ATE178484T1 - Protein enthaltende stabilisierte formulierung und dosierungskit - Google Patents

Protein enthaltende stabilisierte formulierung und dosierungskit

Info

Publication number
ATE178484T1
ATE178484T1 AT95401012T AT95401012T ATE178484T1 AT E178484 T1 ATE178484 T1 AT E178484T1 AT 95401012 T AT95401012 T AT 95401012T AT 95401012 T AT95401012 T AT 95401012T AT E178484 T1 ATE178484 T1 AT E178484T1
Authority
AT
Austria
Prior art keywords
protein containing
stabilized formulation
containing stabilized
dosage kit
kit
Prior art date
Application number
AT95401012T
Other languages
English (en)
Inventor
Alain Bayol
Thierry Breul
Patrice Dupin
Philippe Faure
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Application granted granted Critical
Publication of ATE178484T1 publication Critical patent/ATE178484T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AT95401012T 1994-05-04 1995-05-02 Protein enthaltende stabilisierte formulierung und dosierungskit ATE178484T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9405486A FR2719479B1 (fr) 1994-05-04 1994-05-04 Formulation stable lyophilisée comprenant une protéine: kit de dosage.

Publications (1)

Publication Number Publication Date
ATE178484T1 true ATE178484T1 (de) 1999-04-15

Family

ID=9462880

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95401012T ATE178484T1 (de) 1994-05-04 1995-05-02 Protein enthaltende stabilisierte formulierung und dosierungskit

Country Status (25)

