ATE169930T1 - Steroidderivate, pharmazeutische zusammensetzungen die sie enthalten und ihre verwendung als antibiotika oder desinfektionsmittel - Google Patents
Steroidderivate, pharmazeutische zusammensetzungen die sie enthalten und ihre verwendung als antibiotika oder desinfektionsmittelInfo
- Publication number
- ATE169930T1 ATE169930T1 AT94911470T AT94911470T ATE169930T1 AT E169930 T1 ATE169930 T1 AT E169930T1 AT 94911470 T AT94911470 T AT 94911470T AT 94911470 T AT94911470 T AT 94911470T AT E169930 T1 ATE169930 T1 AT E169930T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- alpha
- side chain
- disinfectants
- antibiotic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2901893A | 1993-03-10 | 1993-03-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE169930T1 true ATE169930T1 (de) | 1998-09-15 |
Family
ID=21846774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT94911470T ATE169930T1 (de) | 1993-03-10 | 1994-03-10 | Steroidderivate, pharmazeutische zusammensetzungen die sie enthalten und ihre verwendung als antibiotika oder desinfektionsmittel |
Country Status (9)
Country | Link |
---|---|
US (3) | US5637691A (de) |
EP (1) | EP0688333B1 (de) |
JP (1) | JP3546886B2 (de) |
AT (1) | ATE169930T1 (de) |
CA (1) | CA2157594A1 (de) |
DE (1) | DE69412596T2 (de) |
DK (1) | DK0688333T3 (de) |
ES (1) | ES2123133T3 (de) |
WO (1) | WO1994020520A1 (de) |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2123133T3 (es) * | 1993-03-10 | 1999-01-01 | Magainin Pharma | Derivados esteroidianos, composiciones farmaceuticas que contienen estos derivados esteroidianos y utilizacion de estos ultimos como antibioticos o desinfectantes. |
US5840740A (en) * | 1995-06-07 | 1998-11-24 | Magainin Pharmaceuticals Inc. | Aminosterol compounds and a method of treating infection using the aminosterol compounds |
US5856535A (en) * | 1994-08-18 | 1999-01-05 | Magainin Pharmaceuticals, Inc. | Aminosterol ester compounds |
US5767099A (en) * | 1994-12-09 | 1998-06-16 | Genzyme Corporation | Cationic amphiphiles containing amino acid or dervatized amino acid groups for intracellular delivery of therapeutic molecules |
US5719131A (en) * | 1994-12-09 | 1998-02-17 | Genzyme Corporation | Cationic amphiphiles containing dialkylamine lipophilic groups for intracellular delivery of therapeutic molecules |
US5840710A (en) * | 1994-12-09 | 1998-11-24 | Genzyme Corporation | Cationic amphiphiles containing ester or ether-linked lipophilic groups for intracellular delivery of therapeutic molecules |
US5948767A (en) * | 1994-12-09 | 1999-09-07 | Genzyme Corporation | Cationic amphiphile/DNA complexes |
US6331524B1 (en) | 1994-12-09 | 2001-12-18 | Genzyme Corporation | Organ-specific targeting of cationic amphiphile / DNA complexes for gene therapy |
US5650096A (en) * | 1994-12-09 | 1997-07-22 | Genzyme Corporation | Cationic amphiphiles for intracellular delivery of therapeutic molecules |
US6071890A (en) * | 1994-12-09 | 2000-06-06 | Genzyme Corporation | Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy |
US6383814B1 (en) | 1994-12-09 | 2002-05-07 | Genzyme Corporation | Cationic amphiphiles for intracellular delivery of therapeutic molecules |
US5910487A (en) * | 1994-12-09 | 1999-06-08 | Genzyme Corporation | Cationic amphiphiles and plasmids for intracellular delivery of therapeutic molecules |
US5747471A (en) * | 1994-12-09 | 1998-05-05 | Genzyme Corporation | Cationic amphiphiles containing steroid lipophilic groups for intracellular delivery of therapeutic molecules |
