DK0450386T3 - Fremstilling af biologisk aktive, rekombinante medlemmer af NGF/BDNF-familien af neurotrope proteiner - Google Patents

Fremstilling af biologisk aktive, rekombinante medlemmer af NGF/BDNF-familien af neurotrope proteiner

Info

Publication number
DK0450386T3
DK0450386T3 DK91104171T DK91104171T DK0450386T3 DK 0450386 T3 DK0450386 T3 DK 0450386T3 DK 91104171 T DK91104171 T DK 91104171T DK 91104171 T DK91104171 T DK 91104171T DK 0450386 T3 DK0450386 T3 DK 0450386T3
Authority
DK
Denmark
Prior art keywords
ngf
proteins
biologically active
bdnf
neurotropic
Prior art date
Application number
DK91104171T
Other languages
Danish (da)
English (en)
Inventor
Frank D Collins
Jack Lile
Susan Bektesh
Drzislav Mismer
Tadahiko Kohno
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27414291&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0450386(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of DK0450386T3 publication Critical patent/DK0450386T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/48—Nerve growth factor [NGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/848—Escherichia
    • Y10S435/849—Escherichia coli

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
DK91104171T 1990-04-06 1991-03-18 Fremstilling af biologisk aktive, rekombinante medlemmer af NGF/BDNF-familien af neurotrope proteiner DK0450386T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50544190A 1990-04-06 1990-04-06
US54775090A 1990-07-02 1990-07-02
US07/594,126 US5235043A (en) 1990-04-06 1990-10-09 Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins

Publications (1)

Publication Number Publication Date
DK0450386T3 true DK0450386T3 (da) 2000-03-06

Family

ID=27414291

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91104171T DK0450386T3 (da) 1990-04-06 1991-03-18 Fremstilling af biologisk aktive, rekombinante medlemmer af NGF/BDNF-familien af neurotrope proteiner

Country Status (17)

Country Link
US (1) US5235043A (de)
EP (1) EP0450386B1 (de)
JP (1) JP2521851B2 (de)
KR (1) KR910018545A (de)
AT (1) ATE183232T1 (de)
AU (1) AU651339B2 (de)
CA (1) CA2038669C (de)
DE (1) DE69131514T2 (de)
DK (1) DK0450386T3 (de)
ES (1) ES2140379T3 (de)
FI (1) FI108146B (de)
GR (1) GR3031632T3 (de)
IE (1) IE910827A1 (de)
IL (1) IL97602A (de)
NO (1) NO308308B1 (de)
NZ (1) NZ237544A (de)
TW (1) TW206258B (de)

Families Citing this family (53)

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US5229500A (en) * 1989-08-30 1993-07-20 Regeneron Pharmaceuticals, Inc. Brain derived neurotrophic factor
US5180820A (en) * 1989-08-30 1993-01-19 Barde Yves Alain Brain-derived neurotrophic factor
US5986070A (en) * 1990-04-06 1999-11-16 Amgen Inc. Production of biologically active NGF proteins
US5606031A (en) * 1990-04-06 1997-02-25 Lile; Jack Production and purification of biologically active recombinant neurotrophic protein in bacteria
AU664021B2 (en) * 1990-09-05 1995-11-02 Natinco Nv Solubilization of proteins in active forms
US5530109A (en) * 1991-04-10 1996-06-25 Ludwig Institute For Cancer Research DNA encoding glial mitogenic factors
PT100580A (pt) * 1991-06-12 1993-09-30 Regeneron Pharma Producao e recuperacao de neurotrofinas recombinantes
US5389529A (en) * 1991-06-12 1995-02-14 Regeneron Pharmaceuticals, Inc. Modified lamβ signal sequence and processes for producing recombinant neurotrophins
DE4139000A1 (de) * 1991-11-27 1993-06-03 Boehringer Mannheim Gmbh Verfahren zur gentechnologischen herstellung von biologisch aktivem ss-ngf
US5488099A (en) * 1992-03-06 1996-01-30 Persson, Deceased; Hakan B. Multifunctional chimeric neurotrophic factors
US5316921A (en) * 1992-05-18 1994-05-31 Genentech, Inc. Single-chain hepatocyte growth factor variants
WO1993023541A1 (en) * 1992-05-18 1993-11-25 Genentech, Inc. Hepatocyte growth factor variants
US5328837A (en) * 1992-05-18 1994-07-12 Genentech, Inc. Hepatocyte growth factor protease domain variants
ATE206056T1 (de) * 1992-06-08 2001-10-15 Takeda Chemical Industries Ltd Therapeutisches agens für neutropenie
US5364645A (en) * 1992-10-30 1994-11-15 The Regents Of The University Of California Method of controlling microorganisms by pulsed ultraviolet laser radiation
ATE163006T1 (de) * 1993-06-01 1998-02-15 Ono Pharmaceutical Co Pentansäurederivate
EP0724598B1 (de) * 1993-10-18 1999-01-13 Regeneron Pharmaceuticals, Inc. Heterodimere der wachstumsfaktoren
US5470719A (en) * 1994-03-18 1995-11-28 Meng; Shi-Yuan Modified OmpA signal sequence for enhanced secretion of polypeptides
US5739307A (en) * 1995-08-28 1998-04-14 Washington University Polynucleotide encoding neurturin neurotrophic factor
US6743628B1 (en) 1995-08-28 2004-06-01 Washington University Method of cell culture using neurturin
US5607711A (en) * 1995-11-01 1997-03-04 The Regents Of The University Of California Method of controlling insects and mites with pulsed ultraviolet light
US5859311A (en) * 1995-11-27 1999-01-12 University Of Kentucky Research Foundation Transgenic mice which overexpress neurotrophin-3 (NT-3) and methods of use
US6716600B1 (en) 1996-03-14 2004-04-06 Washington University Persephin and related growth factors
US6222022B1 (en) 1996-03-14 2001-04-24 Washington University Persephin and related growth factors
EP0886651B1 (de) * 1996-03-14 2005-01-26 Washington University Persephin und verwandte wachstumsfaktoren
JP3288720B2 (ja) * 1996-06-11 2002-06-04 ロシュ ダイアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング 変性タンパク質の活性化方法
US5910435A (en) * 1996-07-25 1999-06-08 Wisconsin Alumni Research Foundation Method of folding proteins with synthetic dithiol catalysts
PL191400B1 (pl) * 1996-11-15 2006-05-31 Genentech Inc Sposób izolowania neurotrofiny z mieszaniny białek i kompozycja neurotrofiny
US6042579A (en) * 1997-04-30 2000-03-28 Medtronic, Inc. Techniques for treating neurodegenerative disorders by infusion of nerve growth factors into the brain
US7495087B2 (en) 1997-07-14 2009-02-24 Bolder Biotechnology, Inc. Cysteine muteins in the C-D loop of human interleukin-11
WO2000042175A1 (en) * 1999-01-14 2000-07-20 Bolder Biotechnology Inc. Methods for making proteins containing free cysteine residues
WO1999003887A1 (en) 1997-07-14 1999-01-28 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins
ES2213861T3 (es) * 1998-10-09 2004-09-01 Scil Proteins Gmbh Procedimiento de obtencion de ngf-beta activa.
EP1126869B1 (de) * 1998-10-28 2008-09-03 Cornell Research Foundation, Inc. Methoden zur regulierung der angiogenese und vaskuläre integrität mittels trk rezeptor liganden bdnf, nt-3 und nt-4
US6329136B1 (en) 1998-10-30 2001-12-11 The Regents Of The University Of California Method for laser inactivation of infectious agents
US6545127B1 (en) * 1999-06-28 2003-04-08 Oklahoma Medical Research Foundation Catalytically active recombinant memapsin and methods of use thereof
US20020049303A1 (en) * 1999-06-28 2002-04-25 Tang Jordan J. N. Catalytically active recombinant memapsin and methods of use thereof
WO2001011085A2 (en) * 1999-08-11 2001-02-15 Whitehead Institute For Biomedical Research Bdnf polymorphism and association with bipolar disorder
US7223406B2 (en) * 2000-07-21 2007-05-29 The Regents Of The University Of California Methods and compositions for preventing and treating male erectile dysfunction and female sexual arousal disorder
WO2002007757A2 (en) * 2000-07-21 2002-01-31 Lue Tom F Prevention and treatment of sexual arousal disorders
US20040121947A1 (en) * 2000-12-28 2004-06-24 Oklahoma Medical Research Foundation Compounds which inhibit beta-secretase activity and methods of use thereof
EP1233075A3 (de) * 2001-02-15 2003-01-08 Whitehead Institute For Biomedical Research BDNF Polymorphismus und Vereinigung mit doppelpoliger Geistesgestörtheit
US20030232365A1 (en) * 2001-02-15 2003-12-18 Whitehead Institute For Biomedical Research BDNF polymorphisms and association with bipolar disorder
US20060234944A1 (en) * 2001-10-23 2006-10-19 Oklahoma Medical Reseach Foundation Beta-secretase inhibitors and methods of use
WO2003039454A2 (en) * 2001-10-23 2003-05-15 Oklahoma Medical Research Foundation Beta-secretase inhibitors and methods of use
US20030219696A1 (en) * 2002-05-23 2003-11-27 Moreland Gerald W. Method and apparatus for preventing backflow in dental saliva evacuators
JP2005305107A (ja) * 2004-03-25 2005-11-04 Sei Matsuoka 価値的情報値の測定装置およびこれを使用した測定方法
EP1922083A2 (de) * 2005-08-10 2008-05-21 Oklahoma Medical Research Foundation Trunkiertes memapsin 2 für die behandlung von morbus alzheimer
WO2008002572A2 (en) * 2006-06-27 2008-01-03 The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services Method for measuring mature brain derived neurotrophic factor
IT1394596B1 (it) * 2008-09-30 2012-07-05 Fond Parco Tecnologico Padano Produzione di ngf in pianta.
EP2594295A1 (de) 2011-11-16 2013-05-22 Servicio Andaluz De Salud Nervenimplantat basierend auf einem kompaktierten, zellhaltigen Biomaterial
GB201804641D0 (en) * 2018-03-22 2018-05-09 Inivata Ltd Methods of sequencing nucleic acids and error correction of sequence reads
IT202000032423A1 (it) 2020-12-24 2022-06-24 Univ Degli Studi Di Trieste Metodo per la produzione di forme processate proteoliticamente di fattori trofici o fattori di crescita

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US4599197A (en) * 1982-12-22 1986-07-08 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4512922A (en) * 1982-12-22 1985-04-23 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4511503A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4511502A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
DK161152C (da) * 1983-03-03 1991-11-11 Genentech Inc Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat
US4766205A (en) * 1985-11-13 1988-08-23 Beatrice Companies, Inc. Method for isolation of recombinant polypeptides in biologically active forms
US4929700A (en) * 1987-04-16 1990-05-29 Cetus Corporation Production of purified, biologically active, bacterially produced recombinant human CSF-1
IT1219874B (it) * 1988-03-18 1990-05-24 Fidia Farmaceutici Utilizzazione del fattore di crescita nervoso umano e sue composizioni farmaceutiche
US6709837B1 (en) * 1989-03-10 2004-03-23 Takeda Chemical Industries, Inc. Polypeptide and production thereof
US5180820A (en) * 1989-08-30 1993-01-19 Barde Yves Alain Brain-derived neurotrophic factor
JPH05161493A (ja) * 1989-08-30 1993-06-29 Max Planck Ges Foerderung Wissenschaft Ev ニューロトロフィン―３
US5229500A (en) * 1989-08-30 1993-07-20 Regeneron Pharmaceuticals, Inc. Brain derived neurotrophic factor
IL95511A (en) * 1989-08-30 2000-10-31 Max Planck Gesellschaft Neurotrophin-3 a novel neurotrophic factor related to nerve growth and brain derived neurotrophic factor

Also Published As

Publication number Publication date
DE69131514T2 (de) 2000-05-04
NO308308B1 (no) 2000-08-28
NO911303D0 (no) 1991-04-03
ES2140379T3 (es) 2000-03-01
EP0450386A2 (de) 1991-10-09
CA2038669A1 (en) 1991-10-07
KR910018545A (ko) 1991-11-30
IL97602A0 (en) 1992-06-21
AU7413091A (en) 1991-11-14
FI911643A0 (fi) 1991-04-05
DE69131514D1 (de) 1999-09-16
AU651339B2 (en) 1994-07-21
IE910827A1 (en) 1991-10-09
GR3031632T3 (en) 2000-01-31
JPH06319549A (ja) 1994-11-22
EP0450386A3 (en) 1992-09-09
FI108146B (fi) 2001-11-30
IL97602A (en) 2005-08-31
JP2521851B2 (ja) 1996-08-07
TW206258B (de) 1993-05-21
CA2038669C (en) 2004-06-29
NZ237544A (en) 1993-07-27
ATE183232T1 (de) 1999-08-15
NO911303L (no) 1991-10-07
FI911643A (fi) 1991-10-07
EP0450386B1 (de) 1999-08-11
US5235043A (en) 1993-08-10

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