ATE185806T1 - Oxopyridylchinoxalin derivate - Google Patents
Oxopyridylchinoxalin derivateInfo
- Publication number
- ATE185806T1 ATE185806T1 AT95302326T AT95302326T ATE185806T1 AT E185806 T1 ATE185806 T1 AT E185806T1 AT 95302326 T AT95302326 T AT 95302326T AT 95302326 T AT95302326 T AT 95302326T AT E185806 T1 ATE185806 T1 AT E185806T1
- Authority
- AT
- Austria
- Prior art keywords
- lower alkyl
- substituted
- nitro
- halogen
- hydrogen
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 4
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 2
- 102000003678 AMPA Receptors Human genes 0.000 abstract 1
- 108090000078 AMPA Receptors Proteins 0.000 abstract 1
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 abstract 1
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003257 excitatory amino acid Substances 0.000 abstract 1
- 230000002461 excitatory amino acid Effects 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Vascular Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7090994 | 1994-04-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE185806T1 true ATE185806T1 (de) | 1999-11-15 |
Family
ID=13445121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95302326T ATE185806T1 (de) | 1994-04-08 | 1995-04-07 | Oxopyridylchinoxalin derivate |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5677305A (enExample) |
| EP (1) | EP0676397B1 (enExample) |
| KR (1) | KR100363003B1 (enExample) |
| CN (1) | CN1044241C (enExample) |
| AT (1) | ATE185806T1 (enExample) |
| AU (1) | AU688459B2 (enExample) |
| CA (1) | CA2146478A1 (enExample) |
| DE (1) | DE69512816T2 (enExample) |
| DK (1) | DK0676397T3 (enExample) |
| ES (1) | ES2140620T3 (enExample) |
| GR (1) | GR3032406T3 (enExample) |
| HU (1) | HUT72064A (enExample) |
| TW (1) | TW300894B (enExample) |
| ZA (1) | ZA952841B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU688459B2 (en) * | 1994-04-08 | 1998-03-12 | Shionogi & Co., Ltd. | Oxopyridinylquinoxaline derivative |
| AUPN842196A0 (en) * | 1996-03-05 | 1996-03-28 | Fujisawa Pharmaceutical Co., Ltd. | New compound |
| CN1161344C (zh) * | 1997-09-01 | 2004-08-11 | 杏林制药株式会社 | 6,7-非对称二取代喹喔啉羧酸衍生物及其加成盐以及它们的制备方法 |
| CN1304404A (zh) | 1998-06-01 | 2001-07-18 | 盐野义制药株式会社 | 氰基亚氨基喹喔啉衍生物 |
| US8039637B2 (en) | 2005-06-23 | 2011-10-18 | Array Biopharma Inc. | Process for preparing benzimidazole compounds |
| US20100113461A1 (en) * | 2008-10-29 | 2010-05-06 | Gilead Palo Alto, Inc. | Substituted heterocyclic compounds |
| US20100113514A1 (en) | 2008-10-30 | 2010-05-06 | Gilead Palo Alto, Inc. | Fused heterocyclic compounds as ion channel modulators |
| EP2338492A1 (en) | 2009-12-24 | 2011-06-29 | Universidad del Pais Vasco | Methods and compositions for the treatment of alzheimer |
| CN103664806B (zh) * | 2013-12-16 | 2016-06-29 | 山东汇海医药化工有限公司 | 一种n-乙酰乙酰基-6-甲氧基-7-氨基喹喔啉-2，3-二酮的制备方法 |
| EP3589616A1 (en) | 2017-02-28 | 2020-01-08 | Universitat Autònoma de Barcelona | (nitro-phenyl)-nitropyridine compounds for treating synucleinopathies |
| WO2019161917A1 (en) | 2018-02-23 | 2019-08-29 | Universitat Autonoma De Barcelona | 4-substituted 1-ethenylsulfonyl-2-nitrobenzene compounds for treating synucleinopathies |
| WO2024083850A1 (en) | 2022-10-18 | 2024-04-25 | ETH Zürich | Electrocatalyst |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE66149B1 (en) * | 1986-09-16 | 1995-12-13 | Novo Nordisk As | Quinoxaline compounds and their preparation and use |
| JP2635662B2 (ja) * | 1987-03-23 | 1997-07-30 | ノボ・ノルデイスク・アクツイエルスカブ | ヘテロ環状化合物，その製造方法及びその使用法 |
| NO179551C (no) * | 1987-11-10 | 1996-10-30 | Novo Nordisk As | Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser |
| DK160941C (da) * | 1988-06-28 | 1991-10-21 | Novo Nordisk As | Kondenserede 2,3-dihydroxypyraziner, fremgangsmaade til deres fremstilling og farmaceutiske praeparater, hvori forbindelserne indgaar |
| US5153195A (en) * | 1988-12-22 | 1992-10-06 | Novo Nordisk A/S | Quinoxaline compounds and their preparation and use |
| DK716188D0 (da) * | 1988-12-22 | 1988-12-22 | Ferrosan As | Quinoxalinforbindelser, deres fremstilling og anvendelse |
| DK715888D0 (da) * | 1988-12-22 | 1988-12-22 | Ferrosan As | Quinoxalinforbindelser, deres fremstilling og anvendelse |
| HU221425B (en) * | 1990-11-06 | 2002-10-28 | Yamanouchi Pharma Co Ltd | Condensed pyrazine derivatives, process for their production and pharmaceutical preparations containing these compounds |
| JPH04193876A (ja) * | 1990-11-26 | 1992-07-13 | Sumitomo Chem Co Ltd | キノキザリン誘導体、その製造法およびそれを有効成分とする除草剤 |
| DK73091D0 (da) * | 1991-04-22 | 1991-04-22 | Novo Nordisk As | Quinoxalinforbindelser, deres fremstilling og anvendelse |
| DE4217952A1 (de) * | 1992-05-30 | 1993-12-02 | Basf Ag | Chinoxalin-2,3(1H,4H)-dione |
| JPH06228112A (ja) * | 1993-02-05 | 1994-08-16 | Yamanouchi Pharmaceut Co Ltd | （１ｈ，４ｈ）キノキサリン誘導体 |
| AU688459B2 (en) * | 1994-04-08 | 1998-03-12 | Shionogi & Co., Ltd. | Oxopyridinylquinoxaline derivative |
-
1995
- 1995-04-05 AU AU16256/95A patent/AU688459B2/en not_active Ceased
- 1995-04-06 ZA ZA952841A patent/ZA952841B/xx unknown
- 1995-04-06 CA CA002146478A patent/CA2146478A1/en not_active Abandoned
- 1995-04-07 HU HU9501026A patent/HUT72064A/hu unknown
- 1995-04-07 DK DK95302326T patent/DK0676397T3/da active
- 1995-04-07 ES ES95302326T patent/ES2140620T3/es not_active Expired - Lifetime
- 1995-04-07 US US08/418,196 patent/US5677305A/en not_active Expired - Fee Related
- 1995-04-07 AT AT95302326T patent/ATE185806T1/de not_active IP Right Cessation
- 1995-04-07 DE DE69512816T patent/DE69512816T2/de not_active Expired - Fee Related
- 1995-04-07 EP EP95302326A patent/EP0676397B1/en not_active Expired - Lifetime
- 1995-04-08 KR KR1019950008201A patent/KR100363003B1/ko not_active Expired - Fee Related
- 1995-04-08 CN CN95105155A patent/CN1044241C/zh not_active Expired - Fee Related
- 1995-04-08 TW TW084103375A patent/TW300894B/zh active
-
2000
- 2000-01-19 GR GR20000400103T patent/GR3032406T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA952841B (en) | 1995-12-18 |
| GR3032406T3 (en) | 2000-05-31 |
| AU688459B2 (en) | 1998-03-12 |
| EP0676397A1 (en) | 1995-10-11 |
| DE69512816T2 (de) | 2000-04-27 |
| DE69512816D1 (de) | 1999-11-25 |
| CA2146478A1 (en) | 1995-10-09 |
| ES2140620T3 (es) | 2000-03-01 |
| KR950032171A (ko) | 1995-12-20 |
| US5677305A (en) | 1997-10-14 |
| HUT72064A (en) | 1996-03-28 |
| TW300894B (enExample) | 1997-03-21 |
| EP0676397B1 (en) | 1999-10-20 |
| DK0676397T3 (da) | 2000-04-03 |
| HU9501026D0 (en) | 1995-06-28 |
| CN1044241C (zh) | 1999-07-21 |
| KR100363003B1 (ko) | 2003-02-11 |
| AU1625695A (en) | 1995-10-19 |
| CN1123792A (zh) | 1996-06-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |