ATE153133T1 - Verfahren und gerät zur messung von optischen eigenschaften biologischer proben - Google Patents

Verfahren und gerät zur messung von optischen eigenschaften biologischer proben

Info

Publication number
ATE153133T1
ATE153133T1 AT90310782T AT90310782T ATE153133T1 AT E153133 T1 ATE153133 T1 AT E153133T1 AT 90310782 T AT90310782 T AT 90310782T AT 90310782 T AT90310782 T AT 90310782T AT E153133 T1 ATE153133 T1 AT E153133T1
Authority
AT
Austria
Prior art keywords
digital data
neighborhood
cell
population
data
Prior art date
Application number
AT90310782T
Other languages
English (en)
Inventor
Louis A Kamentsky
Lee D Kamentsky
Original Assignee
Louis A Kamentsky
Lee D Kamentsky
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/416,031 external-priority patent/US5072382A/en
Application filed by Louis A Kamentsky, Lee D Kamentsky filed Critical Louis A Kamentsky
Application granted granted Critical
Publication of ATE153133T1 publication Critical patent/ATE153133T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1468—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
AT90310782T 1989-10-02 1990-10-02 Verfahren und gerät zur messung von optischen eigenschaften biologischer proben ATE153133T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/416,031 US5072382A (en) 1989-10-02 1989-10-02 Methods and apparatus for measuring multiple optical properties of biological specimens
US07/583,075 US5107422A (en) 1989-10-02 1990-09-14 Method and apparatus for measuring multiple optical properties of biological specimens

Publications (1)

Publication Number Publication Date
ATE153133T1 true ATE153133T1 (de) 1997-05-15

Family

ID=27023207

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90310782T ATE153133T1 (de) 1989-10-02 1990-10-02 Verfahren und gerät zur messung von optischen eigenschaften biologischer proben

Country Status (7)

