DE69307131T2 - Selektive n-acylation von aminoalkoholen - Google Patents
Selektive n-acylation von aminoalkoholenInfo
- Publication number
- DE69307131T2 DE69307131T2 DE69307131T DE69307131T DE69307131T2 DE 69307131 T2 DE69307131 T2 DE 69307131T2 DE 69307131 T DE69307131 T DE 69307131T DE 69307131 T DE69307131 T DE 69307131T DE 69307131 T2 DE69307131 T2 DE 69307131T2
- Authority
- DE
- Germany
- Prior art keywords
- pct
- amino alcohols
- acylation
- selective
- sec
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/20—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP92200968 | 1992-04-03 | ||
PCT/EP1993/000849 WO1993020038A1 (en) | 1992-04-03 | 1993-04-02 | Selective n-acylation of amino alcohols |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69307131D1 DE69307131D1 (de) | 1997-02-13 |
DE69307131T2 true DE69307131T2 (de) | 1997-04-24 |
Family
ID=8210531
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69307131T Expired - Lifetime DE69307131T2 (de) | 1992-04-03 | 1993-04-02 | Selektive n-acylation von aminoalkoholen |
Country Status (9)
Country | Link |
---|---|
US (1) | US5631356A (de) |
EP (1) | EP0633875B1 (de) |
JP (1) | JP3594962B2 (de) |
AT (1) | ATE147067T1 (de) |
AU (1) | AU670818B2 (de) |
CA (1) | CA2131184A1 (de) |
DE (1) | DE69307131T2 (de) |
ES (1) | ES2098735T3 (de) |
WO (1) | WO1993020038A1 (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01256945A (ja) * | 1988-04-06 | 1989-10-13 | Hitachi Ltd | 磁気共鳴イメージング装置における位相歪の補正方式 |
FR2711138B1 (fr) * | 1993-10-12 | 1995-11-24 | Oreal | Céramides, leur procédé de préparation et leurs applications en cosmétique et en dermopharmacie. |
EP0699181B1 (de) * | 1994-03-18 | 1998-04-08 | Gist-Brocades B.V. | Linoleoylamidceramid-derivat und seine verwendung in kosmetischen zubereitungen zur behandlung von trockener haut |
EP0731785B1 (de) * | 1994-09-30 | 1998-12-30 | Gist-Brocades B.V. | Ceramid-3-derivate von einfachungesättigten fettsäuren |
FR2728792A1 (fr) | 1995-01-04 | 1996-07-05 | Oreal | Composition cosmetique ou dermatologique comprenant au moins un ceramide 6 |
FR2730410B1 (fr) * | 1995-02-15 | 1997-03-21 | Oreal | Composition cosmetique comprenant une association de ceramides et son utilisation |
FR2732680B1 (fr) * | 1995-04-05 | 1997-05-09 | Oreal | Composes de type ceramides, leur procede de preparation et leur utilisation |
WO1996037192A1 (en) * | 1995-05-26 | 1996-11-28 | Vesifact Ag | Pharmaceutical and cosmetic compositions containing sphingo- and glycolipids |
JP4101320B2 (ja) * | 1996-10-11 | 2008-06-18 | 高砂香料工業株式会社 | 一級アミド誘導体の製造方法 |
DE69802908T2 (de) * | 1997-03-13 | 2004-05-06 | Cosmoferm B.V. | Salicylsäure - sphingoidbase derivate und ihre verwendung |
US5882665A (en) * | 1997-11-18 | 1999-03-16 | Elizabeth Arden Co., Division Of Conopco, Inc. | Phytosphingosine salicylates in cosmetic compositions |
ES2207023T3 (es) | 1997-12-05 | 2004-05-16 | Cosmoferm B.V. | Composiciones que comprenden una combinacion de una base esfingoide libre y una ceramida y utilizacion de las mismas. |
BR9906444A (pt) * | 1998-05-14 | 2000-09-26 | Dsm Nv | Processo para acilação de amino álcoois |
KR20010108331A (ko) * | 1999-03-09 | 2001-12-07 | 비이체 코이닝 | 스핑고이드 염기 유도체 및 그의 용도 |
EP1815003B1 (de) | 2004-11-05 | 2012-02-01 | Cosmoferm B.V. | Sphingoidbasen produzierende Pichia ciferrii |
TWI363756B (en) | 2004-12-07 | 2012-05-11 | Du Pont | Method for preparing n-phenylpyrazole-1-carboxamides |
ATE455182T1 (de) | 2005-09-22 | 2010-01-15 | Cosmoferm Bv | Mikrobielle stämme zur produktion von sphingosin |
CA2634940A1 (en) * | 2005-12-21 | 2007-07-05 | Schering Corporation | Treatment of nonalcoholic fatty liver disease using cholesterol lowering agents and h3 receptor antagonist/inverse agonist |
MX2009002924A (es) * | 2006-09-15 | 2009-05-28 | Schering Corp | Derivados de azetidinona espirociclica para el tratamiento de trastornos del metabolismo de los lipidos, el dolor, la diabetes y otros trastornos. |
CA2663502A1 (en) * | 2006-09-15 | 2008-03-20 | Schering Corporation | Azetidinone derivatives and methods of use thereof |
US20080076750A1 (en) * | 2006-09-15 | 2008-03-27 | Aslanian Robert G | Azetidinone Derivatives and Methods of Use Thereof |
DE102008002410A1 (de) | 2008-06-13 | 2009-12-17 | Evonik Goldschmidt Gmbh | Enzymatische Synthese von Sphingolipiden |
DE102008002409A1 (de) | 2008-06-13 | 2009-12-17 | Evonik Goldschmidt Gmbh | Enzymatische Synthese von Sphingolipiden |
US9445975B2 (en) | 2008-10-03 | 2016-09-20 | Access Business Group International, Llc | Composition and method for preparing stable unilamellar liposomal suspension |
JP5575718B2 (ja) | 2011-09-13 | 2014-08-20 | 花王株式会社 | N−アシルアミノトリオールの製造法 |
KR101689234B1 (ko) * | 2011-12-02 | 2016-12-23 | 주식회사 엘씨에스바이오텍 | 신규 파이토스핑고신 유도체 및 그 제조방법 |
EP3600228B1 (de) | 2017-03-27 | 2020-09-30 | Evonik Operations GmbH | Verfahren und erzeugnis zur herstellung ceramidhaltiger formulierungen |
CN113825839A (zh) | 2019-03-20 | 2021-12-21 | 雷杰纳荣制药公司 | 用固醇调节元件结合蛋白切割激活蛋白(scap)抑制剂治疗脂质水平升高 |
JP2022525545A (ja) | 2019-03-20 | 2022-05-17 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ステロール調節エレメント結合転写因子1(srebf1)阻害剤による上昇した脂質レベルの治療 |
WO2023156605A1 (en) | 2022-02-21 | 2023-08-24 | Carbocode S.A. | Sphingolipid production |
CN115894278A (zh) * | 2022-11-01 | 2023-04-04 | 深圳市迪克曼生物科技有限公司 | 亚麻酸衍生的神经酰胺及其制备方法和应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2462439A1 (fr) * | 1979-07-26 | 1981-02-13 | Roussel Uclaf | Nouveau procede de preparation de produits derives de l'acide 7-/(2-aryl) 2-hydroxyimino acetamido/cephalosporanique |
DE8335662U1 (de) * | 1983-12-13 | 1984-03-08 | Steimel, Richard, 5202 Hennef | Spaenebrecher |
CA1288774C (en) * | 1985-01-07 | 1991-09-10 | Deborah A. Eppstein | 1,2-dialkoxy-w-trialkylammonium cationic surfactants |
FR2602774B1 (fr) * | 1986-07-29 | 1990-10-19 | Atta | Nouvelles molecules amphiphiles polyhydroxylees et perfluoroalkylees ayant des proprietes tensioactives |
DE3916072A1 (de) * | 1989-05-17 | 1990-11-22 | Thera Ges Fuer Patente | Ceramidderivate und ihre verwendung als inhibitoren der sphingolipidsynthese |
FR2652002B1 (fr) * | 1989-09-21 | 1991-11-29 | Oreal | Nouveaux composes lipidiques derives des sphingosines, leur procede de preparation et leurs applications, notamment en cosmetique et en dermopharmacie. |
-
1993
- 1993-04-02 WO PCT/EP1993/000849 patent/WO1993020038A1/en active IP Right Grant
- 1993-04-02 AU AU49590/93A patent/AU670818B2/en not_active Ceased
- 1993-04-02 EP EP93908917A patent/EP0633875B1/de not_active Expired - Lifetime
- 1993-04-02 JP JP51712093A patent/JP3594962B2/ja not_active Expired - Lifetime
- 1993-04-02 CA CA002131184A patent/CA2131184A1/en not_active Abandoned
- 1993-04-02 ES ES93908917T patent/ES2098735T3/es not_active Expired - Lifetime
- 1993-04-02 AT AT93908917T patent/ATE147067T1/de not_active IP Right Cessation
- 1993-04-02 US US08/313,287 patent/US5631356A/en not_active Expired - Lifetime
- 1993-04-02 DE DE69307131T patent/DE69307131T2/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO1993020038A1 (en) | 1993-10-14 |
ES2098735T3 (es) | 1997-05-01 |
CA2131184A1 (en) | 1993-10-14 |
ATE147067T1 (de) | 1997-01-15 |
DE69307131D1 (de) | 1997-02-13 |
JP3594962B2 (ja) | 2004-12-02 |
AU670818B2 (en) | 1996-08-01 |
US5631356A (en) | 1997-05-20 |
AU4959093A (en) | 1993-11-08 |
EP0633875A1 (de) | 1995-01-18 |
JPH07505163A (ja) | 1995-06-08 |
EP0633875B1 (de) | 1997-01-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: DSM N.V., HEERLEN, NL |
|
8327 | Change in the person/name/address of the patent owner |
Owner name: COSMOFERM B.V., DELFT, NL |
|
R081 | Change of applicant/patentee |
Ref document number: 633875 Country of ref document: EP Owner name: EVONIK GOLDSCHMIDT GMBH, DE Free format text: FORMER OWNER: COSMOFERM B.V., DELFT, NL Effective date: 20121115 |
|
R082 | Change of representative |
Ref document number: 633875 Country of ref document: EP Representative=s name: DIEHL & PARTNER GBR, DE Effective date: 20121115 |