ES2187216T3 - Sistema de tratamiento de un microvolumen de lquido. - Google Patents
Sistema de tratamiento de un microvolumen de lquido.Info
- Publication number
- ES2187216T3 ES2187216T3 ES99971352T ES99971352T ES2187216T3 ES 2187216 T3 ES2187216 T3 ES 2187216T3 ES 99971352 T ES99971352 T ES 99971352T ES 99971352 T ES99971352 T ES 99971352T ES 2187216 T3 ES2187216 T3 ES 2187216T3
- Authority
- ES
- Spain
- Prior art keywords
- solvent
- microarea
- microchannel
- reservoir
- microvolumen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0642—Filling fluids into wells by specific techniques
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N2035/00079—Evaporation covers for slides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2525—Stabilizing or preserving
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25625—Dilution
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Extraction Or Liquid Replacement (AREA)
- Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
Abstract
Un dispositivo microfluídico que comprende un microcanal (2,4), que facilita el contacto del líquido entre una microárea de reacción abierta o una cámara de reacción que porta un microvolumen (1) de un disolvente y un depósito (3; 8) para el disolvente, formando parte dicho microvolumen y dicho disolvente del mencionado dispositivo microfluídico y dicho microvolumen comprende uno o más reactivos para producir una reacción en el disolvente presente en la microárea o en la cámara, y estando adaptados el mencionado depósito (3; 8) y el mencionado microcanal (2,4) para que el disolvente evaporado de la mencionada microárea se pueda sustituir de forma continuada por disolvente del depósito (3; 8) a través del mencionado microcanal (2, 4).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9803734A SE9803734D0 (sv) | 1998-10-30 | 1998-10-30 | Liquid handling system |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2187216T3 true ES2187216T3 (es) | 2003-05-16 |
Family
ID=20413144
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99971352T Expired - Lifetime ES2187216T3 (es) | 1998-10-30 | 1999-10-29 | Sistema de tratamiento de un microvolumen de lquido. |
Country Status (8)
Country | Link |
---|---|
US (1) | US7323345B1 (es) |
EP (1) | EP1124638B1 (es) |
JP (1) | JP2002528264A (es) |
AT (1) | ATE224231T1 (es) |
DE (1) | DE69903054T2 (es) |
ES (1) | ES2187216T3 (es) |
SE (1) | SE9803734D0 (es) |
WO (1) | WO2000025921A1 (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9808836D0 (en) * | 1998-04-27 | 1998-06-24 | Amersham Pharm Biotech Uk Ltd | Microfabricated apparatus for cell based assays |
US6555389B1 (en) | 1999-05-11 | 2003-04-29 | Aclara Biosciences, Inc. | Sample evaporative control |
SE9902474D0 (sv) | 1999-06-30 | 1999-06-30 | Amersham Pharm Biotech Ab | Polymer valves |
SE0004296D0 (sv) | 2000-11-23 | 2000-11-23 | Gyros Ab | Device and method for the controlled heating in micro channel systems |
EP1390144A2 (en) * | 2001-03-19 | 2004-02-25 | Gyros AB | Structural units that define fluidic functions |
US7759067B2 (en) | 2001-03-19 | 2010-07-20 | Gyros Patent Ab | Method for determining the amount of an analyte with a disc-shaped microfluidic device |
US7429354B2 (en) | 2001-03-19 | 2008-09-30 | Gyros Patent Ab | Structural units that define fluidic functions |
US6919058B2 (en) | 2001-08-28 | 2005-07-19 | Gyros Ab | Retaining microfluidic microcavity and other microfluidic structures |
EP2281633A1 (en) | 2001-08-28 | 2011-02-09 | Gyros Patent Ab | Retaining microfluidic microcavity and other microfluidic structures |
DE60237289D1 (de) | 2001-09-17 | 2010-09-23 | Gyros Patent Ab | Einen kontrollierten strom in einer mikrofluidvorrichtung ermöglichende funktionseinheit |
DE10222228A1 (de) | 2002-05-16 | 2003-11-27 | Roche Diagnostics Gmbh | Mikropumpe mit Heizelementen für einen pulsierten Betrieb |
JP4519124B2 (ja) | 2003-01-30 | 2010-08-04 | ユィロス・パテント・アクチボラグ | 微小流動性デバイスの内部の壁 |
SE0300823D0 (sv) | 2003-03-23 | 2003-03-23 | Gyros Ab | Preloaded Microscale Devices |
EP1628905A1 (en) | 2003-05-23 | 2006-03-01 | Gyros Patent Ab | Hydrophilic/hydrophobic surfaces |
DE10354806A1 (de) * | 2003-11-21 | 2005-06-02 | Boehringer Ingelheim Microparts Gmbh | Probenträger |
SE0400181D0 (sv) | 2004-01-29 | 2004-01-29 | Gyros Ab | Segmented porous and preloaded microscale devices |
WO2006075965A1 (en) * | 2005-01-17 | 2006-07-20 | Gyros Patent Ab | A method for detecting an at least bivalent analyte using two affinity reactants |
US7998418B1 (en) * | 2006-06-01 | 2011-08-16 | Nanotek, Llc | Evaporator and concentrator in reactor and loading system |
EP2567213B1 (en) | 2010-05-05 | 2018-01-24 | The Governing Council of the Universtiy of Toronto | Method of processing dried samples using digital microfluidic device |
US9993819B2 (en) | 2014-12-30 | 2018-06-12 | Stmicroelectronics S.R.L. | Apparatus for actuating and reading a centrifugal microfluidic disk for biological and biochemical analyses, and use of the apparatus |
EP3303547A4 (en) | 2015-06-05 | 2018-12-19 | Miroculus Inc. | Air-matrix digital microfluidics apparatuses and methods for limiting evaporation and surface fouling |
US10695762B2 (en) | 2015-06-05 | 2020-06-30 | Miroculus Inc. | Evaporation management in digital microfluidic devices |
WO2018039281A1 (en) | 2016-08-22 | 2018-03-01 | Miroculus Inc. | Feedback system for parallel droplet control in a digital microfluidic device |
JP2020515815A (ja) | 2016-12-28 | 2020-05-28 | ミロキュラス インコーポレイテッド | デジタルマイクロ流体デバイスおよび方法 |
WO2018156460A1 (en) * | 2017-02-22 | 2018-08-30 | The Trustees Of Columbia University In The City Of New York | Method and apparatus for computer-vision guided targeted delivery of small liquid volumes into selected lung regions |
WO2018187476A1 (en) | 2017-04-04 | 2018-10-11 | Miroculus Inc. | Digital microfluidic apparatuses and methods for manipulating and processing encapsulated droplets |
US11413617B2 (en) | 2017-07-24 | 2022-08-16 | Miroculus Inc. | Digital microfluidics systems and methods with integrated plasma collection device |
CA3073058A1 (en) | 2017-09-01 | 2019-03-07 | Miroculus Inc. | Digital microfluidics devices and methods of using them |
CA3096855A1 (en) | 2018-05-23 | 2019-11-28 | Miroculus Inc. | Control of evaporation in digital microfluidics |
US11738345B2 (en) | 2019-04-08 | 2023-08-29 | Miroculus Inc. | Multi-cartridge digital microfluidics apparatuses and methods of use |
WO2021016614A1 (en) | 2019-07-25 | 2021-01-28 | Miroculus Inc. | Digital microfluidics devices and methods of use thereof |
CN114279907B (zh) * | 2021-12-14 | 2022-11-15 | 中国科学院地质与地球物理研究所 | 一种月尘颗粒样品的无损筛分系统及其筛分方法 |
US11857961B2 (en) | 2022-01-12 | 2024-01-02 | Miroculus Inc. | Sequencing by synthesis using mechanical compression |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4507463A (en) * | 1983-05-11 | 1985-03-26 | Ciba-Geigy Corporation | Process for producing polyesters from aliphatic dicarboxylic acids and polyalkylpiperidyldiols |
US4659677A (en) | 1983-05-26 | 1987-04-21 | Eastman Kodak Company | Method providing liquid mixing outside containers |
CA1333850C (en) | 1987-08-27 | 1995-01-10 | Michael M. Gorin | Apparatus and method for dilution and mixing of liquid samples |
GB8816443D0 (en) * | 1988-07-11 | 1988-08-17 | Albright & Wilson | Liquid enzymatic detergents |
AU642444B2 (en) * | 1989-11-30 | 1993-10-21 | Mochida Pharmaceutical Co., Ltd. | Reaction vessel |
US5171989A (en) * | 1992-01-24 | 1992-12-15 | Board Of Trustees Of Leland Stanford Jr. University | Method and apparatus for continuous sample ice matrix production for laser desorption in mass spectrometry |
CA2143365A1 (en) * | 1994-03-14 | 1995-09-15 | Hugh V. Cottingham | Nucleic acid amplification method and apparatus |
DE69533554T2 (de) * | 1994-11-10 | 2005-01-27 | Orchid Biosciences, Inc. | Flüssigkeitsverteilungssystem |
US5585069A (en) | 1994-11-10 | 1996-12-17 | David Sarnoff Research Center, Inc. | Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis |
US6143247A (en) * | 1996-12-20 | 2000-11-07 | Gamera Bioscience Inc. | Affinity binding-based system for detecting particulates in a fluid |
US5785926A (en) | 1995-09-19 | 1998-07-28 | University Of Washington | Precision small volume fluid processing apparatus |
US20010055812A1 (en) * | 1995-12-05 | 2001-12-27 | Alec Mian | Devices and method for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics |
US6033544A (en) * | 1996-10-11 | 2000-03-07 | Sarnoff Corporation | Liquid distribution system |
US5879632A (en) * | 1996-04-09 | 1999-03-09 | Sarnoff Corporation | Apportioning system |
US5863801A (en) * | 1996-06-14 | 1999-01-26 | Sarnoff Corporation | Automated nucleic acid isolation |
US6143248A (en) * | 1996-08-12 | 2000-11-07 | Gamera Bioscience Corp. | Capillary microvalve |
SE9700207D0 (sv) | 1997-01-24 | 1997-01-24 | Erik Litborn | A method of preventing evaporation from liquid samples in small volumes |
US6090251A (en) * | 1997-06-06 | 2000-07-18 | Caliper Technologies, Inc. | Microfabricated structures for facilitating fluid introduction into microfluidic devices |
CA2330119C (en) | 1998-03-04 | 2008-01-15 | Ortho-Mcneil Pharmaceutical, Inc. | System for performing assays on a levitated droplet |
US6086740A (en) * | 1998-10-29 | 2000-07-11 | Caliper Technologies Corp. | Multiplexed microfluidic devices and systems |
US6416642B1 (en) * | 1999-01-21 | 2002-07-09 | Caliper Technologies Corp. | Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection |
US6555389B1 (en) | 1999-05-11 | 2003-04-29 | Aclara Biosciences, Inc. | Sample evaporative control |
US6642061B2 (en) * | 2000-09-25 | 2003-11-04 | Picoliter Inc. | Use of immiscible fluids in droplet ejection through application of focused acoustic energy |
-
1998
- 1998-10-30 SE SE9803734A patent/SE9803734D0/xx unknown
-
1999
- 1999-10-29 AT AT99971352T patent/ATE224231T1/de not_active IP Right Cessation
- 1999-10-29 ES ES99971352T patent/ES2187216T3/es not_active Expired - Lifetime
- 1999-10-29 DE DE69903054T patent/DE69903054T2/de not_active Expired - Lifetime
- 1999-10-29 JP JP2000579351A patent/JP2002528264A/ja active Pending
- 1999-10-29 US US09/830,795 patent/US7323345B1/en not_active Expired - Fee Related
- 1999-10-29 WO PCT/SE1999/001958 patent/WO2000025921A1/en active IP Right Grant
- 1999-10-29 EP EP99971352A patent/EP1124638B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
SE9803734D0 (sv) | 1998-10-30 |
WO2000025921A1 (en) | 2000-05-11 |
DE69903054D1 (de) | 2002-10-24 |
DE69903054T2 (de) | 2003-04-24 |
EP1124638A1 (en) | 2001-08-22 |
US7323345B1 (en) | 2008-01-29 |
JP2002528264A (ja) | 2002-09-03 |
EP1124638B1 (en) | 2002-09-18 |
ATE224231T1 (de) | 2002-10-15 |
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