ATE147067T1 - Selektive n-acylation von aminoalkoholen - Google Patents
Selektive n-acylation von aminoalkoholenInfo
- Publication number
- ATE147067T1 ATE147067T1 AT93908917T AT93908917T ATE147067T1 AT E147067 T1 ATE147067 T1 AT E147067T1 AT 93908917 T AT93908917 T AT 93908917T AT 93908917 T AT93908917 T AT 93908917T AT E147067 T1 ATE147067 T1 AT E147067T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- amino alcohols
- acylation
- selective
- sec
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/20—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP92200968 | 1992-04-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE147067T1 true ATE147067T1 (de) | 1997-01-15 |
Family
ID=8210531
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT93908917T ATE147067T1 (de) | 1992-04-03 | 1993-04-02 | Selektive n-acylation von aminoalkoholen |
Country Status (9)
Country | Link |
---|---|
US (1) | US5631356A (de) |
EP (1) | EP0633875B1 (de) |
JP (1) | JP3594962B2 (de) |
AT (1) | ATE147067T1 (de) |
AU (1) | AU670818B2 (de) |
CA (1) | CA2131184A1 (de) |
DE (1) | DE69307131T2 (de) |
ES (1) | ES2098735T3 (de) |
WO (1) | WO1993020038A1 (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01256945A (ja) * | 1988-04-06 | 1989-10-13 | Hitachi Ltd | 磁気共鳴イメージング装置における位相歪の補正方式 |
FR2711138B1 (fr) * | 1993-10-12 | 1995-11-24 | Oreal | Céramides, leur procédé de préparation et leurs applications en cosmétique et en dermopharmacie. |
DE69501991T2 (de) * | 1994-03-18 | 1998-08-06 | Gist Brocades Bv | Linoleoylamidceramid-derivat und seine verwendung in kosmetischen zubereitungen zur behandlung von trockener haut |
JP3492696B2 (ja) * | 1994-09-30 | 2004-02-03 | コスモフェルム ベースローテン フェンノートシャップ | モノ不飽和脂肪酸を基体としたセラミド3誘導体 |
FR2728792A1 (fr) | 1995-01-04 | 1996-07-05 | Oreal | Composition cosmetique ou dermatologique comprenant au moins un ceramide 6 |
FR2730410B1 (fr) * | 1995-02-15 | 1997-03-21 | Oreal | Composition cosmetique comprenant une association de ceramides et son utilisation |
FR2732680B1 (fr) * | 1995-04-05 | 1997-05-09 | Oreal | Composes de type ceramides, leur procede de preparation et leur utilisation |
WO1996037192A1 (en) * | 1995-05-26 | 1996-11-28 | Vesifact Ag | Pharmaceutical and cosmetic compositions containing sphingo- and glycolipids |
JP4101320B2 (ja) * | 1996-10-11 | 2008-06-18 | 高砂香料工業株式会社 | 一級アミド誘導体の製造方法 |
JP4311766B2 (ja) * | 1997-03-13 | 2009-08-12 | コスモフェルム ベースローテン フェンノートシャップ | サリチル酸−スフィンゴイドベース誘導体及びそれらの使用 |
US5882665A (en) * | 1997-11-18 | 1999-03-16 | Elizabeth Arden Co., Division Of Conopco, Inc. | Phytosphingosine salicylates in cosmetic compositions |
DE69818242T2 (de) | 1997-12-05 | 2004-07-01 | Cosmoferm B.V. | Zusammensetzungen, enthaltend eine kombination aus freier sphingoid-base und ceramide sowie deren verwendung |
JP4255621B2 (ja) | 1998-05-14 | 2009-04-15 | コスモフェルム ベスローテン フェンノートシャップ | アミノアルコールのアシル化方法 |
CN1360567A (zh) * | 1999-03-09 | 2002-07-24 | 科斯莫弗姆有限公司 | 鞘氨基醇碱衍生物和其用途 |
ATE543909T1 (de) | 2004-11-05 | 2012-02-15 | Cosmoferm Bv | Sphingoidbasen produzierende pichia ciferrii |
TWI363756B (en) | 2004-12-07 | 2012-05-11 | Du Pont | Method for preparing n-phenylpyrazole-1-carboxamides |
DE602005018925D1 (de) | 2005-09-22 | 2010-03-04 | Cosmoferm Bv | Mikrobielle Stämme zur Produktion von Sphingosin |
US20070161578A1 (en) * | 2005-12-21 | 2007-07-12 | Hwa Joyce J | Treatment of nonalcoholic fatty liver disease using cholesterol lowering agents and/or H3 receptor antagonist/inverse agonist |
CN101583612A (zh) * | 2006-09-15 | 2009-11-18 | 先灵公司 | 治疗脂质代谢障碍的氮杂环丁酮衍生物 |
