KR870004955A - 다양한 n-치환된 3-피페리딘카복실산 또는 n-치환된 3-피리딘카복실산 및 당해 유도체 - Google Patents

다양한 n-치환된 3-피페리딘카복실산 또는 n-치환된 3-피리딘카복실산 및 당해 유도체 Download PDF

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KR870004955A
KR870004955A KR860009111A KR860009111A KR870004955A KR 870004955 A KR870004955 A KR 870004955A KR 860009111 A KR860009111 A KR 860009111A KR 860009111 A KR860009111 A KR 860009111A KR 870004955 A KR870004955 A KR 870004955A
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South Korea
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compound
ethyl
methoxy
bis
piperidinecarboxylic acid
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KR860009111A
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KR900005023B1 (ko
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알. 파비아 미첼
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크리스틴 에에. 트라우트웨인
워너-램버트 캄퍼니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

내용 없음

Description

다양한 N-치환된 3-피페리딘카복실산 또는 N-치환된 3-피리딘카복실산 및 당해 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (27)

  1. 다음 일반식(1)의 화합물 또는 그것의 부분 입체 이성질체 또는 거울상 이성질체 및 제약학적으로 사용 가능한 당해 염기 염 및 산 부가염.
    [식중, n은 1,2,3 또는 4의 양의 정수;는 단일 또는 이중 결합; Y는가 이중결합일때 Y는 수소 또는 C1-4알킬인 것을 조건으로, 수소, 하이드록시 또는 C1-4알킬; R'는 하이드록시, 저급 알콕시 또는 NR1R2(R1및 R2는 독립적으로 수소 또는 저급 알킬); X는 산소, S(O)z(Z는 0.1, 또는 2) 또는 NR″(R″는 수소 또는 저급 알킬); B는 (i)
    로 R3,R3',R3″는 독립적으로 수소, 할로겐, 트리플루오로메틸, 하이드록시, 저급 알킬, 저급 알콕시, NR5R6(R5및 R6는 독립적으로 수소 또는 저급 알킬), 또는 SO2NR5R6(R5및 R6는 전술한 바와 같음); 및 D는 2-또는 3-티에닐, 2-, 3- 또는 4-피리딜, 또는 임의로 C1-4알킬로 치환된 C5-6환의 사이클로알킬, 특히 사이클록헥실, (ⅱ)
    로 R3,R3',R3″,R4,R4' 및 R4″는 독립적으로 수소, 할로겐, 트리플루오로메틸, 하이드록시, 저급 알킬, 저급 알콕시, NR5R6(R5및 R6는 전술한 바와 같음), 또는 SO2NR5R6(R5및 R6는 전술한 바와 같음); 및 A는 없거나 임의의 결합, -CH2-, -CH2CH-, -CH=CH-, -O-, -S(O)z- (Z는 0.1, 또는 2) 또는 NR7(R7은 수소 저급 알킬)을 형성].
  2. 제1항에 있어서, n이 2,3, 또는 4이고 Y가 수소인 화합물.
  3. 제2항에 있어서, B가 (1a)인 화합물.
  4. 제2항에 있어서, B가 (1b)인 화합물.
  5. 제4항에 있어서, A가 없는 화합물.
  6. 제4항에 있어서, X가 산소인 화합물.
  7. 제4항에 있어서, X가 S(O)z(Z는 전술한 바와 같음)인 화합물.
  8. 제6항에 있어서, 3-피페리딘카복실산, 1-[2-[비스(4-클로로페닐)메톡시]에틸]-또는 그것의 에틸 에스테르인 화합물.
  9. 제6항에 있어서, 3-피페리딘카복실산, 1-[2-(디페닐메톡시)에틸]-또는 그것의 에틸 에스테르인 화합물.
  10. 제6항에 있어서, 1-[3-(디페닐메톡시)프로필]- 또는 그것의 에틸 에스테르인 화합물.
  11. 제6항에 있어서, 3-피페리딘카복실산, 1-[2-[(3,4-디클로로페닐)페닐메톡시]에틸]- 또는 그것의 에틸 에스테르인 화합물.
  12. 제6항에 있어서, 3-피페리딘카복실산, 1-[2-[4-클로로-3-(트리플루오로메틸)페닐]페닐메톡시]에틸]-, 및 그것의 에틸 에스테르인 화합물.
  13. 제6항에 있어서, 3-피페리딘카복실산, 1-[2-[(5H-디벤조-[a,b] 사이클로헵텐-5-일 옥시)에틸]]-, 및 그것의 에틸 에스테르인 화합물.
  14. 제6항에 있어서, 3-피페리딘카복사미드, R(-) 1-[2-[비스(4-클로로페닐)메톡시]에틸]-인 화합물, 및 그것의 모노하이드로클로라이드 염.
  15. 제6항에 있어서, 3-피페리딘카복사미드, 1-[2-[비스(4-플루오로페닐)메톡시]에틸]-인 화합물, 및 그것의 모노하이드로클로라이드 염.
  16. 제6항에 있어서, 3-피페리딘카복실산, 1-[2-[비스(3,4-디클로로페닐)메톡시]-에틸인 화합물, 및 그것의 하이드로클로라이드 염.
  17. 제6항에 있어서, 3-피페리딘카복실산, 1-[2-[비스(4-메틸페닐)메톡시]에틸]-, 그것의 에틸 에스테르인 화합물, 및 그것의 모노하이드로클로라이드 염.
  18. 제6항에 있어서, 3-피페리딘카복실산, 1-[2-[비스[4-(트리플루오로메틸)페닐]메톡시]에틸]-1,2,5,6-테트라하이드로-인 화합물.
  19. 제18항에 있어서 당해 모노하이드로클로라이드 염인 화합물.
  20. 제6항에 있어서, 3-피페리딘카복실산, 1-[2-[비스[4-(트리플루오로메틸)페닐]메톡시]에틸]-인 화합물.
  21. 제20항 화합물의 하이드로클로라이드 염.
  22. 제6항에 있어서, 3-피리딘카복실산, 1-[2-[비스[4-클로로페닐]메톡시]에틸]-1,2,5,6-테트라하이드로-인 화합물.
  23. 제22항 화합물의 하이드로클로라이드 염.
  24. 3-피페리딘카복실산, 1-[2-[(디페닐메틸)티오]에틸]-또는 그것의 에틸 에스테르인 화합물.
  25. 제약학적으로 사용 가능한 담체와 함께 치료하기에 유효한 양의 제1항의 화합물로 구성된 제약학적 조성물.
  26. 간질로부터 고통받고 있는 포유 동물에다 진경제로써 유효량의 제1항 화합물을 단일 복용량 형태로 투약하는 것으로 구성되는 간질을 치료하는 방법.
  27. 식중 B,X 및 n이 전술한 바와 같고, Q가 염소, 브롬 또는 OSO2R (R는 메틸 또는 톨릴)인 일반식 (2)의 화합물을 B-X-(CH2)n-Q (2) 식중, Y 및 R'가 전술한 바와 같은 일반식(3)의 화합물과 반응시키는 것으로 구성되는 제1항 화합물의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860009111A 1985-11-08 1986-10-30 다양한 n-치환된 3-피페리딘카복실산 또는 n-치환된 3-피리딘 카복실산 및 당해 유도체와 그 제조방법 KR900005023B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US79634585A 1985-11-08 1985-11-08
US796,345 1985-11-08
US769345 1985-11-08
US89730886A 1986-08-21 1986-08-21
US897308 1986-08-21
US897,308 1986-08-21

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KR870004955A true KR870004955A (ko) 1987-06-02
KR900005023B1 KR900005023B1 (ko) 1990-07-18

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KR1019860009111A KR900005023B1 (ko) 1985-11-08 1986-10-30 다양한 n-치환된 3-피페리딘카복실산 또는 n-치환된 3-피리딘 카복실산 및 당해 유도체와 그 제조방법

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EP (1) EP0221572B1 (ko)
KR (1) KR900005023B1 (ko)
CN (1) CN86107695A (ko)
AT (1) ATE67756T1 (ko)
AU (1) AU590172B2 (ko)
CA (1) CA1270818A (ko)
DE (1) DE3681690D1 (ko)
DK (1) DK165919C (ko)
ES (1) ES2040201T3 (ko)
FI (1) FI864246A (ko)
GR (1) GR3002842T3 (ko)
NO (1) NO864443L (ko)
NZ (1) NZ218170A (ko)
PH (1) PH24683A (ko)
PT (1) PT83705B (ko)

Families Citing this family (15)

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Publication number Priority date Publication date Assignee Title
DK704488D0 (da) * 1988-12-19 1988-12-19 Novo Industri As Nye n-substituerede azaheterocykliske carboxylsyrer
US4910312A (en) * 1985-11-08 1990-03-20 Warner-Lambert Company Various N-substituted 3-piperidine carboxylic acids or N-substituted 3-pyridinecarboxylic acids and derivatives thereof
DK270488D0 (da) * 1988-05-18 1988-05-18 Novo Industri As Hidtil ukendte o-substituerede ketoximer
DK588189D0 (da) * 1989-11-22 1989-11-22 Novo Nordisk As Nye heterocykliske carboxylsyrer
DK93791D0 (da) * 1991-05-17 1991-05-17 Novo Nordisk As Nye heterocykliske carboxylsyrer
DK74593D0 (da) * 1993-06-23 1993-06-23 Novo Nordisk As Novel heterocyclic chemistry
IL112223A0 (en) * 1994-01-04 1995-03-30 Novo Nordisk As Pharmaceutical compositions for the treatment of neurological inflammatory conditions
US5962449A (en) 1995-04-07 1999-10-05 Novo Nordisk A/S Tricyclic compounds in treating hyperalgesic conditions and NIDDM
CA2217194A1 (en) * 1995-04-07 1996-10-10 Novo Nordisk A/S Novel heterocyclic compounds
CA2217200A1 (en) * 1995-04-07 1996-10-10 Novo Nordisk A/S Novel method
CA2217202A1 (en) * 1995-04-07 1996-10-10 Novo Nordisk A/S Novel heterocyclic compounds
US5952352A (en) * 1995-04-07 1999-09-14 Novo Nordisk A/S Heterocyclic compounds
AU5271896A (en) * 1995-04-07 1996-10-23 Novo Nordisk A/S Novel heterocyclic compounds
US6191165B1 (en) 1996-05-31 2001-02-20 Allelix Neuroscience Inc. Pharmaceutical for treatment of neurological and neuropsychiatric disorders
ATE327986T1 (de) 2001-02-16 2006-06-15 Allelix Neuroscience Inc Thiophen substituierte amin derivate als glyt-1 inhibitoren

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US3929813A (en) * 1973-12-26 1975-12-30 Interx Research Corp Novel pro-drug derivatives of pyridinium aldoxime type cholinesterase reactivators and process for preparing same
AU552050B2 (en) * 1981-05-26 1986-05-22 Smithkline Beckman Corporation N-substituted azeheterocyclic carboxylic acids and their esters

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EP0221572B1 (en) 1991-09-25
DK528086D0 (da) 1986-11-05
KR900005023B1 (ko) 1990-07-18
FI864246A (fi) 1987-05-09
DK528086A (da) 1987-05-09
GR3002842T3 (en) 1993-01-25
NO864443D0 (no) 1986-11-07
EP0221572A3 (en) 1987-07-29
ATE67756T1 (de) 1991-10-15
DK165919C (da) 1993-06-28
PH24683A (en) 1990-09-07
NZ218170A (en) 1990-07-26
DK165919B (da) 1993-02-08
FI864246A0 (fi) 1986-10-20
AU590172B2 (en) 1989-10-26
NO864443L (no) 1987-05-11
PT83705B (pt) 1989-05-12
CA1270818A (en) 1990-06-26
CN86107695A (zh) 1987-05-13
DE3681690D1 (de) 1991-10-31
ES2040201T3 (es) 1993-10-16
PT83705A (en) 1986-12-01
EP0221572A2 (en) 1987-05-13
AU6481286A (en) 1987-05-14

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