US5525339A
(en)
*
|
1986-08-27 |
1996-06-11 |
Dms Pharmaceutical Inc. |
Isolated components of dense microspheres derived from mammalian brain tissue and antibodies thereto
|
US5441870A
(en)
*
|
1992-04-15 |
1995-08-15 |
Athena Neurosciences, Inc. |
Methods for monitoring cellular processing of β-amyloid precursor protein
|
US5837672A
(en)
*
|
1992-07-10 |
1998-11-17 |
Athena Neurosciences, Inc. |
Methods and compositions for the detection of soluble β-amyloid peptide
|
US6610493B1
(en)
*
|
1993-06-17 |
2003-08-26 |
Brigham And Women's Hospital |
Screening compounds for the ability to alter the production of amyloid-β peptide
|
US5605811A
(en)
*
|
1992-10-26 |
1997-02-25 |
Athena Neurosciences, Inc. |
Methods and compositions for monitoring cellular processing of beta-amyloid precursor protein
|
EP0667959B1
(de)
*
|
1992-10-26 |
2003-08-13 |
Elan Pharmaceuticals, Inc. |
Verfahren zur Identifizierung von Hemmstoffe der Produktion des beta-Amyloidpeptids
|
ATE198622T1
(de)
|
1993-10-27 |
2001-01-15 |
Elan Pharm Inc |
Transgene tiere, die app allele mit der schwedischen mutation beherbergen
|
US5589154A
(en)
*
|
1994-11-22 |
1996-12-31 |
Rutgers, The State University Of New Jersey |
Methods for the prevention or treatment of vascular hemorrhaging and Alzheimer's disease
|
US6017887A
(en)
*
|
1995-01-06 |
2000-01-25 |
Sibia Neurosciences, Inc. |
Peptide, peptide analog and amino acid analog protease inhibitors
|
US5804560A
(en)
*
|
1995-01-06 |
1998-09-08 |
Sibia Neurosciences, Inc. |
Peptide and peptide analog protease inhibitors
|
CA2221684A1
(en)
*
|
1995-06-06 |
1996-12-12 |
Athena Neurosciences, Inc. |
Novel cathepsin and methods and compositions for inhibition thereof
|
US5783434A
(en)
*
|
1995-06-06 |
1998-07-21 |
Tung; Jay S. |
Cathepsin and methods and compositions for inhibition thereof
|
US5849711A
(en)
*
|
1995-06-06 |
1998-12-15 |
Athena Neurosciences, Inc. |
Cathepsin and methods and compositions for inhibition thereof
|
US6717031B2
(en)
|
1995-06-07 |
2004-04-06 |
Kate Dora Games |
Method for selecting a transgenic mouse model of alzheimer's disease
|
US6136530A
(en)
*
|
1995-11-29 |
2000-10-24 |
Texas Tech University Health Sciences Center |
Compositions and methods for assessing risk factors in Alzheimer's disease
|
WO1997021728A1
(en)
|
1995-12-12 |
1997-06-19 |
Karolinska Innovations Ab |
PEPTIDE BINDING THE KLVFF-SEQUENCE OF AMYLOID $g(b)
|
JPH09178743A
(ja)
*
|
1995-12-27 |
1997-07-11 |
Oriental Yeast Co Ltd |
可溶性appの定量法
|
GB9701684D0
(en)
|
1997-01-28 |
1997-03-19 |
Smithkline Beecham Plc |
Novel compounds
|
US8173127B2
(en)
*
|
1997-04-09 |
2012-05-08 |
Intellect Neurosciences, Inc. |
Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof
|
WO1999022781A2
(en)
*
|
1997-10-31 |
1999-05-14 |
Children's Medical Center Corporation |
Bladder reconstruction
|
US6761888B1
(en)
*
|
2000-05-26 |
2004-07-13 |
Neuralab Limited |
Passive immunization treatment of Alzheimer's disease
|
US20080050367A1
(en)
*
|
1998-04-07 |
2008-02-28 |
Guriq Basi |
Humanized antibodies that recognize beta amyloid peptide
|
US6710226B1
(en)
|
1997-12-02 |
2004-03-23 |
Neuralab Limited |
Transgenic mouse assay to determine the effect of Aβ antibodies and Aβ Fragments on alzheimer's disease characteristics
|
US6913745B1
(en)
|
1997-12-02 |
2005-07-05 |
Neuralab Limited |
Passive immunization of Alzheimer's disease
|
US7790856B2
(en)
|
1998-04-07 |
2010-09-07 |
Janssen Alzheimer Immunotherapy |
Humanized antibodies that recognize beta amyloid peptide
|
US6750324B1
(en)
|
1997-12-02 |
2004-06-15 |
Neuralab Limited |
Humanized and chimeric N-terminal amyloid beta-antibodies
|
US7588766B1
(en)
|
2000-05-26 |
2009-09-15 |
Elan Pharma International Limited |
Treatment of amyloidogenic disease
|
US7179892B2
(en)
*
|
2000-12-06 |
2007-02-20 |
Neuralab Limited |
Humanized antibodies that recognize beta amyloid peptide
|
US6905686B1
(en)
|
1997-12-02 |
2005-06-14 |
Neuralab Limited |
Active immunization for treatment of alzheimer's disease
|
US6923964B1
(en)
|
1997-12-02 |
2005-08-02 |
Neuralab Limited |
Active immunization of AScr for prion disorders
|
US6787523B1
(en)
*
|
1997-12-02 |
2004-09-07 |
Neuralab Limited |
Prevention and treatment of amyloidogenic disease
|
US7964192B1
(en)
|
1997-12-02 |
2011-06-21 |
Janssen Alzheimer Immunotherapy |
Prevention and treatment of amyloidgenic disease
|
TWI239847B
(en)
*
|
1997-12-02 |
2005-09-21 |
Elan Pharm Inc |
N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
|
US20050059802A1
(en)
*
|
1998-04-07 |
2005-03-17 |
Neuralab Ltd |
Prevention and treatment of amyloidogenic disease
|
US20030147882A1
(en)
*
|
1998-05-21 |
2003-08-07 |
Alan Solomon |
Methods for amyloid removal using anti-amyloid antibodies
|
US7060670B1
(en)
*
|
1999-05-05 |
2006-06-13 |
Neurochem (International) Limited |
Stereoselective antifibrillogenic peptides and peptidomimetics thereof
|
US20040167634A1
(en)
*
|
1999-05-26 |
2004-08-26 |
Anthony Atala |
Prosthetic kidney and its use for treating kidney disease
|
US6787637B1
(en)
|
1999-05-28 |
2004-09-07 |
Neuralab Limited |
N-Terminal amyloid-β antibodies
|
UA81216C2
(en)
*
|
1999-06-01 |
2007-12-25 |
|
Prevention and treatment of amyloid disease
|
US20070135337A2
(en)
*
|
1999-11-29 |
2007-06-14 |
Neurochem (International) Limited |
Vaccine for the Prevention and Treatment of Alzheimer's and Amyloid Related Diseases
|
US20020094335A1
(en)
*
|
1999-11-29 |
2002-07-18 |
Robert Chalifour |
Vaccine for the prevention and treatment of alzheimer's and amyloid related diseases
|
US6479064B1
(en)
*
|
1999-12-29 |
2002-11-12 |
Children's Medical Center Corporation |
Culturing different cell populations on a decellularized natural biostructure for organ reconstruction
|
US6992081B2
(en)
|
2000-03-23 |
2006-01-31 |
Elan Pharmaceuticals, Inc. |
Compounds to treat Alzheimer's disease
|
CA2401749A1
(en)
|
2000-03-23 |
2001-09-27 |
Elan Pharmaceuticals, Inc. |
Compounds and methods to treat alzheimer's disease
|
AU5702201A
(en)
*
|
2000-04-13 |
2001-10-30 |
Mayo Foundation |
Abeta<sub>42</sub> lowering agents
|
EP1666452A2
(de)
|
2000-06-30 |
2006-06-07 |
Elan Pharmaceuticals, Inc. |
Verbindungen zur Behandlung der Alzheimerischen Krankheit
|
CA2410972A1
(en)
*
|
2000-06-30 |
2002-01-10 |
Elan Pharmaceuticals, Inc. |
Compounds to treat alzheimer's disease
|
US6846813B2
(en)
|
2000-06-30 |
2005-01-25 |
Pharmacia & Upjohn Company |
Compounds to treat alzheimer's disease
|
PE20020276A1
(es)
|
2000-06-30 |
2002-04-06 |
Elan Pharm Inc |
COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
|
US20030096864A1
(en)
*
|
2000-06-30 |
2003-05-22 |
Fang Lawrence Y. |
Compounds to treat alzheimer's disease
|
FR2816411B1
(fr)
*
|
2000-11-03 |
2003-07-04 |
Inst Nat Sante Rech Med |
Moyens de detection de la transformation pathologique de la proteine app et leurs applications
|
PE20020574A1
(es)
|
2000-12-06 |
2002-07-02 |
Wyeth Corp |
Anticuerpos humanizados que reconocen el peptido amiloideo beta
|
US7700751B2
(en)
|
2000-12-06 |
2010-04-20 |
Janssen Alzheimer Immunotherapy |
Humanized antibodies that recognize β-amyloid peptide
|
US20030215896A1
(en)
*
|
2001-04-25 |
2003-11-20 |
Yueming Li |
Gamma secretase substrates and in vitro assays
|
AU2002257162A1
(en)
*
|
2001-04-30 |
2002-11-11 |
Eli Lilly And Company |
Humanized antibodies
|
US7196163B2
(en)
*
|
2001-05-22 |
2007-03-27 |
Merk & Co., Inc. |
Assays using amyloid precursor proteins with modified β-secretase cleavage sites to monitor β-secretase activity
|
BR0210122A
(pt)
*
|
2001-06-01 |
2004-06-15 |
Elan Pharm Inc |
Composto ou um sal farmaceuticamente aceitável do mesmo, método para o tratamento ou prevenção de uma doença, uso do composto ou de seu sal, e, método para preparar o mesmo
|
WO2002100818A2
(en)
|
2001-06-13 |
2002-12-19 |
Elan Pharmaceuticals, Inc. |
Aminediols as agents for the treatment of alzheimer's disease
|
WO2003002122A1
(en)
*
|
2001-06-27 |
2003-01-09 |
Elan Pharmaceuticals, Inc. |
Beta-hydroxyamine derivatives useful in treatment of alzheimer's disease
|
US20070213407A1
(en)
*
|
2001-06-29 |
2007-09-13 |
Elan Pharmaceuticals And Pharmacia & Upjohn Company Llc |
Compounds to treat Alzheimer's disease
|
CA2453444A1
(en)
*
|
2001-07-10 |
2003-01-23 |
Elan Pharmaceuticals, Inc. |
Diaminediols for the treatment of alzheimer's disease
|
US7053109B2
(en)
*
|
2001-07-10 |
2006-05-30 |
Pharmacia & Upjohn Company |
Aminediols for the treatment of Alzheimer's disease
|
US7297553B2
(en)
*
|
2002-05-28 |
2007-11-20 |
Nanosphere, Inc. |
Method for attachment of silylated molecules to glass surfaces
|
IL160208A0
(en)
*
|
2001-08-31 |
2004-07-25 |
Neurochem Int Ltd |
Amidine derivatives for treating amyloidosis
|
EP1432674A2
(de)
*
|
2001-10-04 |
2004-06-30 |
Elan Pharmaceuticals, Inc. |
Hydroxypropylamine
|
JP2005520791A
(ja)
|
2001-11-08 |
2005-07-14 |
イーラン ファーマスーティカルズ、インコーポレイテッド |
N,n’−置換−1,3−ジアミノ−2−ヒドロキシプロパン誘導体
|
JP2005509495A
(ja)
*
|
2001-11-16 |
2005-04-14 |
チルドレンズ メディカル センター コーポレーション |
臓器の機能の増強
|
US20050080141A1
(en)
*
|
2001-11-19 |
2005-04-14 |
Schostarez Heinrich J. |
Amino diols useful in the treatment of alzheimer's disease
|
US20050214763A1
(en)
*
|
2002-02-14 |
2005-09-29 |
Rainer Hipfel |
Diagnostic and therapeutic use of an activator protein for vesicle secretion for neurodegenerative diseases
|
AU2003208857A1
(en)
*
|
2002-02-14 |
2003-09-04 |
Evotec Neurosciences Gmbh |
Diagnostic and therapeutic use of caps
|
AU2003216370A1
(en)
*
|
2002-02-27 |
2003-09-09 |
Merck And Co., Inc. |
Assays to monitor amyloid precursor protein processing
|
ES2392247T3
(es)
*
|
2002-03-05 |
2012-12-07 |
Ramot At Tel-Aviv University Ltd. |
Compuesto inmunizante y método para inducir una respuesta inmune contra el sitio de escisión de la beta-secretasa de la proteína precursora de amiloide
|
MY139983A
(en)
|
2002-03-12 |
2009-11-30 |
Janssen Alzheimer Immunotherap |
Humanized antibodies that recognize beta amyloid peptide
|
EP1575482A2
(de)
*
|
2002-04-17 |
2005-09-21 |
Pharmacia & Upjohn Company LLC |
Zusammensetzungen und verfahren zur behandlung der alzheimer-krankheit
|
WO2004058686A1
(en)
*
|
2002-04-30 |
2004-07-15 |
Elan Pharmaceuticals, Inc. |
Hydroxypropyl amides for the treatment of alzheimer’s disease
|
US20040146512A1
(en)
*
|
2002-10-09 |
2004-07-29 |
Arnon Rosenthal |
Methods of treating Alzheimer's disease using antibodies directed against amyloid beta peptide and compositions thereof
|
KR100520495B1
(ko)
*
|
2002-10-23 |
2005-10-11 |
한국과학기술연구원 |
베타아밀로이드 특이 단일 클론 항체 및 그의 제조방법
|
WO2004050609A1
(en)
|
2002-11-27 |
2004-06-17 |
Elan Pharmaceutical, Inc. |
Substituted ureas and carbamates
|
DE10303974A1
(de)
|
2003-01-31 |
2004-08-05 |
Abbott Gmbh & Co. Kg |
Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
|
WO2004069182A2
(en)
*
|
2003-02-01 |
2004-08-19 |
Neuralab Limited |
Active immunization to generate antibodies to soluble a-beta
|
PE20050420A1
(es)
*
|
2003-04-21 |
2005-06-13 |
Elan Pharm Inc |
Fenacilo 2-hidroxi-3-diaminoalcanos
|
JP2006524255A
(ja)
*
|
2003-04-21 |
2006-10-26 |
イーラン ファーマスーティカルズ、インコーポレイテッド |
ベンズアミド2−ヒドロキシ−3−ジアミノアルカン
|
WO2004100998A2
(en)
*
|
2003-05-07 |
2004-11-25 |
General Electric Company |
Compositions and methods for non-invasive imaging of soluble beta-amyloid
|
US20040223912A1
(en)
*
|
2003-05-07 |
2004-11-11 |
Montalto Michael Christopher |
Compositions and methods for non-invasive imaging of soluble beta-amyloid
|
PE20050627A1
(es)
|
2003-05-30 |
2005-08-10 |
Wyeth Corp |
Anticuerpos humanizados que reconocen el peptido beta amiloideo
|
US20060014790A1
(en)
*
|
2004-01-21 |
2006-01-19 |
Varghese John |
Methods of treatment of amyloidosis using spirocyclohexane aspartyl-protease inhibitors
|
US7262223B2
(en)
*
|
2004-01-23 |
