HK78297A - N-phenyl-N-(4-piperidinyl)-amides useful as analgesics - Google Patents
N-phenyl-N-(4-piperidinyl)-amides useful as analgesicsInfo
- Publication number
- HK78297A HK78297A HK78297A HK78297A HK78297A HK 78297 A HK78297 A HK 78297A HK 78297 A HK78297 A HK 78297A HK 78297 A HK78297 A HK 78297A HK 78297 A HK78297 A HK 78297A
- Authority
- HK
- Hong Kong
- Prior art keywords
- lower alkyl
- group
- alkoxy
- member selected
- carbonyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31131189A | 1989-02-15 | 1989-02-15 | |
US07/448,497 US5019583A (en) | 1989-02-15 | 1989-12-11 | N-phenyl-N-(4-piperidinyl)amides useful as analgesics |
Publications (1)
Publication Number | Publication Date |
---|---|
HK78297A true HK78297A (en) | 1997-06-20 |
Family
ID=26977841
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK78297A HK78297A (en) | 1989-02-15 | 1997-06-12 | N-phenyl-N-(4-piperidinyl)-amides useful as analgesics |
Country Status (22)
Country | Link |
---|---|
US (1) | US5019583A (pt) |
EP (1) | EP0383579B1 (pt) |
JP (1) | JP2895145B2 (pt) |
KR (1) | KR0160979B1 (pt) |
AT (1) | ATE140451T1 (pt) |
AU (1) | AU636330B2 (pt) |
CA (1) | CA2010011C (pt) |
CY (1) | CY2002A (pt) |
CZ (1) | CZ402591A3 (pt) |
DE (2) | DE69027794T2 (pt) |
DK (1) | DK0383579T3 (pt) |
ES (1) | ES2088961T4 (pt) |
GR (1) | GR3020719T3 (pt) |
HK (1) | HK78297A (pt) |
IE (1) | IE77156B1 (pt) |
LU (1) | LU90011I2 (pt) |
MX (1) | MX9203024A (pt) |
NL (1) | NL960030I2 (pt) |
NZ (1) | NZ232542A (pt) |
PT (1) | PT93137B (pt) |
SG (1) | SG47967A1 (pt) |
SK (1) | SK402591A3 (pt) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5214148A (en) * | 1990-12-18 | 1993-05-25 | Glaxo Inc. | Analgesic N-phenyl-N-(3-OR1 -3-ME-4-piperidinyl)amides |
US5130321A (en) * | 1990-12-18 | 1992-07-14 | Glaxo Inc. | Analgesic n-phenyl-n-(3-or 1-3-me-4-piperidinyl)amides |
GB9316863D0 (en) * | 1993-08-13 | 1993-09-29 | Glaxo Group Ltd | Chemical process |
US5466700A (en) * | 1993-08-30 | 1995-11-14 | Glaxo Wellcome Inc. | Anesthetic use of N-phenyl-N-(4-piperidinyl)amides |
US5866591A (en) * | 1996-09-11 | 1999-02-02 | Glaxo Wellcome Inc. | Stable formulations of remifentanil |
ES2251121T3 (es) * | 1997-12-24 | 2006-04-16 | Ortho-Mcneil Pharmaceutical, Inc. | (4)-aril(piperidin-4-il) aminobenzamidas que se unen al receptor opioide delta. |
US6858018B1 (en) | 1998-09-28 | 2005-02-22 | Vyteris, Inc. | Iontophoretic devices |
US6436959B1 (en) | 1998-12-23 | 2002-08-20 | Ortho-Mcneil Pharmaceutical, Inc. | 4-[aryl(piperidin-4-yl)]aminobenzamides |
ES2272354T3 (es) | 1999-12-06 | 2007-05-01 | Mallinckrodt Inc. | Metodos para la sintesis de alfentanilo,sufentanilo remifentanilo. |
WO2001068604A2 (en) | 2000-03-14 | 2001-09-20 | Sepracor, Inc. | 3-substituted piperidines comprising urea functionality, and methods of use thereof |
PL207845B1 (pl) * | 2000-07-31 | 2011-02-28 | Nycomed Danmark As | Spray donosowy do dostarczania kompozycji farmaceutycznej zawierającej fentanyl i zastosowanie soli fentanylu do wytwarzania środka leczniczego |
CA2443350A1 (en) * | 2001-04-03 | 2002-12-05 | Aryx Therapeutics | Ultrashort-acting opioids for transdermal application |
AU2002361709A1 (en) * | 2001-12-17 | 2003-06-30 | Aryx Therapeutics | Analgesic delivery systems and methods of use |
JPWO2005030722A1 (ja) * | 2003-09-29 | 2006-12-07 | 日本ケミファ株式会社 | N−置換−n−(4−ピペリジニル)アミド誘導体 |
EP1761493A2 (en) | 2004-06-18 | 2007-03-14 | Neurosearch A/S | Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
WO2006030931A1 (ja) * | 2004-09-14 | 2006-03-23 | Nippon Chemiphar Co., Ltd. | N-置換-n-(4-ピペリジニル)アミド誘導体 |
JP2009515960A (ja) * | 2005-11-17 | 2009-04-16 | マリンクロッド・インコーポレイテッド | レミフェンタニルの合成方法 |
AU2007208438A1 (en) * | 2006-01-24 | 2007-08-02 | Mallinckrodt Inc. | Process for synthesizing remifentanil |
JP2009525329A (ja) * | 2006-02-03 | 2009-07-09 | マリンクロッド・インコーポレイテッド | レミフェンタニル塩酸塩の結晶形 |
EP1867635A1 (en) * | 2006-06-15 | 2007-12-19 | Kern Pharma, S.L. | Process for preparing remifentanil, intermediates thereof, use of said intermediates and processes for their preparation |
KR20090045233A (ko) | 2006-07-10 | 2009-05-07 | 파이온 유케이 리미티드 | 속효형 벤조디아제핀 염 및 이의 중합체 형태 |
GB0613693D0 (en) * | 2006-07-10 | 2006-08-16 | Cenes Ltd | Benzodiazepine salts (3) |
WO2008045192A2 (en) * | 2006-10-05 | 2008-04-17 | Mallinckrodt Inc. | Alternate process for remifentanil preparation |
KR20090083422A (ko) * | 2006-11-29 | 2009-08-03 | 말린크로트, 인코포레이티드 | 레미펜타닐의 신규 합성 방법 |
CN102046607B (zh) | 2008-03-31 | 2014-06-11 | 通用医疗公司 | 具有提高的药物动力学性能和药效学性能的依托咪酯类似物 |
US20110144346A1 (en) * | 2008-07-03 | 2011-06-16 | Cilag Ag | Method for producing n-phenyl-n-(4-piperidinyl) amide salts |
US8299258B2 (en) * | 2008-11-04 | 2012-10-30 | Cambrex Charles City | Method of making piperidine derivatives |
CN102548964B (zh) | 2009-07-10 | 2014-09-24 | 通用医疗公司 | 不抑制肾上腺皮质类固醇合成的依托咪酯类似物 |
EP2450039A1 (en) | 2010-11-08 | 2012-05-09 | PAION UK Ltd. | Dosing regimen for sedation with CNS 7056 (Remimazolam) |
WO2013106717A1 (en) | 2012-01-13 | 2013-07-18 | The General Hospital Corporation | Anesthetic compounds and related methods of use |
WO2014057414A1 (en) | 2012-10-08 | 2014-04-17 | Auckland Uniservices Limited | Ketamine derivatives |
AR094963A1 (es) | 2013-03-04 | 2015-09-09 | Ono Pharmaceutical Co | Reacción de oxidación excelente en el índice de conversión |
CN103728403B (zh) * | 2013-08-30 | 2015-10-07 | 宜昌人福药业有限责任公司 | 一种盐酸瑞芬太尼原料药中有关物质的检测方法 |
SI3199523T1 (sl) | 2016-01-29 | 2018-12-31 | Bioka S.R.O. | Nov postopek za pridobivanje n-fenil-n-(4-piperinidil)amidnih derivatov kot sta remifentanil in karfentanil |
RS61517B1 (sr) | 2018-10-26 | 2021-03-31 | Hameln Pharma Gmbh | Novi intermedijeri za pripremu remifentanil hidrohlorida |
GB202010168D0 (en) | 2020-07-02 | 2020-08-19 | Johnson Matthey Plc | Process for preparing remifentanil hydrochloride |
CN114262320A (zh) * | 2021-12-28 | 2022-04-01 | 宜昌人福药业有限责任公司 | 一种利用连续流微通道反应器制备苯胺基哌啶类药物的合成方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE623427A (pt) * | 1961-10-10 | |||
US3655675A (en) * | 1968-09-09 | 1972-04-11 | Sterling Drug Inc | N-(n-heteryl)-acylanilides |
US3998834A (en) * | 1975-03-14 | 1976-12-21 | Janssen Pharmaceutica N.V. | N-(4-piperidinyl)-n-phenylamides and -carbamates |
US4179569A (en) * | 1975-03-14 | 1979-12-18 | Janssen Pharmaceutica N.V. | N-(4-piperidinyl)-N-phenylamides |
US4167574A (en) * | 1978-03-13 | 1979-09-11 | Janssen Pharmaceutica, N.V. | N-phenyl-N-(4-piperidinyl)amides |
US4584303A (en) * | 1984-04-09 | 1986-04-22 | The Boc Group, Inc. | N-aryl-N-(4-piperidinyl)amides and pharmaceutical compositions and method employing such compounds |
US4801721A (en) * | 1984-08-16 | 1989-01-31 | Ryan James W | Stereospecific synthesis of carboxyalkyl peptides |
CA1317940C (en) * | 1987-09-25 | 1993-05-18 | Georges H. P. Van Daele | Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides |
-
1989
- 1989-12-11 US US07/448,497 patent/US5019583A/en not_active Expired - Lifetime
-
1990
- 1990-02-14 AT AT90301586T patent/ATE140451T1/de active
- 1990-02-14 DE DE69027794T patent/DE69027794T2/de not_active Expired - Lifetime
- 1990-02-14 SG SG1996005735A patent/SG47967A1/en unknown
- 1990-02-14 EP EP90301586A patent/EP0383579B1/en not_active Expired - Lifetime
- 1990-02-14 PT PT93137A patent/PT93137B/pt not_active IP Right Cessation
- 1990-02-14 CA CA002010011A patent/CA2010011C/en not_active Expired - Fee Related
- 1990-02-14 KR KR1019900001796A patent/KR0160979B1/ko not_active IP Right Cessation
- 1990-02-14 NZ NZ232542A patent/NZ232542A/en unknown
- 1990-02-14 DK DK90301586.5T patent/DK0383579T3/da active
- 1990-02-14 AU AU49731/90A patent/AU636330B2/en not_active Expired
- 1990-02-14 JP JP2031680A patent/JP2895145B2/ja not_active Expired - Lifetime
- 1990-02-14 ES ES90301586T patent/ES2088961T4/es not_active Expired - Lifetime
- 1990-02-14 DE DE1996175028 patent/DE19675028I2/de active Active
- 1990-02-14 IE IE53290A patent/IE77156B1/en not_active IP Right Cessation
-
1991
- 1991-12-23 SK SK4025-91A patent/SK402591A3/sk unknown
- 1991-12-23 CZ CS914025A patent/CZ402591A3/cs unknown
-
1992
- 1992-06-19 MX MX9203024A patent/MX9203024A/es unknown
-
1996
- 1996-08-02 GR GR960402083T patent/GR3020719T3/el unknown
- 1996-11-21 NL NL960030C patent/NL960030I2/nl unknown
-
1997
- 1997-01-24 LU LU90011C patent/LU90011I2/fr unknown
- 1997-06-12 HK HK78297A patent/HK78297A/xx not_active IP Right Cessation
- 1997-12-05 CY CY200297A patent/CY2002A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
SG47967A1 (en) | 1998-04-17 |
CA2010011C (en) | 1997-12-02 |
CZ402591A3 (en) | 1993-04-14 |
ES2088961T4 (es) | 1996-12-01 |
CY2002A (en) | 1997-12-05 |
AU636330B2 (en) | 1993-04-29 |
CA2010011A1 (en) | 1990-08-15 |
EP0383579A1 (en) | 1990-08-22 |
ATE140451T1 (de) | 1996-08-15 |
PT93137B (pt) | 1996-02-29 |
ES2088961T3 (es) | 1996-10-01 |
DE69027794D1 (de) | 1996-08-22 |
KR900012906A (ko) | 1990-09-03 |
IE900532L (en) | 1990-08-15 |
IE77156B1 (en) | 1997-12-03 |
US5019583A (en) | 1991-05-28 |
PT93137A (pt) | 1990-08-31 |
NL960030I1 (nl) | 1997-02-03 |
DK0383579T3 (da) | 1996-10-14 |
JP2895145B2 (ja) | 1999-05-24 |
JPH02300167A (ja) | 1990-12-12 |
MX9203024A (es) | 1992-07-01 |
DE19675028I2 (de) | 2002-11-07 |
DE69027794T2 (de) | 1997-01-02 |
SK402591A3 (en) | 2000-09-12 |
EP0383579B1 (en) | 1996-07-17 |
KR0160979B1 (ko) | 1998-12-01 |
NZ232542A (en) | 1992-06-25 |
AU4973190A (en) | 1990-08-23 |
LU90011I2 (fr) | 1997-03-11 |
NL960030I2 (nl) | 1997-05-01 |
GR3020719T3 (en) | 1996-11-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PF | Patent in force | ||
PE | Patent expired |
Effective date: 20100213 |