ATE197993T1 - Gleichzeitiger einstufenimmunoassay - Google Patents

Gleichzeitiger einstufenimmunoassay

Info

Publication number
ATE197993T1
ATE197993T1 AT93308642T AT93308642T ATE197993T1 AT E197993 T1 ATE197993 T1 AT E197993T1 AT 93308642 T AT93308642 T AT 93308642T AT 93308642 T AT93308642 T AT 93308642T AT E197993 T1 ATE197993 T1 AT E197993T1
Authority
AT
Austria
Prior art keywords
antibody
particles
blood sample
antigen
health
Prior art date
Application number
AT93308642T
Other languages
English (en)
Inventor
Robert A Levine
Stephen C Wardlaw
Leon W M M Terstappen
Diether J Recktenwald
Thomas Mercolino
Original Assignee
Becton Dickinson Co
Robert A Levine
Stephen C Wardlaw
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson Co, Robert A Levine, Stephen C Wardlaw filed Critical Becton Dickinson Co
Application granted granted Critical
Publication of ATE197993T1 publication Critical patent/ATE197993T1/de

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5021Test tubes specially adapted for centrifugation purposes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/49Blood
    • G01N33/491Blood by separating the blood components
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/5375Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by changing the physical or chemical properties of the medium or immunochemicals, e.g. temperature, density, pH, partitioning
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966Animal cells
    • G01N33/56972White blood cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/81Packaged device or kit
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/967Standards, controls, materials, e.g. validation studies, buffer systems
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/971Capture of complex after antigen-antibody reaction
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/973Simultaneous determination of more than one analyte
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/805Optical property
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/807Apparatus included in process claim, e.g. physical support structures
    • Y10S436/81Tube, bottle, or dipstick
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/824Immunological separation techniques
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/829Liposomes, e.g. encapsulation
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/11Automated chemical analysis
    • Y10T436/111666Utilizing a centrifuge or compartmented rotor
AT93308642T 1992-10-30 1993-10-29 Gleichzeitiger einstufenimmunoassay ATE197993T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/969,379 US5342790A (en) 1992-10-30 1992-10-30 Apparatus for indirect fluorescent assay of blood samples

Publications (1)

Publication Number Publication Date
ATE197993T1 true ATE197993T1 (de) 2000-12-15

Family

ID=25515489

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93308642T ATE197993T1 (de) 1992-10-30 1993-10-29 Gleichzeitiger einstufenimmunoassay

Country Status (12)

Country Link
US (6) US5342790A (de)
EP (1) EP0595641B1 (de)
JP (1) JP2679945B2 (de)
CN (1) CN1088310A (de)
AT (1) ATE197993T1 (de)
AU (1) AU668212B2 (de)
CA (1) CA2109461A1 (de)
DE (1) DE69329726T2 (de)
ES (1) ES2152243T3 (de)
FI (1) FI934804A (de)
NO (1) NO933919L (de)
TW (1) TW297094B (de)

