ATE282624T1 - Et-743 analoga als antitumoralverbindungen - Google Patents

Et-743 analoga als antitumoralverbindungen

Info

Publication number
ATE282624T1
ATE282624T1 AT01929813T AT01929813T ATE282624T1 AT E282624 T1 ATE282624 T1 AT E282624T1 AT 01929813 T AT01929813 T AT 01929813T AT 01929813 T AT01929813 T AT 01929813T AT E282624 T1 ATE282624 T1 AT E282624T1
Authority
AT
Austria
Prior art keywords
analogas
group
compounds
optionally protected
derivatised
Prior art date
Application number
AT01929813T
Other languages
English (en)
Inventor
Carmen Cuevas
Ignacio Manzanares
Marta Perez
Maria Jesus Martin
Alberto Rodriguez
Simon Munt
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2000/001852 external-priority patent/WO2000069862A2/en
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Application granted granted Critical
Publication of ATE282624T1 publication Critical patent/ATE282624T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT01929813T 2000-05-15 2001-05-15 Et-743 analoga als antitumoralverbindungen ATE282624T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/GB2000/001852 WO2000069862A2 (en) 1999-05-14 2000-05-15 Hemisynthetic method and intermediates thereof
PCT/GB2001/002110 WO2001087894A1 (en) 1999-05-14 2001-05-15 Antitumoral analogs of et-743

Publications (1)

Publication Number Publication Date
ATE282624T1 true ATE282624T1 (de) 2004-12-15

Family

ID=29415238

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01929813T ATE282624T1 (de) 2000-05-15 2001-05-15 Et-743 analoga als antitumoralverbindungen

Country Status (10)

Country Link
US (3) US7247629B2 (de)
JP (1) JP5008812B2 (de)
AT (1) ATE282624T1 (de)
BG (1) BG65897B1 (de)
CA (1) CA2405002C (de)
HK (1) HK1053653A1 (de)
HU (1) HU230699B1 (de)
IL (1) IL152126A (de)
MX (1) MXPA02011319A (de)
SK (1) SK287833B6 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
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AU759281B2 (en) * 1998-05-11 2003-04-10 Pharma Mar S.A. Metabolites of ecteinascidin 743
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
AR035842A1 (es) * 1999-05-14 2004-07-21 Pharma Mar Sa Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
SI1280809T1 (sl) * 2000-04-12 2005-12-31 Pharma Mar Sa Antitumorski ekteinascidin derivati
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
US7420051B2 (en) * 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
CA2428160C (en) * 2000-11-06 2009-10-13 Pharma Mar, S.A. Compositions for antitumor treatment containing ecteinascidin 743
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) * 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
PL1827500T3 (pl) * 2004-10-26 2009-09-30 Pharma Mar Sa Pegylowana liposomalna doksorubicyna w kombinacji z ekteinascydyną 743
ES2290844T3 (es) 2004-10-29 2008-02-16 Pharma Mar S.A., Sociedad Unipersonal Composiciones que comprenden ecteinascidinas y un disacarido.
US20090325971A1 (en) * 2005-03-02 2009-12-31 The Trustees Of Columbia University In The City Of New York Pentacyclic Alkaloid Compounds and Methods of Use Thereof
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
MX2010012501A (es) * 2008-05-16 2010-12-20 Pharma Mar Sa Terapia de combinacion con un alcaloide antitumoral.
NZ589270A (en) * 2008-05-16 2011-12-22 Pharma Mar Sa Multiple myeloma treatments
CN103038240A (zh) 2010-05-25 2013-04-10 法马马有限公司 制备海鞘素化合物的合成方法
ES2790414T3 (es) 2010-11-12 2020-10-27 Pharma Mar Sa Terapia de combinación con un inhibidor de topoisomerasa
GB2519773C (en) * 2013-10-29 2018-01-03 Solus Tech Limited Mode-locking semiconductor disk laser (SDL)
CN107522698B (zh) * 2016-06-20 2021-12-28 浙江海正药业股份有限公司 一种曲贝替定的制备方法及其中间体
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
EP4303221A1 (de) * 2021-03-03 2024-01-10 The University of Tokyo Neuartige tetrahydroisochinolin-alkaloid-verbindung mit einem makrozyklus

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JPS59225189A (ja) 1983-06-03 1984-12-18 Shionogi & Co Ltd キノナミン誘導体およびその製造法
JPS6084288A (ja) 1983-10-13 1985-05-13 Shionogi & Co Ltd シアノキノナミンアセテ−ト類およびその製造法
US5089273A (en) * 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
JP2562162B2 (ja) 1986-06-09 1996-12-11 ユニバーシティ・オブ・イリノイ エクテインアシジン７２９、７４３、７４５、７５９ａ、７５９ｂおよび７７０
US5256663A (en) * 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5149804A (en) * 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
DE3635711A1 (de) 1986-10-21 1988-04-28 Knoll Ag 5-nitrobenzo(de)isochinolin-1,3-dione, ihre herstellung und verwendung
EP0309744A3 (de) * 1987-09-29 1989-06-28 Siemens Aktiengesellschaft Anordnung mit einem flächig sich erstreckenden Dünnfilmwellenleiter
FR2697752B1 (fr) 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
US5478932A (en) * 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US20040059112A1 (en) 1994-02-18 2004-03-25 Rinehart Kenneth L. Ecteinascidins
GB9508195D0 (en) 1995-04-20 1995-06-07 Univ British Columbia Novel biologically active compounds and compositions,their use and derivation
WO1997026258A1 (en) * 1996-01-15 1997-07-24 Janssen Pharmaceutica N.V. Angiogenesis inhibiting pyridazinamines
US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
US5985876A (en) * 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
BR9909488B1 (pt) 1998-04-06 2011-02-08 ecteinascidinas semi-sintéticas e composição farmacêutica.
JP2004506401A (ja) 1998-05-05 2004-03-04 ファーマ　マー，ソシエダッド　アノニマ 付着性海生動物の培養
AU759281B2 (en) * 1998-05-11 2003-04-10 Pharma Mar S.A. Metabolites of ecteinascidin 743
US6124292A (en) * 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
MY164077A (en) 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
AR035842A1 (es) 1999-05-14 2004-07-21 Pharma Mar Sa Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
AU1325101A (en) * 1999-07-23 2001-02-13 American Superconductor Corporation Multi-layer articles and methods of making same
CA2397597A1 (en) * 2000-01-19 2001-07-26 The Trustees Of Columbia University In The City Of New York Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof
US6815544B2 (en) 2000-02-11 2004-11-09 President And Fellows Of Harvard College Synthetic process for an intermediate for ecteinascidin and phthalascidin compounds
US6569859B1 (en) 2000-02-22 2003-05-27 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
SI1280809T1 (sl) * 2000-04-12 2005-12-31 Pharma Mar Sa Antitumorski ekteinascidin derivati
US7420051B2 (en) 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
CA2418320A1 (en) 2000-08-11 2002-02-21 City Of Hope The anti-neoplastic agent et-743 inhibits trans activation by sxr
CA2428160C (en) 2000-11-06 2009-10-13 Pharma Mar, S.A. Compositions for antitumor treatment containing ecteinascidin 743
EP1360337A1 (de) 2001-02-09 2003-11-12 The Regents Of The University Of California Mitglieder der ecteinascidin familie: zusammensetzungen und methoden
GB0117402D0 (en) 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0121285D0 (en) 2001-09-03 2001-10-24 Cancer Res Ventures Ltd Anti-cancer combinations
JP2005509650A (ja) 2001-10-19 2005-04-14 ファルマ・マール・ソシエダード・アノニマ 癌治療における抗腫瘍化合物の改良した使用
US20040019027A1 (en) 2002-04-12 2004-01-29 Barry Forman Method of treating cerebrotendinous xanthomatosis
GB0218813D0 (en) 2002-08-13 2002-09-18 Pharma Mar Sa DNA sequences from an endosymbiont and their uses
GB0312407D0 (en) 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
CA2544320A1 (en) 2003-11-13 2005-06-02 Pharma Mar, S.A.U. Method of treating cancer using a combination comprising et-743 and 5-fluorouracil
US20080255132A1 (en) 2003-11-14 2008-10-16 Eric Rowinsky Combination Therapy Comprising the Use of Et-743 and Paclitaxel for Treating Cancer
GB0326486D0 (en) 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
AU2005288696A1 (en) 2004-09-28 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
PL1827500T3 (pl) 2004-10-26 2009-09-30 Pharma Mar Sa Pegylowana liposomalna doksorubicyna w kombinacji z ekteinascydyną 743
ES2290844T3 (es) 2004-10-29 2008-02-16 Pharma Mar S.A., Sociedad Unipersonal Composiciones que comprenden ecteinascidinas y un disacarido.
AU2008313634A1 (en) 2007-10-19 2009-04-23 Pharma Mar, S.A. Prognostic molecular markers for ET-743 treatment
MX2010012501A (es) 2008-05-16 2010-12-20 Pharma Mar Sa Terapia de combinacion con un alcaloide antitumoral.
NZ589270A (en) 2008-05-16 2011-12-22 Pharma Mar Sa Multiple myeloma treatments

Also Published As

Publication number Publication date
JP2003533532A (ja) 2003-11-11
CA2405002C (en) 2010-09-21
HUP0302327A3 (en) 2006-05-29
BG107302A (bg) 2003-07-31
US8012975B2 (en) 2011-09-06
US20080051407A1 (en) 2008-02-28
US7247629B2 (en) 2007-07-24
US7410969B2 (en) 2008-08-12
IL152126A0 (en) 2003-05-29
HU230699B1 (hu) 2017-09-28
HUP0302327A2 (hu) 2003-10-28
IL152126A (en) 2013-04-30
SK287833B6 (sk) 2011-11-04
JP5008812B2 (ja) 2012-08-22
CA2405002A1 (en) 2001-11-22
US20060019960A1 (en) 2006-01-26
BG65897B1 (bg) 2010-04-30
SK16012002A3 (sk) 2003-05-02
MXPA02011319A (es) 2003-06-06
US20040019056A1 (en) 2004-01-29
HK1053653A1 (en) 2003-10-31

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