2007-08-28 |
Neurochem (International) Limited |
Amidine derivatives for treating amyloidosis
|
EP1734961A2
(de)
*
|
2004-03-09 |
2006-12-27 |
Elan Pharmaceuticals, Inc. |
Verfahren zur behandlung von amyloidose mit bicyclischen aspartyl-proteasehemmern
|
US20050239836A1
(en)
*
|
2004-03-09 |
2005-10-27 |
Varghese John |
Substituted hydroxyethylamine aspartyl protease inhibitors
|
US20060014737A1
(en)
*
|
2004-03-09 |
2006-01-19 |
Varghese John |
Methods of treatment of amyloidosis using bi-aryl aspartyl protease inhibitors
|
EP1734942A1
(de)
*
|
2004-03-09 |
2006-12-27 |
Elan Pharmaceuticals, Inc. |
Substituierte harnstoff und carbamat, phenacyl-2-hydroxy-3-diaminoalkan, und benzamid-2-hydroxy-3-diaminoalkan aspartyl-proteasehemmer
|
WO2005087752A2
(en)
*
|
2004-03-09 |
2005-09-22 |
Elan Pharmaceuticals, Inc. |
Substituted hydroxyethylamine aspartyl protease inhibitors
|
AU2005265354A1
(en)
|
2004-07-09 |
2006-01-26 |
Elan Pharmaceuticals, Inc. |
Oxime derivative hydroxyethylamine aspartyl-protease inhibitors
|
US7385085B2
(en)
*
|
2004-07-09 |
2008-06-10 |
Elan Pharmaceuticals, Inc. |
Oxime derivative substituted hydroxyethylamine aspartyl protease inhibitors
|
MX2007000998A
(es)
*
|
2004-07-30 |
2007-07-11 |
Rinat Neuroscience Corp |
Anticuerpos dirigidos peptido beta-amiloide y procedimientos que usan los mismos.
|
JP2008511644A
(ja)
*
|
2004-08-27 |
2008-04-17 |
エラン ファーマシューティカルズ,インコーポレイテッド |
エタノール環式アミンアスパラギン酸プロテアーゼ阻害剤を用いて、アミロイドーシスを治療する方法
|
AU2005293752A1
(en)
*
|
2004-10-13 |
2006-04-20 |
Ablynx N.V. |
Single domain camelide anti-amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as Alzheimer's disease
|
PE20061401A1
(es)
*
|
2004-12-15 |
2006-12-23 |
Neuralab Ltd |
ANTICUERPOS Aß PARA MEJORAR LA COGNICION
|
TW200636066A
(en)
|
2004-12-15 |
2006-10-16 |
Elan Pharm Inc |
Humanized antibodies that recognize beta amyloid peptide
|
WO2006066089A1
(en)
|
2004-12-15 |
2006-06-22 |
Neuralab Limited |
Humanized amyloid beta antibodies for use in improving cognition
|
AU2006203819A1
(en)
*
|
2005-01-07 |
2006-07-13 |
Roskamp Research Llc |
Compounds for inhibiting beta-amyloid production and methods of identifying the compounds
|
MY148086A
(en)
*
|
2005-04-29 |
2013-02-28 |
Rinat Neuroscience Corp |
Antibodies directed against amyloid-beta peptide and methods using same
|
WO2007014946A1
(en)
*
|
2005-08-03 |
2007-02-08 |
Boehringer Ingelheim International Gmbh |
Substituted ethane-1,2-diamines for the treatment of alzheimer's disease ii
|
WO2007047305A1
(en)
*
|
2005-10-12 |
2007-04-26 |
Elan Pharmaceuticals, Inc. |
Methods of treating amyloidosis using cyclopropyl derivative aspartyl protease inhibitors
|
JP2009511589A
(ja)
*
|
2005-10-12 |
2009-03-19 |
エラン ファーマシューティカルズ,インコーポレイテッド |
アリール−シクロプロピル誘導体のアスパルチルプロテアーゼ阻害剤を使用してアミロイドーシスを治療する方法
|
US7745484B2
(en)
*
|
2005-11-21 |
2010-06-29 |
Amgen Inc. |
Beta-secretase modulators and methods of use
|
US7838676B2
(en)
*
|
2005-11-21 |
2010-11-23 |
Amgen Inc. |
Beta-secretase modulators and methods of use
|
US7872009B2
(en)
*
|
2005-11-21 |
2011-01-18 |
Amgen Inc. |
Beta-Secretase modulators and methods of use
|
CN101506236B
(zh)
|
2005-11-30 |
2012-12-12 |
雅培制药有限公司 |
抗淀粉样β蛋白的单克隆抗体及其用途
|
BRPI0619249A2
(pt)
|
2005-11-30 |
2011-09-20 |
Abbott Lab |
anticorpos anti-globulÈmeros-aß, frações que se ligam a antìgeno destes, hibridomas correspondentes, ácidos nucléicos, vetores, células hospedeiras, métodos de produzir os ditos anticorpos, composições compreendendo os ditos anticorpos, usos dos ditos anticorpos e métodos de usar os ditos anticorpos
|
RU2015111675A
(ru)
|
2005-12-12 |
2015-08-10 |
Ац Иммуне Са |
Специфические в отношении амилоида бета (а бета) 1-42 моноклональные антитела, обладающие терапевтическими свойствами
|
US8784810B2
(en)
|
2006-04-18 |
2014-07-22 |
Janssen Alzheimer Immunotherapy |
Treatment of amyloidogenic diseases
|
US20070292895A1
(en)
*
|
2006-05-19 |
2007-12-20 |
Xiao-Ping Shi |
Assays and methods to detect beta-secretase and its activity in body fluids and tissue extracts
|
EP2035448A4
(de)
*
|
2006-06-01 |
2010-11-03 |
Elan Pharm Inc |
Neuroaktive fragmente von app
|
AR062065A1
(es)
*
|
2006-07-14 |
2008-10-15 |
Ac Immune Sa |
Anticuerpo humanizado
|
US8455626B2
(en)
|
2006-11-30 |
2013-06-04 |
Abbott Laboratories |
Aβ conformer selective anti-aβ globulomer monoclonal antibodies
|
MX2009006685A
(es)
*
|
2006-12-22 |
2009-07-27 |
Genentech Inc |
Antagonistas del dr6 y usos de los mismos en el tratamiento de trastornos neurologicos.
|
EP2486928A1
(de)
|
2007-02-27 |
2012-08-15 |
Abbott GmbH & Co. KG |
Verfahren zur Behandlung von Amyloidosen
|
US8003097B2
(en)
|
2007-04-18 |
2011-08-23 |
Janssen Alzheimer Immunotherapy |
Treatment of cerebral amyloid angiopathy
|
BRPI0810118A8
(pt)
*
|
2007-04-18 |
2015-09-29 |
Janssen Alzheimer Immunotherap |
Método para tratar doença, método para efetuar profilaxia contra caa, uso de um agente, método para reduzir amilóide vascular em um paciente, e, kit para tratamento
|
WO2008137168A2
(en)
*
|
2007-05-07 |
2008-11-13 |
True Charles W |
Collapsible, stackable, semi-rigid universal tank for hazardous and non-hazardous goods
|
US8173810B2
(en)
*
|
2007-05-25 |
2012-05-08 |
Amgen Inc. |
Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use
|
US8163909B2
(en)
|
2007-05-25 |
2012-04-24 |
Amgen Inc. |
Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use
|
US10590391B2
(en)
*
|
2007-06-08 |
2020-03-17 |
Wake Forest University Health Sciences |
Selective cell therapy for the treatment of renal failure
|
EP2162529B1
(de)
*
|
2007-06-08 |
2019-03-27 |
Wake Forest University Health Sciences |
Selektive zelltherapie zur behandlung von nierenversagen
|
US8048420B2
(en)
*
|
2007-06-12 |
2011-11-01 |
Ac Immune S.A. |
Monoclonal antibody
|
MX2009013505A
(es)
*
|
2007-06-12 |
2010-01-27 |
Ac Immune Sa |
Anticuerpos humanizados para amiloide beta.
