ATE140451T1 - N-phenyl-n-(4-piperidinyl)-amide, verwendbar als analgetika - Google Patents

N-phenyl-n-(4-piperidinyl)-amide, verwendbar als analgetika

Info

Publication number
ATE140451T1
ATE140451T1 AT90301586T AT90301586T ATE140451T1 AT E140451 T1 ATE140451 T1 AT E140451T1 AT 90301586 T AT90301586 T AT 90301586T AT 90301586 T AT90301586 T AT 90301586T AT E140451 T1 ATE140451 T1 AT E140451T1
Authority
AT
Austria
Prior art keywords
lower alkyl
group
alkoxy
member selected
carbonyl
Prior art date
Application number
AT90301586T
Other languages
English (en)
Inventor
Paul L Feldman
Michael K James
Marcus F Brackeen
Michael Ross Johnson
Harry Jefferson Leighton
Original Assignee
Glaxo Wellcome Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Wellcome Inc filed Critical Glaxo Wellcome Inc
Application granted granted Critical
Publication of ATE140451T1 publication Critical patent/ATE140451T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT90301586T 1989-02-15 1990-02-14 N-phenyl-n-(4-piperidinyl)-amide, verwendbar als analgetika ATE140451T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31131189A 1989-02-15 1989-02-15
US07/448,497 US5019583A (en) 1989-02-15 1989-12-11 N-phenyl-N-(4-piperidinyl)amides useful as analgesics

Publications (1)

Publication Number Publication Date
ATE140451T1 true ATE140451T1 (de) 1996-08-15

Family

ID=26977841

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90301586T ATE140451T1 (de) 1989-02-15 1990-02-14 N-phenyl-n-(4-piperidinyl)-amide, verwendbar als analgetika

Country Status (22)

Country Link
US (1) US5019583A (de)
EP (1) EP0383579B1 (de)
JP (1) JP2895145B2 (de)
KR (1) KR0160979B1 (de)
AT (1) ATE140451T1 (de)
AU (1) AU636330B2 (de)
CA (1) CA2010011C (de)
CY (1) CY2002A (de)
CZ (1) CZ402591A3 (de)
DE (2) DE69027794T2 (de)
DK (1) DK0383579T3 (de)
ES (1) ES2088961T4 (de)
GR (1) GR3020719T3 (de)
HK (1) HK78297A (de)
IE (1) IE77156B1 (de)
LU (1) LU90011I2 (de)
MX (1) MX9203024A (de)
NL (1) NL960030I2 (de)
NZ (1) NZ232542A (de)
PT (1) PT93137B (de)
SG (1) SG47967A1 (de)
SK (1) SK402591A3 (de)

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US5130321A (en) * 1990-12-18 1992-07-14 Glaxo Inc. Analgesic n-phenyl-n-(3-or 1-3-me-4-piperidinyl)amides
US5214148A (en) * 1990-12-18 1993-05-25 Glaxo Inc. Analgesic N-phenyl-N-(3-OR1 -3-ME-4-piperidinyl)amides
GB9316863D0 (en) * 1993-08-13 1993-09-29 Glaxo Group Ltd Chemical process
US5466700A (en) * 1993-08-30 1995-11-14 Glaxo Wellcome Inc. Anesthetic use of N-phenyl-N-(4-piperidinyl)amides
US5866591A (en) * 1996-09-11 1999-02-02 Glaxo Wellcome Inc. Stable formulations of remifentanil
ATE306472T1 (de) * 1997-12-24 2005-10-15 Ortho Mcneil Pharm Inc (4)-(aryl(piperidin-4-yl) aminobenzamidderivate die an delta-opioid rezeptor binden
US6858018B1 (en) * 1998-09-28 2005-02-22 Vyteris, Inc. Iontophoretic devices
US6436959B1 (en) 1998-12-23 2002-08-20 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(piperidin-4-yl)]aminobenzamides
US7074935B2 (en) 1999-12-06 2006-07-11 Mallinckrodt Inc. Methods for the syntheses of alfentanil, sufentanil and remifentanil
WO2001068604A2 (en) 2000-03-14 2001-09-20 Sepracor, Inc. 3-substituted piperidines comprising urea functionality, and methods of use thereof
ES2302742T5 (es) * 2000-07-31 2011-10-10 Nycomed Danmark Aps Pulverizador nasal para suministrar una composición farmacéutica.
WO2002096351A2 (en) 2001-04-03 2002-12-05 Aryx Therapeutics Ultrashort-acting opioids for transdermal application
AU2002361709A1 (en) * 2001-12-17 2003-06-30 Aryx Therapeutics Analgesic delivery systems and methods of use
JPWO2005030722A1 (ja) * 2003-09-29 2006-12-07 日本ケミファ株式会社 Ｎ−置換−ｎ−（４−ピペリジニル）アミド誘導体
MXPA06013917A (es) 2004-06-18 2007-03-07 Neurosearch As Nuevos derivados de piperidina sustituidos con alquilo y su uso como inhibidores de la recaptacion del neurotransmisor monoamino.
US20090030041A1 (en) * 2004-09-14 2009-01-29 Toshihiro Takahashi N-substituted N-(4-piperidinyl) Amide Derivative
EP1966140A1 (de) * 2005-11-17 2008-09-10 Mallinckrodt, Inc. Verfahren zur synthese von remifentanil
JP2009524659A (ja) * 2006-01-24 2009-07-02 マリンクロッド・インコーポレイテッド レミフェンタニルの合成方法
CN101379032A (zh) * 2006-02-03 2009-03-04 马林克罗特公司 瑞芬太尼盐酸盐的晶型
EP1867635A1 (de) * 2006-06-15 2007-12-19 Kern Pharma, S.L. Verfahren zur Herstellung von Remifentanil, seine Zwischenprodukte, die Verwendung von diesen Zwischenprodukten und das Verfahren zur deren Herstellung
GB0613693D0 (en) * 2006-07-10 2006-08-16 Cenes Ltd Benzodiazepine salts (3)
RU2470935C2 (ru) 2006-07-10 2012-12-27 ПАЙОН ЮКей ЛИМИТЕД Бензодиазепиновые соли кратковременного действия и их полиморфные формы
WO2008045192A2 (en) * 2006-10-05 2008-04-17 Mallinckrodt Inc. Alternate process for remifentanil preparation
AU2007325889A1 (en) * 2006-11-29 2008-06-05 Mallinckrodt Inc. New process for remifentanil synthesis
MX2010010675A (es) 2008-03-31 2010-11-25 Gen Hospital Corp Analogos de etomidato con propiedades farmacocineticas y farmacodinamicas mejoradas.
WO2010000282A1 (de) * 2008-07-03 2010-01-07 Cilag Ag Verfahren zur herstellung von n-phenyl-n-(4-piperidinyl) amidsalzen
WO2010053944A1 (en) * 2008-11-04 2010-05-14 Cambrex Charles City, Inc. Improved method of making piperidine derivatives
BR112012000606A2 (pt) 2009-07-10 2016-11-22 Brigham & Womens Hospital análogos de etomidato que não inibem a síntese de esteróides adrenocorticais
EP2450039A1 (de) 2010-11-08 2012-05-09 PAION UK Ltd. Dosierschema zur Sedierung mit CNS 7056 (Remimazolam)
IN2014DN06132A (de) 2012-01-13 2015-08-14 Gen Hospital Corp
KR20150065873A (ko) 2012-10-08 2015-06-15 오클랜드 유니서비시즈 리미티드 케타민 유도체
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
CN103728403B (zh) * 2013-08-30 2015-10-07 宜昌人福药业有限责任公司 一种盐酸瑞芬太尼原料药中有关物质的检测方法
EP3199523B1 (de) 2016-01-29 2018-08-15 Bioka s. r.o. Das neue verfahren zur herstellung von n-phenyl-n- (4-piperidinyl) amid-derivate wie remifentanil und carfentanil
PL3643704T3 (pl) 2018-10-26 2021-06-14 Hameln Pharma Gmbh Nowe produkty pośrednie do wytwarzania chlorowodorku remifentanilu
GB202010168D0 (en) 2020-07-02 2020-08-19 Johnson Matthey Plc Process for preparing remifentanil hydrochloride
CN114262320A (zh) * 2021-12-28 2022-04-01 宜昌人福药业有限责任公司 一种利用连续流微通道反应器制备苯胺基哌啶类药物的合成方法

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NL284196A (de) * 1961-10-10
US3655675A (en) * 1968-09-09 1972-04-11 Sterling Drug Inc N-(n-heteryl)-acylanilides
US3998834A (en) * 1975-03-14 1976-12-21 Janssen Pharmaceutica N.V. N-(4-piperidinyl)-n-phenylamides and -carbamates
US4179569A (en) * 1975-03-14 1979-12-18 Janssen Pharmaceutica N.V. N-(4-piperidinyl)-N-phenylamides
US4167574A (en) * 1978-03-13 1979-09-11 Janssen Pharmaceutica, N.V. N-phenyl-N-(4-piperidinyl)amides
US4584303A (en) * 1984-04-09 1986-04-22 The Boc Group, Inc. N-aryl-N-(4-piperidinyl)amides and pharmaceutical compositions and method employing such compounds
US4801721A (en) * 1984-08-16 1989-01-31 Ryan James W Stereospecific synthesis of carboxyalkyl peptides
CA1317940C (en) * 1987-09-25 1993-05-18 Georges H. P. Van Daele Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides

Also Published As

Publication number Publication date
GR3020719T3 (en) 1996-11-30
US5019583A (en) 1991-05-28
EP0383579B1 (de) 1996-07-17
CA2010011A1 (en) 1990-08-15
LU90011I2 (fr) 1997-03-11
ES2088961T4 (es) 1996-12-01
CZ402591A3 (en) 1993-04-14
IE77156B1 (en) 1997-12-03
AU4973190A (en) 1990-08-23
SK402591A3 (en) 2000-09-12
NL960030I2 (nl) 1997-05-01
DE19675028I2 (de) 2002-11-07
ES2088961T3 (es) 1996-10-01
KR0160979B1 (ko) 1998-12-01
HK78297A (en) 1997-06-20
CA2010011C (en) 1997-12-02
AU636330B2 (en) 1993-04-29
MX9203024A (es) 1992-07-01
KR900012906A (ko) 1990-09-03
CY2002A (en) 1997-12-05
DE69027794T2 (de) 1997-01-02
DK0383579T3 (da) 1996-10-14
EP0383579A1 (de) 1990-08-22
SG47967A1 (en) 1998-04-17
IE900532L (en) 1990-08-15
PT93137A (pt) 1990-08-31
JPH02300167A (ja) 1990-12-12
NL960030I1 (nl) 1997-02-03
NZ232542A (en) 1992-06-25
DE69027794D1 (de) 1996-08-22
JP2895145B2 (ja) 1999-05-24
PT93137B (pt) 1996-02-29

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