ATE137803T1 - Verfahren zur herstellung von 7-aminocephem- verbindungen oder deren salzen - Google Patents
Verfahren zur herstellung von 7-aminocephem- verbindungen oder deren salzenInfo
- Publication number
- ATE137803T1 ATE137803T1 AT90313988T AT90313988T ATE137803T1 AT E137803 T1 ATE137803 T1 AT E137803T1 AT 90313988 T AT90313988 T AT 90313988T AT 90313988 T AT90313988 T AT 90313988T AT E137803 T1 ATE137803 T1 AT E137803T1
- Authority
- AT
- Austria
- Prior art keywords
- compound
- producing
- aminocephem
- cooh
- acremonium chrysogenum
- Prior art date
Links
- QITDACOZCQXYQY-BAFYGKSASA-N (6r)-7-amino-5-thia-1-azabicyclo[4.2.0]oct-2-en-8-one Chemical class S1CC=CN2C(=O)C(N)[C@H]21 QITDACOZCQXYQY-BAFYGKSASA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- -1 7-aminocephem compound Chemical class 0.000 abstract 8
- 229930186147 Cephalosporin Natural products 0.000 abstract 3
- 229940124587 cephalosporin Drugs 0.000 abstract 3
- 244000005700 microbiome Species 0.000 abstract 3
- 241000228431 Acremonium chrysogenum Species 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 230000002538 fungal effect Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 108010033239 Acremonium chrysogenum alkaline protease Proteins 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 229910052739 hydrogen Chemical group 0.000 abstract 1
- 239000001257 hydrogen Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
- C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
- C12N9/0024—D-Amino acid oxidase (1.4.3.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cephalosporin Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP34211389 | 1989-12-27 | ||
| JP19360990 | 1990-07-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE137803T1 true ATE137803T1 (de) | 1996-05-15 |
Family
ID=26507976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90313988T ATE137803T1 (de) | 1989-12-27 | 1990-12-20 | Verfahren zur herstellung von 7-aminocephem- verbindungen oder deren salzen |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5677141A (de) |
| EP (1) | EP0436355B1 (de) |
| JP (3) | JP3057759B2 (de) |
| KR (1) | KR0171897B1 (de) |
| AT (1) | ATE137803T1 (de) |
| CA (1) | CA2032963C (de) |
| DE (1) | DE69026921T2 (de) |
| DK (1) | DK0436355T3 (de) |
| ES (1) | ES2086386T3 (de) |
| GR (1) | GR3020071T3 (de) |
| HU (1) | HU212767B (de) |
| IE (1) | IE75376B1 (de) |
| TR (1) | TR27317A (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9019724D0 (en) * | 1990-09-10 | 1990-10-24 | Fujisawa Pharmaceutical Co | Cephalosporin c acylase |
| US5318896A (en) * | 1991-09-11 | 1994-06-07 | Merck & Co., Inc. | Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA) |
| KR100227711B1 (ko) * | 1991-10-15 | 1999-12-01 | 한스 발터 라벤 | 7-아미노세팔로스포란산 및 7-아미노데아세틸세팔로스포란산 제조를 위한 신규한 생물학적 공정 |
| CA2100987C (en) * | 1992-07-27 | 1999-06-15 | Kaoru Furuya | A transformant capable of producing d-amino acid oxidase |
| KR100481138B1 (ko) | 1997-09-09 | 2005-04-11 | 바이오케미 게젤샤프트 엠베하 | 효소 활성을 갖는 미생물을 함유하는 구형 입자 및 구형 입자의 제조방법 |
| US6410323B1 (en) * | 1999-08-31 | 2002-06-25 | Isis Pharmaceuticals, Inc. | Antisense modulation of human Rho family gene expression |
| AU2002310863A1 (en) * | 2001-04-19 | 2002-11-05 | Bioferma Murcia, S.A. | Enzymatic process for preparing cephalosporanic acid derivatives using alpha-ketoacid derivatives |
| DE10153792A1 (de) * | 2001-10-31 | 2003-05-22 | Henkel Kgaa | Neue Alkalische Protease-Varianten und Wasch- und Reinigungsmittel enthaltend diese neuen Alkalischen Protease-Varianten |
| ATE302283T1 (de) * | 2002-10-31 | 2005-09-15 | Bioferma Murcia S A | Einfaches enzymatisches verfahren zur herstellung von cefazolin |
| KR100530299B1 (ko) * | 2003-08-11 | 2005-11-22 | 산도즈 게엠베하 | 변이 세팔로스포린 ｃ 아실라제 및 이를 이용한 7-ａｃａ 제조방법 |
| ITMI20040016A1 (it) * | 2004-01-12 | 2004-04-12 | Antibiotics S P A | Cefalosporina c acilasi |
| US8221363B2 (en) | 2006-10-18 | 2012-07-17 | Baxter Healthcare S.A. | Luer activated device with valve element under tension |
| US7981090B2 (en) | 2006-10-18 | 2011-07-19 | Baxter International Inc. | Luer activated device |
| US7753338B2 (en) | 2006-10-23 | 2010-07-13 | Baxter International Inc. | Luer activated device with minimal fluid displacement |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS52143289A (en) * | 1976-05-24 | 1977-11-29 | Meiji Seika Kaisha Ltd | Production of 7-amino-cephem derivatives by filamentous fungi |
| US4925794A (en) * | 1985-01-02 | 1990-05-15 | Fujisawa Pharmaceutical Co., Ltd. | Hybrid plasmids and microorganisms containing them |
| US5208155A (en) * | 1985-01-11 | 1993-05-04 | Klaus Mosbach | D-amino acid oxidase and method for isolation thereof |
| EP0200425B1 (de) * | 1985-04-22 | 1991-12-27 | Eli Lilly And Company | Rekombinante DNS-Expressionsvektoren und DNS-Verbindungen |
| JPH0829114B2 (ja) * | 1986-09-18 | 1996-03-27 | 旭化成工業株式会社 | ７−アミノセフアロスポラン酸およびその誘導体の製造法 |
| EP0322032A3 (de) * | 1987-12-21 | 1991-01-30 | Merck & Co. Inc. | Enzymatische Umwandlung von Cephalosporin C und Derivaten in 7-Aminocephalosporinsäure und Derivate in einem Schritt |
| ES2020792A6 (es) * | 1990-08-03 | 1991-09-16 | Antibioticos Sa | Un procedimiento enzimatico para la presentacion de acido 7-amino-cefa-losporanico y un procedimiento para expresar la enzima 7b (4-carboxibutanamido) cefalosporinacilasa. |
| IT1252308B (it) * | 1990-12-21 | 1995-06-08 | Antibioticos Spa | Procedimento enzimatico per la produzione di acido 7- amminocefalosporanico e derivati |
| KR100227711B1 (ko) * | 1991-10-15 | 1999-12-01 | 한스 발터 라벤 | 7-아미노세팔로스포란산 및 7-아미노데아세틸세팔로스포란산 제조를 위한 신규한 생물학적 공정 |
-
1990
- 1990-08-30 KR KR1019900013653A patent/KR0171897B1/ko not_active Expired - Fee Related
- 1990-11-30 JP JP2338897A patent/JP3057759B2/ja not_active Expired - Fee Related
- 1990-12-20 DK DK90313988.9T patent/DK0436355T3/da active
- 1990-12-20 ES ES90313988T patent/ES2086386T3/es not_active Expired - Lifetime
- 1990-12-20 IE IE464090A patent/IE75376B1/en not_active IP Right Cessation
- 1990-12-20 AT AT90313988T patent/ATE137803T1/de not_active IP Right Cessation
- 1990-12-20 DE DE69026921T patent/DE69026921T2/de not_active Expired - Fee Related
- 1990-12-20 EP EP90313988A patent/EP0436355B1/de not_active Expired - Lifetime
- 1990-12-21 CA CA002032963A patent/CA2032963C/en not_active Expired - Fee Related
- 1990-12-21 HU HU908442A patent/HU212767B/hu not_active IP Right Cessation
-
1991
- 1991-01-18 TR TR00023/91A patent/TR27317A/xx unknown
-
1994
- 1994-09-30 US US08/314,309 patent/US5677141A/en not_active Expired - Fee Related
-
1996
- 1996-05-28 GR GR960401435T patent/GR3020071T3/el unknown
-
2000
- 2000-01-11 JP JP2000002148A patent/JP3239359B2/ja not_active Expired - Fee Related
- 2000-11-17 JP JP2000350331A patent/JP2001186894A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001186894A (ja) | 2001-07-10 |
| JPH04234994A (ja) | 1992-08-24 |
| DE69026921T2 (de) | 1996-11-14 |
| HU212767B (en) | 1996-11-28 |
| CA2032963C (en) | 2002-02-19 |
| HUT58368A (en) | 1992-02-28 |
| EP0436355A2 (de) | 1991-07-10 |
| JP2000152796A (ja) | 2000-06-06 |
| CA2032963A1 (en) | 1991-06-28 |
| IE904640A1 (en) | 1991-07-17 |
| EP0436355A3 (en) | 1991-10-09 |
| DE69026921D1 (de) | 1996-06-13 |
| JP3057759B2 (ja) | 2000-07-04 |
| EP0436355B1 (de) | 1996-05-08 |
| ES2086386T3 (es) | 1996-07-01 |
| US5677141A (en) | 1997-10-14 |
| JP3239359B2 (ja) | 2001-12-17 |
| DK0436355T3 (da) | 1996-05-28 |
| KR910012261A (ko) | 1991-07-30 |
| GR3020071T3 (en) | 1996-08-31 |
| HU908442D0 (en) | 1991-07-29 |
| TR27317A (tr) | 1995-01-12 |
| KR0171897B1 (ko) | 1999-02-01 |
| IE75376B1 (en) | 1997-09-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |