-07-25 2022-12-13 Miroculus Inc. Digital microfluidics devices and methods of use thereof
CN114279907B (zh) * 2021-12-14 2022-11-15 中国科学院地质与地球物理研究所 一种月尘颗粒样品的无损筛分系统及其筛分方法
US11772093B2 (en) 2022-01-12 2023-10-03 Miroculus Inc. Methods of mechanical microfluidic manipulation

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US4507463A (en) * 1983-05-11 1985-03-26 Ciba-Geigy Corporation Process for producing polyesters from aliphatic dicarboxylic acids and polyalkylpiperidyldiols
US4659677A (en) 1983-05-26 1987-04-21 Eastman Kodak Company Method providing liquid mixing outside containers
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US5171989A (en) * 1992-01-24 1992-12-15 Board Of Trustees Of Leland Stanford Jr. University Method and apparatus for continuous sample ice matrix production for laser desorption in mass spectrometry
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US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
CA2204912C (en) * 1994-11-10 2005-01-04 David Sarnoff Research Center, Inc. Liquid distribution system
US5785926A (en) 1995-09-19 1998-07-28 University Of Washington Precision small volume fluid processing apparatus
US20010055812A1 (en) * 1995-12-05 2001-12-27 Alec Mian Devices and method for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
US6033544A (en) * 1996-10-11 2000-03-07 Sarnoff Corporation Liquid distribution system
US5879632A (en) * 1996-04-09 1999-03-09 Sarnoff Corporation Apportioning system
US5863801A (en) * 1996-06-14 1999-01-26 Sarnoff Corporation Automated nucleic acid isolation
US6143248A (en) * 1996-08-12 2000-11-07 Gamera Bioscience Corp. Capillary microvalve
WO1998028623A1 (en) * 1996-12-20 1998-07-02 Gamera Bioscience Corporation An affinity binding-based system for detecting particulates in a fluid
SE9700207D0 (sv) 1997-01-24 1997-01-24 Erik Litborn A method of preventing evaporation from liquid samples in small volumes
US6090251A (en) * 1997-06-06 2000-07-18 Caliper Technologies, Inc. Microfabricated structures for facilitating fluid introduction into microfluidic devices
ES2211044T3 (es) 1998-03-04 2004-07-01 Ortho-Mcneil Pharmaceutical, Inc. Sistemas para realizar ensayos en una gotita sometida a la accion de un levitador.
US6086740A (en) * 1998-10-29 2000-07-11 Caliper Technologies Corp. Multiplexed microfluidic devices and systems
US6416642B1 (en) * 1999-01-21 2002-07-09 Caliper Technologies Corp. Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection
US6555389B1 (en) 1999-05-11 2003-04-29 Aclara Biosciences, Inc. Sample evaporative control
US6642061B2 (en) * 2000-09-25 2003-11-04 Picoliter Inc. Use of immiscible fluids in droplet ejection through application of focused acoustic energy

Also Published As

Publication number Publication date
ATE224231T1 (de) 2002-10-15
US7323345B1 (en) 2008-01-29
SE9803734D0 (sv) 1998-10-30
EP1124638A1 (de) 2001-08-22
JP2002528264A (ja) 2002-09-03
ES2187216T3 (es) 2003-05-16
DE69903054T2 (de) 2003-04-24
EP1124638B1 (de) 2002-09-18
WO2000025921A1 (en) 2000-05-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: GYROS PATENT AB, UPPSALA, SE