ATE183232T1 - Herstellung von biologisch aktiven rekombinanten mitgliedern der ngf/bdnf-familie neurotroper proteine - Google Patents
Herstellung von biologisch aktiven rekombinanten mitgliedern der ngf/bdnf-familie neurotroper proteineInfo
- Publication number
- ATE183232T1 ATE183232T1 AT91104171T AT91104171T ATE183232T1 AT E183232 T1 ATE183232 T1 AT E183232T1 AT 91104171 T AT91104171 T AT 91104171T AT 91104171 T AT91104171 T AT 91104171T AT E183232 T1 ATE183232 T1 AT E183232T1
- Authority
- AT
- Austria
- Prior art keywords
- ngf
- proteins
- biologically active
- bdnf
- neurotropic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/48—Nerve growth factor [NGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factors [FGF]
- C07K14/503—Fibroblast growth factors [FGF] basic FGF [bFGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/848—Escherichia
- Y10S435/849—Escherichia coli
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50544190A | 1990-04-06 | 1990-04-06 | |
US54775090A | 1990-07-02 | 1990-07-02 | |
US07/594,126 US5235043A (en) | 1990-04-06 | 1990-10-09 | Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE183232T1 true ATE183232T1 (de) | 1999-08-15 |
Family
ID=27414291
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT91104171T ATE183232T1 (de) | 1990-04-06 | 1991-03-18 | Herstellung von biologisch aktiven rekombinanten mitgliedern der ngf/bdnf-familie neurotroper proteine |
Country Status (17)
Country | Link |
---|---|
US (1) | US5235043A (de) |
EP (1) | EP0450386B1 (de) |
JP (1) | JP2521851B2 (de) |
KR (1) | KR910018545A (de) |
AT (1) | ATE183232T1 (de) |
AU (1) | AU651339B2 (de) |
CA (1) | CA2038669C (de) |
DE (1) | DE69131514T2 (de) |
DK (1) | DK0450386T3 (de) |
ES (1) | ES2140379T3 (de) |
FI (1) | FI108146B (de) |
GR (1) | GR3031632T3 (de) |
IE (1) | IE910827A1 (de) |
IL (1) | IL97602A (de) |
NO (1) | NO308308B1 (de) |
NZ (1) | NZ237544A (de) |
TW (1) | TW206258B (de) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5180820A (en) * | 1989-08-30 | 1993-01-19 | Barde Yves Alain | Brain-derived neurotrophic factor |
US5229500A (en) * | 1989-08-30 | 1993-07-20 | Regeneron Pharmaceuticals, Inc. | Brain derived neurotrophic factor |
US5606031A (en) * | 1990-04-06 | 1997-02-25 | Lile; Jack | Production and purification of biologically active recombinant neurotrophic protein in bacteria |
US5986070A (en) * | 1990-04-06 | 1999-11-16 | Amgen Inc. | Production of biologically active NGF proteins |
WO1992004382A1 (en) * | 1990-09-05 | 1992-03-19 | Bunge (Australia) Pty. Ltd. | Solubilization of proteins in active forms |
US5530109A (en) * | 1991-04-10 | 1996-06-25 | Ludwig Institute For Cancer Research | DNA encoding glial mitogenic factors |
US5389529A (en) * | 1991-06-12 | 1995-02-14 | Regeneron Pharmaceuticals, Inc. | Modified lamβ signal sequence and processes for producing recombinant neurotrophins |
NZ243084A (en) * | 1991-06-12 | 1995-08-28 | Regeneron Pharma | Production and recovery of recombinant neurotrophins, genes for a modified lamb signal sequence, fusion genes and plasmids |
DE4139000A1 (de) * | 1991-11-27 | 1993-06-03 | Boehringer Mannheim Gmbh | Verfahren zur gentechnologischen herstellung von biologisch aktivem ss-ngf |
US5488099A (en) * | 1992-03-06 | 1996-01-30 | Persson, Deceased; Hakan B. | Multifunctional chimeric neurotrophic factors |
US5316921A (en) * | 1992-05-18 | 1994-05-31 | Genentech, Inc. | Single-chain hepatocyte growth factor variants |
ATE222603T1 (de) * | 1992-05-18 | 2002-09-15 | Genentech Inc | Hepatozytwachstumfaktor variante |
US5328837A (en) * | 1992-05-18 | 1994-07-12 | Genentech, Inc. | Hepatocyte growth factor protease domain variants |
DE69330809T2 (de) * | 1992-06-08 | 2002-05-16 | Takeda Chemical Industries Ltd | Therapeutisches Agens für Neutropenie |
US5364645A (en) * | 1992-10-30 | 1994-11-15 | The Regents Of The University Of California | Method of controlling microorganisms by pulsed ultraviolet laser radiation |
EP0632008B1 (de) * | 1993-06-01 | 1998-02-04 | Ono Pharmaceutical Co., Ltd. | Pentansäurederivate |
WO1995011258A1 (en) * | 1993-10-18 | 1995-04-27 | Regeneron Pharmaceuticals, Inc. | Growth factor heterodimers |
US5470719A (en) * | 1994-03-18 | 1995-11-28 | Meng; Shi-Yuan | Modified OmpA signal sequence for enhanced secretion of polypeptides |
US6743628B1 (en) | 1995-08-28 | 2004-06-01 | Washington University | Method of cell culture using neurturin |
US5739307A (en) | 1995-08-28 | 1998-04-14 | Washington University | Polynucleotide encoding neurturin neurotrophic factor |
US5607711A (en) * | 1995-11-01 | 1997-03-04 | The Regents Of The University Of California | Method of controlling insects and mites with pulsed ultraviolet light |
US5859311A (en) * | 1995-11-27 | 1999-01-12 | University Of Kentucky Research Foundation | Transgenic mice which overexpress neurotrophin-3 (NT-3) and methods of use |
US6222022B1 (en) | 1996-03-14 | 2001-04-24 | Washington University | Persephin and related growth factors |
US7015316B1 (en) | 1996-03-14 | 2006-03-21 | Washington University | Polynucleotides encoding human persephin and related growth factors |
ES2237793T3 (es) * | 1996-03-14 | 2005-08-01 | Washington University | Persefina y factores de crecimiento relacionados. |
JP3288720B2 (ja) * | 1996-06-11 | 2002-06-04 | ロシュ ダイアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 変性タンパク質の活性化方法 |
US5910435A (en) * | 1996-07-25 | 1999-06-08 | Wisconsin Alumni Research Foundation | Method of folding proteins with synthetic dithiol catalysts |
AU729459B2 (en) * | 1996-11-15 | 2001-02-01 | Genentech Inc. | Purification of neurotrophins |
US6042579A (en) * | 1997-04-30 | 2000-03-28 | Medtronic, Inc. | Techniques for treating neurodegenerative disorders by infusion of nerve growth factors into the brain |
US7495087B2 (en) | 1997-07-14 | 2009-02-24 | Bolder Biotechnology, Inc. | Cysteine muteins in the C-D loop of human interleukin-11 |
NZ502375A (en) | 1997-07-14 | 2001-11-30 | Bolder Biotechnology Inc | The addition of non-natural cysteine derivatives to cause the protein to act as antagonists of the GH family |
EP0994188B1 (de) * | 1998-10-09 | 2004-01-07 | Scil proteins GmbH | Verfahren zur Gewinnung von aktivem Beta-NGF |
WO2000024415A2 (en) * | 1998-10-28 | 2000-05-04 | Cornell Research Foundation, Inc. | Methods for regulating angiogenesis and vascular integrity using trk receptor ligands |
US6329136B1 (en) | 1998-10-30 | 2001-12-11 | The Regents Of The University Of California | Method for laser inactivation of infectious agents |
CN1210400C (zh) * | 1999-01-14 | 2005-07-13 | 博尔德生物技术公司 | 制备含游离半胱氨酸残基的蛋白质的方法 |
US20020049303A1 (en) * | 1999-06-28 | 2002-04-25 | Tang Jordan J. N. | Catalytically active recombinant memapsin and methods of use thereof |
WO2001000665A2 (en) * | 1999-06-28 | 2001-01-04 | Oklahoma Medical Research Foundation | Inhibitors of memapsin 2 and use thereof |
EP1206578A2 (de) * | 1999-08-11 | 2002-05-22 | Whitehead Institute For Biomedical Research | Bdnf polymorphismus und zusammenhang mit bipolaren erkrankungen |
US7223406B2 (en) * | 2000-07-21 | 2007-05-29 | The Regents Of The University Of California | Methods and compositions for preventing and treating male erectile dysfunction and female sexual arousal disorder |
WO2002007757A2 (en) * | 2000-07-21 | 2002-01-31 | Lue Tom F | Prevention and treatment of sexual arousal disorders |
US20040121947A1 (en) * | 2000-12-28 | 2004-06-24 | Oklahoma Medical Research Foundation | Compounds which inhibit beta-secretase activity and methods of use thereof |
US20030232365A1 (en) * | 2001-02-15 | 2003-12-18 | Whitehead Institute For Biomedical Research | BDNF polymorphisms and association with bipolar disorder |
EP1233075A3 (de) * | 2001-02-15 | 2003-01-08 | Whitehead Institute For Biomedical Research | BDNF Polymorphismus und Vereinigung mit doppelpoliger Geistesgestörtheit |
CA2464736A1 (en) * | 2001-10-23 | 2003-05-15 | Oklahoma Medical Research Foundation | Beta-secretase inhibitors and methods of use |
US20060234944A1 (en) * | 2001-10-23 | 2006-10-19 | Oklahoma Medical Reseach Foundation | Beta-secretase inhibitors and methods of use |
US20030219696A1 (en) * | 2002-05-23 | 2003-11-27 | Moreland Gerald W. | Method and apparatus for preventing backflow in dental saliva evacuators |
JP2005305107A (ja) * | 2004-03-25 | 2005-11-04 | Sei Matsuoka | 価値的情報値の測定装置およびこれを使用した測定方法 |
WO2007021886A2 (en) * | 2005-08-10 | 2007-02-22 | Oklahoma Medical Research Foundation | Truncated memapsin 2 for use for treating alzheimer's disease |
WO2008002572A2 (en) * | 2006-06-27 | 2008-01-03 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services | Method for measuring mature brain derived neurotrophic factor |
IT1394596B1 (it) * | 2008-09-30 | 2012-07-05 | Fond Parco Tecnologico Padano | Produzione di ngf in pianta. |
EP2594295A1 (de) | 2011-11-16 | 2013-05-22 | Servicio Andaluz De Salud | Nervenimplantat basierend auf einem kompaktierten, zellhaltigen Biomaterial |
GB201804641D0 (en) * | 2018-03-22 | 2018-05-09 | Inivata Ltd | Methods of sequencing nucleic acids and error correction of sequence reads |
IT202000032423A1 (it) | 2020-12-24 | 2022-06-24 | Univ Degli Studi Di Trieste | Metodo per la produzione di forme processate proteoliticamente di fattori trofici o fattori di crescita |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4599197A (en) * | 1982-12-22 | 1986-07-08 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4511502A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4511503A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4512922A (en) * | 1982-12-22 | 1985-04-23 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
DK161152C (da) * | 1983-03-03 | 1991-11-11 | Genentech Inc | Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat |
US4766205A (en) * | 1985-11-13 | 1988-08-23 | Beatrice Companies, Inc. | Method for isolation of recombinant polypeptides in biologically active forms |
US4929700A (en) * | 1987-04-16 | 1990-05-29 | Cetus Corporation | Production of purified, biologically active, bacterially produced recombinant human CSF-1 |
IT1219874B (it) * | 1988-03-18 | 1990-05-24 | Fidia Farmaceutici | Utilizzazione del fattore di crescita nervoso umano e sue composizioni farmaceutiche |
US6709837B1 (en) * | 1989-03-10 | 2004-03-23 | Takeda Chemical Industries, Inc. | Polypeptide and production thereof |
US5229500A (en) * | 1989-08-30 | 1993-07-20 | Regeneron Pharmaceuticals, Inc. | Brain derived neurotrophic factor |
JPH05161493A (ja) * | 1989-08-30 | 1993-06-29 | Max Planck Ges Foerderung Wissenschaft Ev | ニューロトロフィン―3 |
IL95511A (en) * | 1989-08-30 | 2000-10-31 | Max Planck Gesellschaft | Neurotrophin-3 a novel neurotrophic factor related to nerve growth and brain derived neurotrophic factor |
US5180820A (en) * | 1989-08-30 | 1993-01-19 | Barde Yves Alain | Brain-derived neurotrophic factor |
-
1990
- 1990-10-09 US US07/594,126 patent/US5235043A/en not_active Expired - Lifetime
-
1991
- 1991-03-12 IE IE082791A patent/IE910827A1/en not_active IP Right Cessation
- 1991-03-18 AT AT91104171T patent/ATE183232T1/de not_active IP Right Cessation
- 1991-03-18 DE DE69131514T patent/DE69131514T2/de not_active Expired - Lifetime
- 1991-03-18 DK DK91104171T patent/DK0450386T3/da active
- 1991-03-18 EP EP91104171A patent/EP0450386B1/de not_active Expired - Lifetime
- 1991-03-18 ES ES91104171T patent/ES2140379T3/es not_active Expired - Lifetime
- 1991-03-19 IL IL9760291A patent/IL97602A/xx not_active IP Right Cessation
- 1991-03-20 CA CA002038669A patent/CA2038669C/en not_active Expired - Lifetime
- 1991-03-22 NZ NZ237544A patent/NZ237544A/xx unknown
- 1991-04-03 NO NO911303A patent/NO308308B1/no not_active IP Right Cessation
- 1991-04-05 AU AU74130/91A patent/AU651339B2/en not_active Ceased
- 1991-04-05 FI FI911643A patent/FI108146B/fi active
- 1991-04-06 KR KR1019910005514A patent/KR910018545A/ko not_active Application Discontinuation
- 1991-04-06 JP JP3073389A patent/JP2521851B2/ja not_active Expired - Lifetime
- 1991-04-08 TW TW080102624A patent/TW206258B/zh not_active IP Right Cessation
-
1999
- 1999-10-21 GR GR990402673T patent/GR3031632T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0450386A3 (en) | 1992-09-09 |
NZ237544A (en) | 1993-07-27 |
US5235043A (en) | 1993-08-10 |
AU7413091A (en) | 1991-11-14 |
FI911643A (fi) | 1991-10-07 |
AU651339B2 (en) | 1994-07-21 |
JP2521851B2 (ja) | 1996-08-07 |
IL97602A0 (en) | 1992-06-21 |
CA2038669C (en) | 2004-06-29 |
FI911643A0 (fi) | 1991-04-05 |
NO308308B1 (no) | 2000-08-28 |
EP0450386A2 (de) | 1991-10-09 |
FI108146B (fi) | 2001-11-30 |
DE69131514D1 (de) | 1999-09-16 |
ES2140379T3 (es) | 2000-03-01 |
CA2038669A1 (en) | 1991-10-07 |
GR3031632T3 (en) | 2000-01-31 |
KR910018545A (ko) | 1991-11-30 |
DE69131514T2 (de) | 2000-05-04 |
DK0450386T3 (da) | 2000-03-06 |
JPH06319549A (ja) | 1994-11-22 |
IL97602A (en) | 2005-08-31 |
TW206258B (de) | 1993-05-21 |
IE910827A1 (en) | 1991-10-09 |
NO911303D0 (no) | 1991-04-03 |
EP0450386B1 (de) | 1999-08-11 |
NO911303L (no) | 1991-10-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
EELA | Cancelled due to lapse of time |