ATE167662T1 - Verfahren zur herstellung eines lignan-derivats - Google Patents
Verfahren zur herstellung eines lignan-derivatsInfo
- Publication number
- ATE167662T1 ATE167662T1 AT94912092T AT94912092T ATE167662T1 AT E167662 T1 ATE167662 T1 AT E167662T1 AT 94912092 T AT94912092 T AT 94912092T AT 94912092 T AT94912092 T AT 94912092T AT E167662 T1 ATE167662 T1 AT E167662T1
- Authority
- AT
- Austria
- Prior art keywords
- compound
- general formula
- producing
- lower alkyl
- cycloalkyl
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- -1 lignan compound Chemical class 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 238000007259 addition reaction Methods 0.000 abstract 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229930013686 lignan Natural products 0.000 abstract 1
- 235000009408 lignans Nutrition 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8994493 | 1993-04-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE167662T1 true ATE167662T1 (de) | 1998-07-15 |
Family
ID=13984820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94912092T ATE167662T1 (de) | 1993-04-16 | 1994-04-12 | Verfahren zur herstellung eines lignan-derivats |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5488134A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0646570B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP3411036B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR100277242B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN1046937C (cg-RX-API-DMAC7.html) |
| AT (1) | ATE167662T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU666819B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2138264C (cg-RX-API-DMAC7.html) |
| DE (1) | DE69411243T2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK0646570T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2119190T3 (cg-RX-API-DMAC7.html) |
| TW (1) | TW255886B (cg-RX-API-DMAC7.html) |
| WO (1) | WO1994024087A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2121060C (en) * | 1993-04-16 | 2004-04-06 | Sachio Mori | Preparation of lignan analogues |
| US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
| US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
| US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| KR100376281B1 (ko) * | 1995-12-26 | 2003-09-26 | 에스케이케미칼주식회사 | 리그난의 제조방법 |
| CA2305307C (en) | 1997-09-29 | 2004-11-30 | Meiji Seika Kaisha, Ltd. | Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic agents |
| PT1140184E (pt) | 1998-12-23 | 2003-10-31 | Searle Llc | Combinacoes de inibidores de proteina de transferencia de ester de colesterilo com derivados de acido nicotinico para indicacoes cardiovasculares |
| PL348503A1 (en) | 1998-12-23 | 2002-05-20 | Searle Llc | Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications |
| CA2356422C (en) | 1998-12-23 | 2008-09-16 | G.D. Searle Llc | Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications |
| KR20010102964A (ko) | 1998-12-23 | 2001-11-17 | 윌리암스 로저 에이 | 심장혈관 징후를 위한 회장 담즙산 수송 억제인자 및피브린산 유도체의 조합물 |
| DE69908644T2 (de) | 1998-12-23 | 2004-05-13 | G.D. Searle Llc, Chicago | Kombnationen von cholesteryl ester transfer protein inhibitoren und gallensäure sequestriermitteln für kardiovaskuläre indikationen |
| US6462091B1 (en) | 1998-12-23 | 2002-10-08 | G.D. Searle & Co. | Combinations of cholesteryl ester transfer protein inhibitors and HMG coA reductase inhibitors for cardiovascular indications |
| CN1338945A (zh) | 1998-12-23 | 2002-03-06 | G·D·瑟尔有限公司 | 适用于心血管疾病的回肠胆汁酸转运抑制剂和胆汁酸螯合剂组合 |
| WO2001068096A2 (en) * | 2000-03-10 | 2001-09-20 | Pharmacia Corporation | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders |
| HK1052183A1 (zh) | 2000-03-10 | 2003-09-05 | Pharmacia Corporation | 制造tetrahydrobenzothiepines的方法 |
| JP2005518347A (ja) | 2001-11-02 | 2005-06-23 | ジー．ディー． サール エルエルシー | 頂端ナトリウム共依存性胆汁酸輸送（ａｓｂｔ）およびタウロコール酸塩取り込みの阻害剤としての新規一および二フッ化ベンゾチエピン化合物 |
| JP2005521653A (ja) | 2002-01-17 | 2005-07-21 | ファルマシア コーポレイション | 先端ナトリウム同時依存性胆汁酸輸送（ａｓｂｔ）およびタウロコール酸塩取込みの阻害剤としての新規アルキル／アリールヒドロキシまたはケトチエピン化合物 |
| GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
| EP2995317A1 (en) | 2010-05-26 | 2016-03-16 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
| JP6217938B2 (ja) | 2011-10-28 | 2017-10-25 | ルメナ ファーマシューティカルズ エルエルシー | 小児の胆汁うっ滞性肝疾患の処置のための胆汁酸再循環阻害剤 |
| MX363161B (es) | 2011-10-28 | 2019-03-13 | Lumena Pharmaceuticals Inc | Inhibidores de la recirculación de ácidos biliares para el tratamiento de hipercolemia y enfermedad hepática colestásica. |
| EP2968230A2 (en) | 2013-03-15 | 2016-01-20 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease |
| CN105228615A (zh) | 2013-03-15 | 2016-01-06 | 鲁美纳医药公司 | 用于治疗巴雷特食管和胃食管返流疾病的胆汁酸再循环抑制剂 |
| US20220133738A1 (en) | 2019-02-12 | 2022-05-05 | Mirum Pharmaceuticals, Inc. | Genotype and dose-dependent response to an asbti in patients with bile salt export pump deficiency |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0372422A (ja) * | 1989-05-16 | 1991-03-27 | Tanabe Seiyaku Co Ltd | 抗脂血剤 |
| JPH03157351A (ja) * | 1989-11-13 | 1991-07-05 | Tanabe Seiyaku Co Ltd | ナフタレン誘導体及びその製法 |
| DK0701991T3 (da) * | 1991-10-17 | 1999-09-13 | Shionogi & Co | Fremgangsmåde til fremstilling af lignananaloger og udgangsmaterialer dertil |
-
1994
- 1994-04-12 DK DK94912092T patent/DK0646570T3/da active
- 1994-04-12 DE DE69411243T patent/DE69411243T2/de not_active Expired - Fee Related
- 1994-04-12 ES ES94912092T patent/ES2119190T3/es not_active Expired - Lifetime
- 1994-04-12 CN CN94190286A patent/CN1046937C/zh not_active Expired - Fee Related
- 1994-04-12 CA CA002138264A patent/CA2138264C/en not_active Expired - Fee Related
- 1994-04-12 US US08/356,199 patent/US5488134A/en not_active Expired - Fee Related
- 1994-04-12 WO PCT/JP1994/000612 patent/WO1994024087A1/ja not_active Ceased
- 1994-04-12 AU AU64379/94A patent/AU666819B2/en not_active Ceased
- 1994-04-12 KR KR1019940704565A patent/KR100277242B1/ko not_active Expired - Fee Related
- 1994-04-12 EP EP94912092A patent/EP0646570B1/en not_active Expired - Lifetime
- 1994-04-12 AT AT94912092T patent/ATE167662T1/de not_active IP Right Cessation
- 1994-04-12 JP JP52298294A patent/JP3411036B2/ja not_active Expired - Fee Related
- 1994-04-18 TW TW083103432A patent/TW255886B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69411243D1 (de) | 1998-07-30 |
| AU666819B2 (en) | 1996-02-22 |
| EP0646570A1 (en) | 1995-04-05 |
| AU6437994A (en) | 1994-11-08 |
| CN1046937C (zh) | 1999-12-01 |
| EP0646570B1 (en) | 1998-06-24 |
| EP0646570A4 (en) | 1995-08-09 |
| TW255886B (cg-RX-API-DMAC7.html) | 1995-09-01 |
| WO1994024087A1 (fr) | 1994-10-27 |
| CA2138264C (en) | 2004-04-06 |
| KR950701902A (ko) | 1995-05-17 |
| KR100277242B1 (ko) | 2001-02-01 |
| JP3411036B2 (ja) | 2003-05-26 |
| CN1109685A (zh) | 1995-10-04 |
| US5488134A (en) | 1996-01-30 |
| CA2138264A1 (en) | 1994-10-27 |
| ES2119190T3 (es) | 1998-10-01 |
| DE69411243T2 (de) | 1998-11-19 |
| DK0646570T3 (da) | 1998-10-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |