ES2098735T3 - N-acilacion selectiva de amino-alcoholes. - Google Patents

N-acilacion selectiva de amino-alcoholes.

Info

Publication number
ES2098735T3
ES2098735T3 ES93908917T ES93908917T ES2098735T3 ES 2098735 T3 ES2098735 T3 ES 2098735T3 ES 93908917 T ES93908917 T ES 93908917T ES 93908917 T ES93908917 T ES 93908917T ES 2098735 T3 ES2098735 T3 ES 2098735T3
Authority
ES
Spain
Prior art keywords
pct
sec
reacting
salt
alcohols
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93908917T
Other languages
English (en)
Inventor
Jan Willem Hubert Smeets
Pieter Gijsbert Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gist Brocades NV
Original Assignee
Gist Brocades NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades NV filed Critical Gist Brocades NV
Application granted granted Critical
Publication of ES2098735T3 publication Critical patent/ES2098735T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/20—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

LA INVENCION SUMINISTRA UN METODO EFICIENTE PARA LA PRODUCCION DE ALCOHOLES DE N-ACILAMINO POR MEDIO DE LA ACILACION SELECTIVA DE LOS AMINOS LIBRES DE LOS ALCOHOLES DE AMINO MEDIANTE LA REACCION DE UN ACIDO ORGANICO O DE UNA SAL DEL MISMO CON UN CLORURO DE ALQUILSULFONIL O UN CLORURO DE ALQUILFENILSULFONIL, EN UN SOLVENTE ORGANICO EN LA PRESENCIA DE UNA BASE ORGANICA, PARA FORMAR EL ANHIDRIDO MEZCLADO CORRESPONDIENTE SEGUIDA POR LA REACCION DEL ANHIDRIDO MEZCLADO CON UN ALCOHOL DE AMINO O UNA SAL DEL MISMO PARA FORMAR EL CORRESPONDIENTE ALCOHOL DE N-ACILAMIDO.
ES93908917T 1992-04-03 1993-04-02 N-acilacion selectiva de amino-alcoholes. Expired - Lifetime ES2098735T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92200968 1992-04-03

Publications (1)

Publication Number Publication Date
ES2098735T3 true ES2098735T3 (es) 1997-05-01

Family

ID=8210531

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93908917T Expired - Lifetime ES2098735T3 (es) 1992-04-03 1993-04-02 N-acilacion selectiva de amino-alcoholes.

Country Status (9)

Country Link
US (1) US5631356A (es)
EP (1) EP0633875B1 (es)
JP (1) JP3594962B2 (es)
AT (1) ATE147067T1 (es)
AU (1) AU670818B2 (es)
CA (1) CA2131184A1 (es)
DE (1) DE69307131T2 (es)
ES (1) ES2098735T3 (es)
WO (1) WO1993020038A1 (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01256945A (ja) * 1988-04-06 1989-10-13 Hitachi Ltd 磁気共鳴イメージング装置における位相歪の補正方式
FR2711138B1 (fr) * 1993-10-12 1995-11-24 Oreal Céramides, leur procédé de préparation et leurs applications en cosmétique et en dermopharmacie.
WO1995025716A1 (en) * 1994-03-18 1995-09-28 Gist-Brocades B.V. Linoleoylamide based ceramide derivative and its use in cosmetic preparations for the treatment of dry skin
WO1996010557A1 (en) * 1994-09-30 1996-04-11 Gist-Brocades B.V. Ceramide 3 derivatives based on monounsaturated fatty acids
FR2728792A1 (fr) 1995-01-04 1996-07-05 Oreal Composition cosmetique ou dermatologique comprenant au moins un ceramide 6
FR2730410B1 (fr) * 1995-02-15 1997-03-21 Oreal Composition cosmetique comprenant une association de ceramides et son utilisation
FR2732680B1 (fr) * 1995-04-05 1997-05-09 Oreal Composes de type ceramides, leur procede de preparation et leur utilisation
WO1996037192A1 (en) * 1995-05-26 1996-11-28 Vesifact Ag Pharmaceutical and cosmetic compositions containing sphingo- and glycolipids
JP4101320B2 (ja) * 1996-10-11 2008-06-18 高砂香料工業株式会社 一級アミド誘導体の製造方法
JP4311766B2 (ja) * 1997-03-13 2009-08-12 コスモフェルム ベースローテン フェンノートシャップ サリチル酸−スフィンゴイドベース誘導体及びそれらの使用
US5882665A (en) * 1997-11-18 1999-03-16 Elizabeth Arden Co., Division Of Conopco, Inc. Phytosphingosine salicylates in cosmetic compositions
JP2001510487A (ja) 1997-12-05 2001-07-31 デーエスエム ナムローゼ フェンノートシャップ 遊離スフィンゴイド塩基及びセラミドの組合せを含む組成物並びにその使用
JP4255621B2 (ja) 1998-05-14 2009-04-15 コスモフェルム ベスローテン フェンノートシャップ アミノアルコールのアシル化方法
WO2000053568A1 (en) * 1999-03-09 2000-09-14 Cosmoferm B.V. Sphingoid base derivatives and uses thereof
CN101098968B (zh) 2004-11-05 2013-09-18 科斯莫费尔姆有限公司 生产类鞘氨醇碱或其衍生物的微生物菌株
TWI363756B (en) 2004-12-07 2012-05-11 Du Pont Method for preparing n-phenylpyrazole-1-carboxamides
EP1767644B1 (en) 2005-09-22 2010-01-13 Cosmoferm B.V. Microbial strains producing sphingosine
US20070161578A1 (en) * 2005-12-21 2007-07-12 Hwa Joyce J Treatment of nonalcoholic fatty liver disease using cholesterol lowering agents and/or H3 receptor antagonist/inverse agonist
CN101528746A (zh) * 2006-09-15 2009-09-09 先灵公司 治疗脂质代谢障碍、疼痛、糖尿病和其它障碍的螺环氮杂环丁酮衍生物
CN101583612A (zh) * 2006-09-15 2009-11-18 先灵公司 治疗脂质代谢障碍的氮杂环丁酮衍生物
JP2010503678A (ja) * 2006-09-15 2010-02-04 シェーリング コーポレイション アゼチジノン誘導体およびその使用方法
DE102008002410A1 (de) 2008-06-13 2009-12-17 Evonik Goldschmidt Gmbh Enzymatische Synthese von Sphingolipiden
DE102008002409A1 (de) 2008-06-13 2009-12-17 Evonik Goldschmidt Gmbh Enzymatische Synthese von Sphingolipiden
US9445975B2 (en) 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
JP5575718B2 (ja) * 2011-09-13 2014-08-20 花王株式会社 Ｎ−アシルアミノトリオールの製造法
WO2013081226A1 (ko) * 2011-12-02 2013-06-06 주식회사 엘씨에스바이오텍 신규 파이토스핑고신 유도체 및 그 제조방법
CN110494116A (zh) 2017-03-27 2019-11-22 赢创德固赛有限公司 用于制备含神经酰胺的配制物的方法和产品
US11331332B2 (en) 2019-03-20 2022-05-17 Regeneron Pharmaceuticals, Inc. Treatment of increased lipid levels with sterol regulatory element binding protein cleavage-activating protein (SCAP) inhibitors
CN113727732B (zh) 2019-03-20 2023-08-08 雷杰纳荣制药公司 用固醇调节元件结合转录因子1(srebf1)抑制剂治疗脂质水平升高
EP4482820A1 (en) 2022-02-21 2025-01-01 Cataya Bio (Shanghai) Co., Ltd. Sphingolipid production
CN120037152A (zh) * 2022-11-01 2025-05-27 深圳市迪克曼生物科技有限公司 亚麻酸衍生的神经酰胺的应用
EP4417598A1 (en) 2023-02-16 2024-08-21 Roelmi HPC S.r.l A process for the preparation of ceramides
CN120957967A (zh) 2023-03-16 2025-11-14 柯泰亚生物科技(上海)有限公司 神经酰胺的生产
US20250075216A1 (en) 2023-08-29 2025-03-06 Regeneron Pharmaceuticals, Inc. Treatment Of Muscle Disorder With Folliculin Interacting Protein 1 (FNIP1) Inhibitors And/Or Folliculin (FLCN) Inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2462439A1 (fr) * 1979-07-26 1981-02-13 Roussel Uclaf Nouveau procede de preparation de produits derives de l'acide 7-/(2-aryl) 2-hydroxyimino acetamido/cephalosporanique
DE8335662U1 (de) * 1983-12-13 1984-03-08 Steimel, Richard, 5202 Hennef Spaenebrecher
NZ214716A (en) * 1985-01-07 1989-04-26 Syntex Inc 1,2-dialkoxy-omega-trialkylammonium cationic surfactants
FR2602774B1 (fr) * 1986-07-29 1990-10-19 Atta Nouvelles molecules amphiphiles polyhydroxylees et perfluoroalkylees ayant des proprietes tensioactives
DE3916072A1 (de) * 1989-05-17 1990-11-22 Thera Ges Fuer Patente Ceramidderivate und ihre verwendung als inhibitoren der sphingolipidsynthese
FR2652002B1 (fr) * 1989-09-21 1991-11-29 Oreal Nouveaux composes lipidiques derives des sphingosines, leur procede de preparation et leurs applications, notamment en cosmetique et en dermopharmacie.

Also Published As

Publication number Publication date
ATE147067T1 (de) 1997-01-15
AU4959093A (en) 1993-11-08
EP0633875B1 (en) 1997-01-02
DE69307131T2 (de) 1997-04-24
WO1993020038A1 (en) 1993-10-14
AU670818B2 (en) 1996-08-01
JPH07505163A (ja) 1995-06-08
EP0633875A1 (en) 1995-01-18
JP3594962B2 (ja) 2004-12-02
CA2131184A1 (en) 1993-10-14
DE69307131D1 (de) 1997-02-13
US5631356A (en) 1997-05-20

Similar Documents

Publication Publication Date Title
ES2098735T3 (es) N-acilacion selectiva de amino-alcoholes.
ATE415394T1 (de) Zwischeprodukte zur herstellung von retroviralen protease-hemmern
NO914356D0 (no) Mono n-substituerte 1,4,7,10-tetraazacyklododecan-derivater
ES8405364A1 (es) Metodo de preparar amidoaminoacidos n-substituidos.
ATE196509T1 (de) Enzymatische synthese von ceramiden und hybrid- ceramiden
FI862882A0 (fi) 1-substituerade oxindol-3 -karboxiamider som antiinflammatoriska och vaerkstillande medel.
DE69433984D1 (de) Arylpiperazinderivate von indol als liganden der rezeptoren 5 ht1-like, 5 ht1b und 5 ht1d
ATE317912T1 (de) Verfahren zur herstellung von beta-lactamen
DE68917934D1 (de) Fingerabdruck-reagenz.
ATE210136T1 (de) Verfahren zur herstellung von alkylhydrogenchlorsilanen
NO944617L (no) Desferrioksamin-B-salter
BR9206776A (pt) Amino ésteres de ácido 1,3,5-triazina-2,4,6-tris-alquilaminocarboxílico agentes biocidas contendo tais ésteres e processo para prepará-los
ATE206407T1 (de) Verfahren zur herstellung von hiv proteasinhibitoren
ATE163414T1 (de) Verfahren zur herstellung von triazolonderivaten
ES2103794T3 (es) Pirazolinas, pirazolidinas e hidrazinas artropodicidas.
PT99578A (pt) Processo para a reactivacao de uma proteina desnaturada
BR9605027A (pt) Processo para preparar um carboxilato de b-trifluor-metila & b-insaturado
DE69606107D1 (de) Verfahren zur Herstellung von N-(Alkylsulfonyl)amiden
BR8208033A (pt) Processo quimico
ATE237583T1 (de) Verfahren zur herstellung von depsipeptiden und zwischenprodukten davon
DK0662952T3 (da) Fremgangsmåde til stereoselektiv syntese af 3-substituerede 2-sulfonylmethylpropionsyrer samt mellemprodukter
KR860009040A (ko) 디펩티드와 아민과의 부가 화합물의 제조방법
DE59305354D1 (de) Spritzfertige azosemid-injektionslösungen
DE59106994D1 (de) Verfahren zur reinigung von 7-chlor-chinolin-8-carbonsäuren.
DE59506734D1 (de) Verfahren zur herstellung n-z-geschützter n-alkylierter aminosäuren

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 633875

Country of ref document: ES