Families Citing this family (138)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5342790A (en) * 1992-10-30 1994-08-30 Becton Dickinson And Company Apparatus for indirect fluorescent assay of blood samples
US5474687A (en) * 1994-08-31 1995-12-12 Activated Cell Therapy, Inc. Methods for enriching CD34+ human hematopoietic progenitor cells
US5648223A (en) * 1994-08-31 1997-07-15 Activated Cell Therapy, Inc. Methods for enriching breast tumor cells
US5840502A (en) * 1994-08-31 1998-11-24 Activated Cell Therapy, Inc. Methods for enriching specific cell-types by density gradient centrifugation
US5577513A (en) * 1994-08-31 1996-11-26 Activated Cell Therapy, Inc. Centrifugation syringe, system and method
US5663051A (en) * 1994-08-31 1997-09-02 Activated Cell Therapy, Inc. Separation apparatus and method
AUPN214095A0 (en) * 1995-04-03 1995-04-27 Australian Water Technologies Pty Ltd Method for detecting microorganisms using flow cytometry
ES2288306T3 (es) * 1996-09-13 2008-01-01 Sbm Limited Deteccion de microorganismos.
AU5895898A (en) * 1996-12-20 1998-07-17 Gamera Bioscience Corporation An affinity binding-based system for detecting particulates in a fluid
US6436721B1 (en) * 1997-07-25 2002-08-20 Bayer Corporation Device and method for obtaining clinically significant analyte ratios
US6197523B1 (en) 1997-11-24 2001-03-06 Robert A. Levine Method for the detection, identification, enumeration and confirmation of circulating cancer and/or hematologic progenitor cells in whole blood
AU9233698A (en) * 1997-11-22 1999-06-17 Robert A. Levine Method for the detection, identification, enumeration and confirmation of circulating cancer cells and/or hematologic progenitor cells in whole blood
US6670197B2 (en) * 1997-11-24 2003-12-30 David L. Rimm Method for assaying whole blood for the presence or absence of circulating cancer or other target cell fragments
US6911315B2 (en) * 1997-11-24 2005-06-28 David L. Rimm Method for the detection, identification, enumeration and confirmation of virally infected cells and other epitopically defined cells in whole blood
US8071384B2 (en) 1997-12-22 2011-12-06 Roche Diagnostics Operations, Inc. Control and calibration solutions and methods for their use
JP2002505866A (ja) * 1998-03-10 2002-02-26 ラージ・スケール・プローティオーミックス・コーポレイション 微生物の検出および特性付与
AU773645B2 (en) * 1998-08-24 2004-05-27 Centrus International, Inc. Method and device for concentrating selected groups of microorganisms
US7071005B1 (en) 1998-08-24 2006-07-04 Centrus International, Inc. Method and device for concentrating selected groups of microorganisms
US6365104B1 (en) * 1999-06-25 2002-04-02 Becton Dickinson And Company Assembly for analyzing blood samples
US6444436B1 (en) * 2000-02-22 2002-09-03 David L. Rimm Evacuated container assembly for analysis of a blood sample for the presence or absence of rare events
US7205157B2 (en) * 2001-01-08 2007-04-17 Becton, Dickinson And Company Method of separating cells from a sample
US20140008210A1 (en) * 2012-07-06 2014-01-09 Aviva Biosciences Corporation Methods and compositions for separating or enriching cells
AU2003208959A1 (en) * 2002-01-30 2003-09-02 Id Biomedical Corporation Methods for detecting vancomycin-resistant microorganisms and compositions therefor
AU2003241857A1 (en) * 2002-05-30 2003-12-19 Fuji Electric Holdings Co., Ltd. Method of counting microorganisms or cells
US7901630B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Diffraction grating-based encoded microparticle assay stick
US7508608B2 (en) 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
US7872804B2 (en) 2002-08-20 2011-01-18 Illumina, Inc. Encoded particle having a grating with variations in the refractive index
US7164533B2 (en) 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
US7900836B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
US7923260B2 (en) 2002-08-20 2011-04-12 Illumina, Inc. Method of reading encoded particles
US7441703B2 (en) 2002-08-20 2008-10-28 Illumina, Inc. Optical reader for diffraction grating-based encoded optical identification elements
CA2498933C (en) 2002-09-12 2012-08-28 Cyvera Corporation Method and apparatus for aligning elongated microbeads in order to interrogate the same
WO2004025563A1 (en) 2002-09-12 2004-03-25 Cyvera Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
US7092160B2 (en) 2002-09-12 2006-08-15 Illumina, Inc. Method of manufacturing of diffraction grating-based optical identification element
US20100255603A9 (en) 2002-09-12 2010-10-07 Putnam Martin A Method and apparatus for aligning microbeads in order to interrogate the same
US20130084579A1 (en) * 2002-10-03 2013-04-04 Battelle Memorial Institute Drug susceptibility using rare cell detection system
US7220593B2 (en) * 2002-10-03 2007-05-22 Battelle Memorial Institute Buffy coat separator float system and method
US7074577B2 (en) * 2002-10-03 2006-07-11 Battelle Memorial Institute Buffy coat tube and float system and method
US8603345B2 (en) * 2003-02-13 2013-12-10 Becton, Dickinson And Company Devices for component removal during blood collection, and uses thereof
US8058077B2 (en) 2003-06-20 2011-11-15 Roche Diagnostics Operations, Inc. Method for coding information on a biosensor test strip
US7718439B2 (en) 2003-06-20 2010-05-18 Roche Diagnostics Operations, Inc. System and method for coding information on a biosensor test strip
US8148164B2 (en) 2003-06-20 2012-04-03 Roche Diagnostics Operations, Inc. System and method for determining the concentration of an analyte in a sample fluid
US7645373B2 (en) 2003-06-20 2010-01-12 Roche Diagnostic Operations, Inc. System and method for coding information on a biosensor test strip
US8206565B2 (en) 2003-06-20 2012-06-26 Roche Diagnostics Operation, Inc. System and method for coding information on a biosensor test strip
US7452457B2 (en) 2003-06-20 2008-11-18 Roche Diagnostics Operations, Inc. System and method for analyte measurement using dose sufficiency electrodes
US7645421B2 (en) 2003-06-20 2010-01-12 Roche Diagnostics Operations, Inc. System and method for coding information on a biosensor test strip
US7488601B2 (en) 2003-06-20 2009-02-10 Roche Diagnostic Operations, Inc. System and method for determining an abused sensor during analyte measurement
GB0328245D0 (en) * 2003-12-05 2004-01-07 Univ Birmingham Therapeutic use of biological cells
WO2005078118A1 (en) 2004-02-06 2005-08-25 Bayer Healthcare Llc Oxidizable species as an internal reference for biosensors and method of use
US20050179281A1 (en) * 2004-02-17 2005-08-18 Brown David E. Snow & ice eliminator
US7433123B2 (en) 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
US7569126B2 (en) 2004-06-18 2009-08-04 Roche Diagnostics Operations, Inc. System and method for quality assurance of a biosensor test strip
WO2006020363A2 (en) 2004-07-21 2006-02-23 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
WO2006055736A1 (en) 2004-11-16 2006-05-26 Illumina, Inc. And methods and apparatus for reading coded microbeads
WO2006055735A2 (en) 2004-11-16 2006-05-26 Illumina, Inc Scanner having spatial light modulator
US7604173B2 (en) 2004-11-16 2009-10-20 Illumina, Inc. Holographically encoded elements for microarray and other tagging labeling applications, and method and apparatus for making and reading the same
ES2720288T3 (es) 2005-03-30 2019-07-19 Minerva Biotechnologies Corp Proliferación de células que expresan MUC1
WO2006105448A2 (en) * 2005-03-30 2006-10-05 Minerva Biotechnologies Corporation Proliferation of muc1 expressing cells
US20060240569A1 (en) * 2005-04-20 2006-10-26 Becton, Dickinson And Company Semi-quantitative immunochromatographic device
DK2500439T4 (da) * 2005-06-20 2017-11-13 Advanced Cell Diagnostics Inc Kits og produkter til detektering af nukleinsyrer i individuelle celler og til identifikation af sjældne celler fra store heterogene cellepopulationer
KR101503072B1 (ko) 2005-07-20 2015-03-16 바이엘 헬스케어 엘엘씨 게이트형 전류 측정법
KR101577176B1 (ko) 2005-09-30 2015-12-14 바이엘 헬스케어 엘엘씨 게이트형 전압 전류 측정 분석물 결정 방법
US7623624B2 (en) 2005-11-22 2009-11-24 Illumina, Inc. Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
WO2009024834A2 (en) * 2006-12-05 2009-02-26 Rosetta Genomics Ltd Nucleic acids involved in viral infection
WO2008070171A2 (en) * 2006-12-06 2008-06-12 Minerva Biotechnologies Corp. Method for identifying and manipulating cells
WO2009076235A2 (en) * 2007-12-05 2009-06-18 Zyomyx, Inc. Cell assay kit and method
WO2009076302A1 (en) 2007-12-10 2009-06-18 Bayer Healthcare Llc Control markers for auto-detection of control solution and methods of use
US8988881B2 (en) 2007-12-18 2015-03-24 Sandia Corporation Heat exchanger device and method for heat removal or transfer
US8679764B2 (en) * 2008-03-11 2014-03-25 Becton, Dickinson And Company Density-based cell detection system
JP5189201B2 (ja) * 2008-04-02 2013-04-24 アボット ポイント オブ ケア インコーポレイテッド 全血を含む生体体液のイムノアッセイを実施するためのリガンドアッセイにおける結合標識と遊離標識との仮想分離
CN102047116A (zh) * 2008-04-09 2011-05-04 艾博特健康公司 检测包含在薄厚度腔室中的薄膜流体样本内的非常少量的分析物的方法
US9005417B1 (en) 2008-10-01 2015-04-14 Sandia Corporation Devices, systems, and methods for microscale isoelectric fractionation
KR20140101876A (ko) 2008-10-09 2014-08-20 미네르바 바이오테크놀로지 코포레이션 세포내에서 다능성을 유도하기 위한 방법
US8710836B2 (en) * 2008-12-10 2014-04-29 Nanomr, Inc. NMR, instrumentation, and flow meter/controller continuously detecting MR signals, from continuously flowing sample material
EP3633024A1 (de) * 2009-06-11 2020-04-08 Minerva Biotechnologies Corporation Verfahren zur kultivierung von stammzellen und vorläuferzellen
EP2443450A2 (de) * 2009-06-16 2012-04-25 Robert Aaron Levine Gewinnung von zielmaterialien aus zentrifugierten suspensionen
GB2474306A (en) * 2009-10-12 2011-04-13 Bioproducts Ltd Methods and device for detecting an analyte
US20110097816A1 (en) * 2009-10-23 2011-04-28 Goodwin Paul C Methods for changing densities of non-target particles of a suspension
US20130085076A1 (en) * 2009-12-01 2013-04-04 Temple Douglas Borrelia burgdorferi bacterial antigen diagnosic test using polymeric bait containing capture particles
US9428547B2 (en) 2010-04-21 2016-08-30 Dna Electronics, Inc. Compositions for isolating a target analyte from a heterogeneous sample
US9476812B2 (en) 2010-04-21 2016-10-25 Dna Electronics, Inc. Methods for isolating a target analyte from a heterogeneous sample
US8841104B2 (en) 2010-04-21 2014-09-23 Nanomr, Inc. Methods for isolating a target analyte from a heterogeneous sample
US20110262989A1 (en) 2010-04-21 2011-10-27 Nanomr, Inc. Isolating a target analyte from a body fluid
US9186668B1 (en) 2010-06-04 2015-11-17 Sandia Corporation Microfluidic devices, systems, and methods for quantifying particles using centrifugal force
US8962346B2 (en) 2010-07-08 2015-02-24 Sandia Corporation Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation
US8945914B1 (en) 2010-07-08 2015-02-03 Sandia Corporation Devices, systems, and methods for conducting sandwich assays using sedimentation
US9795961B1 (en) 2010-07-08 2017-10-24 National Technology & Engineering Solutions Of Sandia, Llc Devices, systems, and methods for detecting nucleic acids using sedimentation
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
US20120065092A1 (en) 2010-09-14 2012-03-15 Wai Hobert Fusion analyte cytometric bead assay, and systems and kits for performing the same
WO2012065004A2 (en) 2010-11-12 2012-05-18 Incelldx, Inc. Methods and systems for predicting whether a subject has a cervical intraepithelial neoplasia (cin) lesion from a suspension sample of cervical cells
US9522396B2 (en) 2010-12-29 2016-12-20 S.D. Sight Diagnostics Ltd. Apparatus and method for automatic detection of pathogens
WO2012118982A2 (en) 2011-03-02 2012-09-07 Sandia Corporation Axial flow heat exchanger devices and methods for heat transfer using axial flow devices
US20130034841A1 (en) * 2011-08-02 2013-02-07 Seubert Ronald C Systems and methods for isolating and characterizing target materials of a suspension
US20130095008A1 (en) * 2011-08-02 2013-04-18 Rarecyte, Inc. Tube and float systems and methods of using the same
CN103415349A (zh) * 2011-11-08 2013-11-27 瑞尔赛特股份有限公司 使用辅助液体分离悬浮液中各组分的方法与系统
WO2013090189A1 (en) * 2011-12-12 2013-06-20 Rarecyte, Inc. Tube and float systems and methods of using the same
CN106840812B (zh) 2011-12-29 2019-12-17 思迪赛特诊断有限公司 用于检测生物样品中病原体的方法和系统
CN108112999B (zh) * 2012-02-17 2022-12-27 阿尔克雷斯塔股份有限公司 用于供应饮食脂肪酸需要的方法、组合物和装置
US9244065B1 (en) 2012-03-16 2016-01-26 Sandia Corporation Systems, devices, and methods for agglutination assays using sedimentation
US9120095B2 (en) 2012-03-29 2015-09-01 Biomet Biologics, Llc Apparatus and method for separating and concentrating a component of a fluid
WO2013158340A1 (en) * 2012-04-18 2013-10-24 Rarecyte, Inc. Systems and methods for separation and analysis of target analytes
WO2013170048A1 (en) 2012-05-09 2013-11-14 Advanced Animal Diagnostics, Inc. Rapid detection of analytes in liquid samples
US9903001B1 (en) 2012-07-19 2018-02-27 National Technology & Engineering Solutions Of Sandia, Llc Quantitative detection of pathogens in centrifugal microfluidic disks
CN102890040B (zh) * 2012-10-17 2014-09-17 云南省烟草农业科学研究院 一种改良密度梯度离心法测定花粉密度的方法
US10197480B2 (en) 2012-11-07 2019-02-05 Sandstone Diagnostics, Inc. Methods and devices for processing samples and counting cells
WO2014074737A1 (en) 2012-11-07 2014-05-15 Sandstone Diagnostics, Inc. Methods and devices for processing samples and counting cells
US10000557B2 (en) 2012-12-19 2018-06-19 Dnae Group Holdings Limited Methods for raising antibodies
US9995742B2 (en) 2012-12-19 2018-06-12 Dnae Group Holdings Limited Sample entry
US9551704B2 (en) 2012-12-19 2017-01-24 Dna Electronics, Inc. Target detection
US9804069B2 (en) 2012-12-19 2017-10-31 Dnae Group Holdings Limited Methods for degrading nucleic acid
US9599610B2 (en) 2012-12-19 2017-03-21 Dnae Group Holdings Limited Target capture system
US9434940B2 (en) 2012-12-19 2016-09-06 Dna Electronics, Inc. Methods for universal target capture
US9304128B1 (en) 2013-02-01 2016-04-05 Sandia Corporation Toxin activity assays, devices, methods and systems therefor
JP6639235B2 (ja) 2013-02-07 2020-02-05 サンドストーン ダイアグノスティックス インコーポレイテッドSandstone Diagnostics,Inc. 自動化された試料処理、流体分配、及び沈降検定
US9500579B1 (en) 2013-05-01 2016-11-22 Sandia Corporation System and method for detecting components of a mixture including tooth elements for alignment
EP2999988A4 (de) 2013-05-23 2017-01-11 S.D. Sight Diagnostics Ltd. Verfahren und system zur bildgebung einer zellprobe
IL227276A0 (en) 2013-07-01 2014-03-06 Parasight Ltd A method and system for obtaining a monolayer of cells, for use specifically for diagnosis
CN105659151B (zh) 2013-08-26 2018-06-29 思迪赛特诊断有限公司 数码显微系统与方法
US9803238B1 (en) 2013-11-26 2017-10-31 National Technology & Engineering Solutions Of Sandia, Llc Method and apparatus for purifying nucleic acids and performing polymerase chain reaction assays using an immiscible fluid
GB201400115D0 (en) 2014-01-05 2014-02-19 Gerardos Georgios Multiple ligands detection using an immunoassay device
WO2016025527A1 (en) * 2014-08-12 2016-02-18 Rarecyte, Inc. Tube and float systems and methods of using the same
EP3186778B1 (de) 2014-08-27 2023-01-11 S.D. Sight Diagnostics Ltd. System und verfahren zur berechnung der fokusvariation für ein digitales mikroskop
US9702871B1 (en) 2014-11-18 2017-07-11 National Technology & Engineering Solutions Of Sandia, Llc System and method for detecting components of a mixture including a valving scheme for competition assays
CN114989636A (zh) 2015-03-12 2022-09-02 贝克顿·迪金森公司 聚合物bodipy染料及其使用方法
EP4328270A2 (de) 2015-03-12 2024-02-28 Becton, Dickinson and Company Uv-absorbierende polymerfarbstoffe und verfahren zur verwendung davon
US10254298B1 (en) 2015-03-25 2019-04-09 National Technology & Engineering Solutions Of Sandia, Llc Detection of metabolites for controlled substances
EP3350644B1 (de) 2015-09-17 2021-04-28 S.D. Sight Diagnostics Ltd. Verfahren und vorrichtung zur detektion einer entität in einer körperprobe
ES2911298T3 (es) 2015-12-16 2022-05-18 Becton Dickinson Co Colorantes poliméricos en tándem fluorescentes fotoestables que incluyen complejos de metales luminiscentes
US11733150B2 (en) 2016-03-30 2023-08-22 S.D. Sight Diagnostics Ltd. Distinguishing between blood sample components
WO2017195205A1 (en) 2016-05-11 2017-11-16 S.D. Sight Diagnostics Ltd Sample carrier for optical measurements
JP6942148B2 (ja) 2016-05-11 2021-09-29 エス.ディー.サイト ダイアグノスティクス リミテッド 試料に対する光学測定の実施
US10604657B2 (en) 2016-07-07 2020-03-31 Becton, Dickinson And Company Fluorescent water-solvated conjugated polymers
US10406528B1 (en) 2016-08-04 2019-09-10 National Technology & Engineering Solutions Of Sandia, Llc Non-contact temperature control system for microfluidic devices
US10981174B1 (en) 2016-08-04 2021-04-20 National Technology & Engineering Solutions Of Sandia, Llc Protein and nucleic acid detection for microfluidic devices
US10786811B1 (en) 2016-10-24 2020-09-29 National Technology & Engineering Solutions Of Sandia, Llc Detection of active and latent infections with microfluidic devices and systems thereof
WO2019097387A1 (en) 2017-11-14 2019-05-23 S.D. Sight Diagnostics Ltd Sample carrier for optical measurements
EP4155349A1 (de) 2021-09-24 2023-03-29 Becton, Dickinson and Company Wasserlösliche gelbe grünabsorbierende farbstoffe

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3862303A (en) * 1972-02-02 1975-01-21 Atomic Energy Commission Method for rapid detection and identification of serological factors
US4027660A (en) * 1976-04-02 1977-06-07 Wardlaw Stephen C Material layer volume determination
US4137755A (en) * 1976-09-20 1979-02-06 Wardlaw Stephen C Material layer volume determination
IT1103118B (it) * 1977-01-10 1985-10-14 Levine Robert A Dispositiov e tecnica per migliorare la separazione degli strati di cellule in campioni di sangue centrifugati
US4225575A (en) * 1978-05-15 1980-09-30 Ventrex Laboratories, Inc. Method and apparatus for performing in vitro clinical diagnostic tests using a solid phase assay system
US4197287A (en) * 1977-06-10 1980-04-08 Ventrex Laboratories Inc. Method and apparatus for performing in nitro clinical diagnostic tests using a solid phase assay system having special utility for use with automatic pipetting equipment
US4318980A (en) * 1978-04-10 1982-03-09 Miles Laboratories, Inc. Heterogenous specific binding assay employing a cycling reactant as label
US4190328A (en) * 1978-12-01 1980-02-26 Levine Robert A Process for detection of blood-borne parasites
US4378344A (en) * 1979-09-28 1983-03-29 Ventrex Laboratories, Inc. Method and apparatus for performing multiple, simultaneous in vitro diagnostic tests using a solid phase system
US4480038A (en) * 1982-04-30 1984-10-30 E. I. Dupont De Nemours And Company Density separation of protein overproducing bacteria
JPS6035267A (ja) * 1983-08-05 1985-02-23 Fuji Photo Film Co Ltd 多項目免疫検査法
US4717660A (en) * 1984-01-26 1988-01-05 Becton, Dickinson And Company Detection of bacteria by fluorescent staining in an expanded buffy coat
US4567754A (en) * 1985-03-29 1986-02-04 Wardlaw Stephen C Measurement of small heavy constituent layer in stratified mixture
US4721681A (en) * 1985-05-14 1988-01-26 Fisher Scientific Company Immunoassay in centrifugal field with complementary particles of differing specific gravities
US4940668A (en) * 1985-11-01 1990-07-10 Becton Dickinson And Company Method for increasing agglutination of groups of cells to produce improved cell layer interface in centrifuged blood sample
GB2200448B (en) * 1987-01-23 1991-01-16 Univ London Targetted liposomes and their use in immunoassay
US4774965A (en) * 1987-07-01 1988-10-04 Becton Dickinson And Co., Inc. Material layer volume determination with correction band
JPH02504188A (ja) * 1987-07-02 1990-11-29 イン・ヴィトロ・テクノロジーズ・インコーポレイテッド 複数分析の免疫検定用毛細管装置
EP0344276B1 (de) * 1987-12-01 1993-06-23 Boehringer Mannheim Corporation Verfahren und vorrichtungen zur durchführung von untersuchungen
US4875364A (en) * 1988-03-21 1989-10-24 Levine Robert A Method for measuring hemoglobin
US4843869A (en) * 1988-03-21 1989-07-04 Levine Robert A Method for measuring hemoglobin
US4952054A (en) * 1989-01-30 1990-08-28 Levine Robert A Correction of blood count tube readings
CA2011100C (en) * 1989-05-24 1996-06-11 Stephen C. Wardlaw Centrifuged material layer measurements taken in an evacuated tube
DE4041300A1 (de) * 1989-12-22 1991-06-27 Syntex Inc Verfahren zur trennung von komponenten in einer mischung
US5234816A (en) * 1991-07-12 1993-08-10 Becton, Dickinson And Company Method for the classification and monitoring of leukemias
US5321975A (en) * 1991-10-04 1994-06-21 Levine Robert A Differential erythrocyte counts
US5252460A (en) * 1991-10-28 1993-10-12 Fiedler Paul N In vitro detection of ova, parasites, and other formed elements in stool
EP0557595B1 (de) * 1992-02-25 1997-07-23 Levine, Robert Aaron Zielkomponenten-Assay
US5342790A (en) * 1992-10-30 1994-08-30 Becton Dickinson And Company Apparatus for indirect fluorescent assay of blood samples

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EP0595641A2 (de) 1994-05-04
EP0595641B1 (de) 2000-12-06
FI934804A (fi) 1994-05-01
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US5635362A (en) 1997-06-03
US5776710A (en) 1998-07-07
US5759794A (en) 1998-06-02
JP2679945B2 (ja) 1997-11-19
US5460979A (en) 1995-10-24
DE69329726D1 (de) 2001-01-11
ES2152243T3 (es) 2001-02-01
AU4870993A (en) 1994-05-12
DE69329726T2 (de) 2001-04-05
AU668212B2 (en) 1996-04-26
CA2109461A1 (en) 1994-05-01
EP0595641A3 (de) 1995-04-26
US5342790A (en) 1994-08-30
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US5834217A (en) 1998-11-10
CN1088310A (zh) 1994-06-22

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