ATE222923T1 - Fettsäurederivate von gallensäure und gallensäurederivaten - Google Patents
Fettsäurederivate von gallensäure und gallensäurederivatenInfo
- Publication number
- ATE222923T1 ATE222923T1 AT99912026T AT99912026T ATE222923T1 AT E222923 T1 ATE222923 T1 AT E222923T1 AT 99912026 T AT99912026 T AT 99912026T AT 99912026 T AT99912026 T AT 99912026T AT E222923 T1 ATE222923 T1 AT E222923T1
- Authority
- AT
- Austria
- Prior art keywords
- acid
- bile
- bale
- acid derivatives
- fatty acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fats And Perfumes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL12399898A IL123998A (en) | 1998-04-08 | 1998-04-08 | Conjugates of bile salts and pharmaceutical preparations containing them |
| PCT/IL1999/000173 WO1999052932A1 (en) | 1998-04-08 | 1999-03-25 | Fatty acid derivatives of bile acids and bile acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE222923T1 true ATE222923T1 (de) | 2002-09-15 |
Family
ID=11071405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99912026T ATE222923T1 (de) | 1998-04-08 | 1999-03-25 | Fettsäurederivate von gallensäure und gallensäurederivaten |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US6395722B1 (https=) |
| EP (1) | EP1071702B1 (https=) |
| JP (1) | JP5031942B2 (https=) |
| KR (1) | KR100615560B1 (https=) |
| CN (1) | CN100386339C (https=) |
| AT (1) | ATE222923T1 (https=) |
| AU (1) | AU742944B2 (https=) |
| BR (1) | BRPI9909908B8 (https=) |
| CA (1) | CA2325933C (https=) |
| CZ (1) | CZ300824B6 (https=) |
| DE (1) | DE69902647T2 (https=) |
| DK (1) | DK1071702T3 (https=) |
| EA (1) | EA003392B1 (https=) |
| ES (1) | ES2183526T3 (https=) |
| HU (1) | HU229513B1 (https=) |
| ID (1) | ID26042A (https=) |
| IL (1) | IL123998A (https=) |
| NO (1) | NO316875B1 (https=) |
| NZ (1) | NZ507309A (https=) |
| PL (1) | PL199271B1 (https=) |
| PT (1) | PT1071702E (https=) |
| SI (1) | SI1071702T1 (https=) |
| TR (1) | TR200002876T2 (https=) |
| UA (1) | UA70318C2 (https=) |
| WO (1) | WO1999052932A1 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL123998A (en) * | 1998-04-08 | 2004-09-27 | Galmed Int Ltd | Conjugates of bile salts and pharmaceutical preparations containing them |
| IL142650A (en) * | 1998-04-08 | 2007-06-03 | Galmed Int Ltd | Use of bile acid conjugates or bile salts and fatty acids or fatty acids in the preparation of pharmaceuticals for lowering cholesterol, for the treatment of fatty liver and for the treatment of hyperglycemia and diabetes |
| US20030083231A1 (en) * | 1998-11-24 | 2003-05-01 | Ahlem Clarence N. | Blood cell deficiency treatment method |
| US8975246B2 (en) | 2001-04-17 | 2015-03-10 | Galmed Research And Development Ltd. | Bile acid or bile salt fatty acid conjugates |
| US7053076B2 (en) | 2001-08-29 | 2006-05-30 | Xenoport, Inc. | Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs |
| ITMI20021025A1 (it) * | 2002-05-14 | 2003-11-14 | Nicox Sa | Farmaci per il trattamento acuto di disfunzioni del circolo venoso epatico e portale |
| US20080026077A1 (en) * | 2002-11-12 | 2008-01-31 | John Hilfinger | Methods and compositions of gene delivery agents for systemic and local therapy |
| US7906137B2 (en) * | 2004-05-21 | 2011-03-15 | Mediplex Corporation, Korea | Delivery agents for enhancing mucosal absorption of therapeutic agents |
| WO2007084549A2 (en) * | 2006-01-20 | 2007-07-26 | Filiberto Zadini | Drug-eluting stent with atherosclerotic plaques dissolving pharmacological preparation |
| US8304383B2 (en) * | 2005-11-22 | 2012-11-06 | Atheronova Operations, Inc. | Dissolution of arterial plaque |
| US20090035348A1 (en) * | 2005-11-22 | 2009-02-05 | Z & Z Medical Holdings, Inc. | Dissolution of arterial plaque |
| US20080038385A1 (en) * | 2006-03-13 | 2008-02-14 | Nutracea | Therapeutic uses of an anti-cancer composition derived from rice bran |
| US20070212470A1 (en) * | 2006-03-13 | 2007-09-13 | Nutracea | Therapeutic uses of an anti-cancer composition derived from rice bran |
| EP2043451B1 (en) * | 2006-07-18 | 2012-03-21 | Symrise AG | Cyclodextrin blends with crystal growth inhibitors |
| CA2685127C (en) | 2007-04-23 | 2019-01-08 | Alnylam Pharmaceuticals, Inc. | Glycoconjugates of rna interference agents |
| WO2008144458A1 (en) * | 2007-05-15 | 2008-11-27 | Z & Z Medical Holdings, Inc. | Dissolution of arterial cholesterol plaques by pharmacologically induced elevation of endogenous bile salts |
| SI2182954T1 (sl) * | 2007-07-25 | 2019-04-30 | Medizinische Universitat Graz | Uporaba nor-žolčnih kislin pri zdravljenju arterioskleroze |
| CN101367859B (zh) * | 2007-08-17 | 2011-05-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 脂肪酸胆汁酸偶合物及其医药用途 |
| CZ301037B6 (cs) * | 2007-09-06 | 2009-10-21 | Vysoká škola chemicko-technologická v Praze | Amidové konjugáty steroidních a žlucových kyselin s D-glukosaminem a zpusob jejich prípravy |
| WO2009082606A2 (en) | 2007-12-04 | 2009-07-02 | Alnylam Pharmaceuticals, Inc. | Folate conjugates |
| WO2009073809A2 (en) | 2007-12-04 | 2009-06-11 | Alnylam Pharmaceuticals, Inc. | Carbohydrate conjugates as delivery agents for oligonucleotides |
| US20100021538A1 (en) * | 2008-02-29 | 2010-01-28 | Youngro Byun | Pharmaceutical compositions containing heparin derivatives |
| CA2721183C (en) | 2008-04-11 | 2019-07-16 | Alnylam Pharmaceuticals, Inc. | Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components |
| JP5620392B2 (ja) * | 2008-11-03 | 2014-11-05 | タフツ ユニヴァーシティーＴｕｆｔｓ Ｕｎｉｖｅｒｓｉｔｙ | クロストリジウム・ディフィシレ胞子の発芽および伸長を阻害するための方法および組成物 |
| US20120157419A1 (en) * | 2009-02-02 | 2012-06-21 | Tuvia Gilat | Methods and compositions for treating alzheimer's disease |
| GB2480632A (en) | 2010-05-25 | 2011-11-30 | Kythera Biopharmaceuticals Inc | Preparation of 12-keto and 12-alpha-hydroxy steroids |
| CN102115486B (zh) * | 2009-12-30 | 2015-06-03 | 上海特化医药科技有限公司 | 一种3-β-花生酰胺基-7α,12α,5β-胆烷-24-羧酸的制备方法 |
| TWI572616B (zh) * | 2011-06-16 | 2017-03-01 | 凱瑟拉生物製藥有限公司 | 去氧膽酸之組成物及用途及其相關方法 |
| WO2015019359A1 (en) * | 2013-08-08 | 2015-02-12 | Galderm Therapeutics Ltd. | Anti-acne compositions comprising bile acid-fatty acid conjugates |
| US11571431B2 (en) | 2013-12-04 | 2023-02-07 | Galmed Research And Development Ltd | Aramchol salts |
| HUE045209T2 (hu) * | 2013-12-04 | 2019-12-30 | Galmed Res & Development Ltd | Aramchol-sók |
| WO2016199137A1 (en) | 2015-06-10 | 2016-12-15 | Galmed Research And Development Ltd. | Low dose compositions of aramchol salts |
| WO2015186126A1 (en) * | 2014-06-01 | 2015-12-10 | Galmed Research And Development Ltd. | Fatty acid bile acid conjugates for treatment of lipodystrophy |
| KR102545316B1 (ko) | 2014-11-10 | 2023-06-22 | 알닐람 파마슈티칼스 인코포레이티드 | Ｂ형 간염 바이러스(ｈｂｖ) ｉｒｎａ 조성물 및 그의 이용 방법 |
| IL243707A0 (en) | 2016-01-20 | 2016-05-01 | Galmed Res And Dev Ltd | Treatment to regulate the microbiota in the intestine |
| CN106496300B (zh) * | 2016-10-19 | 2018-05-18 | 上海博志研新药物技术有限公司 | 花生胆酸及其中间体的制备方法 |
| JP2019537607A (ja) * | 2016-11-10 | 2019-12-26 | ガルメド リサーチ アンド ディベロップメント リミテッド | 非アルコール性脂肪性肝疾患の患者における線維化の抑制 |
| US11197870B2 (en) | 2016-11-10 | 2021-12-14 | Galmed Research And Development Ltd | Treatment for hepatic fibrosis |
| US11324820B2 (en) | 2017-04-18 | 2022-05-10 | Alnylam Pharmaceuticals, Inc. | Methods for the treatment of subjects having a hepatitis b virus (HBV) infection |
| US11136347B2 (en) | 2017-06-07 | 2021-10-05 | Crystal Pharmaceutical (Suzhou) Co., Ltd. | Crystalline forms of a fatty acid bile acid conjugate, preparation method thereof and use thereof |
| JP7625512B2 (ja) | 2018-08-13 | 2025-02-03 | アルナイラム ファーマシューティカルズ， インコーポレイテッド | Ｂ型肝炎ウイルス（ＨＢＶ）ｄｓＲＮＡ物質組成物およびその使用方法 |
| IT202000000328A1 (it) | 2020-01-10 | 2021-07-10 | Ice S P A | Metodo di preparazione dell'aramchol |
| CN114524857B (zh) * | 2022-02-22 | 2023-06-30 | 中国科学院微生物研究所 | 胆酸衍生物及其应用 |
| CN116687850A (zh) | 2022-02-24 | 2023-09-05 | 甘莱制药有限公司 | 包含环状膦酸酯化合物的药物组合物及其制备方法与用途 |
| WO2023227723A1 (en) * | 2022-05-26 | 2023-11-30 | Pharmazell Gmbh | An improved process for the preparation of aramchol and salts thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3856953A (en) * | 1973-05-15 | 1974-12-24 | Intellectual Property Dev Corp | Method of treating fatty liver |
| IT1167478B (it) * | 1981-07-24 | 1987-05-13 | Carlo Scolastico | Derivati dell'acido ursodesossicolico |
| IT1167479B (it) * | 1981-07-24 | 1987-05-13 | Carlo Scolastico | Derivati dell'acido chenodesossicolico |
| DE3930696A1 (de) * | 1989-09-14 | 1991-03-28 | Hoechst Ag | Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel |
| IL123998A (en) * | 1998-04-08 | 2004-09-27 | Galmed Int Ltd | Conjugates of bile salts and pharmaceutical preparations containing them |
| DE19824123A1 (de) * | 1998-05-29 | 1999-12-02 | Hoechst Marion Roussel De Gmbh | Gallensäurederivat, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
-
1998
- 1998-04-08 IL IL12399898A patent/IL123998A/en not_active IP Right Cessation
-
1999
- 1999-03-25 EP EP99912026A patent/EP1071702B1/en not_active Expired - Lifetime
- 1999-03-25 DE DE69902647T patent/DE69902647T2/de not_active Expired - Lifetime
- 1999-03-25 CA CA002325933A patent/CA2325933C/en not_active Expired - Lifetime
- 1999-03-25 PL PL343360A patent/PL199271B1/pl unknown
- 1999-03-25 UA UA2000095546A patent/UA70318C2/uk unknown
- 1999-03-25 SI SI9930142T patent/SI1071702T1/xx unknown
- 1999-03-25 NZ NZ507309A patent/NZ507309A/xx not_active IP Right Cessation
- 1999-03-25 BR BRPI9909908A patent/BRPI9909908B8/pt not_active IP Right Cessation
- 1999-03-25 ID IDW20001998A patent/ID26042A/id unknown
- 1999-03-25 PT PT99912026T patent/PT1071702E/pt unknown
- 1999-03-25 AT AT99912026T patent/ATE222923T1/de active
- 1999-03-25 CN CNB998049034A patent/CN100386339C/zh not_active Expired - Lifetime
- 1999-03-25 JP JP2000543488A patent/JP5031942B2/ja not_active Expired - Lifetime
- 1999-03-25 WO PCT/IL1999/000173 patent/WO1999052932A1/en not_active Ceased
- 1999-03-25 KR KR1020007010903A patent/KR100615560B1/ko not_active Expired - Lifetime
- 1999-03-25 AU AU30515/99A patent/AU742944B2/en not_active Expired
- 1999-03-25 HU HU0101653A patent/HU229513B1/hu unknown
- 1999-03-25 CZ CZ20003625A patent/CZ300824B6/cs not_active IP Right Cessation
- 1999-03-25 ES ES99912026T patent/ES2183526T3/es not_active Expired - Lifetime
- 1999-03-25 TR TR2000/02876T patent/TR200002876T2/xx unknown
- 1999-03-25 EA EA200000888A patent/EA003392B1/ru not_active IP Right Cessation
- 1999-03-25 DK DK99912026T patent/DK1071702T3/da active
-
2000
- 2000-09-29 US US09/675,656 patent/US6395722B1/en not_active Expired - Lifetime
- 2000-10-04 NO NO20004998A patent/NO316875B1/no not_active IP Right Cessation
- 2000-10-23 US US09/693,928 patent/US6384024B1/en not_active Expired - Lifetime
-
2002
- 2002-02-21 US US10/078,671 patent/US6589946B2/en not_active Expired - Lifetime
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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| EENE | Nomination of inventor |