CA2663503A1 (en) * | 2006-09-15 | 2008-03-20 | Schering Corporation | Azetidinone derivatives and methods of use thereof |
CA2663434A1 (en) * | 2006-09-15 | 2008-03-20 | Schering Corporation | Spirocyclic azetidinone derivatives for the treatment of disorders of lipid metabolism, pain, diabetes and other disorders |
DE102008002410A1 (de) | 2008-06-13 | 2009-12-17 | Evonik Goldschmidt Gmbh | Enzymatische Synthese von Sphingolipiden |
DE102008002409A1 (de) | 2008-06-13 | 2009-12-17 | Evonik Goldschmidt Gmbh | Enzymatische Synthese von Sphingolipiden |
US9445975B2 (en) * | 2008-10-03 | 2016-09-20 | Access Business Group International, Llc | Composition and method for preparing stable unilamellar liposomal suspension |
JP5575718B2 (ja) | 2011-09-13 | 2014-08-20 | 花王株式会社 | N−アシルアミノトリオールの製造法 |
KR101689234B1 (ko) * | 2011-12-02 | 2016-12-23 | 주식회사 엘씨에스바이오텍 | 신규 파이토스핑고신 유도체 및 그 제조방법 |
ES2832555T3 (es) | 2017-03-27 | 2021-06-10 | Evonik Operations Gmbh | Procedimiento y producto para la preparación de formulaciones con contenido en ceramida |
CN116889627A (zh) | 2019-03-20 | 2023-10-17 | 雷杰纳荣制药公司 | 用固醇调节元件结合转录因子1(srebf1)抑制剂治疗脂质水平升高 |
JP2022525546A (ja) | 2019-03-20 | 2022-05-17 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ステロール調節エレメント結合転写タンパク質切断活性化タンパク質(scap)阻害剤による上昇した脂質レベルの治療 |
WO2023156605A1 (en) | 2022-02-21 | 2023-08-24 | Carbocode S.A. | Sphingolipid production |
CN115894278A (zh) * | 2022-11-01 | 2023-04-04 | 深圳市迪克曼生物科技有限公司 | 亚麻酸衍生的神经酰胺及其制备方法和应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2462439A1 (fr) * | 1979-07-26 | 1981-02-13 | Roussel Uclaf | Nouveau procede de preparation de produits derives de l'acide 7-/(2-aryl) 2-hydroxyimino acetamido/cephalosporanique |
DE8335662U1 (de) * | 1983-12-13 | 1984-03-08 | Steimel, Richard, 5202 Hennef | Spaenebrecher |
CA1288774C (en) * | 1985-01-07 | 1991-09-10 | Deborah A. Eppstein | 1,2-dialkoxy-w-trialkylammonium cationic surfactants |
FR2602774B1 (fr) * | 1986-07-29 | 1990-10-19 | Atta | Nouvelles molecules amphiphiles polyhydroxylees et perfluoroalkylees ayant des proprietes tensioactives |
DE3916072A1 (de) * | 1989-05-17 | 1990-11-22 | Thera Ges Fuer Patente | Ceramidderivate und ihre verwendung als inhibitoren der sphingolipidsynthese |
FR2652002B1 (fr) * | 1989-09-21 | 1991-11-29 | Oreal | Nouveaux composes lipidiques derives des sphingosines, leur procede de preparation et leurs applications, notamment en cosmetique et en dermopharmacie. |
-
1993
- 1993-04-02 EP EP93908917A patent/EP0633875B1/de not_active Expired - Lifetime
- 1993-04-02 AU AU49590/93A patent/AU670818B2/en not_active Ceased
- 1993-04-02 WO PCT/EP1993/000849 patent/WO1993020038A1/en active IP Right Grant
- 1993-04-02 JP JP51712093A patent/JP3594962B2/ja not_active Expired - Lifetime
- 1993-04-02 US US08/313,287 patent/US5631356A/en not_active Expired - Lifetime
- 1993-04-02 AT AT93908917T patent/ATE147067T1/de not_active IP Right Cessation
- 1993-04-02 ES ES93908917T patent/ES2098735T3/es not_active Expired - Lifetime
- 1993-04-02 CA CA002131184A patent/CA2131184A1/en not_active Abandoned
- 1993-04-02 DE DE69307131T patent/DE69307131T2/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0633875A1 (de) | 1995-01-18 |
AU4959093A (en) | 1993-11-08 |
DE69307131T2 (de) | 1997-04-24 |
JPH07505163A (ja) | 1995-06-08 |
AU670818B2 (en) | 1996-08-01 |
WO1993020038A1 (en) | 1993-10-14 |
DE69307131D1 (de) | 1997-02-13 |
CA2131184A1 (en) | 1993-10-14 |
JP3594962B2 (ja) | 2004-12-02 |
US5631356A (en) | 1997-05-20 |
EP0633875B1 (de) | 1997-01-02 |
ES2098735T3 (es) | 1997-05-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |