ATE259807T1 - Auf cinchonan basierte chirale selektoren zur trennung von stereoisomeren - Google Patents
Auf cinchonan basierte chirale selektoren zur trennung von stereoisomerenInfo
- Publication number
- ATE259807T1 ATE259807T1 AT97928144T AT97928144T ATE259807T1 AT E259807 T1 ATE259807 T1 AT E259807T1 AT 97928144 T AT97928144 T AT 97928144T AT 97928144 T AT97928144 T AT 97928144T AT E259807 T1 ATE259807 T1 AT E259807T1
- Authority
- AT
- Austria
- Prior art keywords
- chiral
- cinchonan
- enantioseparation
- liquid
- present
- Prior art date
Links
- 238000000926 separation method Methods 0.000 title 1
- 238000003821 enantio-separation Methods 0.000 abstract 4
- UFJOYVQIDSNLHC-YQQAZPJKSA-N cinchonan Chemical class C1=CC=C2C(C[C@H]3C[C@@H]4CC[N@]3C[C@@H]4C=C)=CC=NC2=C1 UFJOYVQIDSNLHC-YQQAZPJKSA-N 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 230000002378 acidificating effect Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- 150000001408 amides Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000008275 binding mechanism Effects 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 238000005342 ion exchange Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2991—Coated
- Y10T428/2993—Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2991—Coated
- Y10T428/2998—Coated including synthetic resin or polymer
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96109072 | 1996-06-05 | ||
| PCT/EP1997/002888 WO1997046557A1 (en) | 1996-06-05 | 1997-06-04 | Cinchonan based chiral selectors for separation of stereoisomers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE259807T1 true ATE259807T1 (de) | 2004-03-15 |
Family
ID=8222853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97928144T ATE259807T1 (de) | 1996-06-05 | 1997-06-04 | Auf cinchonan basierte chirale selektoren zur trennung von stereoisomeren |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US6313247B1 (de) |
| EP (1) | EP0912563B1 (de) |
| AT (1) | ATE259807T1 (de) |
| DE (1) | DE69727679T2 (de) |
| WO (1) | WO1997046557A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0010955D0 (en) * | 2000-05-05 | 2000-06-28 | Novartis Ag | Organic compounds |
| US6616825B1 (en) | 2000-08-23 | 2003-09-09 | The Regents Of The University Of California | Electrochromatographic device for use in enantioselective separation, and enantioselective separation medium for use therein |
| GB0211931D0 (en) * | 2002-05-23 | 2002-07-03 | Univ Liverpool | Methods & device utilizing adsorption of molecules at a surface or interface |
| EP1693108A1 (de) * | 2004-12-04 | 2006-08-23 | MERCK PATENT GmbH | Mischmodus Anionenaustauschertrennungsmaterial |
| EP2114919A2 (de) * | 2007-01-31 | 2009-11-11 | Krka Tovarna Zdravil, D.D., Novo Mesto | Verfahren zur herstellung von optisch reinem omeprazol durch salzbildung mit einem chiralen amin oder behandlung mit einem enantiomer umwandelnden enzym und chromatographische auftrennung |
| EP2048144A1 (de) * | 2007-10-10 | 2009-04-15 | KRKA, tovarna zdravil, d.d., Novo mesto | Herstellungsverfahren für optisch reines Omeprazol via Salzbildung mit einem chiralen Amin |
| JP5689791B2 (ja) * | 2008-05-13 | 2015-03-25 | ウニベルジテート ウィーン | エナンチオ選択的両性イオン性イオン交換材料 |
| KR101098335B1 (ko) | 2008-07-18 | 2011-12-26 | 성균관대학교산학협력단 | 신코나 기재 이작용성 유기 촉매 및 이를 이용한 메소-고리산무수물의 비대칭 고리 열림 반응을 통한 키랄성헤미에스터의 제조방법 |
| KR101073679B1 (ko) * | 2008-11-20 | 2011-10-14 | 성균관대학교산학협력단 | 고분자 지지된 이작용성 유기 촉매 및 이를 이용한 입체선택적인 헤미에스터의 제조방법 |
| CN102325779A (zh) * | 2009-02-18 | 2012-01-18 | 帝斯曼知识产权资产管理有限公司 | (4s,5r)-半酯的制备方法 |
| DE102009014898A1 (de) * | 2009-03-25 | 2010-09-30 | Merck Patent Gmbh | Prozess zur Enantiomerentrennung von 3,6-Dihydro-1,3,5-triazinderivaten |
| CN102059105B (zh) * | 2010-12-03 | 2012-12-05 | 华东理工大学 | 一种类寡肽手性固定相及其制备方法 |
| US20120220729A1 (en) | 2011-02-28 | 2012-08-30 | Boehringer Ingelheim International Gmbh | Liquid phase separation of plasmid dna isoforms and topoisomers |
| WO2013138413A1 (en) * | 2012-03-14 | 2013-09-19 | Merck Sharp & Dohme Corp. | Bis-quarternary cinchona alkaloid salts as asymmetric phase transfer catalysts |
| CN106220529B (zh) * | 2015-09-23 | 2017-12-08 | 成都译山生物科技有限公司 | 一种手性丙谷胺的制备方法与药用组合物 |
| CN107328874B (zh) * | 2017-06-28 | 2019-12-20 | 南京希麦迪医药科技有限公司 | 一种盐酸帕洛诺司琼光学异构体的拆分试剂及分离检测方法 |
| CN107290453B (zh) * | 2017-06-29 | 2019-09-17 | 方达医药技术(上海)有限公司 | 盐酸帕洛诺司琼合成中间产物的hplc分析方法 |
| CN111377851B (zh) * | 2018-12-30 | 2022-12-20 | 鲁南制药集团股份有限公司 | 一种苯磺酸左旋氨氯地平的制备方法 |
| CZ309739B6 (cs) * | 2019-11-29 | 2023-09-06 | Univerzita Karlova | Sloučeniny pro modifikaci povrchu záporně nabitého nosiče, způsob jejich přípravy a jejich použití |
| CN114105972B (zh) * | 2021-12-15 | 2022-12-23 | 安徽广信农化股份有限公司 | 一种辛克宁衍生物及其在高光学纯茚虫威中间体制备中的应用 |
| WO2023239900A1 (en) * | 2022-06-09 | 2023-12-14 | Regents Of The University Of Minnesota | Quinoline-containing monomers and polymers containing the same |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1154663B (it) * | 1980-07-30 | 1987-01-21 | Alfa Chimica Italiana Spa | Procedimento per la risoluzione in antipodi ottici di miscele di acidi d- e l-2-(6-metossi-2-naftil)-propionico |
| EP0543969A1 (de) * | 1991-05-13 | 1993-06-02 | Massachusetts Institute Of Technology | Heterozyklische chirode ligande und verfahren zur katalytischen, asymmetrischen dihydroxylierung von olefinen |
-
1997
- 1997-06-04 AT AT97928144T patent/ATE259807T1/de active
- 1997-06-04 WO PCT/EP1997/002888 patent/WO1997046557A1/en not_active Ceased
- 1997-06-04 EP EP97928144A patent/EP0912563B1/de not_active Expired - Lifetime
- 1997-06-04 DE DE69727679T patent/DE69727679T2/de not_active Expired - Lifetime
- 1997-06-04 US US09/194,892 patent/US6313247B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0912563B1 (de) | 2004-02-18 |
| WO1997046557A1 (en) | 1997-12-11 |
| EP0912563A1 (de) | 1999-05-06 |
| DE69727679T2 (de) | 2004-07-22 |
| DE69727679D1 (de) | 2004-03-25 |
| US6313247B1 (en) | 2001-11-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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