US5795885A (en) * | 1995-06-07 | 1998-08-18 | Magainin Pharmaceuticals Inc. | Method of inhibiting profileration of cells by administering an aminosterol compound |
US5874597A (en) * | 1995-06-07 | 1999-02-23 | Magainin Pharmaceuticals, Inc. | Certain aminosterol compounds and pharmaceutical compositions including these compounds |
US6143738A (en) * | 1995-06-07 | 2000-11-07 | Magainin Pharmaceuticals, Inc. | Therapeutic uses for an aminosterol compound |
EP0832094B1 (de) * | 1995-06-07 | 2004-02-11 | Genaera Corporation | Aminosterinverbindungen als inhibitoren der natrium/proton-pump, pharmazeutische methoden und präparaten davon |
US5792635A (en) * | 1995-06-07 | 1998-08-11 | Magainin Pharmaceuticals, Inc. | Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine |
US5840936A (en) * | 1995-06-07 | 1998-11-24 | Magainin Pharmaceuticals Inc. | Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE) |
US5763430A (en) * | 1995-06-07 | 1998-06-09 | Magainin Pharmaceuticals Inc. | Method of treating a viral infection by administering a steroid compound |
US5847172A (en) * | 1995-06-07 | 1998-12-08 | Magainin Pharmaceuticals Inc. | Certain aminosterol compounds and pharmaceutical compositions including these compounds |
US5994336A (en) * | 1995-06-07 | 1999-11-30 | Magainin Pharmaceuticals Inc. | Method of inhibiting proliferation of cells by administering an aminosterol compound |
FR2744453B1 (fr) * | 1996-02-05 | 1998-07-10 | Transgene Sa | Composes lipopolyamines, compositions pharmaceutiques en comprenant, vecteurs de transfert d'acide nucleique et procede de preparation |
US6596712B2 (en) | 1996-04-26 | 2003-07-22 | Genaera Corporation | Treatment of carcinomas using squalamine in combination with other anti-cancer agents or modalities |
JP2000510460A (ja) * | 1996-04-26 | 2000-08-15 | マゲイニン・ファーマシューティカルズ・インコーポレーテッド | スクアラミンを他の抗癌剤と併用する上皮性悪性腫瘍の治療 |
US7410959B1 (en) | 2000-07-13 | 2008-08-12 | Genaera Corporation | Therapeutic uses for aminosterol compounds |
AU2911197A (en) * | 1996-05-24 | 1998-01-05 | Imperial College Of Science, Technology And Medicine | Polycationic sterol derivatives as transfection agents |
US5935936A (en) * | 1996-06-03 | 1999-08-10 | Genzyme Corporation | Compositions comprising cationic amphiphiles and co-lipids for intracellular delivery of therapeutic molecules |
US6262283B1 (en) | 1996-12-06 | 2001-07-17 | Magainin Pharmaceuticals Inc. | Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds |
US5925628A (en) * | 1997-03-31 | 1999-07-20 | Genzyme Corporation | Cationic amphiphiles for intracellular delivery of therapeutic molecules |
US5912239A (en) * | 1997-04-04 | 1999-06-15 | Genzyme Corporation | Imidazole-containing cationic amphiphiles for intracellular delivery of therapeutic molecules |
US5948925A (en) * | 1997-05-06 | 1999-09-07 | Genzyme Corporation | Cationic amphiphiles containing linkers derived from neutral or positively charged amino acids |
US5952516A (en) * | 1997-05-08 | 1999-09-14 | Genzyme Corporation | Cationic amphiphiles containing multiplesteroid lipophilic groups |
US5942634A (en) * | 1997-05-09 | 1999-08-24 | Genzyme Corporation | Cationic amphiphiles for cell transfections |
US6350738B1 (en) | 1998-03-06 | 2002-02-26 | Brigham Young University | Steroid derived antibiotics |
US6767904B2 (en) | 1998-03-06 | 2004-07-27 | Bringham Young University | Steroid derived antibiotics |
CA2322847C (en) * | 1998-03-06 | 2008-05-13 | Brigham Young University | Steroid derived antibiotics |
CA2330611A1 (en) | 1998-05-22 | 1999-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and therapies based thereon |
DE69937301T2 (de) | 1998-08-12 | 2008-08-14 | Genaera Corp. | Aminosterolderivate und ihre verwendungen |
EP1119361A4 (de) * | 1998-09-10 | 2006-10-04 | Magainin Pharma | Behandlung von karzinomen mit squalamin in kombination mit anderen anti-tumor-agenzien |
US6537554B1 (en) | 1998-09-10 | 2003-03-25 | Curagen Corporation | Nucleotide sequences and amino acid sequences of secreted proteins involved in angiogenesis |
CA2370821A1 (en) * | 1999-05-01 | 2000-11-09 | Genaera Corporation | Asthma associated factors as targets for treating atopic allergies including asthma and related disorders |
AU2004201177B2 (en) * | 1999-10-14 | 2006-03-30 | Sasol Technology (Pty) Limited | Handling of a Catalyst |
CA2393135C (en) | 1999-12-09 | 2009-06-23 | Genaera Corporation | Asthma associated factors as targets for treating atopic allergies including asthma and related disorders |
EP1274718B1 (de) | 2000-04-12 | 2006-10-18 | Genaera Corporation | Ein verfahren zur herstellung von 7.alpha.-hydroxy 3-aminosubstituierten sterol-verbindungen, ohne schutz der 7.alpha.-hydroxy-gruppe |
MXPA02010645A (es) * | 2000-04-28 | 2004-04-20 | Inflazyme Pharm Ltd | Esteroides de 3-nitrogeno-5, 7-dioxigeno y usos relacionados con los mismos. |
CA2416850A1 (en) * | 2000-09-08 | 2003-01-20 | Kuraray Co., Ltd. | Process for the preparation of pregnane derivatives |
US20030104573A1 (en) * | 2000-09-11 | 2003-06-05 | Shimkets Richard A. | Nucleotide sequences and amino acid sequences of secreted proteins involved in angiogenesis |
WO2002027786A1 (fr) * | 2000-09-25 | 2002-04-04 | Ibiden Co., Ltd. | Element semi-conducteur, procede de fabrication d'un element semi-conducteur, carte a circuit imprime multicouche, et procede de fabrication d'une carte a circuit imprime multicouche |
CA2332138A1 (en) * | 2001-01-25 | 2002-07-25 | Michel Roberge | Antiangiogenic compounds and an assay for inhibitors of cell invasion |
JP2004520372A (ja) * | 2001-01-25 | 2004-07-08 | ザ ユニバーシティ オブ ブリティッシュ コロンビア | 抗血管形成性化合物及び細胞浸潤の阻害剤のアッセイ |
WO2002077007A2 (en) * | 2001-03-21 | 2002-10-03 | Leo Pharma A/S | Novel polyaminated fusidic acid derivatives |
ATE445838T1 (de) | 2001-07-25 | 2009-10-15 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
US7557097B2 (en) * | 2004-11-20 | 2009-07-07 | Regents Of The University Of Minnesota | Structural, behavioral characterization, and synthesis of attractants for migratory lamprey |
EP2527355B1 (de) | 2005-04-25 | 2019-02-20 | Enterin, Inc. | Polymorphe und amorphe Salzformen aus Squalamin-Dilactat |
EP2671508B1 (de) | 2005-04-28 | 2020-09-16 | Proteus Digital Health, Inc. | Pharma-Informatiksystem |
JP2009508494A (ja) | 2005-09-16 | 2009-03-05 | ラプトール ファーマシューティカル インコーポレイテッド | Crを含むタンパク質に対して特異的な受容体−結合タンパク質(rap)変異体を含む組成物およびその使用 |
CN100410270C (zh) * | 2005-12-31 | 2008-08-13 | 中山大学 | 胆甾-5-烯-3β,19-二羟基-24-酮及衍生物的合成方法 |
CN100436474C (zh) * | 2005-12-31 | 2008-11-26 | 中山大学 | 胆甾-3β,5α,6β,19-四羟基-24-酮及其衍生物的合成方法 |
AU2007327761A1 (en) * | 2006-12-08 | 2008-06-12 | Jado Technologies Gmbh | Cholesterylamines for the treatment and prevention of infectious diseases |
TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明(cyclopamine)類似物類 |
US9365608B2 (en) | 2007-09-06 | 2016-06-14 | Ohr Pharmaceutical, Inc. | Method for treating diabetes |
CA2710858A1 (en) * | 2007-12-27 | 2009-07-09 | Infinity Pharmaceuticals, Inc. | Methods for stereoselective reduction |
WO2009090063A1 (en) * | 2008-01-16 | 2009-07-23 | Jado Technologies Gmbh | Steroid sapogenin, androstane and triterpenoid sapogenin derivatives for the treatment and prevention of infectious diseases |
CA2725209C (en) | 2008-05-09 | 2016-09-20 | Norbert Beier | Pharmaceutical composition comprising rimeporide for treating diseases associated with insulin resistance and beta-cell dysfunction |
HUE059078T2 (hu) | 2009-02-20 | 2022-10-28 | Enhanx Biopharm Inc | Glutation-alapú hatóanyagszállító rendszer |
JP2012526144A (ja) | 2009-05-06 | 2012-10-25 | ラボラトリー スキン ケア インコーポレイテッド | 活性物質−リン酸カルシウム粒子複合体を含む経皮送達組成物およびその使用方法 |
JP6141015B2 (ja) | 2009-08-05 | 2017-06-07 | インフィニティ ファーマスーティカルズ、インク. | シクロパミン類似体の酵素によるアミノ基転移 |
WO2011056650A2 (en) * | 2009-10-27 | 2011-05-12 | Michael Zasloff | Methods and compositions for treating and preventing viral infections |
JP5147814B2 (ja) * | 2009-11-12 | 2013-02-20 | ブリガム・ヤング・ユニバーシティ | ステロイド由来抗生物質 |
US8623416B2 (en) * | 2009-11-25 | 2014-01-07 | Michael Zasloff | Formulations comprising aminosterols |
US9376447B2 (en) | 2010-09-14 | 2016-06-28 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
EP2649095B1 (de) | 2010-12-10 | 2021-10-06 | Aleksander S. Popel | Aus kollagen des typs iv abgeleitete mimetische peptide und ihre verwendung zur behandlung angiogenese- und lymphangiogenese-vermittelter krankheiten |
FR2981351A1 (fr) | 2011-10-17 | 2013-04-19 | Univ Nice Sophia Antipolis | Derives aminosteroidiens anti-diabetiques |
JP6165843B2 (ja) | 2012-04-20 | 2017-07-19 | オーエイチアール・ファーマシューティカル・インコーポレイテッドOhr Pharmaceutical,Inc. | Ptp1b関連疾患の処置のためのアミノステロイド化合物 |
US10040817B2 (en) | 2013-10-03 | 2018-08-07 | Enterin Laboratories, Inc. | Methods and compositions for stimulation of the intestinal enteroendocrine system for treating diseases or conditions related to the same |
EP3302428A1 (de) | 2015-06-04 | 2018-04-11 | Pellepharm Inc. | Topische formulierungen zur freisetzung von hedgehog-inhibitorverbindungen und verwendung davon |
FR3055801B1 (fr) * | 2016-09-15 | 2020-10-30 | Virbac | Derives esters de squalamine pour le traitement des infections |
MA50094A (fr) | 2017-09-08 | 2020-07-15 | Enterin Inc | Méthodes de traitement des troubles du sommeil, des perturbations du sommeil et de symptômes associés à l'aide de compositions d'aminostérol |
CN108445236B (zh) * | 2018-02-07 | 2021-04-20 | 深圳市新产业生物医学工程股份有限公司 | 甾体类衍生物和其保存液以及其应用 |
US20220372066A1 (en) * | 2019-08-02 | 2022-11-24 | Enterin, Inc. | Human squalamine derivatives (ent-06), related compositions comprising the same, and method of using the same |
EP4007764A4 (de) * | 2019-08-02 | 2023-08-09 | Enterin, Inc. | Menschliche aminosterin-ent-03-verbindungen, diese enthaltende zusammensetzungen und verfahren zu ihrer verwendung |
EP4121434A4 (de) * | 2020-03-19 | 2024-04-24 | Enterin, Inc. | Kristalline formen von squalamin |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3016390A (en) * | 1960-06-30 | 1962-01-09 | Searle & Co | N-(substituted alkyl) amino-5alpha-androstan-17beta-ols |
US3370070A (en) * | 1965-06-16 | 1968-02-20 | Searle & Co | [n-alkyl-17-(dialkylaminoalkyl)amino] androst-4-en-3-ones |
GB1565351A (en) * | 1975-06-02 | 1980-04-16 | Theramex | Steroid aminoethers |
US4220598A (en) * | 1977-11-14 | 1980-09-02 | Abbott Laboratories | Method and reagents for measuring the level of conjugated bile acids |
US4550163A (en) * | 1979-02-05 | 1985-10-29 | Abbott Laboratories | Ligand analog-irreversible enzyme inhibitor conjugates |
US4372888A (en) * | 1980-08-26 | 1983-02-08 | The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services | Nondenaturing zwitterionic detergents |
JPS5842878B2 (ja) * | 1981-12-02 | 1983-09-22 | 名糖産業株式会社 | 12−オキソコラン酸トシルヒドラゾン化合物、その製法ならびに利用 |
EP0101554B1 (de) * | 1982-07-29 | 1986-10-15 | Lehner A.G. | Gallensäurederivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen |
US4994443A (en) * | 1982-12-20 | 1991-02-19 | The Children's Medical Center Corporation | Inhibition of angiogenesis |
US5001116A (en) * | 1982-12-20 | 1991-03-19 | The Children's Medical Center Corporation | Inhibition of angiogenesis |
IT1221734B (it) * | 1983-02-24 | 1990-07-12 | Schiena Michele Giuseppe Di | Ursodesossicolico solfato acido sale sodico |
US4545938A (en) * | 1983-11-02 | 1985-10-08 | Beth Israel Medical Center | Chemical synthesis |
WO1987002367A2 (en) * | 1985-10-18 | 1987-04-23 | The Upjohn Company | Cyclic hydrocarbons with an aminoalkyl sidechain |
US4771042A (en) * | 1985-11-25 | 1988-09-13 | The Upjohn Company | Inhibition of angiogenesis involving the coadministration of steroids with heparin or heparin fragments |
JPS62175497A (ja) * | 1986-01-28 | 1987-08-01 | Wakunaga Pharmaceut Co Ltd | 胆汁酸誘導体およびその製造法 |
US5075464A (en) * | 1987-04-22 | 1991-12-24 | Merrell Dow Pharmaceuticals Inc. | 17β-(cyclopropylamino)androstene derivatives |
SE8702254D0 (sv) * | 1987-05-29 | 1987-05-29 | Kabivitrum Ab | Novel heparin derivatives |
US5135919A (en) * | 1988-01-19 | 1992-08-04 | Children's Medical Center Corporation | Method and a pharmaceutical composition for the inhibition of angiogenesis |
IT1229570B (it) * | 1989-04-17 | 1991-09-04 | Giuliani Spa | Derivati fluorurati di acidi biliari, loro preparazione e composizioni farmaceutiche che li contengono. |
IT1229569B (it) * | 1989-04-17 | 1991-09-04 | Giuliani Spa | Derivati di acidi biliari, loro preparazione e composizioni farmaceutiche che li contengono. |
JPH07116215B2 (ja) * | 1989-04-19 | 1995-12-13 | エスエス製薬株式会社 | 新規なステロイド化合物 |
PT93847A (pt) * | 1989-04-24 | 1990-11-20 | Harvard College | Processo para a preparacao de oligossacaridos de baixo peso molecular derivados de heparina ou de sulfato de heparano despolimerizados e de composicoes farmaceuticas que os contem |
US4966897A (en) * | 1989-08-15 | 1990-10-30 | Merrell Dow Pharmaceuticals Inc. | 4-substituted 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors |
US5004737A (en) * | 1989-09-22 | 1991-04-02 | Pacific Chemical Co., Ltd. | Quaternary ammonium-substituted sterol derivatives |
EP0466315A3 (en) * | 1990-05-30 | 1992-07-01 | Larrian Gillespie | Compositions containing xylan sulphates for affecting growth factor function and for inhibiting fibroblast proliferation |
WO1991019731A1 (en) * | 1990-06-11 | 1991-12-26 | The Upjohn Company | Steroids which inhibit angiogenesis |
DK0489423T3 (da) * | 1990-12-06 | 1997-04-14 | Hoechst Ag | Galdesyrederivater, fremgangsmåde til deres fremstilling og anvendelsen af disse forbindelser som lægemidler |
US5192756A (en) * | 1992-03-18 | 1993-03-09 | The Children's Hospital Of Pennsylvania | Aminosterol antibiotic |
EP0647133A4 (de) * | 1992-06-12 | 1997-10-29 | Affymax Tech Nv | Zusammensetzungen und verfahren zur verbesserte arzneimittelabgabe. |
WO1994019366A1 (en) * | 1993-02-26 | 1994-09-01 | Magainin Pharmaceuticals Inc. | Chemical synthesis of squalamine |
ES2123133T3 (es) * | 1993-03-10 | 1999-01-01 | Magainin Pharma | Derivados esteroidianos, composiciones farmaceuticas que contienen estos derivados esteroidianos y utilizacion de estos ultimos como antibioticos o desinfectantes. |
-
1994
- 1994-03-10 ES ES94911470T patent/ES2123133T3/es not_active Expired - Lifetime
- 1994-03-10 WO PCT/US1994/002397 patent/WO1994020520A1/en active IP Right Grant
- 1994-03-10 DE DE69412596T patent/DE69412596T2/de not_active Expired - Lifetime
- 1994-03-10 CA CA002157594A patent/CA2157594A1/en not_active Abandoned
- 1994-03-10 JP JP52021294A patent/JP3546886B2/ja not_active Expired - Lifetime
- 1994-03-10 AT AT94911470T patent/ATE169930T1/de not_active IP Right Cessation
- 1994-03-10 EP EP94911470A patent/EP0688333B1/de not_active Expired - Lifetime
- 1994-03-10 DK DK94911470T patent/DK0688333T3/da active
- 1994-03-16 US US08/290,826 patent/US5637691A/en not_active Expired - Lifetime
- 1994-09-13 US US08/416,883 patent/US5733899A/en not_active Expired - Fee Related
-
1995
- 1995-06-07 US US08/478,763 patent/US5721226A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69412596T2 (de) | 1999-03-04 |
CA2157594A1 (en) | 1994-09-15 |
EP0688333B1 (de) | 1998-08-19 |
WO1994020520A1 (en) | 1994-09-15 |
EP0688333A1 (de) | 1995-12-27 |
JP3546886B2 (ja) | 2004-07-28 |
US5637691A (en) | 1997-06-10 |
DK0688333T3 (da) | 1999-02-08 |
ES2123133T3 (es) | 1999-01-01 |
DE69412596D1 (de) | 1998-09-24 |
AU6397494A (en) | 1994-09-26 |
US5733899A (en) | 1998-03-31 |
JPH08507527A (ja) | 1996-08-13 |
US5721226A (en) | 1998-02-24 |
AU692766B2 (en) | 1998-06-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE169930T1 (de) | Steroidderivate, pharmazeutische zusammensetzungen die sie enthalten und ihre verwendung als antibiotika oder desinfektionsmittel | |
DE69429364D1 (de) | Verwendung von steroidderivaten als arzneimittel | |
AU5165393A (en) | Substituted benzylaminoquinuclidines as substance p antagonists | |
AU6226494A (en) | Spiroazacyclic derivatives as substance p antagonists | |
MX9700584A (es) | Agentes para combatir las pestes de la plantas. | |
ES2150353A1 (es) | Tienilazolilalcoxietanaminas, su preparacion y su aplicacion como medicamentos. | |
CA2176935A1 (fr) | Arylpiperazines derivees d'indole comme ligands pour les recepteurs 5 ht1-like 5 ht1b et 5 ht1d | |
IL108259A0 (en) | Piperazine derivates, their preparation and pharmaceutical compositions containing them | |
ES2098023T3 (es) | Compuestos de estructura guanidinica y composiciones farmaceuticas que los contienen. | |
DE69227258D1 (de) | Neue Endothelin-Antagonisten und ihre Herstellung | |
AU2692792A (en) | Oxazolidone derivative | |
IE870207L (en) | Amine derivatives. | |
DE59410304D1 (de) | N-substituierte azabicycloheptan-derivate und ihre verwendung, z.b., als neuroleptika | |
CA2252402A1 (en) | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment | |
ATE170851T1 (de) | Guanidinothiazolederivate und ihre anwendung als h2-rezeptor-antagonisten | |
ZA9480B (en) | Pyrrolidine derivatives their preparation and medicaments containing them | |
ES2041679T3 (es) | Compuestos analgesicos de octohidroindolizinas 5-substituidas y productos intermedios 7-ceto. | |
DE69616357D1 (de) | Benzocycloalken-verbindungen mit bindungsaffinität an den melatonin-rezeptor, ihre herstellung und verwendung | |
ATE167180T1 (de) | Cycloalkylhydroxyharnstoffe und ihre verwendung als lipoxy-genase-inhibitoren | |
DK0420224T3 (da) | Anthihepatopatisk middel | |
AU7582396A (en) | Synthesis of carboxylic acid derivatives | |
DE69427225D1 (de) | 2-nitromethyliden/2-cyanimino/2-nitroimino-pyrrolidine und piperidine, zwischenprodukte und ihre verwendung als pesticide | |
FI955142A (fi) | Bentso(f)kinoksaliinidionijohdannaisia, niiden valmistus ja käyttö lääkkeinä | |
EP0579129A3 (de) | ||
ATE52501T1 (de) | Cyclohexan-1,3-dionderivate, diese enthaltende zusammensetzungen, verfahren zu deren herstellung und deren verwendung als herbizide und pflanzenwachstumsregulatoren. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |