DE60327350D1 - Verfahren zur herstellung von carvedilol - Google Patents

Verfahren zur herstellung von carvedilol

Info

Publication number
DE60327350D1
DE60327350D1 DE60327350T DE60327350T DE60327350D1 DE 60327350 D1 DE60327350 D1 DE 60327350D1 DE 60327350 T DE60327350 T DE 60327350T DE 60327350 T DE60327350 T DE 60327350T DE 60327350 D1 DE60327350 D1 DE 60327350D1
Authority
DE
Germany
Prior art keywords
carvedilol
preparation
ethylacetate
crystallization
crude
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60327350T
Other languages
English (en)
Inventor
Richard Hercek
Alojz Skoda
Bohumil Proksa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zentiva KS
Original Assignee
Zentiva KS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva KS filed Critical Zentiva KS
Application granted granted Critical
Publication of DE60327350D1 publication Critical patent/DE60327350D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
DE60327350T 2002-11-08 2003-11-04 Verfahren zur herstellung von carvedilol Expired - Fee Related DE60327350D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SK1595-2002A SK285547B6 (sk) 2002-11-08 2002-11-08 Spôsob prípravy Carvedilolu
PCT/SK2003/000020 WO2004041783A1 (en) 2002-11-08 2003-11-04 Process for preparation of carvedilol

Publications (1)

Publication Number Publication Date
DE60327350D1 true DE60327350D1 (de) 2009-06-04

Family

ID=32311005

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60327350T Expired - Fee Related DE60327350D1 (de) 2002-11-08 2003-11-04 Verfahren zur herstellung von carvedilol

Country Status (8)

Country Link
US (1) US7534895B2 (de)
EP (1) EP1558575B1 (de)
AT (1) ATE429420T1 (de)
AU (1) AU2003301861A1 (de)
DE (1) DE60327350D1 (de)
EA (1) EA007393B1 (de)
SK (1) SK285547B6 (de)
WO (1) WO2004041783A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030017569A (ko) * 2000-06-28 2003-03-03 테바 파마슈티컬 인더스트리즈 리미티드 카르베딜올
JP2005515226A (ja) 2002-01-15 2005-05-26 テバ ファーマシューティカル インダストリーズ リミティド カルベジロールの結晶質固体及びそれらを調製するための方法
SI21616A (sl) * 2003-09-02 2005-04-30 Krka, Tovarna Zdravil, D.D., Novo Mesto Nove kristalne oblike karvedilola
GB0411273D0 (en) * 2004-05-20 2004-06-23 Cipla Ltd Process and product
WO2006135757A1 (en) * 2005-06-09 2006-12-21 Teva Pharmaceutical Industries Ltd. Crystalline forms of carvedilol and processes for their preparation
KR100746455B1 (ko) * 2006-02-23 2007-08-03 안국약품 주식회사 고광학순도의 키랄 카베딜롤의 제조방법
JP5683784B2 (ja) 2006-03-23 2015-03-11 コニカミノルタ株式会社 有機エレクトロルミネッセンス素子、表示装置及び照明装置
US8022094B2 (en) 2006-06-28 2011-09-20 Teva Pharmaceutical Industries Ltd. Carvedilol phosphate
EP2114881A1 (de) * 2007-02-26 2009-11-11 Teva Pharmaceutical Industries Ltd. Verfahren zur reinigung von carvedilol oder von salzen davon
CN102190613B (zh) * 2010-03-14 2014-06-25 浙江华海药业股份有限公司 一种卡维地洛的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2815926A1 (de) 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3319027A1 (de) 1983-05-26 1984-11-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von optisch aktiven carbazol-derivaten, neue r- und s-carbazol-derivate, sowie arzneimittel, die diese verbindungen enthalten
HU227441B1 (en) * 1997-11-24 2011-06-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Process for producing carvedilol, enantiomers and salts thereof
KR20030017569A (ko) 2000-06-28 2003-03-03 테바 파마슈티컬 인더스트리즈 리미티드 카르베딜올

Also Published As

Publication number Publication date
ATE429420T1 (de) 2009-05-15
US7534895B2 (en) 2009-05-19
WO2004041783A1 (en) 2004-05-21
SK285547B6 (sk) 2007-03-01
SK15952002A3 (sk) 2004-07-07
EA200500792A1 (ru) 2005-10-27
US20060167077A1 (en) 2006-07-27
EP1558575B1 (de) 2009-04-22
AU2003301861A1 (en) 2004-06-07
EP1558575A1 (de) 2005-08-03
EA007393B1 (ru) 2006-10-27

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee