PT93137A - Processo para a preparacao de n-fenil-n-(4-piperidinil) amidas - Google Patents
Processo para a preparacao de n-fenil-n-(4-piperidinil) amidasInfo
- Publication number
- PT93137A PT93137A PT93137A PT9313790A PT93137A PT 93137 A PT93137 A PT 93137A PT 93137 A PT93137 A PT 93137A PT 9313790 A PT9313790 A PT 9313790A PT 93137 A PT93137 A PT 93137A
- Authority
- PT
- Portugal
- Prior art keywords
- lower alkyl
- group
- alkoxy
- member selected
- carbonyl
- Prior art date
Links
- -1 4-PIPERIDINYL Chemical class 0.000 title abstract 2
- 150000001408 amides Chemical class 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000000202 analgesic effect Effects 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 230000036592 analgesia Effects 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31131189A | 1989-02-15 | 1989-02-15 | |
| US07/448,497 US5019583A (en) | 1989-02-15 | 1989-12-11 | N-phenyl-N-(4-piperidinyl)amides useful as analgesics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT93137A true PT93137A (pt) | 1990-08-31 |
| PT93137B PT93137B (pt) | 1996-02-29 |
Family
ID=26977841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT93137A PT93137B (pt) | 1989-02-15 | 1990-02-14 | Processo para a preparacao de n-fenil-n-(4-piperidinil) amidas |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5019583A (pt) |
| EP (1) | EP0383579B1 (pt) |
| JP (1) | JP2895145B2 (pt) |
| KR (1) | KR0160979B1 (pt) |
| AT (1) | ATE140451T1 (pt) |
| AU (1) | AU636330B2 (pt) |
| CA (1) | CA2010011C (pt) |
| CY (1) | CY2002A (pt) |
| CZ (1) | CZ402591A3 (pt) |
| DE (2) | DE19675028I2 (pt) |
| DK (1) | DK0383579T3 (pt) |
| ES (1) | ES2088961T4 (pt) |
| GR (1) | GR3020719T3 (pt) |
| HK (1) | HK78297A (pt) |
| IE (1) | IE77156B1 (pt) |
| LU (1) | LU90011I2 (pt) |
| MX (1) | MX9203024A (pt) |
| NL (1) | NL960030I2 (pt) |
| NZ (1) | NZ232542A (pt) |
| PT (1) | PT93137B (pt) |
| SG (1) | SG47967A1 (pt) |
| SK (1) | SK402591A3 (pt) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5130321A (en) * | 1990-12-18 | 1992-07-14 | Glaxo Inc. | Analgesic n-phenyl-n-(3-or 1-3-me-4-piperidinyl)amides |
| US5214148A (en) * | 1990-12-18 | 1993-05-25 | Glaxo Inc. | Analgesic N-phenyl-N-(3-OR1 -3-ME-4-piperidinyl)amides |
| GB9316863D0 (en) * | 1993-08-13 | 1993-09-29 | Glaxo Group Ltd | Chemical process |
| US5466700A (en) * | 1993-08-30 | 1995-11-14 | Glaxo Wellcome Inc. | Anesthetic use of N-phenyl-N-(4-piperidinyl)amides |
| US5866591A (en) * | 1996-09-11 | 1999-02-02 | Glaxo Wellcome Inc. | Stable formulations of remifentanil |
| JP4754068B2 (ja) * | 1997-12-24 | 2011-08-24 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | δ−オピオイドレセプターに結合する４−［アリール（ピペリジン−４−イル）］アミノベンズアミド類 |
| US6858018B1 (en) * | 1998-09-28 | 2005-02-22 | Vyteris, Inc. | Iontophoretic devices |
| US6436959B1 (en) | 1998-12-23 | 2002-08-20 | Ortho-Mcneil Pharmaceutical, Inc. | 4-[aryl(piperidin-4-yl)]aminobenzamides |
| AU2427201A (en) | 1999-12-06 | 2001-06-12 | Mallinckrodt, Inc. | New methods for the syntheses of alfentanil, sufentanil and remifentanil |
| US6476050B2 (en) | 2000-03-14 | 2002-11-05 | Sepracor, Inc. | 3-substituted piperidines comprising urea functionality, and methods of use thereof |
| DE20122843U1 (de) * | 2000-07-31 | 2008-06-26 | Nycomed Danmark Aps | Fentanyl Zusammensetzung zur nasalen Anwendung |
| JP2005503351A (ja) | 2001-04-03 | 2005-02-03 | アリックス セラピューティクス | 経皮適用のための超短時間作用性オピオイド |
| US20030130314A1 (en) * | 2001-12-17 | 2003-07-10 | Pascal Druzgala | Analgesic delivery systems and methods of use |
| WO2005030722A1 (ja) * | 2003-09-29 | 2005-04-07 | Nippon Chemiphar Co., Ltd. | Ｎ－置換－ｎ－（４－ピペリジニル）アミド誘導体 |
| JP2008502651A (ja) | 2004-06-18 | 2008-01-31 | ノイロサーチ アクティーゼルスカブ | モノアミン神経伝達物質再取込み阻害剤としての、新規アルキル置換ピペリジン誘導体及びその使用 |
| EP1795526A4 (en) * | 2004-09-14 | 2010-10-13 | Nippon Chemiphar Co | N-SUBSTITUTED N- (4-PIPERIDINYL) AMIDE DERIVATIVE |
| EP1966140A1 (en) * | 2005-11-17 | 2008-09-10 | Mallinckrodt, Inc. | Process for synthesizing remifentanil |
| US20080312448A1 (en) * | 2006-01-24 | 2008-12-18 | Cheng Brian K | Process for Synthesizing Remifentanil |
| JP2009525329A (ja) * | 2006-02-03 | 2009-07-09 | マリンクロッド・インコーポレイテッド | レミフェンタニル塩酸塩の結晶形 |
| EP1867635A1 (en) * | 2006-06-15 | 2007-12-19 | Kern Pharma, S.L. | Process for preparing remifentanil, intermediates thereof, use of said intermediates and processes for their preparation |
| KR20170091770A (ko) | 2006-07-10 | 2017-08-09 | 파이온 유케이 리미티드 | 속효형 벤조디아제핀 염 및 이의 중합체 형태 |
| GB0613693D0 (en) * | 2006-07-10 | 2006-08-16 | Cenes Ltd | Benzodiazepine salts (3) |
| WO2008045192A2 (en) * | 2006-10-05 | 2008-04-17 | Mallinckrodt Inc. | Alternate process for remifentanil preparation |
| CA2670704A1 (en) * | 2006-11-29 | 2008-06-05 | Mallinckrodt Inc. | New process for remifentanil synthesis |
| JP5580287B2 (ja) * | 2008-03-31 | 2014-08-27 | ザ ジェネラル ホスピタル コーポレイション | 改善された薬物速度論的および薬力学的特性を有するエトミデート類似体 |
| US20110144346A1 (en) * | 2008-07-03 | 2011-06-16 | Cilag Ag | Method for producing n-phenyl-n-(4-piperidinyl) amide salts |
| US8299258B2 (en) * | 2008-11-04 | 2012-10-30 | Cambrex Charles City | Method of making piperidine derivatives |
| RU2559888C2 (ru) | 2009-07-10 | 2015-08-20 | Зе Дженерал Хоспитал Корпорэйшн | Аналоги этомидата, которые не ингибируют синтез адренокортикостероидов |
| EP2450039A1 (en) | 2010-11-08 | 2012-05-09 | PAION UK Ltd. | Dosing regimen for sedation with CNS 7056 (Remimazolam) |
| DK2802325T3 (en) | 2012-01-13 | 2017-03-13 | Massachusetts Gen Hospital | ANESTHETIC RELATIONS AND RELATED APPLICATIONS THEREOF |
| EP2903963A4 (en) | 2012-10-08 | 2016-05-25 | Auckland Uniservices Ltd | KETAMINE DERIVATIVES |
| AR094963A1 (es) | 2013-03-04 | 2015-09-09 | Ono Pharmaceutical Co | Reacción de oxidación excelente en el índice de conversión |
| CN103728403B (zh) * | 2013-08-30 | 2015-10-07 | 宜昌人福药业有限责任公司 | 一种盐酸瑞芬太尼原料药中有关物质的检测方法 |
| ES2699636T3 (es) | 2016-01-29 | 2019-02-12 | Bioka S R O | Nuevo procedimiento para la preparación de derivados de N-fenil-N-(4-piperidinil) amida, como remifentanilo y carfentanilo |
| ES2858404T3 (es) | 2018-10-26 | 2021-09-30 | Hameln Pharma Gmbh | Nuevos intermedios para la preparación de clorhidrato de remifentanilo |
| GB202010168D0 (en) * | 2020-07-02 | 2020-08-19 | Johnson Matthey Plc | Process for preparing remifentanil hydrochloride |
| CN114262320A (zh) * | 2021-12-28 | 2022-04-01 | 宜昌人福药业有限责任公司 | 一种利用连续流微通道反应器制备苯胺基哌啶类药物的合成方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE623427A (pt) * | 1961-10-10 | |||
| US3655675A (en) * | 1968-09-09 | 1972-04-11 | Sterling Drug Inc | N-(n-heteryl)-acylanilides |
| US3998834A (en) * | 1975-03-14 | 1976-12-21 | Janssen Pharmaceutica N.V. | N-(4-piperidinyl)-n-phenylamides and -carbamates |
| US4179569A (en) * | 1975-03-14 | 1979-12-18 | Janssen Pharmaceutica N.V. | N-(4-piperidinyl)-N-phenylamides |
| US4167574A (en) * | 1978-03-13 | 1979-09-11 | Janssen Pharmaceutica, N.V. | N-phenyl-N-(4-piperidinyl)amides |
