ATE211823T1 - Zweidimensionale probe unter anwendung von laps zur messung einer zellaktivität - Google Patents

Zweidimensionale probe unter anwendung von laps zur messung einer zellaktivität

Info

Publication number
ATE211823T1
ATE211823T1 AT96109996T AT96109996T ATE211823T1 AT E211823 T1 ATE211823 T1 AT E211823T1 AT 96109996 T AT96109996 T AT 96109996T AT 96109996 T AT96109996 T AT 96109996T AT E211823 T1 ATE211823 T1 AT E211823T1
Authority
AT
Austria
Prior art keywords
electrode
spot
signal
layer
cell activity
Prior art date
Application number
AT96109996T
Other languages
English (en)
Inventor
Hirokazu Sugihara
Taketani Makoto
Tanabe Matsuigaoka
Akihito Kamei
Hiroshi Iwasaki
Original Assignee
Matsushita Electric Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matsushita Electric Ind Co Ltd filed Critical Matsushita Electric Ind Co Ltd
Application granted granted Critical
Publication of ATE211823T1 publication Critical patent/ATE211823T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/305—Electrodes, e.g. test electrodes; Half-cells optically transparent or photoresponsive electrodes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/806—Electrical property or magnetic property

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of Current Or Voltage (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
AT96109996T 1995-06-20 1996-06-20 Zweidimensionale probe unter anwendung von laps zur messung einer zellaktivität ATE211823T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7153343A JP2930181B2 (ja) 1995-06-20 1995-06-20 神経細胞活動測定用２次元センサ及びこれを用いた測定装置

Publications (1)

Publication Number Publication Date
ATE211823T1 true ATE211823T1 (de) 2002-01-15

Family

ID=15560403

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96109996T ATE211823T1 (de) 1995-06-20 1996-06-20 Zweidimensionale probe unter anwendung von laps zur messung einer zellaktivität

Country Status (9)

Country Link
US (1) US6288527B1 (de)
EP (1) EP0750195B1 (de)
JP (1) JP2930181B2 (de)
KR (1) KR970000190A (de)
CN (1) CN1156825A (de)
AT (1) ATE211823T1 (de)
CA (1) CA2179459A1 (de)
DE (1) DE69618390T2 (de)
TW (1) TW324062B (de)

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US7732127B2 (en) * 2002-12-20 2010-06-08 Acea Biosciences, Inc. Dynamic monitoring of cell adhesion and spreading using the RT-CES system
US8263375B2 (en) * 2002-12-20 2012-09-11 Acea Biosciences Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology
US7560269B2 (en) * 2002-12-20 2009-07-14 Acea Biosciences, Inc. Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays
EP1527328B1 (de) * 2002-07-20 2009-09-09 Acea Biosciences, Inc. Impedanz basierende vorrichtungen und verfahren zur analyse von zellen und partikeln
US7470533B2 (en) * 2002-12-20 2008-12-30 Acea Biosciences Impedance based devices and methods for use in assays
US8206903B2 (en) 2002-12-20 2012-06-26 Acea Biosciences Device and method for electroporation-based delivery of molecules into cells and dynamic monitoring of cell responses
US7468255B2 (en) * 2002-12-20 2008-12-23 Acea Biosciences Method for assaying for natural killer, cytotoxic T-lymphocyte and neutrophil-mediated killing of target cells using real-time microelectronic cell sensing technology
US10215748B2 (en) 2002-12-20 2019-02-26 Acea Biosciences, Inc. Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways
US10539523B2 (en) 2002-12-20 2020-01-21 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties
US10551371B2 (en) 2003-11-10 2020-02-04 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function
US11346797B2 (en) 2002-12-20 2022-05-31 Agilent Technologies, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties
US9612234B2 (en) 2008-05-05 2017-04-04 Acea Biosciences, Inc. Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (RTCA) cardio instruments
CN101421615A (zh) * 2004-03-23 2009-04-29 松下电器产业株式会社 高通量电生理学系统
US7807042B2 (en) * 2005-01-27 2010-10-05 Auburn University System for and method of patch clamp analysis
US20060292549A1 (en) * 2005-06-15 2006-12-28 Neurosilicon Psychotropic drug screening device based on long-term photoconductive stimulation of neurons
KR20070077320A (ko) * 2006-01-23 2007-07-26 삼성전자주식회사 세포 배양을 실시간으로 모니터링 가능한 세포 배양 칩 및그를 이용한 세포 배양 모니터링 방법
US8041515B2 (en) * 2006-09-20 2011-10-18 Acea Biosciences, Inc. Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents
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US8242294B2 (en) 2007-06-19 2012-08-14 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
JOP20180077A1 (ar) 2007-06-19 2019-01-30 Kythera Biopharmaceuticals Inc تركيبات وطرق لحمض صفراوي تخليقي
WO2009137440A1 (en) 2008-05-05 2009-11-12 Acea Biosciences, Inc. Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution
CN101666771B (zh) * 2009-09-27 2012-07-25 南开大学 三明治结构光寻址电位传感器载片台
BR112013003216A2 (pt) 2010-08-12 2016-05-17 Kythera Biopharmaceuticals Inc composições sintéticas de ácido biliar e métodos
CN102221572B (zh) * 2011-03-07 2016-07-20 桂林电子科技大学 一种味觉仿生感知光寻址电位传感器检测装置
CN105307719B (zh) 2013-05-30 2018-05-29 格雷厄姆·H.·克雷西 局部神经刺激仪
US11229789B2 (en) 2013-05-30 2022-01-25 Neurostim Oab, Inc. Neuro activator with controller
US11077301B2 (en) 2015-02-21 2021-08-03 NeurostimOAB, Inc. Topical nerve stimulator and sensor for bladder control
TWI585401B (zh) * 2015-12-17 2017-06-01 長庚大學 光定址電位感測元件
CN106849887B (zh) * 2017-02-28 2024-03-22 河南师范大学 一种隧道结并联电阻法扫描隧道显微镜高带宽前放
EP3589299A4 (de) 2017-03-03 2021-01-13 ACEA Biosciences, Inc. Verfahren und systeme zur funktionellen reifung von kardiomyozyten aus ipsc und esc
EP3706856A4 (de) 2017-11-07 2021-08-18 Neurostim Oab, Inc. Nicht-invasiver nervenaktivator mit adaptiver schaltung
CN110260905A (zh) * 2019-05-29 2019-09-20 西安邮电大学 一种阵列检测光寻址电位传感器的恒相位差闭环测量方法
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112763557A (zh) * 2020-12-23 2021-05-07 西北工业大学 一种光寻址电位传感器蜂巢网状工作电极的制备方法

Also Published As

Publication number Publication date
CA2179459A1 (en) 1996-12-21
JPH095289A (ja) 1997-01-10
EP0750195B1 (de) 2002-01-09
US6288527B1 (en) 2001-09-11
JP2930181B2 (ja) 1999-08-03
CN1156825A (zh) 1997-08-13
EP0750195A1 (de) 1996-12-27
KR970000190A (ko) 1997-01-21
DE69618390D1 (de) 2002-02-14
DE69618390T2 (de) 2002-09-26
TW324062B (en) 1998-01-01

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