ATE221064T1 - Cyclische amidderivate als neurokinin a antagonisten - Google Patents

Cyclische amidderivate als neurokinin a antagonisten

Info

Publication number
ATE221064T1
ATE221064T1 AT95903415T AT95903415T ATE221064T1 AT E221064 T1 ATE221064 T1 AT E221064T1 AT 95903415 T AT95903415 T AT 95903415T AT 95903415 T AT95903415 T AT 95903415T AT E221064 T1 ATE221064 T1 AT E221064T1
Authority
AT
Austria
Prior art keywords
antagonists
neurokin
amide derivatives
cyclic amide
compounds
Prior art date
Application number
AT95903415T
Other languages
English (en)
Inventor
Ashokkumar Bhikkappa Shenvi
Robert Toms Jacobs
Scott Carson Miller
Cyrus John Ohnmacht Jr
Chris Allan Veale
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939325654A external-priority patent/GB9325654D0/en
Priority claimed from GB9423248A external-priority patent/GB9423248D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE221064T1 publication Critical patent/ATE221064T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT95903415T 1993-12-15 1994-12-13 Cyclische amidderivate als neurokinin a antagonisten ATE221064T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939325654A GB9325654D0 (en) 1993-12-15 1993-12-15 Cyclic amide derivatives
GB9423248A GB9423248D0 (en) 1994-11-17 1994-11-17 Cyclic amide derivatives
PCT/GB1994/002726 WO1995016682A1 (en) 1993-12-15 1994-12-13 Cyclic amide derivatives as neurokinin a antagonists

Publications (1)

Publication Number Publication Date
ATE221064T1 true ATE221064T1 (de) 2002-08-15

Family

ID=26304034

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95903415T ATE221064T1 (de) 1993-12-15 1994-12-13 Cyclische amidderivate als neurokinin a antagonisten

Country Status (22)

Country Link
US (3) US5589489A (de)
EP (1) EP0734383B1 (de)
JP (1) JP3819934B2 (de)
CN (1) CN1142822A (de)
AT (1) ATE221064T1 (de)
AU (1) AU690951B2 (de)
BR (1) BR9408325A (de)
CA (1) CA2176036A1 (de)
CZ (1) CZ171796A3 (de)
DE (1) DE69431069T2 (de)
DK (1) DK0734383T3 (de)
ES (1) ES2179094T3 (de)
FI (1) FI962418A0 (de)
HU (1) HUT76275A (de)
IL (1) IL111970A (de)
NO (1) NO962543L (de)
NZ (1) NZ277291A (de)
PL (1) PL315035A1 (de)
PT (1) PT734383E (de)
SG (1) SG52667A1 (de)
SK (1) SK76396A3 (de)
WO (1) WO1995016682A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9322643D0 (en) * 1993-11-03 1993-12-22 Zeneca Ltd Lactam derivatives
GB9325074D0 (en) * 1993-12-07 1994-02-02 Zeneca Ltd Bicyclic heterocycles
GB9408872D0 (en) * 1994-05-03 1994-06-22 Zeneca Ltd Heterocyclic compounds
EP0709375B1 (de) * 1994-10-25 2005-05-18 AstraZeneca AB Therapeutisch wirksame Heterocyclen
US5998444A (en) * 1995-10-24 1999-12-07 Zeneca Ltd. Piperidinyl compounds as NK1 or NK2 antagonists
US6008223A (en) * 1994-10-27 1999-12-28 Zeneca Limited Therapeutic compounds
GB9508786D0 (en) 1995-04-29 1995-06-21 Zeneca Ltd Substituted heterocycles
US5719156A (en) * 1995-05-02 1998-02-17 Schering Corporation Piperazino derivatives as neurokinin antagonists
GB9521781D0 (en) * 1995-10-24 1996-01-03 Merck Sharp & Dohme Therapeutic agents
GB9523526D0 (en) * 1995-11-17 1996-01-17 Zeneca Ltd Therapeutic compounds
US6124319A (en) * 1997-01-21 2000-09-26 Merck & Co., Inc. 3,3-disubstituted piperidines as modulators of chemokine receptor activity
CA2278309A1 (en) * 1997-01-21 1998-07-23 Merck & Co., Inc. 3,3-disubstituted piperidines as modulators of chemokine receptor activity
US7230000B1 (en) 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
US7671200B2 (en) 1999-10-27 2010-03-02 Cytokinetics, Inc. Quinazolinone KSP inhibitors
US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
US6281248B1 (en) 2000-02-16 2001-08-28 Magda Abdel Fattah Ahmed Composition for treating asthma
US6846814B2 (en) 2000-04-06 2005-01-25 Astra Zeneca Ab Neurokinin antagonists for use as medicaments
US20050142495A1 (en) * 2003-10-09 2005-06-30 David Peter Van Heerden Methods of controlling multilayer foil ignition
US7441688B2 (en) * 2003-11-04 2008-10-28 Reactive Nanotechnologies Methods and device for controlling pressure in reactive multilayer joining and resulting product
US7121402B2 (en) * 2003-04-09 2006-10-17 Reactive Nano Technologies, Inc Container hermetically sealed with crushable material and reactive multilayer material
CA2435883A1 (en) 2001-01-26 2002-08-01 Sankyo Company, Limited Benzylamine analogue
WO2003070701A2 (en) 2002-02-15 2003-08-28 Cytokinetics, Inc. Syntheses of quinazolinones
WO2003094839A2 (en) 2002-05-09 2003-11-20 Cytokinetics, Inc. Pyrimidinone compounds, compositions and methods
AU2003270015A1 (en) 2002-05-09 2003-12-02 Cytokinetics, Inc. Compounds, compositions, and methods
JP2005536475A (ja) 2002-05-23 2005-12-02 サイトキネティクス・インコーポレーテッド 化合物、組成物、および方法
EP1556357A4 (de) 2002-06-14 2006-09-13 Cytokinetics Inc Verbindungen, zusammensetzungen und verfahren
EP1537089A4 (de) 2002-07-23 2008-04-16 Cytokinetics Inc Verbindungen, zusammenstellungen und verfahren
EP1558083A4 (de) 2002-09-30 2008-04-16 Cytokinetics Inc Verbindungen, zusammensetzungen und verfahren
JO2696B1 (en) * 2002-12-23 2013-03-03 شركة جانسين فارماسوتيكا ان. في Derivatives of 1-piperdine-4-yl-4-biprolidine-3-yl-piperazine substituted and used as quinine antagonists
AU2004256020A1 (en) * 2003-05-13 2005-01-20 Johns Hopkins University Method of controlling thermal waves in reactive multilayer joining and resulting product
JP2007513154A (ja) 2003-12-08 2007-05-24 サイトキネティクス・インコーポレーテッド 化合物、組成物及び方法
EP1758866A1 (de) 2004-06-18 2007-03-07 Wyeth Verfahren zur herstellung von 6-alkyl-5-arylsulfonyl-dihydrophenanthridinen
IN2015MN00002A (de) 2012-07-09 2015-10-16 Lupin Ltd