Country Link
US (1) US5107422A (de)
EP (1) EP0421736B1 (de)
JP (1) JP3090679B2 (de)
AT (1) ATE153133T1 (de)
CA (1) CA2026617C (de)
DE (1) DE69030703T2 (de)
IL (1) IL95851A (de)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1698727A1 (ru) * 1988-06-02 1991-12-15 Институт электроники им.У.А.Арифова Поверхностно-ионизационный детектор дл анализа газовых смесей
US5297288A (en) * 1989-11-28 1994-03-22 United States Biochemical Corporation System for use with a high resolution scanner for scheduling a sequence of software tools for determining the presence of bands in DNA sequencing samples
US5595707A (en) * 1990-03-02 1997-01-21 Ventana Medical Systems, Inc. Automated biological reaction apparatus
CA2077781A1 (en) * 1991-09-23 1993-03-24 James W. Bacus Method and apparatus for automated assay of biological specimens
ES2152946T3 (es) * 1992-02-18 2001-02-16 Neopath Inc Metodo de identificacion de objetos mediante tecnicas de procesamiento de datos.
US5343536A (en) * 1992-11-20 1994-08-30 Amway Corporation Method of using image analysis under cross-polarized light to evaluate follicular biopsy slides
US5547849A (en) * 1993-02-17 1996-08-20 Biometric Imaging, Inc. Apparatus and method for volumetric capillary cytometry
US5556764A (en) * 1993-02-17 1996-09-17 Biometric Imaging, Inc. Method and apparatus for cell counting and cell classification
GR940100272A (en) * 1993-06-08 1995-11-29 Ortho Diagnostic Systems Inc Three-colour flow cytometry with automatic gating function.
US6136540A (en) 1994-10-03 2000-10-24 Ikonisys Inc. Automated fluorescence in situ hybridization detection of genetic abnormalities
US5352613A (en) * 1993-10-07 1994-10-04 Tafas Triantafillos P Cytological screening method
US5625705A (en) * 1994-06-03 1997-04-29 Neuromedical Systems, Inc. Intensity texture based classification system and method
CA2198853A1 (en) * 1994-09-02 1996-03-14 Biometric Imaging, Inc. Calibration method and apparatus for optical scanner
US5790692A (en) * 1994-09-07 1998-08-04 Jeffrey H. Price Method and means of least squares designed filters for image segmentation in scanning cytometry
DE791205T1 (de) * 1994-09-20 1998-10-22 Neopath Inc Apparat zum selbstkalibrieren eines biologischen analysesystems
US5633945A (en) * 1994-10-05 1997-05-27 Compucyte Corporation Accuracy in cell mitosis analysis
JPH08136546A (ja) * 1994-11-15 1996-05-31 Bio Sensor Kenkyusho:Kk 物質分析法
EP0720012B1 (de) * 1994-12-26 2004-09-08 Sysmex Corporation Durchflusszytometer
US5733739A (en) * 1995-06-07 1998-03-31 Inphocyte, Inc. System and method for diagnosis of disease by infrared analysis of human tissues and cells
US5642433A (en) * 1995-07-31 1997-06-24 Neopath, Inc. Method and apparatus for image contrast quality evaluation
US5732150A (en) * 1995-09-19 1998-03-24 Ihc Health Services, Inc. Method and system for multiple wavelength microscopy image analysis
AU7398996A (en) 1995-10-11 1997-04-30 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
US5736330A (en) * 1995-10-11 1998-04-07 Luminex Corporation Method and compositions for flow cytometric determination of DNA sequences
US5981180A (en) * 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US6215892B1 (en) * 1995-11-30 2001-04-10 Chromavision Medical Systems, Inc. Method and apparatus for automated image analysis of biological specimens
US5989835A (en) * 1997-02-27 1999-11-23 Cellomics, Inc. System for cell-based screening
US6031930A (en) * 1996-08-23 2000-02-29 Bacus Research Laboratories, Inc. Method and apparatus for testing a progression of neoplasia including cancer chemoprevention testing
US6396941B1 (en) 1996-08-23 2002-05-28 Bacus Research Laboratories, Inc. Method and apparatus for internet, intranet, and local viewing of virtual microscope slides
US6272235B1 (en) 1997-03-03 2001-08-07 Bacus Research Laboratories, Inc. Method and apparatus for creating a virtual microscope slide
US6404906B2 (en) * 1997-03-03 2002-06-11 Bacus Research Laboratories,Inc. Method and apparatus for acquiring and reconstructing magnified specimen images from a computer-controlled microscope
US6449562B1 (en) 1996-10-10 2002-09-10 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
US6008010A (en) * 1996-11-01 1999-12-28 University Of Pittsburgh Method and apparatus for holding cells
US7117098B1 (en) 1997-02-27 2006-10-03 Cellomics, Inc. Machine-readable storage medium for analyzing distribution of macromolecules between the cell membrane and the cell cytoplasm
US6759206B1 (en) 1997-02-27 2004-07-06 Cellomics, Inc. System for cell-based screening
US7853411B2 (en) * 1997-02-27 2010-12-14 Cellomics, Inc. System for cell-based screening
CA2282658C (en) 1997-02-27 2003-02-25 Cellomics, Inc. A system for cell-based screening
US6727071B1 (en) 1997-02-27 2004-04-27 Cellomics, Inc. System for cell-based screening
DK176174B1 (da) 1997-09-12 2006-11-20 Foss Analytical As Fremgangsmåde og standardkit til at kontrollere funktionen af et flowcytometer, samt apparat til udövelse af fremgangsmåden
JP3735190B2 (ja) 1997-10-28 2006-01-18 オリンパス株式会社 走査型サイトメータ
ES2305992T3 (es) * 1998-02-16 2008-11-01 METASYSTEMS HARD & SOFTWARE GMBH Kit diagnostico.
CA2321203A1 (en) * 1998-03-02 1999-09-10 Compucyte Corp. Selective cell analysis
US6388788B1 (en) 1998-03-16 2002-05-14 Praelux, Inc. Method and apparatus for screening chemical compounds
US20030036855A1 (en) * 1998-03-16 2003-02-20 Praelux Incorporated, A Corporation Of New Jersey Method and apparatus for screening chemical compounds
DE19860278A1 (de) * 1998-12-24 2000-06-29 Joerg Enderlein Verfahren und Vorrichtung zur optischen Detektion eines auf einer Oberfläche immobilisierten Partikels
MXPA01013398A (es) * 1999-07-21 2003-03-27 Surromed Inc Sistema para citometria de escaneo laser de microvolumen.
GB0004529D0 (en) * 2000-02-25 2000-04-19 The Technology Partnership Plc Screening and diagnostics
DE10043992B4 (de) * 2000-09-05 2013-12-24 Leica Microsystems Cms Gmbh Verfahren zur Untersuchung einer Probe und konfokales Scan-Mikroskop
US6466690C1 (en) * 2000-12-19 2008-11-18 Bacus Res Lab Inc Method and apparatus for processing an image of a tissue sample microarray
US6798571B2 (en) 2001-01-11 2004-09-28 Interscope Technologies, Inc. System for microscopic digital montage imaging using a pulse light illumination system
US6993169B2 (en) * 2001-01-11 2006-01-31 Trestle Corporation System and method for finding regions of interest for microscopic digital montage imaging
US6816606B2 (en) 2001-02-21 2004-11-09 Interscope Technologies, Inc. Method for maintaining high-quality focus during high-throughput, microscopic digital montage imaging
US7155049B2 (en) * 2001-01-11 2006-12-26 Trestle Acquisition Corp. System for creating microscopic digital montage images
EP1405058A4 (de) 2001-03-19 2007-07-04 Ikonisys Inc System und verfahren zur erhöhung des kontrasts eines durch ein epifluoreszenzmikroskop erzeugten bildes
AU2001286615A1 (en) * 2001-08-22 2003-03-18 Union Biometrica, Inc. Improved axial pattern analysis utilizing organisms having defined marker patterns
WO2003023571A2 (en) * 2001-09-12 2003-03-20 Burstein Technologies, Inc. Methods for differential cell counts including related apparatus and software for performing same
US20030092008A1 (en) * 2001-11-14 2003-05-15 Bell Michael L. Method and apparatus for multiplex flow cytometry analysis of diverse mixed analytes from bodily fluid samples
CA2436043C (en) * 2002-02-22 2006-01-10 Bacus Research Laboratories, Inc. Focusable virtual microscopy apparatus and method
US6914229B2 (en) * 2002-02-28 2005-07-05 Agilent Technologies, Inc. Signal offset for prevention of data clipping in a molecular array scanner
JP4387201B2 (ja) * 2002-03-13 2009-12-16 キュー３ディーエム エルエルシー 細胞内区画の分画局在強度の測定のための自動化呈色セグメント化および最小有意応答のためのシステムおよび方法
US7077493B2 (en) * 2002-04-12 2006-07-18 Silverbrook Research Pty Ltd Inkjet printhead with ink chamber inlet etched into wafer
DE10235656A1 (de) * 2002-08-02 2004-02-19 Leica Microsystems Heidelberg Gmbh Verfahren und Anordnung zur Mikroskopie
US7274809B2 (en) * 2002-08-29 2007-09-25 Perceptronix Medical, Inc. And British Columbia Cancer Agency Computerized methods and systems related to the detection of malignancy-associated changes (MAC) to detect cancer
DE10256706A1 (de) * 2002-12-04 2004-07-08 Leica Microsystems Wetzlar Gmbh Verfahren zur Steuerung einer Bildaufnahme und Steuereinrichtung hierfür
US6897954B2 (en) * 2002-12-20 2005-05-24 Becton, Dickinson And Company Instrument setup system for a fluorescence analyzer
TWI340829B (en) * 2002-12-27 2011-04-21 Transpacific Systems Llc Method for determining a response of each probe zone on a test strip
US7197169B2 (en) * 2003-01-02 2007-03-27 Kuo-Jeng Wang Method for detecting a response of each probe zone on a test strip
US7925070B2 (en) * 2004-03-30 2011-04-12 Sysmex Corporation Method for displaying virtual slide and terminal device for displaying virtual slide
WO2005114291A1 (en) * 2004-05-12 2005-12-01 Beth Israel Deaconess Medical Center, Inc. Method and apparatus for detecting microscopic objects
US7468796B2 (en) * 2004-08-06 2008-12-23 Compucyte Corporation Multiple-color monochromatic light absorption and quantification of light absorption in a stained sample
US7792338B2 (en) * 2004-08-16 2010-09-07 Olympus America Inc. Method and apparatus of mechanical stage positioning in virtual microscopy image capture
JP4418362B2 (ja) 2004-12-28 2010-02-17 オリンパス株式会社 画像処理装置
JP4883936B2 (ja) * 2005-05-12 2012-02-22 オリンパス株式会社 走査型サイトメータの画像処理方法及び装置
WO2006124800A2 (en) * 2005-05-12 2006-11-23 Lucid, Inc. Confocal scanning microscope having optical and scanning systems which provide a handheld imaging head
CN102621053B (zh) 2005-09-21 2015-05-06 卢米尼克斯股份有限公司 图像数据处理的方法和系统
US20070116376A1 (en) * 2005-11-18 2007-05-24 Kolterman James C Image based correction for unwanted light signals in a specific region of interest
CN100513669C (zh) * 2006-07-21 2009-07-15 苏州泰和特科技有限公司 中低温半糊化经纱上浆方法
JP2010525299A (ja) * 2007-02-09 2010-07-22 ジーイー・ヘルスケア・バイオサイエンス・コーポレイション 生体物質の動きを追跡するシステム及び方法
US8165663B2 (en) 2007-10-03 2012-04-24 The Invention Science Fund I, Llc Vasculature and lymphatic system imaging and ablation
US8285366B2 (en) 2007-10-04 2012-10-09 The Invention Science Fund I, Llc Vasculature and lymphatic system imaging and ablation associated with a local bypass
US8285367B2 (en) 2007-10-05 2012-10-09 The Invention Science Fund I, Llc Vasculature and lymphatic system imaging and ablation associated with a reservoir
DE102008010435B4 (de) * 2008-02-21 2010-07-29 Tecan Trading Ag Datenerfassungsverfahren mit einem Laser Scanner-Gerät
JP5301232B2 (ja) * 2008-09-30 2013-09-25 シスメックス株式会社 血球画像表示装置、検体分析システム、血球画像表示方法、及びコンピュータプログラム
US8167871B2 (en) * 2009-02-25 2012-05-01 The Invention Science Fund I, Llc Device for actively removing a target cell from blood or lymph of a vertebrate subject
US8317737B2 (en) * 2009-02-25 2012-11-27 The Invention Science Fund I, Llc Device for actively removing a target component from blood or lymph of a vertebrate subject
US8758330B2 (en) 2010-03-05 2014-06-24 The Invention Science Fund I, Llc Device for actively removing a target cell from blood or lymph of a vertebrate subject
US8274656B2 (en) * 2010-06-30 2012-09-25 Luminex Corporation Apparatus, system, and method for increasing measurement accuracy in a particle imaging device
EP2769198B1 (de) 2011-10-18 2016-05-25 Luminex Corporation Verfahren und systeme für die bilddatenverarbeitung
US11480513B2 (en) 2017-09-08 2022-10-25 Sony Corporation Fine particle measurement apparatus, information processing apparatus, and information processing method

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4060713A (en) * 1971-06-23 1977-11-29 The Perkin-Elmer Corporation Analysis of images
US4125828A (en) * 1972-08-04 1978-11-14 Med-El Inc. Method and apparatus for automated classification and analysis of cells
US3999047A (en) * 1972-09-05 1976-12-21 Green James E Method and apparatus utilizing color algebra for analyzing scene regions
US3918812A (en) * 1973-05-07 1975-11-11 Us Energy Diagnoses of disease states by fluorescent measurements utilizing scanning laser beams
US4045772A (en) * 1974-04-29 1977-08-30 Geometric Data Corporation Automatic focusing system
DE2508523C3 (de) * 1975-02-27 1984-02-09 Battelle-Institut E.V., 6000 Frankfurt Verfahren zur Analyse von biologischen Zellen oder strukturierten Partikeln ähnlicher Größenordnung
US4122518A (en) * 1976-05-17 1978-10-24 The United States Of America As Represented By The Administrator Of The National Aeronautics & Space Administration Automated clinical system for chromosome analysis
JPS594058B2 (ja) * 1976-07-23 1984-01-27 株式会社日立製作所 白血球像処理方法
US4129854A (en) * 1976-10-25 1978-12-12 Hitachi, Ltd. Cell classification method
US4097845A (en) * 1976-11-01 1978-06-27 Rush-Presbyterian-St. Luke's Medical Center Method of and an apparatus for automatic classification of red blood cells
US4199748A (en) * 1976-11-01 1980-04-22 Rush-Presbyterian-St. Luke's Medical Center Automated method and apparatus for classification of cells with application to the diagnosis of anemia
US4229797A (en) * 1978-09-06 1980-10-21 National Biomedical Research Foundation Method and system for whole picture image processing
DE2903855A1 (de) * 1979-02-01 1980-08-14 Bloss Werner H Prof Dr Ing Verfahren zum automatischen markieren von zellen und bestimmung der merkmale von zellen aus zytologischen abstrichpraeparaten
US4284412A (en) * 1979-07-13 1981-08-18 Ortho Diagnostics, Inc. Method and apparatus for automated identification and enumeration of specified blood cell subclasses
US4612614A (en) * 1980-09-12 1986-09-16 International Remote Imaging Systems, Inc. Method of analyzing particles in a fluid sample
US4513438A (en) * 1982-04-15 1985-04-23 Coulter Electronics, Inc. Automated microscopy system and method for locating and re-locating objects in an image
JPS59125176A (ja) * 1982-12-30 1984-07-19 インタ−ナシヨナル　ビジネス　マシ−ンズ　コ−ポレ−シヨン ビデオイメ−ジのシエ−ジング効果の補正装置
US4647531A (en) * 1984-02-06 1987-03-03 Ortho Diagnostic Systems, Inc. Generalized cytometry instrument and methods of use
US4665553A (en) * 1984-05-01 1987-05-12 Ortho Diagnostics Systems Inc. Methods and apparatus for analysis of particles and cells
JPS60233642A (ja) * 1984-05-07 1985-11-20 Fuji Photo Film Co Ltd 写真画像の形成方法
US4700298A (en) * 1984-09-14 1987-10-13 Branko Palcic Dynamic microscope image processing scanner
US4794531A (en) * 1984-11-07 1988-12-27 Hitachi, Ltd Unsharp masking for image enhancement
US4672559A (en) * 1984-12-26 1987-06-09 E. I. Du Pont De Nemours And Company Method for operating a microscopical mapping system
US4741043B1 (en) * 1985-11-04 1994-08-09 Cell Analysis Systems Inc Method of and apparatus for image analyses of biological specimens
GB8614212D0 (en) * 1986-06-11 1986-07-16 Kodak Ltd Image processing method
FR2602387B1 (fr) * 1986-07-30 1988-10-21 Trt Telecom Radio Electr Procede d'extraction automatique d'un objet contraste dans une image numerique
FR2604582B1 (fr) * 1986-09-30 1989-01-06 Bertin & Cie Procede pour transformer une image initiale de type video a multiples niveaux de gris en une image binaire
US5016173A (en) * 1989-04-13 1991-05-14 Vanguard Imaging Ltd. Apparatus and method for monitoring visually accessible surfaces of the body

Also Published As

Publication number Publication date
EP0421736A2 (de) 1991-04-10
JPH03255365A (ja) 1991-11-14
JP3090679B2 (ja) 2000-09-25
EP0421736A3 (en) 1992-05-13
CA2026617C (en) 2001-12-18
EP0421736B1 (de) 1997-05-14
IL95851A (en) 1994-07-31
DE69030703T2 (de) 1997-09-04
IL95851A0 (en) 1991-07-18
DE69030703D1 (de) 1997-06-19
US5107422A (en) 1992-04-21
CA2026617A1 (en) 1991-04-03

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