DE69412596D1 - Steroidderivate, pharmazeutische zusammensetzungen die sie enthalten und ihre verwendung als antibiotika oder desinfektionsmittel - Google Patents
Steroidderivate, pharmazeutische zusammensetzungen die sie enthalten und ihre verwendung als antibiotika oder desinfektionsmittelInfo
- Publication number
- DE69412596D1 DE69412596D1 DE69412596T DE69412596T DE69412596D1 DE 69412596 D1 DE69412596 D1 DE 69412596D1 DE 69412596 T DE69412596 T DE 69412596T DE 69412596 T DE69412596 T DE 69412596T DE 69412596 D1 DE69412596 D1 DE 69412596D1
- Authority
- DE
- Germany
- Prior art keywords
- pct
- alpha
- side chain
- disinfectant
- antibiotics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2901893A | 1993-03-10 | 1993-03-10 | |
PCT/US1994/002397 WO1994020520A1 (en) | 1993-03-10 | 1994-03-10 | Steroid derivatives, pharmaceutical compositions containing them, and their use as antibiotics or disinfectants |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69412596D1 true DE69412596D1 (de) | 1998-09-24 |
DE69412596T2 DE69412596T2 (de) | 1999-03-04 |
Family
ID=21846774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69412596T Expired - Lifetime DE69412596T2 (de) | 1993-03-10 | 1994-03-10 | Steroidderivate, pharmazeutische zusammensetzungen die sie enthalten und ihre verwendung als antibiotika oder desinfektionsmittel |
Country Status (9)
Country | Link |
---|---|
US (3) | US5637691A (de) |
EP (1) | EP0688333B1 (de) |
JP (1) | JP3546886B2 (de) |
AT (1) | ATE169930T1 (de) |
CA (1) | CA2157594A1 (de) |
DE (1) | DE69412596T2 (de) |
DK (1) | DK0688333T3 (de) |
ES (1) | ES2123133T3 (de) |
WO (1) | WO1994020520A1 (de) |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0688333T3 (da) * | 1993-03-10 | 1999-02-08 | Magainin Pharma | Steroidderivater, farmaceutiske præparater indeholdende disse og deres anvendelse som antibiotika eller desinfektionsmidler |
US5840740A (en) * | 1995-06-07 | 1998-11-24 | Magainin Pharmaceuticals Inc. | Aminosterol compounds and a method of treating infection using the aminosterol compounds |
US5856535A (en) * | 1994-08-18 | 1999-01-05 | Magainin Pharmaceuticals, Inc. | Aminosterol ester compounds |
US6383814B1 (en) | 1994-12-09 | 2002-05-07 | Genzyme Corporation | Cationic amphiphiles for intracellular delivery of therapeutic molecules |
US5719131A (en) * | 1994-12-09 | 1998-02-17 | Genzyme Corporation | Cationic amphiphiles containing dialkylamine lipophilic groups for intracellular delivery of therapeutic molecules |
US5650096A (en) * | 1994-12-09 | 1997-07-22 | Genzyme Corporation | Cationic amphiphiles for intracellular delivery of therapeutic molecules |
US5948767A (en) * | 1994-12-09 | 1999-09-07 | Genzyme Corporation | Cationic amphiphile/DNA complexes |
US5767099A (en) * | 1994-12-09 | 1998-06-16 | Genzyme Corporation | Cationic amphiphiles containing amino acid or dervatized amino acid groups for intracellular delivery of therapeutic molecules |
US5910487A (en) * | 1994-12-09 | 1999-06-08 | Genzyme Corporation | Cationic amphiphiles and plasmids for intracellular delivery of therapeutic molecules |
US6071890A (en) * | 1994-12-09 | 2000-06-06 | Genzyme Corporation | Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy |
US6331524B1 (en) | 1994-12-09 | 2001-12-18 | Genzyme Corporation | Organ-specific targeting of cationic amphiphile / DNA complexes for gene therapy |
US5840710A (en) * | 1994-12-09 | 1998-11-24 | Genzyme Corporation | Cationic amphiphiles containing ester or ether-linked lipophilic groups for intracellular delivery of therapeutic molecules |
US5747471A (en) * | 1994-12-09 | 1998-05-05 | Genzyme Corporation | Cationic amphiphiles containing steroid lipophilic groups for intracellular delivery of therapeutic molecules |
US6143738A (en) * | 1995-06-07 | 2000-11-07 | Magainin Pharmaceuticals, Inc. | Therapeutic uses for an aminosterol compound |
US5763430A (en) * | 1995-06-07 | 1998-06-09 | Magainin Pharmaceuticals Inc. | Method of treating a viral infection by administering a steroid compound |
US5874597A (en) * | 1995-06-07 | 1999-02-23 | Magainin Pharmaceuticals, Inc. | Certain aminosterol compounds and pharmaceutical compositions including these compounds |
US5792635A (en) * | 1995-06-07 | 1998-08-11 | Magainin Pharmaceuticals, Inc. | Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine |
PT832094E (pt) * | 1995-06-07 | 2004-06-30 | Genaera Corp | Compostos de aminoesterol uteis como inibidores do permutador sodio/protao )nhe) metodos e composicoes farmaceuticas empregando estes inibidores e processos para avaliacao da eficacia inibidora de nhe dos compostos |
US5847172A (en) * | 1995-06-07 | 1998-12-08 | Magainin Pharmaceuticals Inc. | Certain aminosterol compounds and pharmaceutical compositions including these compounds |
US5994336A (en) * | 1995-06-07 | 1999-11-30 | Magainin Pharmaceuticals Inc. | Method of inhibiting proliferation of cells by administering an aminosterol compound |
US5840936A (en) * | 1995-06-07 | 1998-11-24 | Magainin Pharmaceuticals Inc. | Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE) |
US5795885A (en) * | 1995-06-07 | 1998-08-18 | Magainin Pharmaceuticals Inc. | Method of inhibiting profileration of cells by administering an aminosterol compound |
FR2744453B1 (fr) * | 1996-02-05 | 1998-07-10 | Transgene Sa | Composes lipopolyamines, compositions pharmaceutiques en comprenant, vecteurs de transfert d'acide nucleique et procede de preparation |
US6596712B2 (en) | 1996-04-26 | 2003-07-22 | Genaera Corporation | Treatment of carcinomas using squalamine in combination with other anti-cancer agents or modalities |
WO2000015176A2 (en) * | 1998-09-10 | 2000-03-23 | Magainin Pharmaceuticals, Inc. | Treatment of carcinomas using squalamine in combination with other anti-cancer agents or modalities |
DK0910382T3 (da) * | 1996-04-26 | 2003-10-06 | Genaera Corp | Squalamin i kombination med andre anticancermidler til behandling af tumorer |
US7410959B1 (en) | 2000-07-13 | 2008-08-12 | Genaera Corporation | Therapeutic uses for aminosterol compounds |
AU2911197A (en) * | 1996-05-24 | 1998-01-05 | Imperial College Of Science, Technology And Medicine | Polycationic sterol derivatives as transfection agents |
US5935936A (en) * | 1996-06-03 | 1999-08-10 | Genzyme Corporation | Compositions comprising cationic amphiphiles and co-lipids for intracellular delivery of therapeutic molecules |
US6262283B1 (en) | 1996-12-06 | 2001-07-17 | Magainin Pharmaceuticals Inc. | Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds |
US5925628A (en) * | 1997-03-31 | 1999-07-20 | Genzyme Corporation | Cationic amphiphiles for intracellular delivery of therapeutic molecules |
US5912239A (en) * | 1997-04-04 | 1999-06-15 | Genzyme Corporation | Imidazole-containing cationic amphiphiles for intracellular delivery of therapeutic molecules |
US5948925A (en) * | 1997-05-06 | 1999-09-07 | Genzyme Corporation | Cationic amphiphiles containing linkers derived from neutral or positively charged amino acids |
US5952516A (en) * | 1997-05-08 | 1999-09-14 | Genzyme Corporation | Cationic amphiphiles containing multiplesteroid lipophilic groups |
US5942634A (en) * | 1997-05-09 | 1999-08-24 | Genzyme Corporation | Cationic amphiphiles for cell transfections |
US6350738B1 (en) | 1998-03-06 | 2002-02-26 | Brigham Young University | Steroid derived antibiotics |
US6767904B2 (en) | 1998-03-06 | 2004-07-27 | Bringham Young University | Steroid derived antibiotics |
EP1058552B1 (de) * | 1998-03-06 | 2004-06-16 | Brigham Young University | Antibiotische steroidderivate |
AU4093799A (en) | 1998-05-22 | 1999-12-13 | Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and therapies based thereon |
