CN100436474C - 胆甾-3β,5α,6β,19-四羟基-24-酮及其衍生物的合成方法 - Google Patents
胆甾-3β,5α,6β,19-四羟基-24-酮及其衍生物的合成方法 Download PDFInfo
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- CN100436474C CN100436474C CNB200510121374XA CN200510121374A CN100436474C CN 100436474 C CN100436474 C CN 100436474C CN B200510121374X A CNB200510121374X A CN B200510121374XA CN 200510121374 A CN200510121374 A CN 200510121374A CN 100436474 C CN100436474 C CN 100436474C
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- beta
- ketone
- courage steroid
- cholest
- solution
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
Description
Claims (5)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB200510121374XA CN100436474C (zh) | 2005-12-31 | 2005-12-31 | 胆甾-3β,5α,6β,19-四羟基-24-酮及其衍生物的合成方法 |
PCT/CN2006/001627 WO2007076655A1 (en) | 2005-12-31 | 2006-07-10 | METHOD FOR SYNTHESIS OF CHOLEST-3β,5α,6β,19-TETRAHYDROXY-24-ONE AND ITS DERIVATIVES |
AU2006332419A AU2006332419A1 (en) | 2005-12-31 | 2006-07-10 | The use of phthalide derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB200510121374XA CN100436474C (zh) | 2005-12-31 | 2005-12-31 | 胆甾-3β,5α,6β,19-四羟基-24-酮及其衍生物的合成方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1793159A CN1793159A (zh) | 2006-06-28 |
CN100436474C true CN100436474C (zh) | 2008-11-26 |
Family
ID=36804818
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB200510121374XA Active CN100436474C (zh) | 2005-12-31 | 2005-12-31 | 胆甾-3β,5α,6β,19-四羟基-24-酮及其衍生物的合成方法 |
Country Status (2)
Country | Link |
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CN (1) | CN100436474C (zh) |
WO (1) | WO2007076655A1 (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104497086B (zh) * | 2014-12-12 | 2016-08-17 | 中山大学 | 雄甾-3β,5α,6β,19-四醇及其制备方法与应用 |
CN106146593B (zh) * | 2015-04-14 | 2021-06-01 | 南京迈诺威医药科技有限公司 | 一种制备去氧胆酸的方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4298537A (en) * | 1978-11-30 | 1981-11-03 | Teijin Limited | Process for producing steroid compounds having an oxo group in the side chain |
CN1448400A (zh) * | 2003-05-06 | 2003-10-15 | 中山大学 | 24-亚甲基-胆甾-3β,5α,6β,19-四醇的合成方法 |
CN1448399A (zh) * | 2003-04-24 | 2003-10-15 | 中山大学 | 24-亚甲基-胆甾-5-烯-3β,19-二醇的合成方法 |
CN1583781A (zh) * | 2004-05-28 | 2005-02-23 | 中山大学 | 3β,7β,19-三羟基-5-烯-胆甾烷的合成方法 |
CN1583782A (zh) * | 2004-05-28 | 2005-02-23 | 中山大学 | 24-亚甲基-胆甾-5 -烯-3β,7β,19-三醇的合成方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE169930T1 (de) * | 1993-03-10 | 1998-09-15 | Magainin Pharma | Steroidderivate, pharmazeutische zusammensetzungen die sie enthalten und ihre verwendung als antibiotika oder desinfektionsmittel |
-
2005
- 2005-12-31 CN CNB200510121374XA patent/CN100436474C/zh active Active
-
2006
- 2006-07-10 WO PCT/CN2006/001627 patent/WO2007076655A1/zh active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4298537A (en) * | 1978-11-30 | 1981-11-03 | Teijin Limited | Process for producing steroid compounds having an oxo group in the side chain |
CN1448399A (zh) * | 2003-04-24 | 2003-10-15 | 中山大学 | 24-亚甲基-胆甾-5-烯-3β,19-二醇的合成方法 |
CN1448400A (zh) * | 2003-05-06 | 2003-10-15 | 中山大学 | 24-亚甲基-胆甾-3β,5α,6β,19-四醇的合成方法 |
CN1583781A (zh) * | 2004-05-28 | 2005-02-23 | 中山大学 | 3β,7β,19-三羟基-5-烯-胆甾烷的合成方法 |
CN1583782A (zh) * | 2004-05-28 | 2005-02-23 | 中山大学 | 24-亚甲基-胆甾-5 -烯-3β,7β,19-三醇的合成方法 |
Non-Patent Citations (9)
Title |
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24-亚甲基胆甾-4-烯-3β ,6β-二醇的合成. 陆伟刚,何延红,苏镜娱,曾陇梅.中山大学学报(自然科学版),第43卷第4期. 2004 |
24-亚甲基胆甾-4-烯-3β,6β-二醇的合成. 陆伟刚,何延红,苏镜娱,曾陇梅.中山大学学报(自然科学版),第43卷第4期. 2004 * |
24-亚甲基胆甾-5-烯-3β,19-二醇的合成. 陆伟刚等.高等学校化学学报,第25卷第9期. 2004 |
24-亚甲基胆甾-5-烯-3β,19-二醇的合成. 陆伟刚等.高等学校化学学报,第25卷第9期. 2004 * |
3-乙酰氧基胆甾-5-烯-19-羟基-24-酮的制备与表征. 崔建国等.广西科学,第10卷第1期. 2003 |
3-乙酰氧基胆甾-5-烯-19-羟基-24-酮的制备与表征. 崔建国等.广西科学,第10卷第1期. 2003 * |
Reduction of 3b-chloro-6-nitrocholest-5-ene withRaneynickel-hydrazine hydrate: a synthesis of dimers.. Shafiullah,Husain Shakir,Basha D. M., Ansari M. R.Indian J. Chem., Sect. B,Vol.28B No.8. 1989 |
Synthesis of polyhydroxysterols (IV): synthesis of24-methylene-cholesta-3b,5a,6b,19-tetrol,a cytotoxic naturalhydroxylated sterol. Weigang Lu, Longmei Zeng, Jingyu Su.Steroids,Vol.69 . 2004 |
Δ5 23β,7β2二羟基甾醇和Δ5 23β,7α2二羟基甾醇的立体选择合成及其对胆碱酯酶的抑制活性. 陆伟刚,张军,苏镜娱,曾陇梅.中国药物化学杂志,第15卷第4期. 2005 |
Also Published As
Publication number | Publication date |
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WO2007076655A1 (en) | 2007-07-12 |
CN1793159A (zh) | 2006-06-28 |
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Owner name: GUANGZHOU SEPATEC PHARMACEUTICAL TECHNOLOGY CO., L Free format text: FORMER OWNER: ZHONGSHAN UNIVERSITY Effective date: 20120704 |
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Free format text: CORRECT: ADDRESS; FROM: 510275 NO.135, XINGANG ROAD(WEST), GUANGZHOU CITY, GUANGDONG PROVINCE TO: 510663 C208, GUOJIQIYEFUHUAQI, GUANG STATE, NO.3, JUQUAN ROAD, GUANGZHOU CITY SCIENCE CITY, GUANGDONG PROVINCE |
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Effective date of registration: 20120704 Address after: 510663 Guangdong province Guangzhou Science City skim Springs Road No. 3, Guangzhou international business incubator C208 Patentee after: Guangzhou Saipute Medical Technology Co., Ltd. Address before: 510275 Xingang West Road, Guangdong, China, No. 135, No. Patentee before: Sun Yat-sen University |
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Address after: Moon Road, Science City high tech Industrial Development Zone of Guangzhou City, Guangdong province 510663 No. 3 Guangzhou international business incubator C District No. G401-415 room Patentee after: GUANGZHOU SAIPUTE PHARMACEUTICAL TECHNOLOGY CO., LTD. Address before: 510663 Guangdong province Guangzhou Science City skim Springs Road No. 3, Guangzhou international business incubator C208 Patentee before: Guangzhou Saipute Medical Technology Co., Ltd. |