PT93137A - Processo para a preparacao de n-fenil-n-(4-piperidinil) amidas - Google Patents

Processo para a preparacao de n-fenil-n-(4-piperidinil) amidas

Info

Publication number
PT93137A
PT93137A PT93137A PT9313790A PT93137A PT 93137 A PT93137 A PT 93137A PT 93137 A PT93137 A PT 93137A PT 9313790 A PT9313790 A PT 9313790A PT 93137 A PT93137 A PT 93137A
Authority
PT
Portugal
Prior art keywords
lower alkyl
group
alkoxy
member selected
carbonyl
Prior art date
Application number
PT93137A
Other languages
English (en)
Other versions
PT93137B (pt
Inventor
Paul L Feldman
Michael K James
Marcus F Brackeen
Michael Ross Johnson
Harry Jefferson Leighton
Original Assignee
Glaxo Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Inc filed Critical Glaxo Inc
Publication of PT93137A publication Critical patent/PT93137A/pt
Publication of PT93137B publication Critical patent/PT93137B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
PT93137A 1989-02-15 1990-02-14 Processo para a preparacao de n-fenil-n-(4-piperidinil) amidas PT93137B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31131189A 1989-02-15 1989-02-15
US07/448,497 US5019583A (en) 1989-02-15 1989-12-11 N-phenyl-N-(4-piperidinyl)amides useful as analgesics

Publications (2)

Publication Number Publication Date
PT93137A true PT93137A (pt) 1990-08-31
PT93137B PT93137B (pt) 1996-02-29

Family

ID=26977841

Family Applications (1)

Application Number Title Priority Date Filing Date
PT93137A PT93137B (pt) 1989-02-15 1990-02-14 Processo para a preparacao de n-fenil-n-(4-piperidinil) amidas

Country Status (22)

Country Link
US (1) US5019583A (pt)
EP (1) EP0383579B1 (pt)
JP (1) JP2895145B2 (pt)
KR (1) KR0160979B1 (pt)
AT (1) ATE140451T1 (pt)
AU (1) AU636330B2 (pt)
CA (1) CA2010011C (pt)
CY (1) CY2002A (pt)
CZ (1) CZ402591A3 (pt)
DE (2) DE19675028I2 (pt)
DK (1) DK0383579T3 (pt)
ES (1) ES2088961T4 (pt)
GR (1) GR3020719T3 (pt)
HK (1) HK78297A (pt)
IE (1) IE77156B1 (pt)
LU (1) LU90011I2 (pt)
MX (1) MX9203024A (pt)
NL (1) NL960030I2 (pt)
NZ (1) NZ232542A (pt)
PT (1) PT93137B (pt)
SG (1) SG47967A1 (pt)
SK (1) SK402591A3 (pt)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
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US5130321A (en) * 1990-12-18 1992-07-14 Glaxo Inc. Analgesic n-phenyl-n-(3-or 1-3-me-4-piperidinyl)amides
US5214148A (en) * 1990-12-18 1993-05-25 Glaxo Inc. Analgesic N-phenyl-N-(3-OR1 -3-ME-4-piperidinyl)amides
GB9316863D0 (en) * 1993-08-13 1993-09-29 Glaxo Group Ltd Chemical process
US5466700A (en) * 1993-08-30 1995-11-14 Glaxo Wellcome Inc. Anesthetic use of N-phenyl-N-(4-piperidinyl)amides
US5866591A (en) * 1996-09-11 1999-02-02 Glaxo Wellcome Inc. Stable formulations of remifentanil
JP4754068B2 (ja) * 1997-12-24 2011-08-24 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド δ−オピオイドレセプターに結合する４−［アリール（ピペリジン−４−イル）］アミノベンズアミド類
US6858018B1 (en) * 1998-09-28 2005-02-22 Vyteris, Inc. Iontophoretic devices
US6436959B1 (en) 1998-12-23 2002-08-20 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(piperidin-4-yl)]aminobenzamides
BR0016063A (pt) 1999-12-06 2002-08-06 Mallinckrodt Inc Métodos para a sìntese de alfentanila, sufentanila e remifentanila
WO2001068604A2 (en) 2000-03-14 2001-09-20 Sepracor, Inc. 3-substituted piperidines comprising urea functionality, and methods of use thereof
CA2417727C (en) * 2000-07-31 2009-09-01 Nycomed Danmark A/S Fentanyl composition for nasal administration
WO2002096351A2 (en) * 2001-04-03 2002-12-05 Aryx Therapeutics Ultrashort-acting opioids for transdermal application
JP2005516926A (ja) * 2001-12-17 2005-06-09 アリックス セラピューティクス 鎮痛薬の送達システム及び使用方法
WO2005030722A1 (ja) * 2003-09-29 2005-04-07 Nippon Chemiphar Co., Ltd. Ｎ－置換－ｎ－（４－ピペリジニル）アミド誘導体
CA2570075A1 (en) 2004-06-18 2005-12-29 Neurosearch A/S Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
JPWO2006030931A1 (ja) * 2004-09-14 2008-05-15 日本ケミファ株式会社 Ｎ−置換−ｎ−（４−ピペリジニル）アミド誘導体
US20080319196A1 (en) * 2005-11-17 2008-12-25 Cheng Brian K Process for Synthesizing Remifentanil
JP2009524659A (ja) * 2006-01-24 2009-07-02 マリンクロッド・インコーポレイテッド レミフェンタニルの合成方法
US20080319197A1 (en) * 2006-02-03 2008-12-25 Cheng Brian K Crystalline Form of Remifentanil Hydrochloride
EP1867635A1 (en) * 2006-06-15 2007-12-19 Kern Pharma, S.L. Process for preparing remifentanil, intermediates thereof, use of said intermediates and processes for their preparation
GB0613693D0 (en) * 2006-07-10 2006-08-16 Cenes Ltd Benzodiazepine salts (3)
PT2081921E (pt) 2006-07-10 2010-12-10 Paion Uk Ltd Sais de benzodiazepina de acção curta e suas formas polimórficas
WO2008045192A2 (en) * 2006-10-05 2008-04-17 Mallinckrodt Inc. Alternate process for remifentanil preparation
AU2007325889A1 (en) * 2006-11-29 2008-06-05 Mallinckrodt Inc. New process for remifentanil synthesis
WO2009146024A1 (en) * 2008-03-31 2009-12-03 The General Hospital Corporation Etomidate analogues with improved pharmacokinetic and pharmacodynamic properties
JP2011526257A (ja) * 2008-07-03 2011-10-06 シラグ アーゲー Ｎ−フェニル−ｎ−（４−ピペリジニル）アミド塩の製造方法
WO2010053944A1 (en) * 2008-11-04 2010-05-14 Cambrex Charles City, Inc. Improved method of making piperidine derivatives
CN102548964B (zh) 2009-07-10 2014-09-24 通用医疗公司 不抑制肾上腺皮质类固醇合成的依托咪酯类似物
EP2450039A1 (en) 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
EP3184512B1 (en) 2012-01-13 2020-12-23 The General Hospital Corporation Anesthetic compounds and related methods of use
CA2922340A1 (en) 2012-10-08 2014-04-17 Auckland Uniservices Limited Ketamine derivatives
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
CN103728403B (zh) * 2013-08-30 2015-10-07 宜昌人福药业有限责任公司 一种盐酸瑞芬太尼原料药中有关物质的检测方法
ES2699636T3 (es) 2016-01-29 2019-02-12 Bioka S R O Nuevo procedimiento para la preparación de derivados de N-fenil-N-(4-piperidinil) amida, como remifentanilo y carfentanilo
EP3643704B1 (en) 2018-10-26 2020-12-16 hameln pharma gmbh New intermediates for the preparation of remifentanil hydrochloride
GB202010168D0 (en) 2020-07-02 2020-08-19 Johnson Matthey Plc Process for preparing remifentanil hydrochloride
CN114262320A (zh) * 2021-12-28 2022-04-01 宜昌人福药业有限责任公司 一种利用连续流微通道反应器制备苯胺基哌啶类药物的合成方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL284196A (pt) * 1961-10-10
US3655675A (en) * 1968-09-09 1972-04-11 Sterling Drug Inc N-(n-heteryl)-acylanilides
US4179569A (en) * 1975-03-14 1979-12-18 Janssen Pharmaceutica N.V. N-(4-piperidinyl)-N-phenylamides
US3998834A (en) * 1975-03-14 1976-12-21 Janssen Pharmaceutica N.V. N-(4-piperidinyl)-n-phenylamides and -carbamates
US4167574A (en) * 1978-03-13 1979-09-11 Janssen Pharmaceutica, N.V. N-phenyl-N-(4-piperidinyl)amides
US4584303A (en) * 1984-04-09 1986-04-22 The Boc Group, Inc. N-aryl-N-(4-piperidinyl)amides and pharmaceutical compositions and method employing such compounds
US4801721A (en) * 1984-08-16 1989-01-31 Ryan James W Stereospecific synthesis of carboxyalkyl peptides
CA1317940C (en) * 1987-09-25 1993-05-18 Georges H. P. Van Daele Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides

Also Published As

Publication number Publication date
HK78297A (en) 1997-06-20
KR0160979B1 (ko) 1998-12-01
IE900532L (en) 1990-08-15
US5019583A (en) 1991-05-28
DE69027794D1 (de) 1996-08-22
CA2010011C (en) 1997-12-02
EP0383579B1 (en) 1996-07-17
CA2010011A1 (en) 1990-08-15
ATE140451T1 (de) 1996-08-15
DK0383579T3 (da) 1996-10-14
MX9203024A (es) 1992-07-01
LU90011I2 (fr) 1997-03-11
KR900012906A (ko) 1990-09-03
DE19675028I2 (de) 2002-11-07
AU4973190A (en) 1990-08-23
JPH02300167A (ja) 1990-12-12
ES2088961T4 (es) 1996-12-01
SG47967A1 (en) 1998-04-17
PT93137B (pt) 1996-02-29
NL960030I1 (nl) 1997-02-03
EP0383579A1 (en) 1990-08-22
NL960030I2 (nl) 1997-05-01
GR3020719T3 (en) 1996-11-30
ES2088961T3 (es) 1996-10-01
DE69027794T2 (de) 1997-01-02
AU636330B2 (en) 1993-04-29
SK402591A3 (en) 2000-09-12
IE77156B1 (en) 1997-12-03
NZ232542A (en) 1992-06-25
JP2895145B2 (ja) 1999-05-24
CY2002A (en) 1997-12-05
CZ402591A3 (en) 1993-04-14

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19951114

PC4A Transfer of assignment

Owner name: GLAXO WELLCOME INC., US

Effective date: 20090624

Owner name: SMITHKLINE BEECHAM CORPORATION, US

Effective date: 20090624

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20101115