ATE226580T1 - Eine methode zur herstellung eines polymorphes von einem doxazosin-mesylat - Google Patents
Eine methode zur herstellung eines polymorphes von einem doxazosin-mesylatInfo
- Publication number
- ATE226580T1 ATE226580T1 AT00909370T AT00909370T ATE226580T1 AT E226580 T1 ATE226580 T1 AT E226580T1 AT 00909370 T AT00909370 T AT 00909370T AT 00909370 T AT00909370 T AT 00909370T AT E226580 T1 ATE226580 T1 AT E226580T1
- Authority
- AT
- Austria
- Prior art keywords
- polymorph
- preparing
- alcohol
- mesylate
- solvent
- Prior art date
Links
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 title abstract 3
- 229960001389 doxazosin Drugs 0.000 title abstract 2
- RUZYUOTYCVRMRZ-UHFFFAOYSA-N doxazosin Chemical compound C1OC2=CC=CC=C2OC1C(=O)N(CC1)CCN1C1=NC(N)=C(C=C(C(OC)=C2)OC)C2=N1 RUZYUOTYCVRMRZ-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000002904 solvent Substances 0.000 abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 238000004821 distillation Methods 0.000 abstract 1
- 229960000220 doxazosin mesylate Drugs 0.000 abstract 1
- VJECBOKJABCYMF-UHFFFAOYSA-N doxazosin mesylate Chemical compound [H+].CS([O-])(=O)=O.C1OC2=CC=CC=C2OC1C(=O)N(CC1)CCN1C1=NC(N)=C(C=C(C(OC)=C2)OC)C2=N1 VJECBOKJABCYMF-UHFFFAOYSA-N 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 229940098779 methanesulfonic acid Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES009900535A ES2164520B1 (es) | 1999-03-16 | 1999-03-16 | "procedimiento de obtencion del polimorfo a del mesilato de doxazosina" |
| PCT/ES2000/000086 WO2000055157A1 (es) | 1999-03-16 | 2000-03-13 | Procedimiento de obtencion del polimorfo a del mesilato de doxazosina |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE226580T1 true ATE226580T1 (de) | 2002-11-15 |
Family
ID=8307680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00909370T ATE226580T1 (de) | 1999-03-16 | 2000-03-13 | Eine methode zur herstellung eines polymorphes von einem doxazosin-mesylat |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6525195B1 (de) |
| EP (1) | EP1162202B1 (de) |
| AT (1) | ATE226580T1 (de) |
| AU (1) | AU3167500A (de) |
| CA (1) | CA2367671C (de) |
| DE (1) | DE60000661T2 (de) |
| DK (1) | DK1162202T3 (de) |
| ES (2) | ES2164520B1 (de) |
| PT (1) | PT1162202E (de) |
| WO (1) | WO2000055157A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19912573A1 (de) * | 1999-03-19 | 2000-09-21 | Knoll Ag | Arzneimittel, enthaltend Doxazosin-Mesylat der Kristallmodifikaton D |
| US7067700B2 (en) | 2001-05-31 | 2006-06-27 | Fermion Oy | Process for preparing sertraline hydrochloride polymorphic form II |
| CN1304374C (zh) | 2002-04-30 | 2007-03-14 | 永进药品工业株式会社 | 可用做caspase－3抑制剂的喹啉衍生物及其制备方法和药用组合物 |
| EP2222666B1 (de) * | 2007-12-24 | 2016-08-17 | Cipla Limited | Kristallines polymorph von doxazosin-mesylat (form iv) und verfahren zu deren herstellung |
| WO2016151466A1 (en) * | 2015-03-26 | 2016-09-29 | Unichem Laboratories Limited | Process of preparing potassium salt of azilsartan medoxomil |
| CN111303130B (zh) * | 2018-12-11 | 2021-09-14 | 合肥立方制药股份有限公司 | 一种多沙唑嗪甲磺酸盐晶型、其制备方法及用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4188390A (en) | 1977-11-05 | 1980-02-12 | Pfizer Inc. | Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines |
| CA2223404C (en) * | 1995-06-06 | 2001-01-16 | Thomas A. Morris | Novel crystal form of anhydrous 7-(¬1.alpha., 5.alpha., 6.alpha.|-6-amino-3-azabicyclo¬3.1.0|hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt |
| IT1287588B1 (it) * | 1996-12-13 | 1998-08-06 | Alfa Chem Ital | Forma cristallina del doxazosin mesilato e processo per la sua produzione |
| EP0849265A1 (de) | 1996-12-20 | 1998-06-24 | HEUMANN PHARMA GmbH | Neue polymorphe Form von Doxazosin-Mesylat (Form II) |
| EP0849266B8 (de) | 1996-12-20 | 2007-10-03 | Heumann PCS GmbH | Neue polymorphe Form von Doxazosinmesylat (Form III) |
| EP0849264A1 (de) | 1996-12-20 | 1998-06-24 | HEUMANN PHARMA GmbH | Neue polymorphe Form von doxazosinmesylat (Form I) |
| DE19800214A1 (de) | 1998-01-06 | 1999-07-15 | Knoll Ag | Verfahren zur Herstellung von Doxazosin-Mcsylat in einer als Form A bezeichneten Kristallmodifikation und ein Zwischenprodukt dafür |
-
1999
- 1999-03-16 ES ES009900535A patent/ES2164520B1/es not_active Expired - Lifetime
-
2000
- 2000-03-13 US US09/913,778 patent/US6525195B1/en not_active Expired - Fee Related
- 2000-03-13 AU AU31675/00A patent/AU3167500A/en not_active Abandoned
- 2000-03-13 ES ES00909370T patent/ES2184698T3/es not_active Expired - Lifetime
- 2000-03-13 DK DK00909370T patent/DK1162202T3/da active
- 2000-03-13 PT PT00909370T patent/PT1162202E/pt unknown
- 2000-03-13 EP EP00909370A patent/EP1162202B1/de not_active Expired - Lifetime
- 2000-03-13 WO PCT/ES2000/000086 patent/WO2000055157A1/es not_active Ceased
- 2000-03-13 CA CA2367671A patent/CA2367671C/en not_active Expired - Fee Related
- 2000-03-13 AT AT00909370T patent/ATE226580T1/de not_active IP Right Cessation
- 2000-03-13 DE DE60000661T patent/DE60000661T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2164520A1 (es) | 2002-02-16 |
| DE60000661D1 (de) | 2002-11-28 |
| ES2164520B1 (es) | 2003-04-01 |
| DE60000661T2 (de) | 2003-06-26 |
| AU3167500A (en) | 2000-10-04 |
| WO2000055157A1 (es) | 2000-09-21 |
| DK1162202T3 (da) | 2003-02-24 |
| CA2367671A1 (en) | 2000-09-21 |
| US6525195B1 (en) | 2003-02-25 |
| EP1162202B1 (de) | 2002-10-23 |
| ES2184698T3 (es) | 2003-04-16 |
| EP1162202A1 (de) | 2001-12-12 |
| CA2367671C (en) | 2010-06-01 |
| PT1162202E (pt) | 2003-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1162202 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |