SK287833B6 - Antitumour compound, pharmaceutical composition containing it and its use - Google Patents
Antitumour compound, pharmaceutical composition containing it and its use Download PDFInfo
- Publication number
- SK287833B6 SK287833B6 SK1601-2002A SK16012002A SK287833B6 SK 287833 B6 SK287833 B6 SK 287833B6 SK 16012002 A SK16012002 A SK 16012002A SK 287833 B6 SK287833 B6 SK 287833B6
- Authority
- SK
- Slovakia
- Prior art keywords
- compound
- alkyl
- formula
- alkenyl
- carbon atoms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Compounds Of Unknown Constitution (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/GB2000/001852 WO2000069862A2 (en) | 1999-05-14 | 2000-05-15 | Hemisynthetic method and intermediates thereof |
PCT/GB2001/002110 WO2001087894A1 (en) | 1999-05-14 | 2001-05-15 | Antitumoral analogs of et-743 |
Publications (2)
Publication Number | Publication Date |
---|---|
SK16012002A3 SK16012002A3 (sk) | 2003-05-02 |
SK287833B6 true SK287833B6 (sk) | 2011-11-04 |
Family
ID=29415238
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK1601-2002A SK287833B6 (sk) | 2000-05-15 | 2001-05-15 | Antitumour compound, pharmaceutical composition containing it and its use |
Country Status (10)
Country | Link |
---|---|
US (3) | US7247629B2 (de) |
JP (1) | JP5008812B2 (de) |
AT (1) | ATE282624T1 (de) |
BG (1) | BG65897B1 (de) |
CA (1) | CA2405002C (de) |
HK (1) | HK1053653A1 (de) |
HU (1) | HU230699B1 (de) |
IL (1) | IL152126A (de) |
MX (1) | MXPA02011319A (de) |
SK (1) | SK287833B6 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1077698B1 (de) * | 1998-05-11 | 2005-03-02 | Pharma Mar, S.A. | Ecteinascidinderivate |
MY164077A (en) * | 1999-05-13 | 2017-11-30 | Pharma Mar Sa | Compositions and uses of et743 for treating cancer |
AR035842A1 (es) | 1999-05-14 | 2004-07-21 | Pharma Mar Sa | Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo |
PT1280809E (pt) * | 2000-04-12 | 2005-11-30 | Pharma Mar Sa | Derivados antitumorais de ecteinascidina |
US7919493B2 (en) * | 2000-04-12 | 2011-04-05 | Pharma Mar, S.A. | Anititumoral ecteinascidin derivatives |
MXPA02011319A (es) * | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
US7420051B2 (en) * | 2000-05-15 | 2008-09-02 | Pharma Mar, S.A. | Synthetic process for the manufacture of an ecteinaschidin compound |
DK1365808T3 (da) * | 2000-11-06 | 2011-05-16 | Pharma Mar Sa | Sammensætninger til antitumorbehandling indeholdende ecteinascidin 743 |
GB0117402D0 (en) * | 2001-07-17 | 2001-09-05 | Pharma Mar Sa | New antitumoral derivatives of et-743 |
GB0119243D0 (en) * | 2001-08-07 | 2001-10-03 | Pharma Mar Sa | Antitumoral analogs of ET-743 |
GB0202544D0 (en) * | 2002-02-04 | 2002-03-20 | Pharma Mar Sa | The synthesis of naturally occuring ecteinascidins and related compounds |
ATE430586T1 (de) * | 2004-10-26 | 2009-05-15 | Pharma Mar Sa | Pegyliertes liposomales doxorubicin in kombination mit ecteinescidin 743 |
DK1658848T3 (da) * | 2004-10-29 | 2007-11-26 | Pharma Mar Sa | Formuleringer omfattende ecteinascidin og et disaccharid |
WO2006094012A2 (en) * | 2005-03-02 | 2006-09-08 | The Trustees Of Columbia University In The City Of New York | Pentacyclic alkaloid compounds and methods of use thereof |
GB0522082D0 (en) * | 2005-10-31 | 2005-12-07 | Pharma Mar Sa | Formulations |
NZ589270A (en) * | 2008-05-16 | 2011-12-22 | Pharma Mar Sa | Multiple myeloma treatments |
JP2011520921A (ja) * | 2008-05-16 | 2011-07-21 | ファルマ・マール・ソシエダード・アノニマ | 抗腫瘍アルカロイドとの併用療法 |
ES2534331T3 (es) | 2010-05-25 | 2015-04-21 | Pharma Mar S.A. | Proceso sintético para la producción de compuestos e intermedios de ecteinascidina |
RS58609B1 (sr) | 2010-11-12 | 2019-05-31 | Pharma Mar Sa | Kombinovana terapija sa inhibitorom mitoze |
GB2519773C (en) * | 2013-10-29 | 2018-01-03 | Solus Tech Limited | Mode-locking semiconductor disk laser (SDL) |
CN107522698B (zh) * | 2016-06-20 | 2021-12-28 | 浙江海正药业股份有限公司 | 一种曲贝替定的制备方法及其中间体 |