| US4584303A (en) * | 1984-04-09 | 1986-04-22 | The Boc Group, Inc. | N-aryl-N-(4-piperidinyl)amides and pharmaceutical compositions and method employing such compounds |
| US4801721A (en) * | 1984-08-16 | 1989-01-31 | Ryan James W | Stereospecific synthesis of carboxyalkyl peptides |
| CA1317940C (en) * | 1987-09-25 | 1993-05-18 | Georges H. P. Van Daele | Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides |
-
1989
- 1989-12-11 US US07/448,497 patent/US5019583A/en not_active Expired - Lifetime
-
1990
- 1990-02-14 AU AU49731/90A patent/AU636330B2/en not_active Expired
- 1990-02-14 DE DE1996175028 patent/DE19675028I2/de active Active
- 1990-02-14 ES ES90301586T patent/ES2088961T4/es not_active Expired - Lifetime
- 1990-02-14 KR KR1019900001796A patent/KR0160979B1/ko not_active Expired - Lifetime
- 1990-02-14 DK DK90301586.5T patent/DK0383579T3/da active
- 1990-02-14 NZ NZ232542A patent/NZ232542A/en unknown
- 1990-02-14 PT PT93137A patent/PT93137B/pt not_active IP Right Cessation
- 1990-02-14 EP EP90301586A patent/EP0383579B1/en not_active Expired - Lifetime
- 1990-02-14 JP JP2031680A patent/JP2895145B2/ja not_active Expired - Lifetime
- 1990-02-14 IE IE53290A patent/IE77156B1/en not_active IP Right Cessation
- 1990-02-14 SG SG1996005735A patent/SG47967A1/en unknown
- 1990-02-14 DE DE69027794T patent/DE69027794T2/de not_active Expired - Lifetime
- 1990-02-14 AT AT90301586T patent/ATE140451T1/de active
- 1990-02-14 CA CA002010011A patent/CA2010011C/en not_active Expired - Fee Related
-
1991
- 1991-12-23 SK SK4025-91A patent/SK402591A3/sk unknown
- 1991-12-23 CZ CS914025A patent/CZ402591A3/cs unknown
-
1992
- 1992-06-19 MX MX9203024A patent/MX9203024A/es unknown
-
1996
- 1996-08-02 GR GR960402083T patent/GR3020719T3/el unknown
- 1996-11-21 NL NL960030C patent/NL960030I2/nl unknown
-
1997
- 1997-01-24 LU LU90011C patent/LU90011I2/fr unknown
- 1997-06-12 HK HK78297A patent/HK78297A/en not_active IP Right Cessation
- 1997-12-05 CY CY200297A patent/CY2002A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL960030I2 (nl) | 1997-05-01 |
| CZ402591A3 (en) | 1993-04-14 |
| KR0160979B1 (ko) | 1998-12-01 |
| CY2002A (en) | 1997-12-05 |
| JPH02300167A (ja) | 1990-12-12 |
| IE77156B1 (en) | 1997-12-03 |
| HK78297A (en) | 1997-06-20 |
| AU4973190A (en) | 1990-08-23 |
| PT93137B (pt) | 1996-02-29 |
| CA2010011A1 (en) | 1990-08-15 |
| ES2088961T4 (es) | 1996-12-01 |
| EP0383579A1 (en) | 1990-08-22 |
| KR900012906A (ko) | 1990-09-03 |
| MX9203024A (es) | 1992-07-01 |
| DE69027794D1 (de) | 1996-08-22 |
| GR3020719T3 (en) | 1996-11-30 |
| AU636330B2 (en) | 1993-04-29 |
| DK0383579T3 (da) | 1996-10-14 |
| DE19675028I2 (de) | 2002-11-07 |
| CA2010011C (en) | 1997-12-02 |
| ES2088961T3 (es) | 1996-10-01 |
| SG47967A1 (en) | 1998-04-17 |
| IE900532L (en) | 1990-08-15 |
| EP0383579B1 (en) | 1996-07-17 |
| ATE140451T1 (de) | 1996-08-15 |
| SK402591A3 (en) | 2000-09-12 |
| JP2895145B2 (ja) | 1999-05-24 |
| DE69027794T2 (de) | 1997-01-02 |
| NL960030I1 (nl) | 1997-02-03 |
| LU90011I2 (fr) | 1997-03-11 |
| NZ232542A (en) | 1992-06-25 |
| US5019583A (en) | 1991-05-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19951114 |
|
| PC4A | Transfer of assignment |
Owner name: GLAXO WELLCOME INC., US Effective date: 20090624 Owner name: SMITHKLINE BEECHAM CORPORATION, US Effective date: 20090624 |
|
| MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20101115 |