Country Link
US (1) US5763409A (de)
EP (1) EP0682944B1 (de)
JP (1) JP2948125B2 (de)
KR (1) KR100273053B1 (de)
CN (1) CN1088583C (de)
AT (1) ATE178484T1 (de)
AU (1) AU694763B2 (de)
CA (1) CA2148537C (de)
CZ (1) CZ286195B6 (de)
DE (1) DE69508837T2 (de)
DK (1) DK0682944T3 (de)
ES (1) ES2131781T3 (de)
FI (1) FI117321B (de)
FR (1) FR2719479B1 (de)
GR (1) GR3030146T3 (de)
HU (1) HU220220B (de)
IL (1) IL113578A (de)
MX (1) MX9502034A (de)
NO (1) NO320364B1 (de)
NZ (1) NZ272045A (de)
PL (1) PL179240B1 (de)
RU (1) RU2136306C1 (de)
SI (1) SI0682944T1 (de)
TW (1) TW397687B (de)
ZA (1) ZA953596B (de)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6685940B2 (en) * 1995-07-27 2004-02-03 Genentech, Inc. Protein formulation
CA2226575C (en) * 1995-07-27 2011-10-18 Genentech, Inc. Stabile isotonic lyophilized protein formulation
ZA966075B (en) * 1995-07-27 1998-01-19 Genentech Inc Protein formulation.
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
DE19539574A1 (de) * 1995-10-25 1997-04-30 Boehringer Mannheim Gmbh Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren
FR2740686B1 (fr) 1995-11-03 1998-01-16 Sanofi Sa Formulation pharmaceutique lyophilisee stable
EP0852951A1 (de) * 1996-11-19 1998-07-15 Roche Diagnostics GmbH Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern
FR2768341B1 (fr) 1997-09-18 2000-04-14 Lab Francais Du Fractionnement Composition pharmaceutique placebo lyophilisable destinee a imiter un medicament, notamment a base de proteines ou de polypeptides
EP0913178A1 (de) * 1997-11-03 1999-05-06 Boehringer Mannheim Gmbh Verfahren zur Herstellung trockener, amorpher Produkte enthaltend biologisch aktive Materialen mittels Konvektionstrocknung und die erhaltenen Produkte
EP0913177A1 (de) * 1997-11-03 1999-05-06 Roche Diagnostics GmbH Verfahren zur Herstellung trockener, amorpher Produkte enthaltend biologisch aktive Materialien mittels Konvektionstrocknung, insbesondere Sprühtrocknung
AU2945199A (en) * 1998-03-18 1999-10-11 Ronai, Peter Amorphous glasses for stabilising sensitive products
CA2634663C (en) * 1999-02-22 2009-08-25 University Of Connecticut Novel albumin-free factor viii formulations
IL149355A0 (en) * 1999-10-28 2002-11-10 Inst Neftechimicheskogo Sintez Polypeptide corporation
US6653062B1 (en) 2000-07-26 2003-11-25 Wisconsin Alumni Research Foundation Preservation and storage medium for biological materials
HU228583B1 (en) * 2000-11-07 2013-04-29 Novartis Vaccines & Diagnostic Stabilized interferon compositions
US6887462B2 (en) * 2001-04-09 2005-05-03 Chiron Corporation HSA-free formulations of interferon-beta
JP2005508220A (ja) * 2001-10-24 2005-03-31 パーリ・ゲーエムベーハー 薬用組成物調製用具
AU2003234382B2 (en) 2002-05-13 2010-07-08 Becton, Dickinson And Company Protease inhibitor sample collection system
US6803046B2 (en) * 2002-08-16 2004-10-12 Bracco International B.V. Sincalide formulations
EP1589949B1 (de) * 2003-01-08 2008-08-13 Novartis Vaccines and Diagnostics, Inc. Stabilisierte lyophilisierte zubereitungen mit gewebefaktor-inhibitor (tfpi) oder varianten des gewebefaktor-inhibitors
GB0304636D0 (en) * 2003-02-28 2003-04-02 Britannia Pharmaceuticals Ltd Pharmaceutical composition for nasal delivery
AU2004229335C1 (en) * 2003-04-04 2010-06-17 Genentech, Inc. High concentration antibody and protein formulations
DE10333317A1 (de) * 2003-07-22 2005-02-17 Biotecon Therapeutics Gmbh Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA)
GB0404586D0 (en) * 2004-03-01 2004-04-07 Britannia Pharmaceuticals Ltd Improvements in or relating to organic materials
US11229746B2 (en) 2006-06-22 2022-01-25 Excelsior Medical Corporation Antiseptic cap
CA2668834C (en) 2006-11-07 2016-10-11 Sanofi Pasteur Biologics Co. Stabilization of vaccines by lyophilization
US7951368B2 (en) * 2007-06-25 2011-05-31 Amgen Inc. Compositions of specific binding agents to hepatocyte growth factor
GB0715285D0 (en) * 2007-08-06 2007-09-12 Britannia Pharmaceuticals Ltd Improvements in or relating to powdered medicaments for nasal delivery
US9078992B2 (en) 2008-10-27 2015-07-14 Pursuit Vascular, Inc. Medical device for applying antimicrobial to proximal end of catheter
EP2385825B1 (de) 2008-11-07 2018-10-10 University of Connecticut Faktor-viii-formulierungen
MX2011005672A (es) * 2008-11-28 2011-06-20 Abbott Lab Composiciones de anticuerpo estables y metodos para estabilizar a las mismas.
PT2496246T (pt) * 2009-11-03 2018-07-31 Grifols Therapeutics Llc Composição, método e kit para o inibidor da alfa-1 protease
SG181628A1 (en) * 2009-12-22 2012-07-30 Celldex Therapeutics Inc Vaccine compositions
RU2448156C1 (ru) * 2011-03-17 2012-04-20 Эспосито Трейдинг Лтд Способ получения лиофилизированной субстанции
RU2448158C1 (ru) * 2011-03-24 2012-04-20 Эспосито Трейдинг Лтд Способ получения препарата фортелизин, обладающего фибринолитическими свойствами, и его применение для лечения инфаркта миокарда
US10166381B2 (en) 2011-05-23 2019-01-01 Excelsior Medical Corporation Antiseptic cap
ES2797649T3 (es) 2011-07-12 2020-12-03 Icu Medical Inc Dispositivo para entrega de agente antimicrobiano en un catéter transdérmico
EP2760998B1 (de) * 2011-11-22 2017-02-01 Siemens Healthcare Diagnostics Inc. Vorrichtungen mit vewendung von trockenreagenzien zur rekonstitution als kalibrier- und/oder qualitätskontrolllösungen sowie verfahren zu ihrer herstellung und verwendung
US20140017318A1 (en) * 2012-07-10 2014-01-16 Kevin O'Connell Method to produce a medicinal product comprising a biologically active protein and the resulting product
US9314519B2 (en) 2012-08-21 2016-04-19 Intervet Inc. Liquid stable virus vaccines
US9393298B2 (en) 2013-03-15 2016-07-19 Intervet Inc. Liquid stable bovine virus vaccines
US9480739B2 (en) 2013-03-15 2016-11-01 Intervet Inc. Bovine virus vaccines that are liquid stable
BR112016006455A2 (pt) 2013-09-27 2017-08-01 Hanmi Pharm Ind Co Ltd ?formulação de conjugado de hormônio de crescimento humano de ação prolongada?
AR097762A1 (es) 2013-09-27 2016-04-13 Intervet Int Bv Formulaciones secas de vacunas que son estables a temperatura ambiente
AR099470A1 (es) 2014-02-17 2016-07-27 Intervet Int Bv Vacunas de virus de aves de corral líquidas
TWI670085B (zh) 2014-02-19 2019-09-01 荷蘭商英特威國際公司 液體穩定之豬病毒疫苗
AU2015252808B2 (en) 2014-05-02 2019-02-21 Excelsior Medical Corporation Strip package for antiseptic cap
WO2016182822A1 (en) 2015-05-08 2016-11-17 Icu Medical, Inc. Medical connectors configured to receive emitters of therapeutic agents
WO2016201202A1 (en) 2015-06-11 2016-12-15 Attwill Medical Solutions Inc. Medical devices, systems, and methods utilizing antithrombin-heparin compositions
EP4194043A1 (de) 2016-10-14 2023-06-14 ICU Medical, Inc. Desinfektionskappen fur medizinische konnektoren
WO2018204206A2 (en) 2017-05-01 2018-11-08 Icu Medical, Inc. Medical fluid connectors and methods for providing additives in medical fluid lines
US11110063B2 (en) 2017-08-25 2021-09-07 MAIA Pharmaceuticals, Inc. Storage stable sincalide formulations
US11534595B2 (en) 2018-11-07 2022-12-27 Icu Medical, Inc. Device for delivering an antimicrobial composition into an infusion device
US11541220B2 (en) 2018-11-07 2023-01-03 Icu Medical, Inc. Needleless connector with antimicrobial properties
US11400195B2 (en) 2018-11-07 2022-08-02 Icu Medical, Inc. Peritoneal dialysis transfer set with antimicrobial properties
US11517732B2 (en) 2018-11-07 2022-12-06 Icu Medical, Inc. Syringe with antimicrobial properties
US11541221B2 (en) 2018-11-07 2023-01-03 Icu Medical, Inc. Tubing set with antimicrobial properties
AU2019384564B2 (en) 2018-11-21 2023-11-23 Icu Medical, Inc. Antimicrobial device comprising a cap with ring and insert
JP2024500319A (ja) 2020-12-07 2024-01-09 アイシーユー・メディカル・インコーポレーテッド 腹膜透析キャップ、システム、及び方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5822445B2 (ja) * 1982-07-08 1983-05-09 株式会社 ミドリ十字 安定な固体の人血漿コリンエステラ−ゼ製剤の製法
JPS6197229A (ja) * 1984-10-18 1986-05-15 Chugai Pharmaceut Co Ltd 安定なエリトロポエチン製剤
US5037644A (en) * 1986-10-27 1991-08-06 Cetus Corporation Pharmaceutical compositions of recombinant interleukin-2 and formulation processes
DE3729863A1 (de) * 1987-09-05 1989-03-16 Boehringer Mannheim Gmbh Stabilisierte erythropoietin-lyophilisate
US5266310A (en) * 1987-09-17 1993-11-30 Boehringer Ingelheim International Gmbh Stabilization of therapeutically active proteins in pharmaceutical preparations
US5096885A (en) * 1988-04-15 1992-03-17 Genentech, Inc. Human growth hormone formulation
JPH0296536A (ja) * 1988-09-29 1990-04-09 Green Cross Corp:The プラスミノゲン乾燥製剤
KR900701310A (ko) * 1988-11-14 1990-12-01 오스카 아끼히꼬 인터페론 경비투여용 제제
EP0437662B1 (de) * 1990-01-18 1994-09-14 Cereria Amos Sgarbi S.P.A. Grablicht
US5192743A (en) * 1992-01-16 1993-03-09 Genentech, Inc. Reconstitutable lyophilized protein formulation
SE9201073D0 (sv) * 1992-04-03 1992-04-03 Kabi Pharmacia Ab Protein formulation
DE4239877C1 (de) * 1992-11-27 1994-03-17 Boehringer Ingelheim Int Stabilisierte Superoxid-Dismutase (SOD)-Zusammensetzung

Also Published As

Publication number Publication date
AU1777495A (en) 1995-11-16
CZ286195B6 (cs) 2000-02-16
HU9501276D0 (en) 1995-06-28
HU220220B (hu) 2001-11-28
RU2136306C1 (ru) 1999-09-10
SI0682944T1 (en) 1999-08-31
FI952119A0 (fi) 1995-05-03
KR100273053B1 (ko) 2000-12-01
CA2148537A1 (en) 1995-11-05
IL113578A (en) 1999-10-28
IL113578A0 (en) 1995-08-31
EP0682944A1 (de) 1995-11-22
NZ272045A (en) 1996-02-27
CN1116522A (zh) 1996-02-14
NO320364B1 (no) 2005-11-28
KR950031103A (ko) 1995-12-18
NO951724L (no) 1995-11-06
AU694763B2 (en) 1998-07-30
CZ108195A3 (en) 1996-02-14
DE69508837T2 (de) 1999-11-04
CA2148537C (en) 2002-07-16
US5763409A (en) 1998-06-09
HUT72325A (en) 1996-04-29
PL308416A1 (en) 1995-11-13
FI117321B (fi) 2006-09-15
JP2948125B2 (ja) 1999-09-13
GR3030146T3 (en) 1999-08-31
FI952119L (fi) 1995-11-05
DE69508837D1 (de) 1999-05-12
ZA953596B (en) 1996-11-04
FR2719479A1 (fr) 1995-11-10
PL179240B1 (pl) 2000-08-31
TW397687B (en) 2000-07-11
JPH0853361A (ja) 1996-02-27
DK0682944T3 (da) 1999-10-18
FR2719479B1 (fr) 1996-07-26
NO951724D0 (no) 1995-05-03
MX9502034A (es) 1997-02-28
EP0682944B1 (de) 1999-04-07
ES2131781T3 (es) 1999-08-01
CN1088583C (zh) 2002-08-07

Similar Documents

Publication Publication Date Title
DE69508837D1 (de) Protein enthaltende stabilisierte Formulierung und Dosierungskit
HRP20000181B1 (en) 2-methyl-thieno-benzodiazepine formulation
IT1227154B (it) Composizioni farmaceutiche per uso ginecologico a base di lattobacilli
SE8903042L (sv) Pharmaceutical compositions comprising cyklosporins
DE68924540D1 (de) Medizinische Aerosolformulierungen.
ATA27290A (de) Neue cyclosporin enthaltende galenische formulierungen
NO985981D0 (no) Insulinpreparater som inneholder NaCl
NO921256D0 (no) Aminosyre-beta-lyaseenzyminhibitor som deodoranter
SV1998000040A (es) Composiciones farmaceuticas ref. pu3210/sv
DE69009795D1 (de) Muramylpeptid-Derivate und diese enthaltende immunregulierende Zusammensetzungen.
ITMI911604A1 (it) Procedimento per la preparazione della n- (2, 6-diclorofenil) -n-fenil-n-(cloroacetil)-ammina.
DK0626173T3 (da) Aerosolpræparat indeholdende fusafungin
ATE80143T1 (de) Isomere formyl-trimethylbicyclo(2,2,2)oct-7-ene.
ATE119940T1 (de) Gewebs-plasminogen-aktivator-derivat.
RU96106995A (ru) Свечи с лидазой
DE69002027D1 (de) (3-diethylaminopropyl)-1-amino-5-methyldipyrido(4,3-b)(3,4-f)indoltrihydrochlorid.
ATE62593T1 (de) Physiologisch wirksame und naehrende zusammensetzung.
IT1230571B (it) Procedimento per la preparazione di formulazioni antiacido ad azione protratta e formulazioni cosi'ottenute.
IT215496Z2 (it) Gioco di pazienza ed abilita'.
ATE82855T1 (de) 2',3'-dideoxypurinnucleosid/purinnucleosidphosphorylase-inhibitor kombinationstherapie und zusammensetzungen dafuer.
IT8620976A0 (it) Composizione farmaceutica a base di n-acil-fosfatidiletanolammina, procedimento per la preparazione della stessa, specialita'farmaceutica e uso della stessa.