|
US8613923B2
(en)
*
|
2007-06-12 |
2013-12-24 |
Ac Immune S.A. |
Monoclonal antibody
|
EP2183598A1
(de)
*
|
2007-07-13 |
2010-05-12 |
Elan Pharmaceuticals Inc. |
Zusammensetzungen und verfahren zur identifizierung der substratspezifität von gammasekretasehemmern
|
PL2182983T3
(pl)
|
2007-07-27 |
2014-10-31 |
Janssen Alzheimer Immunotherap |
Leczenie chorób amyloidowych z wykorzystaniem humanizowanych przeciwciał specyficznych względem Abeta
|
CN101883790B
(zh)
|
2007-10-05 |
2015-09-09 |
基因技术公司 |
抗淀粉样蛋白β抗体在眼病中的用途
|
US20100297012A1
(en)
*
|
2007-10-05 |
2010-11-25 |
Andrea Pfeifer |
Humanized antibody
|
JO3076B1
(ar)
|
2007-10-17 |
2017-03-15 |
Janssen Alzheimer Immunotherap |
نظم العلاج المناعي المعتمد على حالة apoe
|
US20090163594A1
(en)
*
|
2007-10-31 |
2009-06-25 |
Elan Pharmaceuticals, Inc. |
Triple Assay System for Identifying Substrate Selectivity of Gamma Secretase Inhibitors
|
US7803809B2
(en)
*
|
2008-11-12 |
2010-09-28 |
Amgen Inc. |
Substituted pyrano [2,3-b] pyridinamine compounds as beta-secretase modulators and methods of use
|
EP2231180B1
(de)
*
|
2008-01-16 |
2016-08-17 |
Ben-gurion University Of The Negev Research And Development Authority |
Impfstoff für die alzheimerkrankheit
|
AU2009257297A1
(en)
*
|
2008-06-12 |
2009-12-17 |
Genentech, Inc. |
Method for screening for compounds that inhibit neurodegeneration
|
CA2736130C
(en)
*
|
2008-09-11 |
2014-01-14 |
Amgen Inc. |
Spiro-tetracyclic ring compounds as beta-secretase modulators and methods of use
|
WO2010046332A1
(en)
*
|
2008-10-20 |
2010-04-29 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Method for detecting soluble amyloid precursor protein (app) alpha and/or soluble app beta
|
US9067981B1
(en)
|
2008-10-30 |
2015-06-30 |
Janssen Sciences Ireland Uc |
Hybrid amyloid-beta antibodies
|
WO2010057015A1
(en)
*
|
2008-11-14 |
2010-05-20 |
Wake Forest University Health Sciences |
Kidney structures and methods of forming the same
|
MX2011005481A
(es)
|
2008-11-25 |
2011-08-17 |
Biogen Idec Inc |
Uso de antagonistas de receptor de muerte 6 (drg6) y de p75 para promover la supervivencia de células del sistema nervioso.
|
CA2780319A1
(en)
*
|
2009-11-12 |
2011-05-19 |
Genentech, Inc. |
A method of promoting dendritic spine density
|
WO2011063233A1
(en)
|
2009-11-23 |
2011-05-26 |
Amgen Inc. |
Amino heteroaryl compounds as beta-secretase modulators and methods of use
|
WO2011063272A1
(en)
|
2009-11-23 |
2011-05-26 |
Amgen Inc. |
Amino heteroaryl compounds as beta-secretase modulators and methods of use
|
EP2526092B1
(de)
|
2010-01-19 |
2014-08-06 |
Amgen Inc. |
Amino-heteraryl verbindungen als beta-secretase modulatoren und verfahren zu ihrer verwendung
|
US8497264B2
(en)
|
2010-03-15 |
2013-07-30 |
Amgen Inc. |
Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
|
US8883782B2
(en)
|
2010-03-15 |
2014-11-11 |
Amgen Inc. |
Spiro-tetracyclic ring compounds as beta-secretase modulators and methods of use
|
MX360403B
(es)
|
2010-04-15 |
2018-10-31 |
Abbvie Inc |
Proteinas de union a amiloide beta.
|
RU2607368C2
(ru)
|
2010-07-30 |
2017-01-10 |
Ац Иммуне С.А. |
Безопасные и функциональные гуманизированные антитела
|
US8921363B2
(en)
|
2010-08-05 |
2014-12-30 |
Amgen Inc. |
Derivatives of 1 H-isoindol-3-amine, 1 H-iso-aza-indol-3amine, 3,4-dihydroisoquinolin-1-amine, and 1,4-dihydroisoquinolin-3-amine as beta-secretase inhibitors
|
JP6147665B2
(ja)
|
2010-08-14 |
2017-06-14 |
アッヴィ・インコーポレイテッド |
アミロイドベータ結合タンパク質
|
EP2643325A1
(de)
|
2010-11-23 |
2013-10-02 |
Amgen Inc. |
Spiro-amino-imidazolon- und spiro-amino-dihydro-pyrimidinonverbindungen als beta-sekretase-modulatoren und verwendungsverfahren dafür
|
US9346827B2
(en)
|
2011-02-07 |
2016-05-24 |
Amgen Inc. |
5-amino-oxazepine and 5-amino-thiazepane compounds as beta secretase antagonists and methods of use
|
US8962859B2
(en)
|
2011-02-15 |
2015-02-24 |
Amgen Inc. |
Spiro-amino-imidazo-fused heterocyclic compounds as beta-secretase modulators and methods of use
|
WO2012142301A2
(en)
|
2011-04-12 |
2012-10-18 |
Quanterix Corporation |
Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury
|
WO2013044092A1
(en)
|
2011-09-21 |
2013-03-28 |
Amgen Inc. |
Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
|
CA2865756A1
(en)
*
|
2012-02-03 |
2013-08-08 |
Shionogi & Co., Ltd. |
Anti-sapp.beta. antibody
|
WO2014059185A1
(en)
|
2012-10-12 |
2014-04-17 |
Amgen Inc. |
Amino - dihydrothiazine and amino - dioxido dihydrothiazine compounds as beta-secretase antagonists and methods of use
|
US9725469B2
(en)
|
2012-11-15 |
2017-08-08 |
Amgen, Inc. |
Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
|
US9309263B2
(en)
|
2013-01-29 |
2016-04-12 |
Amgen Inc. |
Fused multi-cyclic sulfone compounds as inhibitors of beta-secretase and methods of use thereof
|
WO2014134341A1
(en)
|
2013-03-01 |
2014-09-04 |
Amgen Inc. |
Perfluorinated 5,6-dihydro-4h-1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use
|
EP2964644B1
(de)
|
2013-03-08 |
2018-12-26 |
Amgen, Inc. |
Perfluorierte cyclopropylfusionierte 1,3-oxazin-2-amin-verbindungen als beta-sekretase-hemmer und verfahren zur verwendung
|
US9096615B2
(en)
*
|
2013-07-30 |
2015-08-04 |
Amgen Inc. |
Bridged bicyclic amino thiazine dioxide compounds as inhibitors of beta-secretase and methods of use thereof
|
WO2016022724A1
(en)
|
2014-08-08 |
2016-02-11 |
Amgen Inc. |
Cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use
|
EP3070096A1
(de)
*
|
2015-03-19 |
2016-09-21 |
Ludwig-Maximilians-Universität München |
Peptid oder sammlung von peptiden aus amyloid-vorläuferprotein
|
WO2017024180A1
(en)
|
2015-08-06 |
2017-02-09 |
Amgen Inc. |
Vinyl fluoride cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use
|
MX2019007101A
(es)
|
2016-12-15 |
2019-12-16 |
Amgen Inc |
Derivados de oxazina como inhibidores de beta secretasa y metodos de uso.
|
CA3047287A1
(en)
|
2016-12-15 |
2018-06-21 |
Amgen Inc. |
Cyclopropyl fused thiazine derivatives as beta-secretase inhibitors and methods of use
|
EP3555086B1
(de)
|
2016-12-15 |
2021-09-01 |
Amgen Inc. |
1,4-thiazin-dioxide und 1,2,4-thiadiazin-dioxid-derivate als beta-sekretase-hemmer und verfahren zur verwendung
|
JP7149272B2
(ja)
|
2016-12-15 |
2022-10-06 |
アムジエン・インコーポレーテツド |
β-セクレターゼ阻害剤としてのチアジン誘導体および使用方法
|
ES2910367T3
(es)
|
2016-12-15 |
2022-05-12 |
Amgen Inc |
Derivados de tiazina y oxazina bicíclicos como inhibidores de beta-secretasa y métodos de uso
|