US6388108B1 (en) | 1998-08-12 | 2002-05-14 | Genaera Corporation | Aminosterol compounds and uses thereof |
US6537554B1 (en) | 1998-09-10 | 2003-03-25 | Curagen Corporation | Nucleotide sequences and amino acid sequences of secreted proteins involved in angiogenesis |
EP1181037A4 (de) * | 1999-05-01 | 2006-01-18 | Genaera Corp | Asthma-assoziierte faktoren als ziel der behandlung atopischer allergien und verwandte erkrankungen |
AU2004201177B2 (en) * | 1999-10-14 | 2006-03-30 | Sasol Technology (Pty) Limited | Handling of a Catalyst |
WO2001042273A2 (en) * | 1999-12-09 | 2001-06-14 | Genaera Corporation | Asthma associated factors as targets for treating atopic allergies including asthma and related disorders |
ATE342912T1 (de) | 2000-04-12 | 2006-11-15 | Genaera Corp | Ein verfahren zur herstellung von 7.alpha.- hydroxy 3-aminosubstituierten sterol-verbindungen,ohne schutz der 7.alpha.-hydroxy-gruppe |
CN1214039C (zh) * | 2000-04-28 | 2005-08-10 | 茵弗莱采姆药物有限公司 | 3-氮-6,7-二氧甾族化合物及其应用 |
CA2416850A1 (en) * | 2000-09-08 | 2003-01-20 | Kuraray Co., Ltd. | Process for the preparation of pregnane derivatives |
US20030104573A1 (en) * | 2000-09-11 | 2003-06-05 | Shimkets Richard A. | Nucleotide sequences and amino acid sequences of secreted proteins involved in angiogenesis |
WO2002027786A1 (fr) * | 2000-09-25 | 2002-04-04 | Ibiden Co., Ltd. | Element semi-conducteur, procede de fabrication d'un element semi-conducteur, carte a circuit imprime multicouche, et procede de fabrication d'une carte a circuit imprime multicouche |
AU2002231500B2 (en) * | 2001-01-25 | 2006-04-27 | The University Of British Columbia | Antiangiogenic compounds and an assay for inhibitors of cell invasion |
CA2332138A1 (en) * | 2001-01-25 | 2002-07-25 | Michel Roberge | Antiangiogenic compounds and an assay for inhibitors of cell invasion |
MXPA03008085A (es) * | 2001-03-21 | 2004-03-10 | Leo Pharma As | Derivados de acido fusidico poliaminados novedosos. |
AU2002322720B2 (en) | 2001-07-25 | 2008-11-13 | Raptor Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
US7557097B2 (en) * | 2004-11-20 | 2009-07-07 | Regents Of The University Of Minnesota | Structural, behavioral characterization, and synthesis of attractants for migratory lamprey |
TW200716136A (en) | 2005-04-25 | 2007-05-01 | Genaera Corp | Polymorphic and amorphous salt forms of squalamine dilactate |
JP2008539047A (ja) | 2005-04-28 | 2008-11-13 | プロテウス バイオメディカル インコーポレイテッド | ファーマインフォーマティックスシステム |
WO2007035716A2 (en) | 2005-09-16 | 2007-03-29 | Raptor Pharmaceutical Inc. | Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof |
CN100410270C (zh) * | 2005-12-31 | 2008-08-13 | 中山大学 | 胆甾-5-烯-3β,19-二羟基-24-酮及衍生物的合成方法 |
CN100436474C (zh) * | 2005-12-31 | 2008-11-26 | 中山大学 | 胆甾-3β,5α,6β,19-四羟基-24-酮及其衍生物的合成方法 |
CN101600429A (zh) * | 2006-12-08 | 2009-12-09 | 哈多技术有限公司 | 治疗和预防传染性疾病的胆固醇胺 |
TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明(cyclopamine)類似物類 |
JP2010538072A (ja) * | 2007-09-06 | 2010-12-09 | ジェナエラ コーポレイション | 糖尿病を治療する方法 |
EP2224807B1 (de) * | 2007-12-27 | 2016-11-09 | Infinity Pharmaceuticals, Inc. | Verfahren für stereoselektive reduktion |
WO2009090063A1 (en) * | 2008-01-16 | 2009-07-23 | Jado Technologies Gmbh | Steroid sapogenin, androstane and triterpenoid sapogenin derivatives for the treatment and prevention of infectious diseases |
EP2671576B1 (de) | 2008-05-09 | 2020-04-08 | Merck Patent GmbH | Pharmazeutische Zusammensetzung zur Behandlung von Erkrankungen im Zusammenhang mit Insulinresistenz und ß-Zellen-Dysfunktion |
ES2919563T3 (es) | 2009-02-20 | 2022-07-27 | Enhanx Biopharm Inc | Sistema de administración de medicamentos a base de glutatión |
ES2942923T3 (es) | 2009-05-06 | 2023-06-07 | Laboratory Skin Care Inc | Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas |
EP2462115B1 (de) | 2009-08-05 | 2016-01-06 | Infinity Pharmaceuticals, Inc. | Enzymatische transaminierung von cyclopamin-analogen |
US8729058B2 (en) * | 2009-10-27 | 2014-05-20 | Michael Zasloff | Methods and compositions for treating and preventing viral infections |
JP5147814B2 (ja) * | 2009-11-12 | 2013-02-20 | ブリガム・ヤング・ユニバーシティ | ステロイド由来抗生物質 |
US8623416B2 (en) * | 2009-11-25 | 2014-01-07 | Michael Zasloff | Formulations comprising aminosterols |
US9394313B2 (en) | 2010-09-14 | 2016-07-19 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
EP2649095B1 (de) | 2010-12-10 | 2021-10-06 | Aleksander S. Popel | Aus kollagen des typs iv abgeleitete mimetische peptide und ihre verwendung zur behandlung angiogenese- und lymphangiogenese-vermittelter krankheiten |
FR2981351A1 (fr) | 2011-10-17 | 2013-04-19 | Univ Nice Sophia Antipolis | Derives aminosteroidiens anti-diabetiques |
KR20150003798A (ko) * | 2012-04-20 | 2015-01-09 | 오에이치알 파마서티컬, 인코포레이티드 | Ptp1b 연관 질병의 치료용 아미노스테로이드 |
US10040817B2 (en) | 2013-10-03 | 2018-08-07 | Enterin Laboratories, Inc. | Methods and compositions for stimulation of the intestinal enteroendocrine system for treating diseases or conditions related to the same |
AU2016271468B2 (en) | 2015-06-04 | 2020-01-02 | Sol-Gel Technologies Ltd. | Topical formulations for delivery of hedgehog inhibitor compounds and use thereof |
FR3055801B1 (fr) * | 2016-09-15 | 2020-10-30 | Virbac | Derives esters de squalamine pour le traitement des infections |
EP3678671A4 (de) | 2017-09-08 | 2022-12-07 | Enterin, Inc. | Verfahren zur behandlung von schlafkrankheiten, schlafstörungen und verwandten symptomen mithilfe von aminosterolzusammensetzungen |
CN108445236B (zh) * | 2018-02-07 | 2021-04-20 | 深圳市新产业生物医学工程股份有限公司 | 甾体类衍生物和其保存液以及其应用 |
WO2021025973A1 (en) * | 2019-08-02 | 2021-02-11 | Enterin, Inc. | Human aminosterol ent-03 compounds, related compositions comprising the same, and methods of using the same |
EP4007765A4 (de) * | 2019-08-02 | 2023-08-23 | Enterin, Inc. | Menschliche squalaminderivate, diese enthaltende zusammensetzungen und verfahren zu ihrer verwendung |
CN115551871A (zh) * | 2020-03-19 | 2022-12-30 | 因特尔公司 | 角鲨胺的晶型 |
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DK0688333T3 (da) * | 1993-03-10 | 1999-02-08 | Magainin Pharma | Steroidderivater, farmaceutiske præparater indeholdende disse og deres anvendelse som antibiotika eller desinfektionsmidler |
-
1994
- 1994-03-10 DK DK94911470T patent/DK0688333T3/da active
- 1994-03-10 JP JP52021294A patent/JP3546886B2/ja not_active Expired - Lifetime
- 1994-03-10 ES ES94911470T patent/ES2123133T3/es not_active Expired - Lifetime
- 1994-03-10 WO PCT/US1994/002397 patent/WO1994020520A1/en active IP Right Grant
- 1994-03-10 AT AT94911470T patent/ATE169930T1/de not_active IP Right Cessation
- 1994-03-10 DE DE69412596T patent/DE69412596T2/de not_active Expired - Lifetime
- 1994-03-10 CA CA002157594A patent/CA2157594A1/en not_active Abandoned
- 1994-03-10 EP EP94911470A patent/EP0688333B1/de not_active Expired - Lifetime
- 1994-03-16 US US08/290,826 patent/US5637691A/en not_active Expired - Lifetime
- 1994-09-13 US US08/416,883 patent/US5733899A/en not_active Expired - Fee Related
-
1995
- 1995-06-07 US US08/478,763 patent/US5721226A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO1994020520A1 (en) | 1994-09-15 |
US5637691A (en) | 1997-06-10 |
JPH08507527A (ja) | 1996-08-13 |
AU6397494A (en) | 1994-09-26 |
ES2123133T3 (es) | 1999-01-01 |
ATE169930T1 (de) | 1998-09-15 |
DE69412596T2 (de) | 1999-03-04 |
JP3546886B2 (ja) | 2004-07-28 |
CA2157594A1 (en) | 1994-09-15 |
US5733899A (en) | 1998-03-31 |
AU692766B2 (en) | 1998-06-18 |
DK0688333T3 (da) | 1999-02-08 |
EP0688333B1 (de) | 1998-08-19 |
US5721226A (en) | 1998-02-24 |
EP0688333A1 (de) | 1995-12-27 |
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