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI97540C (fi) * 1989-11-06 1997-01-10 Sanofi Sa Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi
FR2654725B1 (fr) * 1989-11-23 1992-02-14 Rhone Poulenc Sante Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.
IL99320A (en) * 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical compositions containing them
FR2676055B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676054B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676053B1 (fr) * 1991-05-03 1993-08-27 Sanofi Elf Nouveaux composes dialkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2688219B1 (fr) * 1992-03-03 1994-07-08 Sanofi Elf Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant.
GB9321557D0 (en) * 1992-11-03 1993-12-08 Zeneca Ltd Carboxamide derivatives
GB9310066D0 (en) * 1993-05-17 1993-06-30 Zeneca Ltd Alkyl substituted heterocycles
GB9310713D0 (en) * 1993-05-24 1993-07-07 Zeneca Ltd Aryl substituted heterocycles
JPH08511522A (ja) * 1993-06-07 1996-12-03 メルク エンド カンパニー インコーポレーテッド ニューロキニンアンタゴニストとしてのスピロ置換アザ環
GB9317104D0 (en) * 1993-08-17 1993-09-29 Zeneca Ltd Therapeutic heterocycles
GB9322643D0 (en) * 1993-11-03 1993-12-22 Zeneca Ltd Lactam derivatives

Also Published As

Publication number Publication date
SK76396A3 (en) 1996-12-04
NZ277291A (en) 1997-12-19
US5965576A (en) 1999-10-12
HU9601568D0 (en) 1996-08-28
FI962418L (fi) 1996-06-11
CZ171796A3 (en) 1996-09-11
JPH09506608A (ja) 1997-06-30
EP0734383A1 (de) 1996-10-02
JP3819934B2 (ja) 2006-09-13
PT734383E (pt) 2002-12-31
DE69431069D1 (de) 2002-08-29
US5589489A (en) 1996-12-31
AU690951B2 (en) 1998-05-07
WO1995016682A1 (en) 1995-06-22
SG52667A1 (en) 1998-09-28
CN1142822A (zh) 1997-02-12
AU1247195A (en) 1995-07-03
HUT76275A (en) 1997-07-28
ES2179094T3 (es) 2003-01-16
US5705505A (en) 1998-01-06
BR9408325A (pt) 1997-08-19
DE69431069T2 (de) 2003-05-08
IL111970A (en) 1999-03-12
FI962418A7 (fi) 1996-06-11
NO962543L (no) 1996-08-14
PL315035A1 (en) 1996-09-30
IL111970A0 (en) 1995-03-15
DK0734383T3 (da) 2002-10-14
FI962418A0 (fi) 1996-06-11
CA2176036A1 (en) 1995-06-22
NO962543D0 (no) 1996-06-14
EP0734383B1 (de) 2002-07-24

Similar Documents

Publication Publication Date Title
ATE221064T1 (de) Cyclische amidderivate als neurokinin a antagonisten
GB9322643D0 (en) Lactam derivatives
MY112102A (en) Therapeutic heterocycles.
NO982222L (no) 3-(4-Subst.-piperidinyl-1)-1-(3,4-diklorfenyl)propylkarbamater og -ureaer og derivater som neurokinin-antagonister
GB9601722D0 (en) Heterocyclic derivatives
DK0733051T3 (da) Bicykliske, heterocykliske forbindelser som neurokinin A-antagonister
DK0992509T3 (da) Nye makrolid-derivater

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee