CN1046937C - 木酚素系化合物的制备方法 - Google Patents

木酚素系化合物的制备方法 Download PDF

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Publication number
CN1046937C
CN1046937C CN94190286A CN94190286A CN1046937C CN 1046937 C CN1046937 C CN 1046937C CN 94190286 A CN94190286 A CN 94190286A CN 94190286 A CN94190286 A CN 94190286A CN 1046937 C CN1046937 C CN 1046937C
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CN
China
Prior art keywords
compound
formula
reaction
synthesis
reference example
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Expired - Fee Related
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CN94190286A
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English (en)
Chinese (zh)
Other versions
CN1109685A (zh
Inventor
森幸雄
武智正三
木田士郎
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Shionogi and Co Ltd
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Shionogi and Co Ltd
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Publication of CN1109685A publication Critical patent/CN1109685A/zh
Application granted granted Critical
Publication of CN1046937C publication Critical patent/CN1046937C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
CN94190286A 1993-04-16 1994-04-12 木酚素系化合物的制备方法 Expired - Fee Related CN1046937C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8994493 1993-04-16
JP89944/93 1993-04-16

Publications (2)

Publication Number Publication Date
CN1109685A CN1109685A (zh) 1995-10-04
CN1046937C true CN1046937C (zh) 1999-12-01

Family

ID=13984820

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94190286A Expired - Fee Related CN1046937C (zh) 1993-04-16 1994-04-12 木酚素系化合物的制备方法

Country Status (13)

Country Link
US (1) US5488134A (cg-RX-API-DMAC7.html)
EP (1) EP0646570B1 (cg-RX-API-DMAC7.html)
JP (1) JP3411036B2 (cg-RX-API-DMAC7.html)
KR (1) KR100277242B1 (cg-RX-API-DMAC7.html)
CN (1) CN1046937C (cg-RX-API-DMAC7.html)
AT (1) ATE167662T1 (cg-RX-API-DMAC7.html)
AU (1) AU666819B2 (cg-RX-API-DMAC7.html)
CA (1) CA2138264C (cg-RX-API-DMAC7.html)
DE (1) DE69411243T2 (cg-RX-API-DMAC7.html)
DK (1) DK0646570T3 (cg-RX-API-DMAC7.html)
ES (1) ES2119190T3 (cg-RX-API-DMAC7.html)
TW (1) TW255886B (cg-RX-API-DMAC7.html)
WO (1) WO1994024087A1 (cg-RX-API-DMAC7.html)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2121060C (en) * 1993-04-16 2004-04-06 Sachio Mori Preparation of lignan analogues
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
KR100376281B1 (ko) * 1995-12-26 2003-09-26 에스케이케미칼주식회사 리그난의 제조방법
CA2305307C (en) 1997-09-29 2004-11-30 Meiji Seika Kaisha, Ltd. Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic agents
PT1140184E (pt) 1998-12-23 2003-10-31 Searle Llc Combinacoes de inibidores de proteina de transferencia de ester de colesterilo com derivados de acido nicotinico para indicacoes cardiovasculares
PL348503A1 (en) 1998-12-23 2002-05-20 Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications
CA2356422C (en) 1998-12-23 2008-09-16 G.D. Searle Llc Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications
KR20010102964A (ko) 1998-12-23 2001-11-17 윌리암스 로저 에이 심장혈관 징후를 위한 회장 담즙산 수송 억제인자 및피브린산 유도체의 조합물
DE69908644T2 (de) 1998-12-23 2004-05-13 G.D. Searle Llc, Chicago Kombnationen von cholesteryl ester transfer protein inhibitoren und gallensäure sequestriermitteln für kardiovaskuläre indikationen
US6462091B1 (en) 1998-12-23 2002-10-08 G.D. Searle & Co. Combinations of cholesteryl ester transfer protein inhibitors and HMG coA reductase inhibitors for cardiovascular indications
CN1338945A (zh) 1998-12-23 2002-03-06 G·D·瑟尔有限公司 适用于心血管疾病的回肠胆汁酸转运抑制剂和胆汁酸螯合剂组合
WO2001068096A2 (en) * 2000-03-10 2001-09-20 Pharmacia Corporation Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders
HK1052183A1 (zh) 2000-03-10 2003-09-05 Pharmacia Corporation 制造tetrahydrobenzothiepines的方法
JP2005518347A (ja) 2001-11-02 2005-06-23 ジー．ディー． サール エルエルシー 頂端ナトリウム共依存性胆汁酸輸送（ａｓｂｔ）およびタウロコール酸塩取り込みの阻害剤としての新規一および二フッ化ベンゾチエピン化合物
JP2005521653A (ja) 2002-01-17 2005-07-21 ファルマシア コーポレイション 先端ナトリウム同時依存性胆汁酸輸送（ａｓｂｔ）およびタウロコール酸塩取込みの阻害剤としての新規アルキル／アリールヒドロキシまたはケトチエピン化合物
GB0307918D0 (en) 2003-04-05 2003-05-14 Astrazeneca Ab Therapeutic use
EP2995317A1 (en) 2010-05-26 2016-03-16 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
JP6217938B2 (ja) 2011-10-28 2017-10-25 ルメナ ファーマシューティカルズ エルエルシー 小児の胆汁うっ滞性肝疾患の処置のための胆汁酸再循環阻害剤
MX363161B (es) 2011-10-28 2019-03-13 Lumena Pharmaceuticals Inc Inhibidores de la recirculación de ácidos biliares para el tratamiento de hipercolemia y enfermedad hepática colestásica.
EP2968230A2 (en) 2013-03-15 2016-01-20 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease
CN105228615A (zh) 2013-03-15 2016-01-06 鲁美纳医药公司 用于治疗巴雷特食管和胃食管返流疾病的胆汁酸再循环抑制剂
US20220133738A1 (en) 2019-02-12 2022-05-05 Mirum Pharmaceuticals, Inc. Genotype and dose-dependent response to an asbti in patients with bile salt export pump deficiency

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0372422A (ja) * 1989-05-16 1991-03-27 Tanabe Seiyaku Co Ltd 抗脂血剤
JPH03157351A (ja) * 1989-11-13 1991-07-05 Tanabe Seiyaku Co Ltd ナフタレン誘導体及びその製法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0701991T3 (da) * 1991-10-17 1999-09-13 Shionogi & Co Fremgangsmåde til fremstilling af lignananaloger og udgangsmaterialer dertil

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0372422A (ja) * 1989-05-16 1991-03-27 Tanabe Seiyaku Co Ltd 抗脂血剤
JPH03157351A (ja) * 1989-11-13 1991-07-05 Tanabe Seiyaku Co Ltd ナフタレン誘導体及びその製法

Also Published As

Publication number Publication date
ATE167662T1 (de) 1998-07-15
DE69411243D1 (de) 1998-07-30
AU666819B2 (en) 1996-02-22
EP0646570A1 (en) 1995-04-05
AU6437994A (en) 1994-11-08
EP0646570B1 (en) 1998-06-24
EP0646570A4 (en) 1995-08-09
TW255886B (cg-RX-API-DMAC7.html) 1995-09-01
WO1994024087A1 (fr) 1994-10-27
CA2138264C (en) 2004-04-06
KR950701902A (ko) 1995-05-17
KR100277242B1 (ko) 2001-02-01
JP3411036B2 (ja) 2003-05-26
CN1109685A (zh) 1995-10-04
US5488134A (en) 1996-01-30
CA2138264A1 (en) 1994-10-27
ES2119190T3 (es) 1998-10-01
DE69411243T2 (de) 1998-11-19
DK0646570T3 (da) 1998-10-26

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