JOP20190254A1 (ar) * | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
EP4303221A1 (de) * | 2021-03-03 | 2024-01-10 | The University of Tokyo | Neuartige tetrahydroisochinolin-alkaloid-verbindung mit einem makrozyklus |
Family Cites Families (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59225189A (ja) | 1983-06-03 | 1984-12-18 | Shionogi & Co Ltd | キノナミン誘導体およびその製造法 |
JPS6084288A (ja) | 1983-10-13 | 1985-05-13 | Shionogi & Co Ltd | シアノキノナミンアセテ−ト類およびその製造法 |
US5149804A (en) * | 1990-11-30 | 1992-09-22 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins 736 and 722 |
AU589282B2 (en) | 1986-06-09 | 1989-10-05 | University Of Illinois | Ecteinascidins 729, 743, 745, 759a, 759b and 770 |
US5256663A (en) * | 1986-06-09 | 1993-10-26 | The Board Of Trustees Of The University Of Illinois | Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith |
US5089273A (en) * | 1986-06-09 | 1992-02-18 | Board Of Trustees Of The University Of Illinois | Ecteinascidins 729, 743, 745, 759A, 759B and 770 |
DE3635711A1 (de) * | 1986-10-21 | 1988-04-28 | Knoll Ag | 5-nitrobenzo(de)isochinolin-1,3-dione, ihre herstellung und verwendung |
EP0309744A3 (de) * | 1987-09-29 | 1989-06-28 | Siemens Aktiengesellschaft | Anordnung mit einem flächig sich erstreckenden Dünnfilmwellenleiter |
FR2697752B1 (fr) * | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Compositions antitumorales contenant des dérivés du taxane. |
US5478932A (en) * | 1993-12-02 | 1995-12-26 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins |
US20040059112A1 (en) * | 1994-02-18 | 2004-03-25 | Rinehart Kenneth L. | Ecteinascidins |
GB9508195D0 (en) * | 1995-04-20 | 1995-06-07 | Univ British Columbia | Novel biologically active compounds and compositions,their use and derivation |
ZA97288B (en) * | 1996-01-15 | 1998-07-14 | Janssen Pharmaceutica Nv | Angiogenesis inhibiting pyridazinamines |
US5721362A (en) | 1996-09-18 | 1998-02-24 | President And Fellows Of Harvard College | Process for producing ecteinascidin compounds |
US5985876A (en) * | 1997-04-15 | 1999-11-16 | Univ Illinois | Nucleophile substituted ecteinascidins and N-oxide ecteinascidins |
DE69936845T2 (de) | 1998-04-06 | 2008-05-08 | The Board Of Trustees Of The University Of Illinois, Urbana | Halbsynthetische ectein-ascidine |
AU759494B2 (en) * | 1998-05-05 | 2003-04-17 | Pharma Mar S.A. | Culture of sessile marine animals |
EP1077698B1 (de) | 1998-05-11 | 2005-03-02 | Pharma Mar, S.A. | Ecteinascidinderivate |
US6124292A (en) | 1998-09-30 | 2000-09-26 | President And Fellows Of Harvard College | Synthetic analogs of ecteinascidin-743 |
MY164077A (en) | 1999-05-13 | 2017-11-30 | Pharma Mar Sa | Compositions and uses of et743 for treating cancer |
AR035842A1 (es) * | 1999-05-14 | 2004-07-21 | Pharma Mar Sa | Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo |
JP4041672B2 (ja) * | 1999-07-23 | 2008-01-30 | アメリカン スーパーコンダクター コーポレイション | 接合高温超伝導性被覆テープ |
AU783562B2 (en) * | 2000-01-19 | 2005-11-10 | Trustees Of Columbia University In The City Of New York, The | Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof |
US6815544B2 (en) * | 2000-02-11 | 2004-11-09 | President And Fellows Of Harvard College | Synthetic process for an intermediate for ecteinascidin and phthalascidin compounds |
US6569859B1 (en) * | 2000-02-22 | 2003-05-27 | President And Fellows Of Harvard College | Synthetic analogs of ecteinascidin-743 |
PT1280809E (pt) * | 2000-04-12 | 2005-11-30 | Pharma Mar Sa | Derivados antitumorais de ecteinascidina |
MXPA02011319A (es) * | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
US7420051B2 (en) * | 2000-05-15 | 2008-09-02 | Pharma Mar, S.A. | Synthetic process for the manufacture of an ecteinaschidin compound |
EP1356097A2 (de) * | 2000-08-11 | 2003-10-29 | City of Hope | Der antineoplastische wirkstoff et-743 inhibiert die transaktivierung durch sxr |
DK1365808T3 (da) | 2000-11-06 | 2011-05-16 | Pharma Mar Sa | Sammensætninger til antitumorbehandling indeholdende ecteinascidin 743 |
EP1360337A1 (de) | 2001-02-09 | 2003-11-12 | The Regents Of The University Of California | Mitglieder der ecteinascidin familie: zusammensetzungen und methoden |
GB0117402D0 (en) | 2001-07-17 | 2001-09-05 | Pharma Mar Sa | New antitumoral derivatives of et-743 |
GB0121285D0 (en) | 2001-09-03 | 2001-10-24 | Cancer Res Ventures Ltd | Anti-cancer combinations |
RU2306933C2 (ru) | 2001-10-19 | 2007-09-27 | Фарма Мар, С.А. | Улучшенная схема применения противоопухолевого соединения в терапии рака |
US20040019027A1 (en) * | 2002-04-12 | 2004-01-29 | Barry Forman | Method of treating cerebrotendinous xanthomatosis |
GB0218813D0 (en) * | 2002-08-13 | 2002-09-18 | Pharma Mar Sa | DNA sequences from an endosymbiont and their uses |
GB0312407D0 (en) * | 2003-05-29 | 2003-07-02 | Pharma Mar Sau | Treatment |
GB0324201D0 (en) * | 2003-10-15 | 2003-11-19 | Pharma Mar Sau | Improved antitumoral combinations |
ATE406897T1 (de) * | 2003-11-13 | 2008-09-15 | Pharma Mar Sau | Kombination von et-743 mit 5-fluorouracil pro- drugs zur behandlung von krebs |
GB0326486D0 (en) * | 2003-11-14 | 2003-12-17 | Pharma Mar Sau | Combination treatment |
EP1691809A1 (de) | 2003-11-14 | 2006-08-23 | Pharma Mar, S.A. | Kombinationstherapie mit verwendung von et-743 und paclitaxel zur behandlung von krebs |
WO2006035244A2 (en) | 2004-09-29 | 2006-04-06 | Pharma Mar S.A., Sociedad Unipersonal | Ecteinascidin compounds as anti -inflammatory agents |
ATE430586T1 (de) | 2004-10-26 | 2009-05-15 | Pharma Mar Sa | Pegyliertes liposomales doxorubicin in kombination mit ecteinescidin 743 |
DK1658848T3 (da) * | 2004-10-29 | 2007-11-26 | Pharma Mar Sa | Formuleringer omfattende ecteinascidin og et disaccharid |
JP2011500046A (ja) | 2007-10-19 | 2011-01-06 | ファルマ・マール・ソシエダード・アノニマ | Et−743治療のための予後分子マーカー |
NZ589270A (en) | 2008-05-16 | 2011-12-22 | Pharma Mar Sa | Multiple myeloma treatments |
JP2011520921A (ja) | 2008-05-16 | 2011-07-21 | ファルマ・マール・ソシエダード・アノニマ | 抗腫瘍アルカロイドとの併用療法 |
-
2000
- 2000-05-15 MX MXPA02011319A patent/MXPA02011319A/es active IP Right Grant
-
2001
- 2001-05-15 HU HU0302327A patent/HU230699B1/hu unknown
- 2001-05-15 US US10/257,857 patent/US7247629B2/en not_active Expired - Lifetime
- 2001-05-15 CA CA2405002A patent/CA2405002C/en not_active Expired - Lifetime
- 2001-05-15 JP JP2001584288A patent/JP5008812B2/ja not_active Expired - Lifetime
- 2001-05-15 IL IL152126A patent/IL152126A/en active IP Right Grant
- 2001-05-15 AT AT01929813T patent/ATE282624T1/de active
- 2001-05-15 SK SK1601-2002A patent/SK287833B6/sk not_active IP Right Cessation
-
2002
- 2002-11-20 BG BG107302A patent/BG65897B1/bg unknown
-
2003
- 2003-08-21 HK HK03105992A patent/HK1053653A1/xx not_active IP Right Cessation
-
2005
- 2005-01-26 US US11/045,595 patent/US7410969B2/en not_active Expired - Lifetime
-
2006
- 2006-12-22 US US11/645,356 patent/US8012975B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE282624T1 (de) | 2004-12-15 |
MXPA02011319A (es) | 2003-06-06 |
CA2405002C (en) | 2010-09-21 |
US7247629B2 (en) | 2007-07-24 |
HK1053653A1 (en) | 2003-10-31 |
US7410969B2 (en) | 2008-08-12 |
BG65897B1 (bg) | 2010-04-30 |
JP2003533532A (ja) | 2003-11-11 |
CA2405002A1 (en) | 2001-11-22 |
US20040019056A1 (en) | 2004-01-29 |
BG107302A (bg) | 2003-07-31 |
US8012975B2 (en) | 2011-09-06 |
HUP0302327A2 (hu) | 2003-10-28 |
HU230699B1 (hu) | 2017-09-28 |
IL152126A0 (en) | 2003-05-29 |
JP5008812B2 (ja) | 2012-08-22 |
SK16012002A3 (sk) | 2003-05-02 |
US20080051407A1 (en) | 2008-02-28 |
US20060019960A1 (en) | 2006-01-26 |
HUP0302327A3 (en) | 2006-05-29 |
IL152126A (en) | 2013-04-30 |
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EP1289999B1 (de) | Et-743 analoga als antitumoralverbindungen | |
AU2001256496A1 (en) | Synthetic process for the manufacture of an ecteinascidin compound | |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK4A | Expiry of patent |
Expiry date: 20210515 |