ATE224395T1 - Verfahren zur herstellung von 2-substituierten 1- (tetrazol-5-yl)benzenverbindungen durch ortho- metallierung - Google Patents

Verfahren zur herstellung von 2-substituierten 1- (tetrazol-5-yl)benzenverbindungen durch ortho- metallierung

Info

Publication number
ATE224395T1
ATE224395T1 AT98936398T AT98936398T ATE224395T1 AT E224395 T1 ATE224395 T1 AT E224395T1 AT 98936398 T AT98936398 T AT 98936398T AT 98936398 T AT98936398 T AT 98936398T AT E224395 T1 ATE224395 T1 AT E224395T1
Authority
AT
Austria
Prior art keywords
metalation
tetrazole
ortho
substituted
producing
Prior art date
Application number
AT98936398T
Other languages
German (de)
English (en)
Inventor
Marco Villa
Pietro Allegrini
Katiuscia Arrighi
Maurizio Paiocchi
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Application granted granted Critical
Publication of ATE224395T1 publication Critical patent/ATE224395T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/02—Magnesium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT98936398T 1997-06-30 1998-06-29 Verfahren zur herstellung von 2-substituierten 1- (tetrazol-5-yl)benzenverbindungen durch ortho- metallierung ATE224395T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97MI001544A IT1292437B1 (it) 1997-06-30 1997-06-30 Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
PCT/EP1998/003969 WO1999001459A1 (en) 1997-06-30 1998-06-29 Ortho-metalation process for the synthesis of 2-substituted-1-(tetrazol-5-yl)benzenes

Publications (1)

Publication Number Publication Date
ATE224395T1 true ATE224395T1 (de) 2002-10-15

Family

ID=11377464

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98936398T ATE224395T1 (de) 1997-06-30 1998-06-29 Verfahren zur herstellung von 2-substituierten 1- (tetrazol-5-yl)benzenverbindungen durch ortho- metallierung

Country Status (12)

Country Link
US (1) US6271375B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0994881B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP4128633B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE224395T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2294609C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CZ (1) CZ293277B6 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE69808093T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2182349T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU226471B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL133249A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IT (1) IT1292437B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1999001459A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU226948B1 (en) * 1999-04-28 2010-03-29 Takeda Pharmaceutical Use of angiotensin ii antagonist for prevention or therapy of progression of simplex retinopathy or preproliferating retinopathy
EP1545400B1 (en) 2002-07-26 2012-09-26 AMO Groningen B.V. Method for manipulation of an intraocular lens
WO2004065383A2 (en) * 2003-01-16 2004-08-05 Teva Pharmaceutical Industries Ltd. Novel synthesis of irbesartan
US7199144B2 (en) * 2003-04-21 2007-04-03 Teva Pharmaceuticals Industries, Ltd. Process for the preparation of valsartan and intermediates thereof
CA2519490A1 (en) * 2003-03-17 2004-09-30 Teva Pharmaceutical Industries Ltd Polymorphis of valsartan
EP1950204A1 (en) 2003-03-17 2008-07-30 Teva Pharmaceutical Industries Ltd. Amorphous form of valsartan
EP1556363A2 (en) * 2003-04-21 2005-07-27 Teva Pharmaceutical Industries Limited Process for the preparation of valsartan and intermediates thereof
US7378531B2 (en) * 2003-04-21 2008-05-27 Teva Pharmaceutical Industries Ltd Process for the preparation of valsartan
WO2005014560A1 (en) * 2003-08-08 2005-02-17 Dipharma S.P.A. A process for the preparation of phenyltetrazole derivatives
WO2005049587A1 (en) * 2003-11-21 2005-06-02 Ranbaxy Laboratories Limited Process for preparation of biphenyl tetrazole
AU2005249794A1 (en) 2004-06-04 2005-12-15 Teva Pharmaceutical Industries, Ltd. Pharmaceutical composition containing irbesartan
PT1833801E (pt) * 2004-12-22 2008-08-25 Algry Quimica S L Compostos intermediários para a preparação de antagonistas do receptor da angiotensina ii
WO2006067216A2 (en) * 2004-12-22 2006-06-29 Enantia, S. L. Intermediate compounds for the preparation of an angiotensin ii receptor and process for the preparation of valsartan
EP1812411A2 (en) * 2005-07-05 2007-08-01 Teva Pharmaceutical Industries Ltd. Process for preparing valsartan
US20090304797A1 (en) * 2006-06-23 2009-12-10 Tarur Venkatasubramanian Radha Process for the Preparation of Micronized Valsartan
EP2090567A3 (en) 2008-02-13 2011-06-01 Ranbaxy Laboratories Limited Processes for the preparation of intermediates of valsartan
EP2260018A2 (en) * 2008-04-07 2010-12-15 Hetero Research Foundation Process for preparation of valsartan intermediate
WO2012056294A1 (en) 2010-10-29 2012-05-03 Jubilant Life Sciences Ltd. An improved process for the preparation of n-pentanoyl-n-[[2'-(1h-tetrazol-5-yi)[1,1'-biphenyl]-4-yi]methyl]-l-valine
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists
WO2021111464A1 (en) 2019-12-02 2021-06-10 Harman Finochem Limited A process for the preparation of highly pure valsartan

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5039814A (en) * 1990-05-02 1991-08-13 Merck & Co., Inc. Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl)benzenes
US5149699A (en) 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists
TW226375B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1991-10-24 1994-07-11 American Home Prod
US5256654A (en) 1991-10-24 1993-10-26 American Home Products Corporation Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists
EP0550313A1 (fr) * 1991-12-30 1993-07-07 Synthelabo Nouveaux dérivés de 2-(tétrazol-5-yl)-(1,1'-biphényle), leur préparation et leur utilisation comme intermédiaires de synthèse
US5310929A (en) * 1992-08-06 1994-05-10 E. I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
FR2696746B1 (fr) * 1992-10-12 1994-11-18 Synthelabo Dérivés de l'acide benzèneborinique, leur préparation et leur utilisation comme intermédiaires de synthèse.
US5760220A (en) 1995-06-07 1998-06-02 American Home Products Corporation Process for preparation of biphenyl derivatives
CN1073110C (zh) * 1995-06-07 2001-10-17 美国家用产品公司 联苯衍生物的制备方法

Also Published As

Publication number Publication date
DE69808093T2 (de) 2003-06-05
EP0994881A1 (en) 2000-04-26
ITMI971544A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1997-06-30
ITMI971544A1 (it) 1998-12-30
HU226471B1 (en) 2008-12-29
ES2182349T3 (es) 2003-03-01
CZ293277B6 (cs) 2004-03-17
US6271375B1 (en) 2001-08-07
EP0994881B1 (en) 2002-09-18
WO1999001459A1 (en) 1999-01-14
IL133249A (en) 2003-12-10
CA2294609C (en) 2008-08-19
IL133249A0 (en) 2001-04-30
JP2002510314A (ja) 2002-04-02
IT1292437B1 (it) 1999-02-08
HUP0004227A3 (en) 2003-03-28
CA2294609A1 (en) 1999-01-14
HUP0004227A2 (hu) 2001-06-28
DE69808093D1 (de) 2002-10-24
JP4128633B2 (ja) 2008-07-30
CZ477499A3 (cs) 2000-07-12

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